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CY2019026I2 - Μη νουκλεοσιδικοι αναστολεις αναστροφης μεταγραφασης - Google Patents

Μη νουκλεοσιδικοι αναστολεις αναστροφης μεταγραφασης

Info

Publication number
CY2019026I2
CY2019026I2 CY2019026C CY2019026C CY2019026I2 CY 2019026 I2 CY2019026 I2 CY 2019026I2 CY 2019026 C CY2019026 C CY 2019026C CY 2019026 C CY2019026 C CY 2019026C CY 2019026 I2 CY2019026 I2 CY 2019026I2
Authority
CY
Cyprus
Prior art keywords
reverse transcription
nucleoside inhibitors
nucleoside
inhibitors
transcription
Prior art date
Application number
CY2019026C
Other languages
English (en)
Other versions
CY2019026I1 (el
Original Assignee
Merck Canada Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44710363&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY2019026(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Canada Inc. filed Critical Merck Canada Inc.
Publication of CY2019026I1 publication Critical patent/CY2019026I1/el
Publication of CY2019026I2 publication Critical patent/CY2019026I2/el

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CY2019026C 2010-03-30 2019-05-16 Μη νουκλεοσιδικοι αναστολεις αναστροφης μεταγραφασης CY2019026I2 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31882410P 2010-03-30 2010-03-30
US32157310P 2010-04-07 2010-04-07
PCT/CA2011/000320 WO2011120133A1 (en) 2010-03-30 2011-03-28 Non-nucleoside reverse transcriptase inhibitors

Publications (2)

Publication Number Publication Date
CY2019026I1 CY2019026I1 (el) 2020-05-29
CY2019026I2 true CY2019026I2 (el) 2020-05-29

Family

ID=44710363

Family Applications (3)

Application Number Title Priority Date Filing Date
CY20171100114T CY1118774T1 (el) 2010-03-30 2017-01-25 Φαρμακευτικη συνθεση η οποια περιλαμβανει εναν μη νουκλεοσιδικο αναστολεα αναστροφης μεταγραφασης
CY2019026C CY2019026I2 (el) 2010-03-30 2019-05-16 Μη νουκλεοσιδικοι αναστολεις αναστροφης μεταγραφασης
CY2019025C CY2019025I2 (el) 2010-03-30 2019-05-16 Φαρμακευτικη συνθεση η οποια περιλαμβανει εναν μη νουκλεοσιδικο αναστολεα αναστροφης μεταγραφασης

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20171100114T CY1118774T1 (el) 2010-03-30 2017-01-25 Φαρμακευτικη συνθεση η οποια περιλαμβανει εναν μη νουκλεοσιδικο αναστολεα αναστροφης μεταγραφασης

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY2019025C CY2019025I2 (el) 2010-03-30 2019-05-16 Φαρμακευτικη συνθεση η οποια περιλαμβανει εναν μη νουκλεοσιδικο αναστολεα αναστροφης μεταγραφασης

Country Status (44)

Country Link
US (2) US8486975B2 (el)
EP (2) EP2552902B1 (el)
JP (2) JP5281718B2 (el)
KR (1) KR101421861B1 (el)
CN (1) CN102971308B (el)
AR (1) AR080859A1 (el)
AU (1) AU2011235568B2 (el)
BR (1) BR112012024691B1 (el)
CA (1) CA2794377C (el)
CL (1) CL2012002744A1 (el)
CO (1) CO6630126A2 (el)
CR (1) CR20120503A (el)
CY (3) CY1118774T1 (el)
DK (2) DK2552902T3 (el)
DO (1) DOP2012000256A (el)
EA (1) EA024804B1 (el)
EC (1) ECSP12012201A (el)
ES (2) ES2609636T3 (el)
FI (1) FIC20190021I1 (el)
GE (1) GEP20156368B (el)
HN (1) HN2012002039A (el)
HR (2) HRP20150427T1 (el)
HU (4) HUE025336T2 (el)
IL (2) IL222030A (el)
LT (3) LT2924034T (el)
LU (2) LUC00113I9 (el)
MA (1) MA34170B1 (el)
ME (2) ME02570B (el)
MX (1) MX2012011379A (el)
MY (1) MY163979A (el)
NI (1) NI201200146A (el)
NL (1) NL300980I2 (el)
NO (2) NO2019019I1 (el)
NZ (1) NZ602670A (el)
PE (1) PE20130158A1 (el)
PH (1) PH12012501923A1 (el)
PL (2) PL2552902T3 (el)
PT (2) PT2924034T (el)
RS (2) RS54017B1 (el)
SG (1) SG184347A1 (el)
SI (2) SI2552902T1 (el)
TN (1) TN2012000455A1 (el)
TW (1) TWI458719B (el)
WO (1) WO2011120133A1 (el)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE025336T2 (en) * 2010-03-30 2016-03-29 Merck Canada Inc Non-nucleoside reverse transcriptase inhibitors
EP2625292B1 (en) 2010-10-07 2018-12-05 The General Hospital Corporation Biomarkers of cancer
US9150539B2 (en) 2012-09-26 2015-10-06 Merck Sharp & Dohme Corp. Crystalline form of a reverse transcriptase inhibitor
JO3470B1 (ar) * 2012-10-08 2020-07-05 Merck Sharp & Dohme مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv
BR112015012843B8 (pt) 2012-12-05 2023-04-25 Merck Sharp & Dohme Método para sintetizar o composto
CN105722392B (zh) * 2013-11-22 2019-07-23 默沙东公司 非核苷逆转录酶抑制剂的组合物
ES2977643T3 (es) * 2013-12-04 2024-08-28 Merck Sharp & Dohme Llc Proceso para fabricar inhibidores de la transcriptasa inversa
LT3125894T (lt) 2014-04-01 2020-12-10 Merck Sharp & Dohme Corp. Živ atvirkštinės transkriptazės inhibitorių provaistai
EP3760208B1 (en) 2014-06-25 2024-05-29 The General Hospital Corporation Targeting human satellite ii (hsatii)
KR102774942B1 (ko) 2015-12-02 2025-02-27 머크 샤프 앤드 돔 엘엘씨 도라비린, 테노포비르 디소프록실 푸마레이트 및 라미부딘을 함유하는 제약 조성물
US11077050B2 (en) 2017-03-24 2021-08-03 Merck Sharp & Dohme Corp. Formulation for parenteral administration
EP3612226A1 (en) 2017-04-18 2020-02-26 Cipla Limited Combination therapy for use in treating retroviral infections
CN112533613A (zh) 2018-02-06 2021-03-19 通用医疗公司 作为肿瘤免疫应答的生物标志物的重复rna
US12005072B2 (en) 2018-07-17 2024-06-11 Merck Sharp & Dohme Llc HIV drug combination for increasing barrier against resistance
AU2019402998B2 (en) 2018-12-18 2022-12-15 Merck Sharp & Dohme Llc Pyrimidone derivatives as selective cytotoxic agents against HIV infected cells
CN110801455B (zh) * 2019-11-12 2020-06-02 河北医科大学第二医院 用于治疗mrsa的药物组合物及其应用
CN114163309B (zh) * 2021-12-27 2023-04-25 甘肃皓天医药科技有限责任公司 一种多拉韦林中间体的制备方法
CN114349690B (zh) * 2022-02-15 2023-04-25 甘肃皓天医药科技有限责任公司 一种多拉韦林中间体合成方法
CN116903590A (zh) * 2023-06-06 2023-10-20 延边大学 一种含杂环结构的吡啶酮类化合物及其制备方法和用途
CN120157613A (zh) * 2023-12-15 2025-06-17 山东诚创蓝海医药科技有限公司 多拉韦林中间体及其应用和合成方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9904045D0 (sv) 1999-11-09 1999-11-09 Astra Ab Compounds
TW200423930A (en) * 2003-02-18 2004-11-16 Hoffmann La Roche Non-nucleoside reverse transcriptase inhibitors
TW200505441A (en) 2003-03-24 2005-02-16 Hoffmann La Roche Non-nucleoside reverse transcriptase inhibitorsⅠ
CA2518823A1 (en) 2003-03-24 2004-10-07 F.Hoffmann-La Roche Ag Benzyl-pyridazinons as reverse transcriptase inhibitors
US7166738B2 (en) 2004-04-23 2007-01-23 Roche Palo Alto Llc Non-nucleoside reverse transcriptase inhibitors
WO2005102989A1 (en) 2004-04-23 2005-11-03 F. Hoffmann-La Roche Ag Non-nucleoside reverse transcriptase inhibitors
EP1831157A2 (en) 2004-12-22 2007-09-12 Pfizer Limited Nonnucleoside inhibitors of hiv-1 reverse transcriptase
AR057455A1 (es) 2005-07-22 2007-12-05 Merck & Co Inc Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica
ES2320042T3 (es) 2005-10-19 2009-05-18 F. Hoffmann-La Roche Ag Inhibidores de transcriptasa reversa con nucleosidos de n-fenil fenilacetamida.
KR20080056220A (ko) 2005-10-19 2008-06-20 에프. 호프만-라 로슈 아게 페닐-아세트아마이드 nnrt 저해제
TW200831085A (en) 2006-12-13 2008-08-01 Merck & Co Inc Non-nucleoside reverse transcriptase inhibitors
WO2009067166A2 (en) 2007-11-20 2009-05-28 Merck & Co., Inc. Non-nucleoside reverse transcriptase inhibitors
HUE025336T2 (en) * 2010-03-30 2016-03-29 Merck Canada Inc Non-nucleoside reverse transcriptase inhibitors

Also Published As

Publication number Publication date
EP2924034B1 (en) 2016-11-02
PT2924034T (pt) 2017-01-06
ME02570B (me) 2017-06-20
RS54017B1 (sr) 2015-10-30
LTPA2019506I1 (lt) 2019-04-25
HN2012002039A (es) 2015-08-24
BR112012024691B1 (pt) 2020-11-17
GEP20156368B (en) 2015-09-25
CY1118774T1 (el) 2017-07-12
PT2552902E (pt) 2015-06-02
EP2924034A1 (en) 2015-09-30
LT2924034T (lt) 2016-12-27
CO6630126A2 (es) 2013-03-01
IL233334A0 (en) 2014-09-01
MY163979A (en) 2017-11-15
DK2924034T3 (en) 2017-02-06
DK2552902T3 (en) 2015-06-15
ECSP12012201A (es) 2012-10-30
SI2552902T1 (sl) 2015-10-30
CR20120503A (es) 2013-01-09
FIC20190021I1 (fi) 2019-04-17
HUE025336T2 (en) 2016-03-29
CA2794377A1 (en) 2011-10-06
NZ602670A (en) 2014-09-26
CY2019026I1 (el) 2020-05-29
EA024804B1 (ru) 2016-10-31
AU2011235568B2 (en) 2013-09-12
BR112012024691A2 (pt) 2019-07-02
WO2011120133A1 (en) 2011-10-06
MA34170B1 (fr) 2013-04-03
MX2012011379A (es) 2012-11-30
TWI458719B (zh) 2014-11-01
CL2012002744A1 (es) 2012-12-14
NO2019019I1 (no) 2019-04-24
TW201139409A (en) 2011-11-16
HRP20150427T1 (hr) 2015-07-03
NO2019018I1 (no) 2019-04-24
PL2552902T3 (pl) 2015-10-30
ES2536295T3 (es) 2015-05-22
TN2012000455A1 (en) 2014-01-30
US20130296382A1 (en) 2013-11-07
RS55505B1 (sr) 2017-05-31
HK1209121A1 (en) 2016-03-24
US8486975B2 (en) 2013-07-16
ME02181B (me) 2015-10-20
KR101421861B1 (ko) 2014-07-22
CY2019025I1 (el) 2019-11-27
KR20120128703A (ko) 2012-11-27
LUC00114I1 (el) 2019-04-17
US20110245296A1 (en) 2011-10-06
AR080859A1 (es) 2012-05-16
JP5281718B2 (ja) 2013-09-04
LUC00113I9 (el) 2024-06-07
ES2609636T3 (es) 2017-04-21
PH12012501923A1 (en) 2013-02-04
LTC2924034I2 (lt) 2020-10-12
NL300980I1 (nl) 2019-04-24
CN102971308B (zh) 2015-02-04
LUC00113I2 (el) 2024-05-22
JP5886790B2 (ja) 2016-03-16
CA2794377C (en) 2015-06-16
SG184347A1 (en) 2012-11-29
EP2552902A1 (en) 2013-02-06
DOP2012000256A (es) 2012-12-15
EP2552902B1 (en) 2015-03-11
SI2924034T1 (sl) 2017-05-31
HK1175471A1 (en) 2013-07-05
HUE031785T2 (en) 2017-08-28
HRP20161680T1 (hr) 2017-01-27
PL2924034T3 (pl) 2017-07-31
HUS1900021I1 (hu) 2019-05-28
IL233334A (en) 2015-09-24
CY2019025I2 (el) 2019-11-27
NI201200146A (es) 2013-03-18
LTPA2019507I1 (lt) 2019-04-25
AU2011235568A1 (en) 2012-11-01
NL300980I2 (nl) 2021-06-17
CN102971308A (zh) 2013-03-13
HUS1900022I1 (hu) 2019-05-28
PE20130158A1 (es) 2013-02-28
EA201290976A1 (ru) 2013-03-29
IL222030A (en) 2014-07-31
EP2552902A4 (en) 2013-09-04
JP2013209405A (ja) 2013-10-10
LTC2552902I2 (lt) 2019-12-10
JP2013510800A (ja) 2013-03-28
LUC00114I2 (el) 2020-07-10

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