[go: up one dir, main page]

CY2165B1 - Heterocyclic compounds - Google Patents

Heterocyclic compounds

Info

Publication number
CY2165B1
CY2165B1 CY0000009A CY0000009A CY2165B1 CY 2165 B1 CY2165 B1 CY 2165B1 CY 0000009 A CY0000009 A CY 0000009A CY 0000009 A CY0000009 A CY 0000009A CY 2165 B1 CY2165 B1 CY 2165B1
Authority
CY
Cyprus
Prior art keywords
heterocyclic compounds
pharmaceutically acceptable
acceptable esters
ara
useful
Prior art date
Application number
CY0000009A
Other languages
English (en)
Inventor
Thomas Anthony Krenitsky
Devron Randolph Averett
Jeffrey Douglas Wilson
Allan Ray Moorman
George Walter Koszalka
Stanley Dawes Chamberlain
David Porter
Gerald Wolberg
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of CY2165B1 publication Critical patent/CY2165B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Earth Drilling (AREA)
  • Stereophonic System (AREA)
  • Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
CY0000009A 1990-07-19 2000-04-10 Heterocyclic compounds CY2165B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909015914A GB9015914D0 (en) 1990-07-19 1990-07-19 Heterocyclic compounds

Publications (1)

Publication Number Publication Date
CY2165B1 true CY2165B1 (en) 2002-08-23

Family

ID=10679359

Family Applications (1)

Application Number Title Priority Date Filing Date
CY0000009A CY2165B1 (en) 1990-07-19 2000-04-10 Heterocyclic compounds

Country Status (23)

Country Link
US (3) US5492897A (xx)
EP (1) EP0539479B1 (xx)
JP (1) JP2873086B2 (xx)
KR (1) KR100187326B1 (xx)
AT (1) ATE151637T1 (xx)
CA (1) CA2087543C (xx)
CY (1) CY2165B1 (xx)
DE (1) DE69125715T2 (xx)
DK (1) DK0539479T3 (xx)
ES (1) ES2103311T3 (xx)
GB (1) GB9015914D0 (xx)
GR (1) GR3023776T3 (xx)
HU (2) HU9300115D0 (xx)
IE (1) IE912513A1 (xx)
IL (1) IL98881A (xx)
MC (1) MC2289A1 (xx)
MY (1) MY111871A (xx)
NZ (1) NZ239025A (xx)
PT (1) PT98371B (xx)
RU (1) RU2114860C1 (xx)
TW (1) TW208655B (xx)
WO (1) WO1992001456A1 (xx)
ZA (1) ZA915656B (xx)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9015914D0 (en) * 1990-07-19 1990-09-05 Wellcome Found Heterocyclic compounds
AU6771198A (en) * 1997-03-24 1998-10-20 Glaxo Group Limited Method for treating b-cell tumors with ara-g nucleoside derivatives
CA2336412C (en) * 1998-07-02 2007-11-27 Junichi Shimada Medicament for treatment of diabetes
US6753322B2 (en) * 2000-06-06 2004-06-22 Pfizer Inc 2-aminocarbonyl-9H-purine derivatives
US7321033B2 (en) * 2001-11-27 2008-01-22 Anadys Pharmaceuticals, Inc. 3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof
UA79764C2 (en) * 2001-11-27 2007-07-25 Anadys Pharmaceuticals Inc 3-?-D-RIBOFURANOSYLTHIAZOLO[4,5-d]PYRIDIMINE NUCLEOSIDES AND USES THEREOF
AU2003261354A1 (en) * 2002-08-02 2004-02-23 The Regents Of The University Of California New uses for inhibitors of inosine monophosphate dehydrogenase
CA2537450C (en) 2003-09-05 2012-04-17 Anadys Pharmaceuticals, Inc. Administration of tlr7 ligands and prodrugs thereof for treatment of infection by hepatitis c virus
GB0321613D0 (en) * 2003-09-15 2003-10-15 Drug Discovery Lab As Compounds
EP1804838A2 (en) * 2004-09-15 2007-07-11 Drug Discovery Laboratory AS Drug conjugates of long chain fatty acid or ester moieties as protein binding prodrugs
AU2005304320A1 (en) * 2004-11-12 2006-05-18 Board Of Regents, The University Of Texas System Methods of treating hematological malignancies with nucleoside analog drugs
DK2561872T3 (en) 2004-12-17 2014-12-08 Anadys Pharmaceuticals Inc 3,5-DISUBSTITUTED AND 3,5,7-TRISUBSTITUTED 3H-OXAZOLO- [4,5-d] PYRIMIDIN-2-ON COMPOUNDS AND PRODRUGS THEREOF
US20060189543A1 (en) * 2005-02-23 2006-08-24 Rosenbloom Richard A Compositions and methods for the treatment of leukemia
JP5117391B2 (ja) 2005-11-21 2013-01-16 アナディス ファーマシューティカルズ インク ５−アミノ−３Ｈ−チアゾロ［４，５−ｄ］ピリミジン−２−オンを調製するための新規な方法
MX2008016518A (es) * 2006-06-22 2009-01-19 Anadys Pharmaceuticals Inc Profarmacos de 5-amino-3-(3'-desoxi-beta-d-ribofuranosil)-tiazolo[ 4,5-d]pirimidin-2,7-dion.
DE602007012881D1 (en) 2006-07-18 2011-04-14 Anadys Pharmaceuticals Inc Carbonat- und carbamat-prodrugs von thiazolo ä4,5-dü-pyrimidinen
CN101768197A (zh) * 2008-12-29 2010-07-07 北京德众万全药物技术开发有限公司 一种奈拉滨的制备方法
EP2658857B1 (en) 2010-12-29 2016-11-02 Inhibitex, Inc. Substituted purine nucleosides, phosphoroamidate and phosphorodiamidate derivatives for treatment of viral infections
WO2018230479A1 (ja) * 2017-06-13 2018-12-20 大原薬品工業株式会社 ヌクレオシド系抗がん剤又は抗ウィルス剤の５'位シリルエーテル誘導体
EP4267582A4 (en) * 2020-12-30 2024-06-05 Southern University of Science and Technology METHODS AND MODIFIED NUCLEOSIDES FOR THE TREATMENT OF CORONAVIRUS INFECTIONS

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2152486A1 (de) 1970-11-20 1972-06-29 Akad Wissenschaften Ddr Verfahren zur Herstellung von 5'-Desoxy-5'-fluor-6-methyl-mercaptopurinribosid
US3872084A (en) 1972-10-10 1975-03-18 Syntex Inc Purine nucleoside 3,5-cyclicphosphate compounds
US4081534A (en) * 1973-09-11 1978-03-28 Burroughs Wellcome Co. Amino purine nucleosides as autoimmune suppressant agents
GB1573777A (en) * 1977-11-03 1980-08-28 Wellcome Found 9-d-arabinonucleosides and an enzymatic process for their preparation
JPS61233696A (ja) * 1985-04-08 1986-10-17 Kanegafuchi Chem Ind Co Ltd ７−ヒドロキシグアニン誘導体及びその製造方法並びにそれを有効成分とする抗腫瘍剤
JPH0633263B2 (ja) * 1985-05-27 1994-05-02 鐘淵化学工業株式会社 ７−ヒドロキシグアニン誘導体及びその製造方法並びにそれを有効成分とする抗腫瘍剤
GB8712745D0 (en) * 1987-05-30 1987-07-01 Wellcome Found Antiviral compounds
CA1317291C (en) * 1987-12-14 1993-05-04 Naeem Botros Hanna Antitumor 6-sulfenamide, 6-sulfinamide and 6-sulfonamide purines, purine nucleosides, purine nucleotides and related compounds
US5352669A (en) * 1990-03-13 1994-10-04 The Of The United States Of America As Represented By The Department Of Health And Human Services O6 -benzylated guanine, guanosine and 2'-deoxyguanosine compounds possessing O6 -alkylguanine-DNA alkyltransferase depleting activity
GB9015914D0 (en) * 1990-07-19 1990-09-05 Wellcome Found Heterocyclic compounds

Also Published As

Publication number Publication date
ATE151637T1 (de) 1997-05-15
US5492897A (en) 1996-02-20
CA2087543A1 (en) 1992-01-20
PT98371A (pt) 1992-06-30
DK0539479T3 (da) 1997-08-25
IE912513A1 (en) 1992-01-29
EP0539479B1 (en) 1997-04-16
CA2087543C (en) 1998-08-25
MY111871A (en) 2001-02-28
JP2873086B2 (ja) 1999-03-24
JPH05508649A (ja) 1993-12-02
ZA915656B (en) 1993-03-31
GB9015914D0 (en) 1990-09-05
RU2114860C1 (ru) 1998-07-10
HU9300115D0 (en) 1993-04-28
US5821236A (en) 1998-10-13
DE69125715D1 (de) 1997-05-22
GR3023776T3 (en) 1997-09-30
EP0539479A1 (en) 1993-05-05
IL98881A (en) 1996-01-19
ES2103311T3 (es) 1997-09-16
PT98371B (pt) 1999-01-29
NZ239025A (en) 1993-08-26
MC2289A1 (fr) 1993-07-14
WO1992001456A1 (en) 1992-02-06
HUT62911A (en) 1993-06-28
KR100187326B1 (ko) 1999-05-01
AU8196091A (en) 1992-02-18
DE69125715T2 (de) 1997-08-07
AU641533B2 (en) 1993-09-23
US5747472A (en) 1998-05-05
TW208655B (xx) 1993-07-01
IL98881A0 (en) 1992-07-15

Similar Documents

Publication Publication Date Title
CY2165B1 (en) Heterocyclic compounds
CA2272705A1 (en) Fused bicyclic pyrimidine derivatives
MY108616A (en) Pyridine and pyridine n-oxide derivatives of diaryl methyl piperidines of piperazines, and compositions and methods of use thereof
ES8801303A1 (es) Un procedimiento para preparar una formulacion farmaceutica que contiene un 2'3'-didesoxi-nucleosido.
FI963424A0 (fi) Menetelmä terapeuttisesti aktiivisten tiofeenisulfonamidien valmistamiseksi
NZ516347A (en) Indanyl-substituted benzenecarboxamides, process for their preparation, their use as a medicament and pharmaceutical formulations containing them
UA32512C2 (uk) Похідні ксантину, спосіб їх одержання, та фармацевтична композиція
MY102986A (en) Benzo (5,6) cycloheptapyridines, compositions and methods of use
PT86186A (en) Process for the preparation of benzimidazol derivatives and of pharmaceutical compositions containing the same
HU912013D0 (en) Process for the production of benzopyrane derivatives and their heterocyclic analogues, antiyschemic medical preparations
RU93004860A (ru) Гетероциклические соединения, способ их получения, использование и фармацевтическая композиция
AU563762B2 (en) S-adenosyl-l-methionine salts preparation
IL88971A0 (en) Disubstituted pyridines,their preparation and pharmaceutical compositions containing them
TW374085B (en) Novel piperidine derivatives, their preparation, pharmaceutical formulation and medical use
MY104124A (en) Therapeutic compounds.
HU9201358D0 (en) 2-amino-pirimidine-4-carboxamide derivatives, process for their production and for the production of medical preparations containing them as active agents
MX9605131A (es) Formulacion estable de lactona de 7-etil-camptotecina y metodo para usar la misma.
UA41326C2 (uk) Фармацевтична композиція для профілактики або лікування вірусних захворювань, засіб для профілактики або лікування вірусних захворювань
JO2296B1 (en) Substituted pyrolates
ZA91901B (en) Side-chain homologous vitamin d derivatives,process for their production,pharmaceutical preparations containing these derivatives and their use as pharmaceutical agents
AU7111587A (en) Perhydrothiazepine and perhydroazepine derivatives,their preparation and their therapeutic use
EP0523013A3 (en) Use of benzimidazoline-2-oxo-1-carboxylic acid derivatives in the treatment of organic mental diseases
WO1998036778A8 (en) Sustained drug delivery and compositions useful therefor
AP9200405A0 (en) Pharmaceutical formulations comprised of micronised halofantrine.
JO2360B1 (en) Substituted pyrolates