AU2001277032A1 - 2-(4-pyridyl)amino-6-dialkoxyphenyl-pyrido(2,3-d)pyrimidin-7 ones - Google Patents
2-(4-pyridyl)amino-6-dialkoxyphenyl-pyrido(2,3-d)pyrimidin-7 onesInfo
- Publication number
- AU2001277032A1 AU2001277032A1 AU2001277032A AU7703201A AU2001277032A1 AU 2001277032 A1 AU2001277032 A1 AU 2001277032A1 AU 2001277032 A AU2001277032 A AU 2001277032A AU 7703201 A AU7703201 A AU 7703201A AU 2001277032 A1 AU2001277032 A1 AU 2001277032A1
- Authority
- AU
- Australia
- Prior art keywords
- dialkoxyphenyl
- pyrido
- pyrimidin
- pyridyl
- ones
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22308300P | 2000-08-04 | 2000-08-04 | |
| US60223083 | 2000-08-04 | ||
| PCT/US2001/022881 WO2002012238A2 (en) | 2000-08-04 | 2001-07-20 | 2-(4-PYRIDYL)AMINO-6-DIALKOXYPHENYL-PYRIDO[2,3-d]PYRIMIDIN-7-ONES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2001277032A1 true AU2001277032A1 (en) | 2002-02-18 |
Family
ID=22834955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2001277032A Abandoned AU2001277032A1 (en) | 2000-08-04 | 2001-07-20 | 2-(4-pyridyl)amino-6-dialkoxyphenyl-pyrido(2,3-d)pyrimidin-7 ones |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7022711B2 (en) |
| EP (1) | EP1307450B1 (en) |
| JP (1) | JP2004519422A (en) |
| AP (1) | AP1333A (en) |
| AR (1) | AR030310A1 (en) |
| AT (1) | ATE408613T1 (en) |
| AU (1) | AU2001277032A1 (en) |
| BR (1) | BR0112857A (en) |
| CA (1) | CA2417942C (en) |
| DE (1) | DE60135854D1 (en) |
| DO (1) | DOP2001000227A (en) |
| ES (1) | ES2311532T3 (en) |
| GT (1) | GT200100158A (en) |
| HN (1) | HN2001000171A (en) |
| MX (1) | MXPA02011263A (en) |
| PA (1) | PA8524101A1 (en) |
| PE (1) | PE20020305A1 (en) |
| SV (1) | SV2002000572A (en) |
| TN (1) | TNSN01118A1 (en) |
| UY (1) | UY26867A1 (en) |
| WO (1) | WO2002012238A2 (en) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004505974A (en) * | 2000-08-04 | 2004-02-26 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | Method for producing 2- (4-pyridyl) amino-6-dialkyloxyphenylpyrido [2,3-d] pyrimidin-7-one |
| CA2424057A1 (en) * | 2000-08-04 | 2003-04-03 | Warner-Lambert Company | Process for preparing 2-(4-pyridyl) amino-6-dialkyloxyphenyl-pyrido [2,3-d]pyrimidin-7-ones |
| DE60303009T2 (en) * | 2002-01-22 | 2006-07-13 | Warner-Lambert Co. Llc | 2- (pyridin-2-ylamino) -pyrido [2,3-d] pyrimidine-7-ONE |
| US7196090B2 (en) * | 2002-07-25 | 2007-03-27 | Warner-Lambert Company | Kinase inhibitors |
| EP1527345A2 (en) * | 2002-07-29 | 2005-05-04 | Axxima Pharmaceuticals AG | Method for isolating atp binding proteins by means of immobilized protein inhibitors |
| CN100420687C (en) * | 2002-12-20 | 2008-09-24 | 霍夫曼-拉罗奇有限公司 | Pyrido [2, 3-D ] pyrimidine derivatives as selective KDR and FGFR inhibitors |
| US7098332B2 (en) * | 2002-12-20 | 2006-08-29 | Hoffmann-La Roche Inc. | 5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones |
| JP4887139B2 (en) | 2003-03-25 | 2012-02-29 | 武田薬品工業株式会社 | Dipeptidyl peptidase inhibitor |
| US7638638B2 (en) | 2003-05-14 | 2009-12-29 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
| CA2535619A1 (en) | 2003-08-13 | 2005-02-24 | Takeda Pharmaceutical Company Limited | 4-pyrimidone derivatives and their use as peptidyl peptidase inhibitors |
| US7678909B1 (en) | 2003-08-13 | 2010-03-16 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| US7169926B1 (en) | 2003-08-13 | 2007-01-30 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| WO2005026148A1 (en) | 2003-09-08 | 2005-03-24 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
| CA2545258A1 (en) | 2003-11-10 | 2005-05-26 | Synta Pharmaceuticals, Corp. | Pyridine compounds |
| AU2005209231B8 (en) | 2004-01-21 | 2011-07-28 | Emory University | Compositions and methods of use for tyrosine kinase inhibitors to treat pathogenic infection |
| US7732446B1 (en) | 2004-03-11 | 2010-06-08 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| CN102127057A (en) | 2004-03-15 | 2011-07-20 | 武田药品工业株式会社 | Dipeptidyl peptidase inhibitors |
| US7687638B2 (en) | 2004-06-04 | 2010-03-30 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
| FR2873118B1 (en) | 2004-07-15 | 2007-11-23 | Sanofi Synthelabo | PYRIDO-PYRIMIDINE DERIVATIVES, THEIR APPLICATION IN THERAPEUTICS |
| WO2006019965A2 (en) | 2004-07-16 | 2006-02-23 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
| WO2006038112A1 (en) * | 2004-10-01 | 2006-04-13 | Warner-Lambert Company Llc | Use of kinase inhibitors to promote neochondrogenesis |
| WO2006068978A2 (en) | 2004-12-21 | 2006-06-29 | Takeda Pharmaceutial Company Limited | Dipeptidyl peptidase inhibitors |
| FR2887882B1 (en) | 2005-07-01 | 2007-09-07 | Sanofi Aventis Sa | PYRIDO [2,3-D] PYRIMIDINE DERIVATIVES, THEIR PREPARATION, THEIR THERAPEUTIC APPLICATION |
| EP1942898B2 (en) | 2005-09-14 | 2014-05-14 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors for treating diabetes |
| CN102675221A (en) | 2005-09-16 | 2012-09-19 | 武田药品工业株式会社 | Intermediate in method for preparing pyrimidinedione derivative |
| FR2896246B1 (en) * | 2006-01-13 | 2008-08-15 | Sanofi Aventis Sa | PYRIDO-PYRIMIDONE DERIVATIVES, THEIR PREPARATION, THEIR THERAPEUTIC APPLICATION |
| WO2007112347A1 (en) | 2006-03-28 | 2007-10-04 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| GEP20125701B (en) * | 2006-09-13 | 2012-12-10 | Takeda Pharmaceuticals Co | Application of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2h-pyrimidin-1-ylmethyl]-4-fluoro-benzonitrile |
| US8324383B2 (en) | 2006-09-13 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile |
| JP2010509265A (en) * | 2006-11-09 | 2010-03-25 | エフ．ホフマン−ラ ロシュ アーゲー | Substituted 6-phenyl-pyrido [2,3-D] pyrimidin-7-one derivatives as kinase inhibitors and methods of use thereof |
| TW200838536A (en) | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
| US8131527B1 (en) | 2006-12-22 | 2012-03-06 | Astex Therapeutics Ltd. | FGFR pharmacophore compounds |
| CA2672213C (en) | 2006-12-22 | 2016-02-16 | Astex Therapeutics Limited | Bicyclic amine derivatives as protein tyrosine kinase inhibitors |
| WO2008078091A1 (en) | 2006-12-22 | 2008-07-03 | Astex Therapeutics Limited | Bicyclic heterocyclic compounds as fgfr inhibitors |
| FR2910813B1 (en) | 2006-12-28 | 2009-02-06 | Sanofi Aventis Sa | NEW THERAPEUTIC USE FOR THE TREATMENT OF LEUKEMIA |
| WO2008104473A2 (en) * | 2007-02-28 | 2008-09-04 | F. Hoffmann-La Roche Ag | Pyrazolopyriidine derivatives and their use as kinase inhibitors |
| US8093236B2 (en) | 2007-03-13 | 2012-01-10 | Takeda Pharmaceuticals Company Limited | Weekly administration of dipeptidyl peptidase inhibitors |
| GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
| GB0720041D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
| GB0810902D0 (en) | 2008-06-13 | 2008-07-23 | Astex Therapeutics Ltd | New compounds |
| US20120189641A1 (en) | 2009-02-25 | 2012-07-26 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
| WO2010099138A2 (en) | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
| EP2401614A1 (en) | 2009-02-27 | 2012-01-04 | OSI Pharmaceuticals, LLC | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
| EP2401613A2 (en) | 2009-02-27 | 2012-01-04 | OSI Pharmaceuticals, LLC | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
| GB0906472D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| GB0906470D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| CN101671336B (en) | 2009-09-23 | 2013-11-13 | 辽宁利锋科技开发有限公司 | Aromatic heterocyclic pyrimidine derivatives and analogs, preparation methods and uses thereof |
| WO2012002577A1 (en) | 2010-06-30 | 2012-01-05 | 富士フイルム株式会社 | Novel nicotinamide derivatives or salts thereof |
| WO2012149014A1 (en) | 2011-04-25 | 2012-11-01 | OSI Pharmaceuticals, LLC | Use of emt gene signatures in cancer drug discovery, diagnostics, and treatment |
| WO2013152252A1 (en) | 2012-04-06 | 2013-10-10 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
| KR102163776B1 (en) * | 2012-07-11 | 2020-10-12 | 블루프린트 메디신즈 코포레이션 | Inhibitors of the fibroblast growth factor receptor |
| MX374558B (en) | 2013-03-15 | 2025-03-06 | Sanofi Sa | HETEROARYL COMPOUNDS AND THEIR USES. |
| AR095464A1 (en) | 2013-03-15 | 2015-10-21 | Celgene Avilomics Res Inc | HETEROARILO COMPOUNDS AND USES OF THE SAME |
| NZ711376A (en) | 2013-03-15 | 2020-01-31 | Sanofi Sa | Heteroaryl compounds and uses thereof |
| BR112016008849B8 (en) | 2013-10-25 | 2022-09-06 | Blueprint Medicines Corp | COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, USE OF THE SAID COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS |
| WO2015108992A1 (en) | 2014-01-15 | 2015-07-23 | Blueprint Medicines Corporation | Heterobicyclic compounds and their use as fgfr4 receptor inhibitors |
| WO2016015597A1 (en) | 2014-07-26 | 2016-02-04 | Sunshine Lake Pharma Co., Ltd. | Compounds as cdk small-molecule inhibitors and uses thereof |
| US10449195B2 (en) | 2016-03-29 | 2019-10-22 | Shenzhen Pharmacin Co., Ltd. | Pharmaceutical formulation of palbociclib and a preparation method thereof |
| KR102445288B1 (en) * | 2016-07-01 | 2022-09-19 | 쥐원 쎄라퓨틱스, 인크. | Synthesis of N-(heteroaryl)-pyrrolo[3,2-d]pyrimidin-2-amine |
| WO2018153373A1 (en) * | 2017-02-27 | 2018-08-30 | 贝达药业股份有限公司 | Fgfr inhibitor and application thereof |
| CN112839657B (en) | 2018-08-24 | 2025-07-25 | 法码科思莫斯控股有限公司 | Improved synthesis of 1, 4-diazaspiro [5.5] undecan-3-one |
| KR102531596B1 (en) | 2018-09-14 | 2023-05-11 | 아비스코 테라퓨틱스 컴퍼니 리미티드 | FGFR inhibitor, manufacturing method and use thereof |
| AU2019413683B2 (en) * | 2018-12-28 | 2025-05-22 | Spv Therapeutics Inc. | Cyclin-dependent kinase inhibitors |
| CN114306245A (en) | 2020-09-29 | 2022-04-12 | 深圳市药欣生物科技有限公司 | Pharmaceutical composition of amorphous solid dispersion and preparation method thereof |
| US20240024216A1 (en) * | 2021-01-06 | 2024-01-25 | The Penn State Research Foundation | Methods and materials for treating hair loss |
| US12268677B2 (en) | 2022-04-27 | 2025-04-08 | The Penn State Research Foundation | 4-aminopyridine (4-AP) and bone morphogenetic protein 2 (BMP-2) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5620981A (en) * | 1995-05-03 | 1997-04-15 | Warner-Lambert Company | Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation |
| US5945422A (en) * | 1997-02-05 | 1999-08-31 | Warner-Lambert Company | N-oxides of amino containing pyrido 2,3-D! pyrimidines |
| JP2004505974A (en) * | 2000-08-04 | 2004-02-26 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | Method for producing 2- (4-pyridyl) amino-6-dialkyloxyphenylpyrido [2,3-d] pyrimidin-7-one |
| CA2424057A1 (en) * | 2000-08-04 | 2003-04-03 | Warner-Lambert Company | Process for preparing 2-(4-pyridyl) amino-6-dialkyloxyphenyl-pyrido [2,3-d]pyrimidin-7-ones |
-
2001
- 2001-07-20 BR BR0112857-4A patent/BR0112857A/en not_active IP Right Cessation
- 2001-07-20 MX MXPA02011263A patent/MXPA02011263A/en active IP Right Grant
- 2001-07-20 CA CA2417942A patent/CA2417942C/en not_active Expired - Fee Related
- 2001-07-20 AP APAP/P/2001/002230A patent/AP1333A/en active
- 2001-07-20 WO PCT/US2001/022881 patent/WO2002012238A2/en not_active Ceased
- 2001-07-20 US US10/343,847 patent/US7022711B2/en not_active Expired - Fee Related
- 2001-07-20 DE DE60135854T patent/DE60135854D1/en not_active Expired - Lifetime
- 2001-07-20 EP EP01954811A patent/EP1307450B1/en not_active Expired - Lifetime
- 2001-07-20 JP JP2002518213A patent/JP2004519422A/en active Pending
- 2001-07-20 AT AT01954811T patent/ATE408613T1/en not_active IP Right Cessation
- 2001-07-20 ES ES01954811T patent/ES2311532T3/en not_active Expired - Lifetime
- 2001-07-20 AU AU2001277032A patent/AU2001277032A1/en not_active Abandoned
- 2001-07-27 SV SV2001000572A patent/SV2002000572A/en not_active Application Discontinuation
- 2001-08-01 TN TNTNSN01118A patent/TNSN01118A1/en unknown
- 2001-08-03 HN HN2001000171A patent/HN2001000171A/en unknown
- 2001-08-03 GT GT200100158A patent/GT200100158A/en unknown
- 2001-08-03 PA PA20018524101A patent/PA8524101A1/en unknown
- 2001-08-03 PE PE2001000776A patent/PE20020305A1/en not_active Application Discontinuation
- 2001-08-03 UY UY26867A patent/UY26867A1/en not_active Application Discontinuation
- 2001-08-03 DO DO2001000227A patent/DOP2001000227A/en unknown
- 2001-08-03 AR ARP010103716A patent/AR030310A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US7022711B2 (en) | 2006-04-04 |
| JP2004519422A (en) | 2004-07-02 |
| WO2002012238A3 (en) | 2002-05-10 |
| EP1307450A2 (en) | 2003-05-07 |
| GT200100158A (en) | 2002-07-18 |
| ATE408613T1 (en) | 2008-10-15 |
| AP2001002230A0 (en) | 2001-09-30 |
| SV2002000572A (en) | 2002-07-18 |
| WO2002012238A2 (en) | 2002-02-14 |
| AR030310A1 (en) | 2003-08-20 |
| EP1307450B1 (en) | 2008-09-17 |
| US20030220345A1 (en) | 2003-11-27 |
| ES2311532T3 (en) | 2009-02-16 |
| CA2417942A1 (en) | 2002-02-14 |
| DE60135854D1 (en) | 2008-10-30 |
| CA2417942C (en) | 2010-06-29 |
| AP1333A (en) | 2004-11-28 |
| TNSN01118A1 (en) | 2005-11-10 |
| UY26867A1 (en) | 2001-10-25 |
| PE20020305A1 (en) | 2002-05-09 |
| DOP2001000227A (en) | 2002-12-15 |
| HN2001000171A (en) | 2001-09-21 |
| BR0112857A (en) | 2005-02-09 |
| MXPA02011263A (en) | 2003-03-10 |
| PA8524101A1 (en) | 2002-10-24 |
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