[go: up one dir, main page]

DE69613365D1 - Ester der 5-aminolevulinsäure als mittel zur photosensibilisierung in der chemotherapie - Google Patents

Ester der 5-aminolevulinsäure als mittel zur photosensibilisierung in der chemotherapie

Info

Publication number
DE69613365D1
DE69613365D1 DE69613365T DE69613365T DE69613365D1 DE 69613365 D1 DE69613365 D1 DE 69613365D1 DE 69613365 T DE69613365 T DE 69613365T DE 69613365 T DE69613365 T DE 69613365T DE 69613365 D1 DE69613365 D1 DE 69613365D1
Authority
DE
Germany
Prior art keywords
pct
photosensitization
chemotherapy
ester
aminolevulinic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69613365T
Other languages
English (en)
Other versions
DE122006000051I1 (de
DE69613365T2 (de
Inventor
Erik Gierskcky
Johan Moan
Qian Peng
Harald Steen
Trond Warloe
Alf Bjorseth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Photocure ASA
Original Assignee
Photocure ASA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26306657&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69613365(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9504948.2A external-priority patent/GB9504948D0/en
Priority claimed from GBGB9525822.4A external-priority patent/GB9525822D0/en
Application filed by Photocure ASA filed Critical Photocure ASA
Publication of DE69613365D1 publication Critical patent/DE69613365D1/de
Application granted granted Critical
Publication of DE69613365T2 publication Critical patent/DE69613365T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555—Hetero-N

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69613365T 1995-03-10 1996-03-08 Ester der 5-aminolevulinsäure als mittel zur photosensibilisierung in der chemotherapie Expired - Lifetime DE69613365T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9504948.2A GB9504948D0 (en) 1995-03-10 1995-03-10 Compounds
GBGB9525822.4A GB9525822D0 (en) 1995-12-18 1995-12-18 Compounds
PCT/GB1996/000553 WO1996028412A1 (en) 1995-03-10 1996-03-08 Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy

Publications (2)

Publication Number Publication Date
DE69613365D1 true DE69613365D1 (de) 2001-07-19
DE69613365T2 DE69613365T2 (de) 2002-05-02

Family

ID=26306657

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69613365T Expired - Lifetime DE69613365T2 (de) 1995-03-10 1996-03-08 Ester der 5-aminolevulinsäure als mittel zur photosensibilisierung in der chemotherapie
DE122006000051C Active DE122006000051I2 (de) 1995-03-10 1996-03-08 Ester der 5-Aminolevulinsäure als Mittel zur Photosensibilisierung in der Chemotherapie
DE1996613365 Pending DE122006000051I1 (de) 1995-03-10 1996-03-08 Ester der 5-Aminolevulins{ure als Mittel zur Photosensibillisierung in der Chemotherapie

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE122006000051C Active DE122006000051I2 (de) 1995-03-10 1996-03-08 Ester der 5-Aminolevulinsäure als Mittel zur Photosensibilisierung in der Chemotherapie
DE1996613365 Pending DE122006000051I1 (de) 1995-03-10 1996-03-08 Ester der 5-Aminolevulins{ure als Mittel zur Photosensibillisierung in der Chemotherapie

Country Status (19)

Country Link
US (1) US6034267A (de)
EP (1) EP0820432B1 (de)
JP (1) JP3955093B2 (de)
KR (1) KR100444007B1 (de)
CN (1) CN1137087C (de)
AT (1) ATE202076T1 (de)
AU (1) AU708076B2 (de)
CA (1) CA2215069C (de)
CZ (1) CZ291132B6 (de)
DE (3) DE69613365T2 (de)
ES (1) ES2157424T3 (de)
FR (1) FR05C0042I2 (de)
HU (1) HU225148B1 (de)
LU (1) LU90956I2 (de)
NL (2) NL300176I2 (de)
NO (3) NO318379B1 (de)
NZ (1) NZ303251A (de)
PT (1) PT820432E (de)
WO (1) WO1996028412A1 (de)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6992107B1 (en) * 1995-03-10 2006-01-31 Photocure Asa Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy
US7530461B2 (en) 1995-03-10 2009-05-12 Photocure Asa Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
US6492420B2 (en) * 1995-03-10 2002-12-10 Photocure As Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
US5895786A (en) * 1996-05-08 1999-04-20 New York Blood Center, Inc. Method for treating viral infections
GB9700396D0 (en) * 1997-01-10 1997-02-26 Photocure As Photochemotherapeutic compositions
FR2777782B1 (fr) * 1998-04-22 2001-05-18 Alexandre Marti Solution pour la preparation d'une substance pharmaceutique pour le diagnostic et/ou le traitement de lesions tissulaires
US6223071B1 (en) * 1998-05-01 2001-04-24 Dusa Pharmaceuticals Inc. Illuminator for photodynamic therapy and diagnosis which produces substantially uniform intensity visible light
DE19852245A1 (de) * 1998-11-12 2000-05-18 Asat Ag Applied Science & Tech 5-Aminolävulinsäure-Nanoemulsion
CA2379927A1 (en) 1999-07-28 2001-02-01 Genset S.A. Integration of biochemical protocols in a continuous flow microfluidic device
JP3970492B2 (ja) * 1999-12-14 2007-09-05 コスモ石油株式会社 ピーリング用組成物
DE10003620A1 (de) * 2000-01-28 2001-08-02 Asat Ag Applied Science & Tech 5-Aminolävulinsäure-Formulierung in nichtwässrigen Lösungsmitteln
NO20002428D0 (no) 2000-05-10 2000-05-10 Radiumhospitalets Forskningsst Hudpreparat
US6454790B1 (en) * 2000-07-21 2002-09-24 Ceramoptec Industries, Inc. Treatment for Barrett's syndrome
GB0018528D0 (en) * 2000-07-27 2000-09-13 Photocure Asa Compounds
GB0018527D0 (en) * 2000-07-27 2000-09-13 Photocure Asa Composition
WO2002013820A1 (en) * 2000-08-11 2002-02-21 Ceramoptec Industries, Inc. Photosensitizing ointment
ATE319079T1 (de) * 2000-11-06 2006-03-15 Alfons Prof Dr Med Hofstetter Tumorzellenidentifizierungsverfahren
PT1339862E (pt) * 2000-11-29 2014-02-17 Pci Biotech As Internalização fotoquímica para entrega de molécula no ciosol mediada por vírus
KR20080080685A (ko) * 2000-11-29 2008-09-04 피씨아이 바이오테크 에이에스 사이토졸 내로의 분자 전달을 위한 광화학적 내부이행
EP1312353A1 (de) * 2001-11-16 2003-05-21 Ecole Polytechnique Federale De Lausanne (Epfl) Haarentfernungsmethode
US6723750B2 (en) 2002-03-15 2004-04-20 Allergan, Inc. Photodynamic therapy for pre-melanomas
US20040073277A1 (en) * 2002-04-05 2004-04-15 Geronemus Roy G. High fluence rate activation of photosensitizers for dermatological applications
DE10301917B4 (de) * 2003-01-17 2007-02-01 Gerhard Saalmann Verwendung von Substanzen der Porphyrinsynthese bei der Phototherapie von Haut- oder Gelenkerkrankungen des Menschen oder von Säugetieren
DE10312659A1 (de) * 2003-03-21 2004-10-07 Universität Regensburg 5-Aminolävulinsäurederivate und ihre Verwendung
US20050209331A1 (en) * 2004-03-22 2005-09-22 Syneron Medical Ltd. Method of treatment of skin
GB0406917D0 (en) * 2004-03-26 2004-04-28 Photocure Asa Compounds
KR100873664B1 (ko) * 2004-04-28 2008-12-11 코스모세키유 가부시키가이샤 육모제
JP2005350418A (ja) * 2004-06-11 2005-12-22 Shibuya Kogyo Co Ltd 標的細胞の死滅方法と標的細胞を死滅させるための薬剤及び該薬剤の製造装置
JP5034032B2 (ja) * 2004-09-29 2012-09-26 Ｓｂｉファーマ株式会社 腫瘍診断剤
GB0424833D0 (en) * 2004-11-10 2004-12-15 Photocure Asa Method
GB0515550D0 (en) 2005-07-29 2005-09-07 Univ Strathclyde Inactivation of staphylococcus species
US20070225518A1 (en) * 2006-03-22 2007-09-27 Zvi Malik 5-Aminolevulinic acid salts and their use
KR100796450B1 (ko) * 2006-06-29 2008-01-22 전남대학교산학협력단 5-아미노레불린산의 불포화 알킬 에스터 및 약학적으로허용되는 그의 염, 이의 제조방법 및 이의 용도
GB0700580D0 (en) * 2007-01-11 2007-02-21 Photocure Asa Use
JP5098051B2 (ja) 2007-04-05 2012-12-12 Ｓｂｉファーマ株式会社 ミトコンドリア障害脳疾患治療剤及び診断剤
GB0724279D0 (en) * 2007-12-12 2008-01-23 Photocure Asa Use
AU2014200004B2 (en) * 2007-12-12 2016-10-27 Photocure Asa Use of 5-aminolevulinic acid and derivatives in a solid form for photodynamic treatment and diagnosis
AU2008337067A1 (en) * 2007-12-14 2009-06-25 Photoderma Sa Novel compounds useful in therapeutic and cosmetic methods
US8916502B2 (en) 2008-05-13 2014-12-23 Cosmo Oil Co., Ltd. Agent for improving lawn grass qualities
CA2722578C (en) 2008-05-14 2014-02-11 Sbi Alapromo Co., Ltd. Use of .delta.-amino levulinic acid to treat male infertility
CA2735426A1 (en) * 2008-09-01 2010-03-04 Swedish Pharma Ab New 5-aminolevulinic acid prodrugs for use in photodynamic therapy and photodynamic diagnosis
CN101745102B (zh) * 2008-12-16 2013-08-07 上海复旦张江生物医药股份有限公司 5-氨基酮戊酸及其衍生物的组合物及其用途
GB0823472D0 (en) * 2008-12-23 2009-01-28 Photocure Asa Product
GB0900461D0 (en) 2009-01-12 2009-02-11 Photocure Asa Photodynamic therapy device
US20100256125A1 (en) * 2009-04-06 2010-10-07 Zila Pharmaceuticals, Inc. Use of improved toluidine blue in photodynamic therapy
WO2010144257A1 (en) 2009-05-26 2010-12-16 The General Hospital Corporation Method and apparatus for dermal delivery of a substance
BRPI1010761A2 (pt) 2009-06-11 2016-03-22 Photocure Asa "composições semi-sólidas e produtos farmacêuticos"
PE20120858A1 (es) * 2009-06-11 2012-08-01 Photocure Asa Composiciones solidas que comprenden acido 5-aminolevulinico
KR101133770B1 (ko) * 2009-10-27 2012-04-09 주식회사 엔씨테크론 메틸 5-아미노레불리네이트 염산염의 제조방법과 이를 이용한 여드름 및 피부 개선을 위한 피부 외용 화장료 조성물 및 이의 제조방법
EP2542208A1 (de) 2010-03-01 2013-01-09 Photocure ASA Kosmetische zusammensetzungen
EP2394642A1 (de) 2010-06-10 2011-12-14 Universite De Geneve 5-ALA-Ester-Formulierungen und deren Verwendung
US20130211215A1 (en) 2010-06-23 2013-08-15 Photocure Asa Hyperosmotic preparations comprising 5-aminolevulinic acid or derivative as photosensitizing agent
CA2804337A1 (en) 2010-07-09 2012-01-12 Photocure Asa Dry compositions and devices containing such dry compositions for use in photodynamic therapy or photodynamic diagnosis
CN103096884B (zh) 2010-09-14 2017-11-03 学校法人东京农业大学 癌温热疗法的作用增强剂
CN103140457B (zh) * 2010-09-30 2015-05-13 克斯莫石油株式会社 含5-氨基乙酰丙酸的固体肥料及其制造方法
CN104152530B (zh) 2010-12-24 2017-09-19 爱科来株式会社 癌细胞的检测方法
CN102617378B (zh) * 2011-01-26 2016-04-27 上海泺安医药技术有限公司 一种2-(3’-氨基-2’-氧-丙基)丙二酸酯盐及制备
CN102649767A (zh) * 2011-02-25 2012-08-29 上海泺安医药技术有限公司 一种n-取代氨基乙酰丙酸及其酯制备新工艺
CN102649769B (zh) * 2011-02-25 2015-12-16 上海泺安医药技术有限公司 一种盐酸氨基乙酰丙酸酯的制备工艺
CN102649768B (zh) * 2011-02-25 2016-05-25 上海泺安医药技术有限公司 一种盐酸氨基乙酰丙酸的制备工艺
CN102179010B (zh) * 2011-05-27 2013-01-09 吉林大学 脑胶质瘤光动力直接照射治疗装置
JP5885743B2 (ja) * 2011-07-01 2016-03-15 Ｓｂｉファーマ株式会社 光増感剤又は５−アミノレブリン酸類を用いる光線力学的治療
US20140276107A1 (en) 2011-10-14 2014-09-18 Photocure Asa Photodynamic diagnosis
US20140316534A1 (en) 2011-10-14 2014-10-23 Photocure Asa Stent
RU2615870C2 (ru) 2011-12-19 2017-04-11 ФотоКьюэр АСА Устройство облучения
WO2013092936A2 (en) 2011-12-20 2013-06-27 Galderma Research & Development Use of 5-aminolevulinic acid and esters, in combination with a vitamin d derivative or analog in photochemotherapy, and their uses in treating acne
JP5836402B2 (ja) 2012-01-25 2015-12-24 Ｓｂｉファーマ株式会社 腫瘍診断剤
EP2835094A4 (de) 2012-04-05 2016-03-09 Sbi Pharmaceuticals Co Ltd Vorrichtung zur bestimmung der metastase von krebs auf wächterlymphknoten
IN2015DN00837A (de) * 2012-08-03 2015-06-12 Photocure Asa
US20140067024A1 (en) 2012-08-30 2014-03-06 Photocure Asa Dual panel photodynamic therapy lamp
GB201221123D0 (en) 2012-11-23 2013-01-09 Photocure As Device for photodynamic treatment
GB201306369D0 (en) 2013-04-09 2013-05-22 Photocure As Irradiation device
WO2015091037A1 (en) 2013-12-20 2015-06-25 Galderma Research & Development Pulse photodynamic treatment of photodamaged skin
EP3095464A1 (de) 2015-05-19 2016-11-23 Universite De Geneve 5-ala-derivate und verwendung davon
GB201522311D0 (en) 2015-12-17 2016-02-03 Photocure Asa Use
JP6995755B2 (ja) 2015-12-17 2022-01-17 フォトキュア エイエスエイ 膀胱癌に対する光線力学的療法（ｐｄｔ）の方法
GB201522309D0 (en) 2015-12-17 2016-02-03 Photocure Asa Use
GB201522398D0 (en) 2015-12-18 2016-02-03 Photocure As Device for photodynamic therapy
CN106187793A (zh) 2016-01-26 2016-12-07 赵鸣 5‑氨基酮戊酸及其衍生物的盐化合物和应用
HRP20210323T1 (hr) 2017-02-06 2021-05-14 3Skin As Pripravak za zaštitu od sunca
EP3636256B1 (de) * 2017-05-31 2024-07-03 SBI Pharmaceuticals Co., Ltd. Prophylaktikum oder therapeutikum für hyperaktive blase
CN107976508A (zh) * 2017-11-27 2018-05-01 上海百灵医药科技有限公司 一种分析盐酸氨酮戊酸含量和纯度的方法
EP3868372A1 (de) 2020-02-19 2021-08-25 JLP Health GmbH Pharmazeutische kombination aus einer artemisinin-verbindung und einem häme-synthese-modulator zur behandlung von krebs
CN113651708A (zh) * 2021-08-17 2021-11-16 湖南复瑞生物医药技术有限责任公司 一种5-氨基酮戊酸酯化物的制备及后处理方法
KR20250154511A (ko) 2023-03-07 2025-10-28 포토큐어 에이에스에이 방광암 치료

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2411382C3 (de) * 1974-03-09 1979-09-06 C.H. Boehringer Sohn, 6507 Ingelheim 2-Tetrahydrofurfuryl-6,7-benzomorphane, Verfahren zur Herstellung und deren Verwendung
GB2058077B (en) * 1979-06-08 1983-03-09 Szelke M Enkephalin analogues
CA1236029A (en) * 1984-05-14 1988-05-03 Edmund Sandborn Pharmaceutical solutions comprising dimethyl sulfoxide
JPH0745502B2 (ja) * 1987-11-10 1995-05-17 株式会社トクヤマ 新規化合物及びそれを含む組成物
US5079262A (en) * 1989-07-28 1992-01-07 Queen's University At Kingston Method of detection and treatment of malignant and non-malignant lesions utilizing 5-aminolevulinic acid
US5422093A (en) * 1989-07-28 1995-06-06 Queen's University Photochemotherapeutic method using 5-aminolevulinic acid and precursors thereof
US5234940A (en) * 1989-07-28 1993-08-10 Queen's University Photochemotherapeutic method using 5-aminolevulinic acid and precursors thereof
JP2767318B2 (ja) * 1990-04-11 1998-06-18 株式会社コスモ総合研究所 ５―アミノレブリン酸アルキルエステル又はその塩及びその製造方法並びにこれを有効成分とする除草剤
EP0553116A1 (de) * 1990-10-05 1993-08-04 Queen's University At Kingston Porphyrinderivate
US5219878A (en) * 1990-10-05 1993-06-15 Queen's University Tetrapyrrole hydroxyalkylamide photochemotherapeutic agents
GB9318841D0 (en) * 1993-09-10 1993-10-27 Res Foundation Of The Norwegia Composition

Also Published As

Publication number Publication date
NL300207I2 (nl) 2005-12-01
CA2215069A1 (en) 1996-09-19
DE122006000051I1 (de) 2007-01-04
NO2005024I1 (no) 2005-11-14
FR05C0042I2 (de) 2009-10-30
EP0820432A1 (de) 1998-01-28
NL300176I1 (nl) 2005-05-02
NO2005019I1 (no) 2005-09-26
PT820432E (pt) 2001-09-28
NO2005019I2 (no) 2007-04-23
CZ284897A3 (cs) 1998-03-18
LU90956I2 (fr) 2002-11-13
ATE202076T1 (de) 2001-06-15
NO974163L (no) 1997-09-09
JPH11501914A (ja) 1999-02-16
NL300176I2 (nl) 2005-05-02
AU708076B2 (en) 1999-07-29
KR100444007B1 (ko) 2004-12-03
HU225148B1 (en) 2006-07-28
CZ291132B6 (cs) 2002-12-11
AU4950096A (en) 1996-10-02
WO1996028412A1 (en) 1996-09-19
NO2005024I2 (no) 2007-04-23
EP0820432B1 (de) 2001-06-13
NZ303251A (en) 2000-10-27
DE122006000051I2 (de) 2010-07-08
CN1137087C (zh) 2004-02-04
US6034267A (en) 2000-03-07
HUP9800460A3 (en) 1998-08-28
JP3955093B2 (ja) 2007-08-08
HUP9800460A2 (hu) 1998-07-28
FR05C0042I1 (de) 2005-02-12
CA2215069C (en) 2006-09-12
DE69613365T2 (de) 2002-05-02
NL300207I1 (nl) 2005-12-01
CN1178521A (zh) 1998-04-08
ES2157424T3 (es) 2001-08-16
NO318379B1 (no) 2005-03-14
NO974163D0 (no) 1997-09-09

Similar Documents

Publication Publication Date Title
DE69613365D1 (de) Ester der 5-aminolevulinsäure als mittel zur photosensibilisierung in der chemotherapie
MA27568A1 (fr) Derives de pyrrolopyrimidine
TNSN98154A1 (fr) Derives de 2-aminopyridine nouveaux et compositions pharmaceutiques les contenant
MY123354A (en) 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives
PT1227806E (pt) Formulacao farmaceutica contendo tolterodina e sua utilizacao
DK0583421T3 (da) Substituerede dibenzoxazepinforbindelser, lægemidler og fremgangsmåder til anvendelse
ATE269865T1 (de) Pyrazolo(3,4-g)chinoxaline als pdgf-rezeptor protein tyrosin-kinase inhibitoren
RU98103388A (ru) (r)-5-бром-n-(1-этил-4-метилгексагидро-1н-1,4-диазепин-6-ил)-2-метокси-6-м етиламино-3-пиридинкарбоксамид, способ его получения и фармацевтическая композиция, содержащая указанное соединение
DE69315836D1 (de) Pyrazolpyridine für die behandlung der anämie
DK0823909T3 (da) Hidtil ukendte heterocykliske forbindelser
KR890003378A (ko) 혐기성균에 대해 항균작용을 갖는 나프티리딘 화합물
ATE169635T1 (de) Therapeutische verbindungen für die behandlung von krankheiten, die mit einem glutathion-defizit assoziiert sind, herstellungsprozess und diese enthaltene pharmazeutische zusammensetzungen
TNSN08287A1 (en) 3,5-substituted piperidine compounds as renin inhibitors
BR0214293A (pt) Composto e métodos para tratar um paciente que tenha, ou de prevenir um paciente de adquirir, uma doença ou condição e para produzir um composto ou um sal ou éster farmaceuticamente aceitável do mesmo
ATE172736T1 (de) Neue 2.4-diphosphonoglutarsäurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
PL304334A1 (en) Pharmaceutical composition of gastric protective action, including antiulceric one and method of treating diseases of gastrointestinal tract
DE69622868D1 (de) Inhibitoren der blutplättchen-aggregation, die c-terminale aminosäurereste mit aminergen seitenketten enthalten