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MC2289A1 - Composes heterocycliques - Google Patents

Composes heterocycliques

Info

Publication number
MC2289A1
MC2289A1 MC91@@D MC2289D MC2289A1 MC 2289 A1 MC2289 A1 MC 2289A1 MC 2289 D MC2289 D MC 2289D MC 2289 A1 MC2289 A1 MC 2289A1
Authority
MC
Monaco
Prior art keywords
heterocyclic compounds
pharmaceutically acceptable
acceptable esters
ara
useful
Prior art date
Application number
MC91@@D
Other languages
English (en)
Inventor
Thomas Krenitsky
Devron Averett
Jeffrey Wilson
Allan Moorman
George KOSZALKA
Stanley Chamberlain
David Porter
Gerald Wolberg
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of MC2289A1 publication Critical patent/MC2289A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Earth Drilling (AREA)
  • Stereophonic System (AREA)
  • Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
MC91@@D 1990-07-19 1991-07-18 Composes heterocycliques MC2289A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909015914A GB9015914D0 (en) 1990-07-19 1990-07-19 Heterocyclic compounds
PCT/GB1991/001196 WO1992001456A1 (fr) 1990-07-19 1991-07-18 Composes heterocycliques

Publications (1)

Publication Number Publication Date
MC2289A1 true MC2289A1 (fr) 1993-07-14

Family

ID=10679359

Family Applications (1)

Application Number Title Priority Date Filing Date
MC91@@D MC2289A1 (fr) 1990-07-19 1991-07-18 Composes heterocycliques

Country Status (23)

Country Link
US (3) US5492897A (fr)
EP (1) EP0539479B1 (fr)
JP (1) JP2873086B2 (fr)
KR (1) KR100187326B1 (fr)
AT (1) ATE151637T1 (fr)
CA (1) CA2087543C (fr)
CY (1) CY2165B1 (fr)
DE (1) DE69125715T2 (fr)
DK (1) DK0539479T3 (fr)
ES (1) ES2103311T3 (fr)
GB (1) GB9015914D0 (fr)
GR (1) GR3023776T3 (fr)
HU (2) HU9300115D0 (fr)
IE (1) IE912513A1 (fr)
IL (1) IL98881A (fr)
MC (1) MC2289A1 (fr)
MY (1) MY111871A (fr)
NZ (1) NZ239025A (fr)
PT (1) PT98371B (fr)
RU (1) RU2114860C1 (fr)
TW (1) TW208655B (fr)
WO (1) WO1992001456A1 (fr)
ZA (1) ZA915656B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9015914D0 (en) * 1990-07-19 1990-09-05 Wellcome Found Heterocyclic compounds
WO1998042352A1 (fr) * 1997-03-24 1998-10-01 Glaxo Group Ltd. Procede de traitement des tumeurs a cellules b par des derives nucleosidiques ara-g
EP1092435B1 (fr) * 1998-07-02 2007-04-04 Kyowa Hakko Kogyo Co., Ltd. Medicaments antidiabetiques
US6753322B2 (en) * 2000-06-06 2004-06-22 Pfizer Inc 2-aminocarbonyl-9H-purine derivatives
IL162137A0 (en) * 2001-11-27 2005-11-20 Anadys Pharmaceuticals Inc D-ribofuranosylthiazolo -3-Ä4,5-dÜpyridimine nucl eosides and uses thereof
US7321033B2 (en) * 2001-11-27 2008-01-22 Anadys Pharmaceuticals, Inc. 3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof
US20040127435A1 (en) * 2002-08-02 2004-07-01 Regents Of The University Of California Uses for inhibitors of inosine monophosphate dehydrogenase
ATE465742T1 (de) * 2003-09-05 2010-05-15 Anadys Pharmaceuticals Inc Tlr7-liganden zur behandlung von hepatitis c
GB0321613D0 (en) * 2003-09-15 2003-10-15 Drug Discovery Lab As Compounds
EP1804838A2 (fr) * 2004-09-15 2007-07-11 Drug Discovery Laboratory AS Conjugues de medicaments comprenant des motifs d'acide gras a longue chaine ou d'esters comme prodrugues de liaison aux proteines
WO2006053252A2 (fr) * 2004-11-12 2006-05-18 Northwestern University Methodes permettant de traiter des malignites hematologiques a l'aide de medicaments du type analogues nucleosidiques
US7560544B2 (en) 2004-12-17 2009-07-14 Anadys Pharmaceuticals, Inc. 3,5-Disubsitituted and 3,5,7-trisubstituted-3H-oxazolo and 3H-thiazolo[4,5-d]pyrimidin-2-one compounds and prodrugs thereof
US20060189543A1 (en) * 2005-02-23 2006-08-24 Rosenbloom Richard A Compositions and methods for the treatment of leukemia
DE602006015700D1 (de) 2005-11-21 2010-09-02 Anadys Pharmaceuticals Inc Neues verfahren zur herstellung von 5-amino-3h-thiazoloä4,5-düpyrimidin-2-on
BRPI0713680A2 (pt) * 2006-06-22 2012-10-23 Anadys Pharmaceuticals Inc composto, composição farmacêutica e métodos de modulação das atividades imuno da citocina, de tratamento de infecção de vìrus da hepatite c em paciente e de tratamento de desordem de proliferação relacionada em mamìfero carecido do mesmo
WO2008011406A2 (fr) 2006-07-18 2008-01-24 Anadys Pharmaceuticals, Inc. Promédicaments à groupes fonctionnels carbonate et carbamate de thiazolo [4,5-d] pyrimidines
CN101768197A (zh) * 2008-12-29 2010-07-07 北京德众万全药物技术开发有限公司 一种奈拉滨的制备方法
WO2012092484A2 (fr) * 2010-12-29 2012-07-05 Inhibitex, Inc. Nucléosides puriques substitués, dérivés phosphoramidate et phosphorodiamidate pour le traitement d'infections virales
WO2018230479A1 (fr) * 2017-06-13 2018-12-20 大原薬品工業株式会社 Dérivé d'éther de silyle en position 5' pour agent anticancéreux nucléosidique ou agent anti-viral
CN117777141A (zh) * 2020-12-30 2024-03-29 南方科技大学 一种抗病毒感染的核苷类化合物及其用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2152486A1 (de) 1970-11-20 1972-06-29 Akad Wissenschaften Ddr Verfahren zur Herstellung von 5'-Desoxy-5'-fluor-6-methyl-mercaptopurinribosid
US3872084A (en) 1972-10-10 1975-03-18 Syntex Inc Purine nucleoside 3,5-cyclicphosphate compounds
US4081534A (en) * 1973-09-11 1978-03-28 Burroughs Wellcome Co. Amino purine nucleosides as autoimmune suppressant agents
GB1573777A (en) * 1977-11-03 1980-08-28 Wellcome Found 9-d-arabinonucleosides and an enzymatic process for their preparation
JPS61233696A (ja) * 1985-04-08 1986-10-17 Kanegafuchi Chem Ind Co Ltd ７−ヒドロキシグアニン誘導体及びその製造方法並びにそれを有効成分とする抗腫瘍剤
JPH0633263B2 (ja) * 1985-05-27 1994-05-02 鐘淵化学工業株式会社 ７−ヒドロキシグアニン誘導体及びその製造方法並びにそれを有効成分とする抗腫瘍剤
GB8712745D0 (en) * 1987-05-30 1987-07-01 Wellcome Found Antiviral compounds
CA1317291C (fr) * 1987-12-14 1993-05-04 Naeem Botros Hanna Pyrines a proprietes antitumorales de type 6-sulfenamide, 6-sulfinamide et 6-sulfonamide, nucleosides et nucleotides de type purine, et composes connexes
US5352669A (en) * 1990-03-13 1994-10-04 The Of The United States Of America As Represented By The Department Of Health And Human Services O6 -benzylated guanine, guanosine and 2'-deoxyguanosine compounds possessing O6 -alkylguanine-DNA alkyltransferase depleting activity
GB9015914D0 (en) * 1990-07-19 1990-09-05 Wellcome Found Heterocyclic compounds

Also Published As

Publication number Publication date
HUT62911A (en) 1993-06-28
US5821236A (en) 1998-10-13
CA2087543C (fr) 1998-08-25
HU9300115D0 (en) 1993-04-28
EP0539479B1 (fr) 1997-04-16
IL98881A (en) 1996-01-19
MY111871A (en) 2001-02-28
IE912513A1 (en) 1992-01-29
GB9015914D0 (en) 1990-09-05
TW208655B (fr) 1993-07-01
JPH05508649A (ja) 1993-12-02
GR3023776T3 (en) 1997-09-30
AU641533B2 (en) 1993-09-23
CA2087543A1 (fr) 1992-01-20
EP0539479A1 (fr) 1993-05-05
JP2873086B2 (ja) 1999-03-24
CY2165B1 (en) 2002-08-23
PT98371B (pt) 1999-01-29
US5492897A (en) 1996-02-20
PT98371A (pt) 1992-06-30
ZA915656B (en) 1993-03-31
US5747472A (en) 1998-05-05
DE69125715D1 (de) 1997-05-22
AU8196091A (en) 1992-02-18
DK0539479T3 (da) 1997-08-25
WO1992001456A1 (fr) 1992-02-06
DE69125715T2 (de) 1997-08-07
NZ239025A (en) 1993-08-26
ATE151637T1 (de) 1997-05-15
RU2114860C1 (ru) 1998-07-10
IL98881A0 (en) 1992-07-15
ES2103311T3 (es) 1997-09-16
KR100187326B1 (ko) 1999-05-01

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