DE69232064D1 - Peptide als Amylin-Agonisten und ihre Verwendung - Google Patents

Peptide als Amylin-Agonisten und ihre Verwendung

Info

Publication number: DE69232064D1
Authority: DE; Germany
Prior art keywords: pro; ser; thr; asn; leu
Prior art date: 1991-11-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69232064T

Other languages

English (en)

Other versions

DE69232064T2 (de

Inventor

S Gaeta

Howard Jones

Elisabeth Albrecht

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Amylin Pharmaceuticals LLC

Original Assignee

Amylin Pharmaceuticals LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-11-19

Filing date

1992-11-19

Publication date

2001-10-25

1992-11-19 Application filed by Amylin Pharmaceuticals LLC filed Critical Amylin Pharmaceuticals LLC

2001-10-25 Publication of DE69232064D1 publication Critical patent/DE69232064D1/de

2002-03-28 Application granted granted Critical

2002-03-28 Publication of DE69232064T2 publication Critical patent/DE69232064T2/de

2012-11-20 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Diabetes (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Endocrinology (AREA)
Obesity (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Immunology (AREA)
Biochemistry (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DE69232064T 1991-11-19 1992-11-19 Peptide als Amylin-Agonisten und ihre Verwendung Expired - Lifetime DE69232064T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US79426691A	1991-11-19	1991-11-19
PCT/US1992/009842 WO1993010146A1 (en)	1991-11-19	1992-11-19	Amylin agonist peptides and uses therefor

Publications (2)

Publication Number	Publication Date
DE69232064D1 true DE69232064D1 (de)	2001-10-25
DE69232064T2 DE69232064T2 (de)	2002-03-28

Family

ID=25162163

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69232064T Expired - Lifetime DE69232064T2 (de)	1991-11-19	1992-11-19	Peptide als Amylin-Agonisten und ihre Verwendung

Country Status (17)

Country	Link
EP (2)	EP0567626B1 (de)
JP (4)	JP2902115B2 (de)
AT (1)	ATE205854T1 (de)
AU (1)	AU714439B2 (de)
CA (1)	CA2100745C (de)
CZ (1)	CZ288029B6 (de)
DE (1)	DE69232064T2 (de)
DK (1)	DK0567626T3 (de)
ES (1)	ES2161697T3 (de)
FI (1)	FI118601B (de)
GR (1)	GR3036794T3 (de)
HK (1)	HK1041891A1 (de)
MD (1)	MD960317A (de)
NO (2)	NO324405B1 (de)
RU (1)	RU2130463C1 (de)
SK (1)	SK88793A3 (de)
WO (1)	WO1993010146A1 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU222249B1 (hu)	1991-03-08	2003-05-28	Amylin Pharmaceuticals Inc.	Eljárás amilin agonista peptidszármazékok és ezeket tartalmazó gyógyszerkészítmények előállítására
US5625032A (en) *	1993-07-21	1997-04-29	Amylin Pharmaceuticals, Inc.	Selective amylin antagonist peptides and uses therefor
BR9407424A (pt)	1993-09-07	1996-04-09	Amylin Pharmaceuticals Inc	Métodos para regular motilidade gastrointestinal
US6143718A (en)	1995-06-07	2000-11-07	Amylin Pharmaceuticals, Inc.	Treatment of Type II diabetes mellutis with amylin agonists
US5739106A (en) *	1995-06-07	1998-04-14	Rink; Timothy J.	Appetite regulating compositions
US6410511B2 (en)	1997-01-08	2002-06-25	Amylin Pharmaceuticals, Inc.	Formulations for amylin agonist peptides
US7312196B2 (en)	1997-01-08	2007-12-25	Amylin Pharmaceuticals, Inc.	Formulations for amylin agonist peptides
US7101853B2 (en) *	1997-05-06	2006-09-05	Amylin Pharmaceuticals, Inc.	Method for treating or preventing gastritis using amylin or amylin agonists
US7910548B2 (en)	1997-06-06	2011-03-22	Amylin Pharmaceuticals, Inc.	Methods for treating obesity
JP4353544B2 (ja) *	1998-01-09	2009-10-28	アミリン・ファーマシューティカルズ，インコーポレイテッド	アミリン作動薬ペプチド用製剤
CN1279053C (zh) *	1999-03-04	2006-10-11	普雷西斯药品公司	含有D－氨基酸的β－淀粉样肽聚集的调节因子
GB0002952D0 (en) *	2000-02-09	2000-03-29	Pharma Mar Sa	Process for producing kahalalide F compounds
RU2228174C2 (ru) *	2000-04-10	2004-05-10	Помыткин Игорь Анатольевич	Янтарнокислый бис(2-гидрокси-n,n,n-триметилэтанаминий) для лечения инсулиновой резистентности, сахарного диабета, гиперлипидемии и дислипидемии
GB0128583D0 (en)	2001-11-28	2002-01-23	Rsr Ltd	Detection of autoantibodies indicative of diabetes
GB0304367D0 (en) *	2003-02-26	2003-04-02	Pharma Mar Sau	Methods for treating psoriasis
WO2004037168A2 (en)	2002-10-18	2004-05-06	Amylin Pharmaceuticals, Inc.	Treatment of pancreatitis with amylin
WO2004083243A1 (en) *	2003-03-18	2004-09-30	Applied Research Systems Ars Holding N.V.	Amylin aggregation inhibitors and use thereof.
EP1807442A1 (de) *	2004-10-26	2007-07-18	Lonza Ag	S-alkyl-sulphenyl-schutzgruppen bei der festphasensynthese
CA2584806C (en)	2004-11-01	2014-06-17	Amylin Pharmaceuticals, Inc.	Treatment of obesity and related disorders
US8394765B2 (en)	2004-11-01	2013-03-12	Amylin Pharmaceuticals Llc	Methods of treating obesity with two different anti-obesity agents
EP2258382A3 (de)	2005-03-31	2014-05-14	Amylin Pharmaceuticals, LLC	Amylin und Amylin-Antagonisten zur Behandlung psychiatrischer Erkrankungen und Störungen
US8168592B2 (en)	2005-10-21	2012-05-01	Amgen Inc.	CGRP peptide antagonists and conjugates
NZ574710A (en)	2006-09-07	2012-02-24	Nycomed Gmbh	Combination treatment comprising the PDE4 inhibitor Compound A ((2R,4aR, 10bR)6-(2,6-Dimethoxy-pyridin-3-yl)-9-ethoxy-8-methoxy-1 ,2,3,4,4a,10b-hexahydrophenanthridin-2-ol) for diabetes mellitus
US8309522B2 (en)	2007-02-05	2012-11-13	Amylin Pharmaceuticals, Llc	Neuromedin and FN-38 peptides for treating psychiatric diseases
JP2009149684A (ja) *	2009-03-11	2009-07-09	Amylin Pharmaceut Inc	アミリン作動薬ペプチド用製剤
CA2755068C (en)	2009-03-12	2018-11-06	Nordic Bioscience A/S	Treatment of diabetes and metabolic syndrome
AR097701A1 (es) *	2013-09-19	2016-04-13	Zealand Pharma As	Análogos de amilina
MX2016005995A (es)	2013-11-05	2016-08-17	Ben-Gurion Univ Of The Negev Res And Dev Authority	Compuestos para el tratamiento de diabetes y complicaciones de la enfermedad derivadas de la misma.
WO2015168488A2 (en) *	2014-05-02	2015-11-05	The Research Foundation For The State University Of New York	Islet amyloid polypeptides with improved solubility
CN107567459B (zh)	2015-03-18	2021-09-24	西兰制药公司	胰淀素类似物
TWI784968B (zh)	2016-09-09	2022-12-01	丹麥商西蘭製藥公司	澱粉素類似物
US11028137B2 (en)	2017-02-01	2021-06-08	The Research Foundation For The State University Of New York	Mutant islet amyloid polypeptides with improved solubility and methods for using the same
KR102130354B1 (ko) *	2019-08-14	2020-07-06	엘아이지넥스원 주식회사	코어 제거용 이형장치
EP4319798B1 (de)	2022-05-30	2024-12-11	Zealand Pharma A/S	Flüssige formulierungen von amylin-analoga
EP4590326A1 (de)	2022-09-19	2025-07-30	Zealand Pharma A/S	Kombinationstherapie
TW202515598A (zh)	2023-06-21	2025-04-16	丹麥商西蘭製藥公司	具有增進性能之類似物
TW202504913A (zh)	2023-06-21	2025-02-01	丹麥商西蘭製藥公司	減重
TW202517291A (zh)	2023-06-30	2025-05-01	丹麥商西蘭製藥公司	組合療法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5120712A (en) *	1986-05-05	1992-06-09	The General Hospital Corporation	Insulinotropic hormone
GB8720115D0 (en) *	1987-08-26	1987-09-30	Cooper G J S	Treatment of diabetes mellitus
WO1989006135A1 (en) *	1988-01-11	1989-07-13	Amylin Corporation	Treatment of type 2 diabetes mellitus
JPH04500688A (ja) *	1989-07-10	1992-02-06	アミリン・コーポレイション	肥満および本態性高血圧および関連疾患の治療
US5234906A (en) *	1991-01-10	1993-08-10	Amylin Pharmaceuticals, Inc.	Hyperglycemic compositions
WO1992015317A1 (en) *	1991-03-08	1992-09-17	Amylin Pharmaceuticals, Inc.	Synthetic preparation of amylin and amylin analogues

1992
- 1992-11-19 JP JP5509441A patent/JP2902115B2/ja not_active Expired - Lifetime
- 1992-11-19 DK DK92924442T patent/DK0567626T3/da active
- 1992-11-19 RU RU93053497A patent/RU2130463C1/ru active
- 1992-11-19 EP EP92924442A patent/EP0567626B1/de not_active Expired - Lifetime
- 1992-11-19 CA CA002100745A patent/CA2100745C/en not_active Expired - Lifetime
- 1992-11-19 AT AT92924442T patent/ATE205854T1/de active
- 1992-11-19 WO PCT/US1992/009842 patent/WO1993010146A1/en not_active Ceased
- 1992-11-19 SK SK887-93A patent/SK88793A3/sk unknown
- 1992-11-19 CZ CZ19931689A patent/CZ288029B6/cs not_active IP Right Cessation
- 1992-11-19 ES ES92924442T patent/ES2161697T3/es not_active Expired - Lifetime
- 1992-11-19 EP EP01114132A patent/EP1162207A1/de not_active Ceased
- 1992-11-19 DE DE69232064T patent/DE69232064T2/de not_active Expired - Lifetime
- 1992-11-19 MD MD96-0317A patent/MD960317A/ro unknown
1993
- 1993-07-16 FI FI933252A patent/FI118601B/fi not_active IP Right Cessation
- 1993-07-19 NO NO19932603A patent/NO324405B1/no not_active IP Right Cessation
1997
- 1997-01-31 AU AU12456/97A patent/AU714439B2/en not_active Expired
1998
- 1998-09-30 JP JP10277573A patent/JPH11152299A/ja not_active Withdrawn
2001
- 2001-10-04 GR GR20010401656T patent/GR3036794T3/el unknown
2002
- 2002-05-02 HK HK02103291.8A patent/HK1041891A1/en unknown
2003
- 2003-01-15 JP JP2003007228A patent/JP2003238594A/ja not_active Withdrawn
2006
- 2006-02-03 JP JP2006027334A patent/JP4018116B2/ja not_active Expired - Lifetime
2007
- 2007-06-25 NO NO20073265A patent/NO20073265L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
JPH06504794A (ja)	1994-06-02
GR3036794T3 (en)	2002-01-31
CZ288029B6 (cs)	2001-04-11
JP2902115B2 (ja)	1999-06-07
FI933252L (fi)	1993-08-23
SK88793A3 (en)	1994-12-07
EP1162207A1 (de)	2001-12-12
MD960317A (ro)	1998-05-31
AU1245697A (en)	1997-03-27
CA2100745C (en)	2007-07-31
EP0567626A1 (de)	1993-11-03
FI933252A0 (fi)	1993-07-16
WO1993010146A1 (en)	1993-05-27
AU714439B2 (en)	2000-01-06
HK1041891A1 (en)	2002-07-26
NO932603L (no)	1993-09-17
CZ168993A3 (en)	1994-04-13
ATE205854T1 (de)	2001-10-15
JP2003238594A (ja)	2003-08-27
NO20073265L (no)	1993-09-17
CA2100745A1 (en)	1993-05-20
ES2161697T3 (es)	2001-12-16
DK0567626T3 (da)	2001-12-17
NO324405B1 (no)	2007-10-08
NO932603D0 (no)	1993-07-19
AU673147B2 (en)	1996-10-31
JP2006213716A (ja)	2006-08-17
FI118601B (fi)	2008-01-15
JP4018116B2 (ja)	2007-12-05
EP0567626B1 (de)	2001-09-19
AU3075392A (en)	1993-06-15
RU2130463C1 (ru)	1999-05-20
DE69232064T2 (de)	2002-03-28
JPH11152299A (ja)	1999-06-08

Publication	Publication Date	Title
ATE205854T1 (de)	2001-10-15	Peptide als amylin-agonisten und ihre verwendung
Wilkinson	1976	The amino acid sequence of troponin C from chicken skeletal muscle
DE10075019I1 (de)	2000-09-21	Neue Proteine mit TNF-Hemmender wirkung und ihre Herstellung.
DE3750197D1 (de)	1994-08-18	Antagonisten des Fibroblasten-Wachstumsfaktors.
IL89541A0 (en)	1989-09-10	Urethane-protected amino acid-n-carboxyanhydrides and their use in the synthesis of polypeptides
WO1995030750A8 (fr)	1999-07-29	Fractions polypeptidiques solubles de la proteine lag-3; procede de production; composition therapeutique; anticorps anti-idiotype
CA2094027A1 (en)	1992-04-19	Osteogenic peptides
RU94036776A (ru)	1996-09-27	Домен ингибитора протеазы, днк, вектор, клетка, способ получения ингибитора протеазы, фармацевтическая композиция, применение домена ингибитора протеазы
ES2054365T3 (es)	1994-08-01	Inhibicion de la via de la regla del n final en celulas vivas.
JPS55143945A (en)	1980-11-10	Novel polypeptide
BR9306272A (pt)	1998-06-23	Peptídeo e composiçao farmacêutica
ZA896980B (en)	1990-06-27	Peptide compounds
Huang et al.	1992	An antiplatelet peptide, gabonin, from Bitis gabonica snake venom
EP0292257A3 (de)	1990-06-06	Peptide mit ANF-Wirksamkeit
ATE124955T1 (de)	1995-07-15	Substrat-peptide.
ES2044928T3 (es)	1994-01-16	Enzima alfa-amidante en terminal c y procedimiento para la produccion y el uso del mismo.
EP0232435A3 (de)	1988-02-24	Serumthymischer Faktor von Peptidanalogen und deren Verfahren zur Herstellung
EP0687685A4 (de)	1998-07-01	Physiologisch-aktive peptide
CA2083286A1 (en)	1992-01-27	Recombinant fibrinogenases, preparation and use thereof
DE58909261D1 (de)	1995-06-29	Ancrod-proteine, ihre herstellung und verwendung.
DK200200302A (da)	2002-02-27	Rekombinante polypeptider omfattende aminosyresekvensen af moden vævsfaktorinhibitor (TFI), polypeptidfragmenter deraf, ekspressionsvektorer der koder for disse, værtsceller transformeret dermed, og fremgangsmåde til fremstilling af et ........
ES2051152B1 (es)	1994-12-16	Procedimiento de sistesis de peptidos con capacidad de detectar anticuerpos anti-virus de la hepatitis c (vhc) en suero de individuos afectados.
Judd et al.	1990	Peptides: chemistry, biology, and pharmacology
ES2069476A1 (es)	1995-05-01	Procedimiento de sintesis de peptidos con capacidad de detectar anticuerpos ant-virus de la hepatitis c (vhc) en suero de individuos afectados.

Legal Events

Date	Code	Title	Description
2002-10-17	8364	No opposition during term of opposition