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DE69913697D1 - Naphtho- und dihydrobenzothiophenderivate als cytotoxische antitumormittel - Google Patents

Naphtho- und dihydrobenzothiophenderivate als cytotoxische antitumormittel

Info

Publication number
DE69913697D1
DE69913697D1 DE69913697T DE69913697T DE69913697D1 DE 69913697 D1 DE69913697 D1 DE 69913697D1 DE 69913697 T DE69913697 T DE 69913697T DE 69913697 T DE69913697 T DE 69913697T DE 69913697 D1 DE69913697 D1 DE 69913697D1
Authority
DE
Germany
Prior art keywords
naphtho
cytotoxic
antituary
agents
dihydrobenzothiophene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69913697T
Other languages
English (en)
Other versions
DE69913697T2 (de
Inventor
Kuo-Hsiung Lee
Sheng-Chu Kuo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of North Carolina at Chapel Hill
Original Assignee
University of North Carolina at Chapel Hill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of North Carolina at Chapel Hill filed Critical University of North Carolina at Chapel Hill
Application granted granted Critical
Publication of DE69913697D1 publication Critical patent/DE69913697D1/de
Publication of DE69913697T2 publication Critical patent/DE69913697T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/74—Naphthothiophenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE69913697T 1998-06-05 1999-06-04 Naphtho- und dihydrobenzothiophenderivate als cytotoxische antitumormittel Expired - Fee Related DE69913697T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/092,929 US6174913B1 (en) 1998-06-05 1998-06-05 Naphtho- and dihydrobenzo-thiophene derivatives as cytotoxic antitumor agents
US92929 1998-07-15
PCT/US1999/012647 WO1999062909A2 (en) 1998-06-05 1999-06-04 Naphtho- and dihydrobenzo-thiophene derivatives as cytotoxic antitumor agents

Publications (2)

Publication Number Publication Date
DE69913697D1 true DE69913697D1 (de) 2004-01-29
DE69913697T2 DE69913697T2 (de) 2004-08-19

Family

ID=22235827

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69913697T Expired - Fee Related DE69913697T2 (de) 1998-06-05 1999-06-04 Naphtho- und dihydrobenzothiophenderivate als cytotoxische antitumormittel

Country Status (9)

Country Link
US (2) US6174913B1 (de)
EP (1) EP1093456B1 (de)
JP (1) JP2002517397A (de)
CN (1) CN1150197C (de)
AU (1) AU4548899A (de)
DE (1) DE69913697T2 (de)
HK (1) HK1041482B (de)
TW (1) TWI238165B (de)
WO (1) WO1999062909A2 (de)

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AR035216A1 (es) * 2000-12-01 2004-05-05 Astrazeneca Ab Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios
AR034517A1 (es) 2001-06-21 2004-02-25 Astrazeneca Ab Formulacion farmaceutica
SE0201661D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab New salts
US20060142271A1 (en) * 2002-09-17 2006-06-29 Klaus Muller Novel lapacho compounds and methods of use thereof
US7781424B2 (en) * 2003-05-27 2010-08-24 Astrazeneca Ab Modified release pharmaceutical formulation
TWI366459B (en) * 2004-09-28 2012-06-21 Ind Tech Res Inst Novel hydrophilic analogs of 4,8-dihydrobenzodithiophene-4,8-diones as anticancer agents
TW200827336A (en) * 2006-12-06 2008-07-01 Astrazeneca Ab New crystalline forms
HUE027443T2 (en) 2007-09-10 2016-10-28 Boston Biomedical Inc A novel class of Stat3 pathway inhibitors and tumor stem cell inhibitors
CN103025159A (zh) 2010-03-19 2013-04-03 波士顿生物医学公司 靶向癌症干细胞的新方法
JP6069787B2 (ja) * 2012-03-08 2017-02-01 学校法人早稲田大学 ベンゾジチオフェンキノンポリマー、電荷貯蔵材料、電極活物質、電極、及び電池
JP6433085B2 (ja) 2013-04-09 2018-12-05 ボストン バイオメディカル， インコーポレイテッド がんの処置に使用するための２−アセチルナフト［２，３−ｂ］フラン−４，９−ジオン
WO2015120304A1 (en) * 2014-02-07 2015-08-13 Boston Biomedical, Inc. 3-substituted carbonyl-naphtho[2,3-b]furane derivative or pharmaceutically acceptable salt thereof
US20170015677A1 (en) 2014-03-31 2017-01-19 Boston Biomedical, Inc. New tricyclic quinone derivative
WO2018054304A1 (zh) * 2016-09-20 2018-03-29 东莞市真兴贝特医药技术有限公司 呋喃并喹啉二酮类化合物及其医药用途
US11299469B2 (en) 2016-11-29 2022-04-12 Sumitomo Dainippon Pharma Oncology, Inc. Naphthofuran derivatives, preparation, and methods of use thereof
WO2018213424A1 (en) 2017-05-17 2018-11-22 Boston Biomedical, Inc. Methods for treating cancer
KR102518835B1 (ko) 2017-10-26 2023-04-05 엘지디스플레이 주식회사 유기 화합물, 이를 포함하는 발광다이오드 및 발광장치
EP3762391A4 (de) * 2018-03-08 2022-08-03 ExxonMobil Technology and Engineering Company Spirozentrische verbindungen und polymere davon
CN110183463B (zh) * 2019-05-29 2022-05-06 中国科学院重庆绿色智能技术研究院 一种小分子电子给体材料及其制备与应用

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DK44278A (da) 1977-02-08 1978-08-09 Sandoz Ag Fremgangsmaade til fremstilling af thiophenderivater
LU76760A1 (de) 1977-02-11 1978-10-18
GB2011455B (en) * 1977-12-21 1982-03-03 Ici Ltd Chemical process
US4419354A (en) * 1982-06-03 1983-12-06 American Cyanamid Company 9,10-Bis(aminoalkoxy)anthracenes
JPS5927894A (ja) 1982-08-06 1984-02-14 Mitsubishi Petrochem Co Ltd ９Ｈ−チエノ〔３，２−ｂ〕又は４Ｈ−チエノ〔２，３−ｂ〕〔１〕ベンゾピラン誘導体
HU195800B (en) 1983-10-13 1988-07-28 Sandoz Ltd Process for producing 4h-benzo/4,5/cylopenta/1,2-b/ thiofene derivatives and pharmaceutical compositions containing them
GB8428930D0 (en) * 1984-11-15 1984-12-27 Wellcome Found Polycyclic biocidal compounds
US4866070A (en) 1984-11-20 1989-09-12 Burroughs Wellcome Co. Acenaphtho[1,2b]quinolinylmethylamino derivatives and pharmaceutical compositions containing them
US4965285A (en) 1984-11-20 1990-10-23 Burroughs Wellcome Co. Dibenzothiphene and naphthalenethiophene derivatives
US5017600A (en) 1984-11-20 1991-05-21 Burroughs Wellcome Co. Tricyclic derivatives
US4761424A (en) 1985-10-01 1988-08-02 Warner-Lambert Company Enolamides, pharmaceutical compositions and methods for treating inflammation
US4960886A (en) * 1986-12-15 1990-10-02 Fuji Xerox Co., Ltd. Charge transfer complex formed between benzoquinone derivative and electron donor and process for producing the same
JPH01135766A (ja) * 1987-11-20 1989-05-29 Tanabe Seiyaku Co Ltd ビフェニル誘導体
DE69131033T2 (de) * 1990-07-10 1999-11-18 Canon K.K., Tokio/Tokyo Lichtempfindliches elektrophotographisches Element
US5645988A (en) * 1991-05-08 1997-07-08 The United States Of America As Represented By The Department Of Health And Human Services Methods of identifying drugs with selective effects against cancer cells
DE4204969A1 (de) 1992-02-19 1993-08-26 Basf Ag Verfahren zur herstellung von benzo(b)thiophenen
US5679694A (en) * 1992-07-20 1997-10-21 The Wellcome Foundation Ltd. Tetracyclic compounds, intermediates for their preparation and their use as antitumor agents
US5530139A (en) * 1993-05-31 1996-06-25 Showa Denko Kabushiki Kaisha Condensed heterocyclic compound with a sulfonic acid group and process for producing the same
US5718997A (en) * 1995-06-23 1998-02-17 Konica Corporation Electrophotographic photoreceptor
CA2214196A1 (en) * 1996-09-26 1998-03-26 Eli Lilly And Company Benzo[b]indeno[2,1-d]thiophene compounds, intermediates, processes, compositions and methods
US5728846A (en) * 1996-12-12 1998-03-17 Allergan Benzo 1,2-g!-chrom-3-ene and benzo 1,2-g!-thiochrom-3-ene derivatives
JPH1165141A (ja) * 1997-08-11 1999-03-05 Canon Inc 電子写真感光体、該電子写真感光体を有するプロセスカ−トリッジ及び電子写真装置
JPH1195465A (ja) * 1997-09-16 1999-04-09 Konica Corp 電子写真感光体

Also Published As

Publication number Publication date
CN1150197C (zh) 2004-05-19
CN1322206A (zh) 2001-11-14
AU4548899A (en) 1999-12-20
JP2002517397A (ja) 2002-06-18
DE69913697T2 (de) 2004-08-19
WO1999062909A3 (en) 2000-03-02
TWI238165B (en) 2005-08-21
US6174913B1 (en) 2001-01-16
HK1041482B (zh) 2005-03-11
WO1999062909A2 (en) 1999-12-09
EP1093456A2 (de) 2001-04-25
EP1093456B1 (de) 2003-12-17
WO1999062909A9 (en) 2000-04-27
US6337346B1 (en) 2002-01-08
HK1041482A1 (en) 2002-07-12

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee