DE60135854D1 - 2-(4-Pyridyl)amino-6-dialkoxyphenyl-pyrido(2,3-d)pyrimidin-7-one - Google Patents
2-(4-Pyridyl)amino-6-dialkoxyphenyl-pyrido(2,3-d)pyrimidin-7-oneInfo
- Publication number
- DE60135854D1 DE60135854D1 DE60135854T DE60135854T DE60135854D1 DE 60135854 D1 DE60135854 D1 DE 60135854D1 DE 60135854 T DE60135854 T DE 60135854T DE 60135854 T DE60135854 T DE 60135854T DE 60135854 D1 DE60135854 D1 DE 60135854D1
- Authority
- DE
- Germany
- Prior art keywords
- dialkoxyphenyl
- pyrido
- pyrimidin
- pyridyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22308300P | 2000-08-04 | 2000-08-04 | |
| PCT/US2001/022881 WO2002012238A2 (en) | 2000-08-04 | 2001-07-20 | 2-(4-PYRIDYL)AMINO-6-DIALKOXYPHENYL-PYRIDO[2,3-d]PYRIMIDIN-7-ONES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60135854D1 true DE60135854D1 (de) | 2008-10-30 |
Family
ID=22834955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60135854T Expired - Lifetime DE60135854D1 (de) | 2000-08-04 | 2001-07-20 | 2-(4-Pyridyl)amino-6-dialkoxyphenyl-pyrido(2,3-d)pyrimidin-7-one |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7022711B2 (de) |
| EP (1) | EP1307450B1 (de) |
| JP (1) | JP2004519422A (de) |
| AP (1) | AP1333A (de) |
| AR (1) | AR030310A1 (de) |
| AT (1) | ATE408613T1 (de) |
| AU (1) | AU2001277032A1 (de) |
| BR (1) | BR0112857A (de) |
| CA (1) | CA2417942C (de) |
| DE (1) | DE60135854D1 (de) |
| DO (1) | DOP2001000227A (de) |
| ES (1) | ES2311532T3 (de) |
| GT (1) | GT200100158A (de) |
| HN (1) | HN2001000171A (de) |
| MX (1) | MXPA02011263A (de) |
| PA (1) | PA8524101A1 (de) |
| PE (1) | PE20020305A1 (de) |
| SV (1) | SV2002000572A (de) |
| TN (1) | TNSN01118A1 (de) |
| UY (1) | UY26867A1 (de) |
| WO (1) | WO2002012238A2 (de) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001278908A1 (en) * | 2000-08-04 | 2002-02-18 | Warner Lambert Company | Process for preparing 2-(4-pyridyl)amino-6-dialkyloxyphenyl-pyrido(2,3-d)pyrimidin 7-ones |
| JP2005507392A (ja) * | 2000-08-04 | 2005-03-17 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | ２−（４−ピリジル）アミノ−６−ジアルキルオキシフェニルピリド〔２，３−ｄ〕ピリミジン−７−オン類の製造方法 |
| JP4291696B2 (ja) * | 2002-01-22 | 2009-07-08 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | ２−（ピリジン−２−イルアミノ）−ピリド［２，３−ｄ］ピリミジン−７−オン |
| PA8577501A1 (es) * | 2002-07-25 | 2004-02-07 | Warner Lambert Co | Inhibidores de quinasas |
| WO2004013633A2 (en) * | 2002-07-29 | 2004-02-12 | Axxima Pharmaceuticals Ag | Method for isolating atp binding proteins by means of immobolized protein inhibitors |
| US7098332B2 (en) * | 2002-12-20 | 2006-08-29 | Hoffmann-La Roche Inc. | 5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones |
| CN100420687C (zh) * | 2002-12-20 | 2008-09-24 | 霍夫曼-拉罗奇有限公司 | 作为选择性kdr和fgfr抑制剂的吡啶并[2,3-d]嘧啶衍生物 |
| US20040242566A1 (en) | 2003-03-25 | 2004-12-02 | Syrrx, Inc. | Dipeptidyl peptidase inhibitors |
| JP2007511467A (ja) | 2003-05-14 | 2007-05-10 | タケダ サン ディエゴ インコーポレイテッド | ジペプチジルペプチダーゼインヒビター |
| MXPA06001601A (es) | 2003-08-13 | 2006-08-25 | Takeda Pharmaceutical | Derivados de 4-pirimidona y su uso como inhibidores de dipeptidilpeptidasa. |
| US7169926B1 (en) | 2003-08-13 | 2007-01-30 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| US7678909B1 (en) | 2003-08-13 | 2010-03-16 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| WO2005026148A1 (en) | 2003-09-08 | 2005-03-24 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
| WO2005046603A2 (en) * | 2003-11-10 | 2005-05-26 | Synta Pharmaceuticals, Corp. | Pyridine compounds |
| DE602005023587D1 (de) * | 2004-01-21 | 2010-10-28 | Univ Emory | Zusammensetzungen und verwendung von tyrosinkinase-hemmern zur behandlung von pathogenen infektionen |
| US7732446B1 (en) | 2004-03-11 | 2010-06-08 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| CN102127057A (zh) | 2004-03-15 | 2011-07-20 | 武田药品工业株式会社 | 二肽基肽酶抑制剂 |
| WO2005118555A1 (en) | 2004-06-04 | 2005-12-15 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| FR2873118B1 (fr) | 2004-07-15 | 2007-11-23 | Sanofi Synthelabo | Derives de pyrido-pyrimidine, leur application en therapeutique |
| WO2006019965A2 (en) | 2004-07-16 | 2006-02-23 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
| WO2006038112A1 (en) * | 2004-10-01 | 2006-04-13 | Warner-Lambert Company Llc | Use of kinase inhibitors to promote neochondrogenesis |
| EP1828192B1 (de) | 2004-12-21 | 2014-12-03 | Takeda Pharmaceutical Company Limited | Dipeptidylpeptidasehemmer |
| FR2887882B1 (fr) | 2005-07-01 | 2007-09-07 | Sanofi Aventis Sa | Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique |
| SI1942898T2 (sl) | 2005-09-14 | 2014-08-29 | Takeda Pharmaceutical Company Limited | Dipeptidil-peptidazni inhibitorji za zdravljenje diabetesa |
| EP1924567B1 (de) | 2005-09-16 | 2012-08-22 | Takeda Pharmaceutical Company Limited | Verfahren zur herstellung von pyrimidindionderivaten |
| FR2896246B1 (fr) * | 2006-01-13 | 2008-08-15 | Sanofi Aventis Sa | Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique. |
| WO2007112347A1 (en) | 2006-03-28 | 2007-10-04 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| RS51965B (sr) * | 2006-09-13 | 2012-02-29 | Takeda Pharmaceutical Company Limited | Upotreba 2-6-(3-amino-piperidin-1-il)-3-metil-2,4-diokso-3,4-dihidro-2h-pirimidin-1-ilmetil-4-fluoro-benzonitrila za lečenje dijabetesa, kancera, autoimunih poremećaja i hiv infekcije |
| US8324383B2 (en) | 2006-09-13 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile |
| CN101535308A (zh) * | 2006-11-09 | 2009-09-16 | 霍夫曼-拉罗奇有限公司 | 作为激酶抑制剂的取代的6-苯基-吡啶并[2，3-d]嘧啶-7-酮衍生物及其使用方法 |
| TW200838536A (en) | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
| CN101679408B (zh) | 2006-12-22 | 2016-04-27 | Astex治疗学有限公司 | 作为fgfr抑制剂的双环杂环化合物 |
| HRP20151398T1 (hr) | 2006-12-22 | 2016-02-12 | Astex Therapeutics Limited | Tricikliäśni derivati amina kao inhibitori protein tirozin kinaze |
| US8131527B1 (en) | 2006-12-22 | 2012-03-06 | Astex Therapeutics Ltd. | FGFR pharmacophore compounds |
| FR2910813B1 (fr) | 2006-12-28 | 2009-02-06 | Sanofi Aventis Sa | Nouvelle utilisation therapeutique pour le traitement des leucemies |
| WO2008104473A2 (en) * | 2007-02-28 | 2008-09-04 | F. Hoffmann-La Roche Ag | Pyrazolopyriidine derivatives and their use as kinase inhibitors |
| US8093236B2 (en) | 2007-03-13 | 2012-01-10 | Takeda Pharmaceuticals Company Limited | Weekly administration of dipeptidyl peptidase inhibitors |
| GB0720041D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
| GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
| GB0810902D0 (en) | 2008-06-13 | 2008-07-23 | Astex Therapeutics Ltd | New compounds |
| EP2400985A2 (de) | 2009-02-25 | 2012-01-04 | OSI Pharmaceuticals, LLC | Kombination eines anti-igf-1r-antikörpers oder eines igf-bindungsproteins und eines kleinmoleküligen igf-1r-kinase-inhibitors |
| WO2010099138A2 (en) | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
| JP2012519281A (ja) | 2009-02-27 | 2012-08-23 | オーエスアイ・ファーマシューティカルズ，エルエルシー | 間葉様腫瘍細胞またはその生成を阻害する薬剤を同定するための方法 |
| JP2012519282A (ja) | 2009-02-27 | 2012-08-23 | オーエスアイ・ファーマシューティカルズ，エルエルシー | 間葉様腫瘍細胞またはその生成を阻害する薬剤を同定するための方法 |
| GB0906470D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| GB0906472D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| CN101671336B (zh) | 2009-09-23 | 2013-11-13 | 辽宁利锋科技开发有限公司 | 芳杂环并嘧啶衍生物和类似物及其制备方法和用途 |
| PH12012502572A1 (en) | 2010-06-30 | 2022-03-30 | Fujifilm Corp | Novel nicotinamide derivative or salt thereof |
| EP2702173A1 (de) | 2011-04-25 | 2014-03-05 | OSI Pharmaceuticals, LLC | Verwendung von emt-gensignaturen bei der entdeckung von krebswirkstoffen, -diagnostika und -behandlungen |
| WO2013152252A1 (en) | 2012-04-06 | 2013-10-10 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
| US8802697B2 (en) * | 2012-07-11 | 2014-08-12 | Blueprint Medicines Corporation | Inhibitors of the fibroblast growth factor receptor |
| AU2014228746B2 (en) | 2013-03-15 | 2018-08-30 | Celgene Car Llc | Heteroaryl compounds and uses thereof |
| ES2892423T3 (es) | 2013-03-15 | 2022-02-04 | Celgene Car Llc | Compuestos de heteroarilo y usos de los mismos |
| TWI647220B (zh) | 2013-03-15 | 2019-01-11 | 美商西建卡爾有限責任公司 | 雜芳基化合物及其用途 |
| AU2014339972B9 (en) | 2013-10-25 | 2019-05-30 | Blueprint Medicines Corporation | Inhibitors of the fibroblast growth factor receptor |
| WO2015108992A1 (en) | 2014-01-15 | 2015-07-23 | Blueprint Medicines Corporation | Heterobicyclic compounds and their use as fgfr4 receptor inhibitors |
| AU2015296322B2 (en) | 2014-07-26 | 2019-09-19 | Sunshine Lake Pharma Co., Ltd. | 2-amino-pyrido[2,3-d]pyrimidin-7(8h)-one derivatives as CDK inhibitors and uses thereof |
| US10449195B2 (en) | 2016-03-29 | 2019-10-22 | Shenzhen Pharmacin Co., Ltd. | Pharmaceutical formulation of palbociclib and a preparation method thereof |
| EA201990189A1 (ru) * | 2016-07-01 | 2019-06-28 | Г1 Терапьютикс, Инк. | Синтез n-(гетероарил)пирроло[3,2-d]пиримидин-2-аминов |
| SG11201907909TA (en) * | 2017-02-27 | 2019-09-27 | Betta Pharmaceuticals Co Ltd | Fgfr inhibitor and application thereof |
| KR20210049847A (ko) | 2018-08-24 | 2021-05-06 | 쥐원 쎄라퓨틱스, 인크. | 1,4-디아자스피로[5.5]운데칸-3-온의 개선된 합성 |
| MX2020013757A (es) | 2018-09-14 | 2021-03-02 | Abbisko Therapeutics Co Ltd | Inhibidor del fgfr, metodo de preparacion y aplicacion del mismo. |
| AU2019413683B2 (en) * | 2018-12-28 | 2025-05-22 | Spv Therapeutics Inc. | Cyclin-dependent kinase inhibitors |
| CN114306245A (zh) | 2020-09-29 | 2022-04-12 | 深圳市药欣生物科技有限公司 | 无定形固体分散体的药物组合物及其制备方法 |
| CA3207296A1 (en) * | 2021-01-06 | 2022-07-14 | The Penn State Research Foundation | Methods and materials for treating hair loss |
| US12268677B2 (en) | 2022-04-27 | 2025-04-08 | The Penn State Research Foundation | 4-aminopyridine (4-AP) and bone morphogenetic protein 2 (BMP-2) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5620981A (en) * | 1995-05-03 | 1997-04-15 | Warner-Lambert Company | Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation |
| US5945422A (en) * | 1997-02-05 | 1999-08-31 | Warner-Lambert Company | N-oxides of amino containing pyrido 2,3-D! pyrimidines |
| AU2001278908A1 (en) * | 2000-08-04 | 2002-02-18 | Warner Lambert Company | Process for preparing 2-(4-pyridyl)amino-6-dialkyloxyphenyl-pyrido(2,3-d)pyrimidin 7-ones |
| JP2005507392A (ja) * | 2000-08-04 | 2005-03-17 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | ２−（４−ピリジル）アミノ−６−ジアルキルオキシフェニルピリド〔２，３−ｄ〕ピリミジン−７−オン類の製造方法 |
-
2001
- 2001-07-20 AT AT01954811T patent/ATE408613T1/de not_active IP Right Cessation
- 2001-07-20 AP APAP/P/2001/002230A patent/AP1333A/en active
- 2001-07-20 MX MXPA02011263A patent/MXPA02011263A/es active IP Right Grant
- 2001-07-20 JP JP2002518213A patent/JP2004519422A/ja active Pending
- 2001-07-20 DE DE60135854T patent/DE60135854D1/de not_active Expired - Lifetime
- 2001-07-20 EP EP01954811A patent/EP1307450B1/de not_active Expired - Lifetime
- 2001-07-20 ES ES01954811T patent/ES2311532T3/es not_active Expired - Lifetime
- 2001-07-20 WO PCT/US2001/022881 patent/WO2002012238A2/en not_active Ceased
- 2001-07-20 CA CA2417942A patent/CA2417942C/en not_active Expired - Fee Related
- 2001-07-20 US US10/343,847 patent/US7022711B2/en not_active Expired - Fee Related
- 2001-07-20 BR BR0112857-4A patent/BR0112857A/pt not_active IP Right Cessation
- 2001-07-20 AU AU2001277032A patent/AU2001277032A1/en not_active Abandoned
- 2001-07-27 SV SV2001000572A patent/SV2002000572A/es not_active Application Discontinuation
- 2001-08-01 TN TNTNSN01118A patent/TNSN01118A1/en unknown
- 2001-08-03 DO DO2001000227A patent/DOP2001000227A/es unknown
- 2001-08-03 PA PA20018524101A patent/PA8524101A1/es unknown
- 2001-08-03 UY UY26867A patent/UY26867A1/es not_active Application Discontinuation
- 2001-08-03 PE PE2001000776A patent/PE20020305A1/es not_active Application Discontinuation
- 2001-08-03 AR ARP010103716A patent/AR030310A1/es not_active Application Discontinuation
- 2001-08-03 HN HN2001000171A patent/HN2001000171A/es unknown
- 2001-08-03 GT GT200100158A patent/GT200100158A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HN2001000171A (es) | 2001-09-21 |
| TNSN01118A1 (en) | 2005-11-10 |
| UY26867A1 (es) | 2001-10-25 |
| ES2311532T3 (es) | 2009-02-16 |
| SV2002000572A (es) | 2002-07-18 |
| AP2001002230A0 (en) | 2001-09-30 |
| AP1333A (en) | 2004-11-28 |
| CA2417942C (en) | 2010-06-29 |
| MXPA02011263A (es) | 2003-03-10 |
| WO2002012238A3 (en) | 2002-05-10 |
| DOP2001000227A (es) | 2002-12-15 |
| US7022711B2 (en) | 2006-04-04 |
| AR030310A1 (es) | 2003-08-20 |
| US20030220345A1 (en) | 2003-11-27 |
| WO2002012238A2 (en) | 2002-02-14 |
| EP1307450A2 (de) | 2003-05-07 |
| PE20020305A1 (es) | 2002-05-09 |
| BR0112857A (pt) | 2005-02-09 |
| GT200100158A (es) | 2002-07-18 |
| EP1307450B1 (de) | 2008-09-17 |
| PA8524101A1 (es) | 2002-10-24 |
| ATE408613T1 (de) | 2008-10-15 |
| CA2417942A1 (en) | 2002-02-14 |
| JP2004519422A (ja) | 2004-07-02 |
| AU2001277032A1 (en) | 2002-02-18 |
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