HN2012002039A - Inhibidores no nucleosidicos de la transcriptasa inversa - Google Patents
Inhibidores no nucleosidicos de la transcriptasa inversaInfo
- Publication number
- HN2012002039A HN2012002039A HN2012002039A HN2012002039A HN2012002039A HN 2012002039 A HN2012002039 A HN 2012002039A HN 2012002039 A HN2012002039 A HN 2012002039A HN 2012002039 A HN2012002039 A HN 2012002039A HN 2012002039 A HN2012002039 A HN 2012002039A
- Authority
- HN
- Honduras
- Prior art keywords
- compounds
- reverse transcript
- nucleosidic inhibitors
- prophylaxis
- aids
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
LOS COMPUESTOSHETEROAROMATICOS DE FORMULA (I). SON INHIBIDORES DE LA TRANSCRIPTASA INVERSA DEL VIH EN LA QUE R1, R2, R3, R4 Y R5 SE DEFINEN EN ESTE DOCUMENTO. LOS COMPUESTOS DE LA FORMULA I Y SUS SALES FARMACEUTICAMENTE ACEPTABLES SON UTILES EN LA INHIBICION DE LA TRANSCRIPTASA INVERSA DEL VIH, LA PROFILAXIS Y EL TRATAMIENTO DE LA INFECCION POR VIH Y EN LA PROFILAXIS, RETRASO EN LA APARICION O PROGRESION, Y TRATAMIENTO DEL SIDA. LOS COMPUESTOS Y SUS SALES PUEDEN EMPLEARSE COMO INGREDIENTES EN COMPOSICIONES FARMACEUTICAMENTE, OPCIONALMENTE JUNTO CON OTROS ANTIVIRALES, INMUNOMODULARES, ANTIBIOTICOS O VACUNAS.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31882410P | 2010-03-30 | 2010-03-30 | |
| US32157310P | 2010-04-07 | 2010-04-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HN2012002039A true HN2012002039A (es) | 2015-08-24 |
Family
ID=44710363
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HN2012002039A HN2012002039A (es) | 2010-03-30 | 2012-09-27 | Inhibidores no nucleosidicos de la transcriptasa inversa |
Country Status (44)
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2924034T (pt) * | 2010-03-30 | 2017-01-06 | Merck Canada Inc | Composição farmacêutica compreendendo um inibidor de transcritase reversa não nucleosídico |
| US20140031250A1 (en) | 2010-10-07 | 2014-01-30 | David Tsai Ting | Biomarkers of Cancer |
| CN109384765A (zh) * | 2012-09-26 | 2019-02-26 | 默沙东公司 | 逆转录酶抑制剂的晶型 |
| JO3470B1 (ar) * | 2012-10-08 | 2020-07-05 | Merck Sharp & Dohme | مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv |
| CA2892919A1 (en) * | 2012-12-05 | 2014-06-12 | Merck Sharp & Dohme Corp. | Process for making reverse transcriptase inhibitors |
| WO2015077273A1 (en) * | 2013-11-22 | 2015-05-28 | Merck Sharp & Dohme Corp. | Composition of a non-nucleoside reverse transcriptase inhibitor |
| KR101803671B1 (ko) * | 2013-12-04 | 2017-11-30 | 머크 샤프 앤드 돔 코포레이션 | 역전사효소 억제제의 제조 방법 |
| CA2944187C (en) * | 2014-04-01 | 2018-06-19 | Merck Sharp & Dohme Corp. | Prodrugs of hiv reverse transcriptase inhibitors |
| WO2015200697A1 (en) | 2014-06-25 | 2015-12-30 | The General Hospital Corporation | Targeting human satellite ii (hsatii) |
| HUE056978T2 (hu) | 2015-12-02 | 2022-04-28 | Merck Sharp & Dohme | Doravirint, tenofovir-dizoproxil-fumarátot és lamivudint tartalmazó gyógyszerészeti kompozíciók |
| WO2018175271A1 (en) * | 2017-03-24 | 2018-09-27 | Merck Sharp & Dohme Corp. | Formulation for parenteral administration |
| CA3060222A1 (en) | 2017-04-18 | 2018-10-25 | Cipla Limited | Combination therapy for use in treating retroviral infections |
| JP2021512956A (ja) | 2018-02-06 | 2021-05-20 | ザ ジェネラル ホスピタル コーポレイション | 腫瘍免疫応答のバイオマーカーとしてのリピートｒｎａ |
| US12005072B2 (en) | 2018-07-17 | 2024-06-11 | Merck Sharp & Dohme Llc | HIV drug combination for increasing barrier against resistance |
| EA202191711A1 (ru) | 2018-12-18 | 2021-10-04 | Мерк Шарп И Доум Корп. | Производные пиримидона в качестве селективных цитотоксических агентов против вич-инфицированных клеток |
| CN110801455B (zh) * | 2019-11-12 | 2020-06-02 | 河北医科大学第二医院 | 用于治疗mrsa的药物组合物及其应用 |
| CN114163309B (zh) * | 2021-12-27 | 2023-04-25 | 甘肃皓天医药科技有限责任公司 | 一种多拉韦林中间体的制备方法 |
| CN114349690B (zh) * | 2022-02-15 | 2023-04-25 | 甘肃皓天医药科技有限责任公司 | 一种多拉韦林中间体合成方法 |
| CN116903590A (zh) * | 2023-06-06 | 2023-10-20 | 延边大学 | 一种含杂环结构的吡啶酮类化合物及其制备方法和用途 |
| CN120157613A (zh) * | 2023-12-15 | 2025-06-17 | 山东诚创蓝海医药科技有限公司 | 多拉韦林中间体及其应用和合成方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9904045D0 (sv) | 1999-11-09 | 1999-11-09 | Astra Ab | Compounds |
| TW200423930A (en) | 2003-02-18 | 2004-11-16 | Hoffmann La Roche | Non-nucleoside reverse transcriptase inhibitors |
| CA2518823A1 (en) | 2003-03-24 | 2004-10-07 | F.Hoffmann-La Roche Ag | Benzyl-pyridazinons as reverse transcriptase inhibitors |
| TW200505441A (en) * | 2003-03-24 | 2005-02-16 | Hoffmann La Roche | Non-nucleoside reverse transcriptase inhibitorsⅠ |
| ES2333802T3 (es) | 2004-04-23 | 2010-03-01 | F. Hoffmann-La Roche Ag | Inhibidores no nucleicos de transcriptasa inversa. |
| US7166738B2 (en) | 2004-04-23 | 2007-01-23 | Roche Palo Alto Llc | Non-nucleoside reverse transcriptase inhibitors |
| JP2008525419A (ja) | 2004-12-22 | 2008-07-17 | ファイザー・リミテッド | Ｈｉｖ−１逆転写酵素の非ヌクレオシド阻害剤 |
| AR057455A1 (es) | 2005-07-22 | 2007-12-05 | Merck & Co Inc | Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica |
| JP2009515826A (ja) | 2005-10-19 | 2009-04-16 | エフ．ホフマン−ラ ロシュ アーゲー | フェニル−アセトアミドｎｎｒｔ阻害剤 |
| EP1940782B1 (en) | 2005-10-19 | 2009-03-11 | F.Hoffmann-La Roche Ag | N-phenyl phenylacetamide non-nucleoside reverse transcriptase inhibitors |
| TW200831085A (en) | 2006-12-13 | 2008-08-01 | Merck & Co Inc | Non-nucleoside reverse transcriptase inhibitors |
| EP2222661B1 (en) | 2007-11-20 | 2016-04-20 | Merck Sharp & Dohme Corp. | Non-nucleoside reverse transcriptase inhibitors |
| PT2924034T (pt) * | 2010-03-30 | 2017-01-06 | Merck Canada Inc | Composição farmacêutica compreendendo um inibidor de transcritase reversa não nucleosídico |
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2011
- 2011-03-28 PT PT151573482T patent/PT2924034T/pt unknown
- 2011-03-28 EA EA201290976A patent/EA024804B1/ru active Protection Beyond IP Right Term
- 2011-03-28 KR KR1020127025733A patent/KR101421861B1/ko active Active
- 2011-03-28 JP JP2012538161A patent/JP5281718B2/ja active Active
- 2011-03-28 NZ NZ602670A patent/NZ602670A/en unknown
- 2011-03-28 ME MEP-2016-282A patent/ME02570B/me unknown
- 2011-03-28 DK DK15157348.2T patent/DK2924034T3/en active
- 2011-03-28 US US13/073,631 patent/US8486975B2/en active Active
- 2011-03-28 MX MX2012011379A patent/MX2012011379A/es active IP Right Grant
- 2011-03-28 PE PE2012001823A patent/PE20130158A1/es active IP Right Grant
- 2011-03-28 LT LTEP15157348.2T patent/LT2924034T/lt unknown
- 2011-03-28 SG SG2012072401A patent/SG184347A1/en unknown
- 2011-03-28 ME MEP-2015-76A patent/ME02181B/me unknown
- 2011-03-28 RS RS20161093A patent/RS55505B1/sr unknown
- 2011-03-28 CA CA2794377A patent/CA2794377C/en active Active
- 2011-03-28 HU HUE11761856A patent/HUE025336T2/en unknown
- 2011-03-28 ES ES11761856.1T patent/ES2536295T3/es active Active
- 2011-03-28 ES ES15157348.2T patent/ES2609636T3/es active Active
- 2011-03-28 CN CN201180018074.2A patent/CN102971308B/zh active Active
- 2011-03-28 SI SI201130491T patent/SI2552902T1/sl unknown
- 2011-03-28 MA MA35324A patent/MA34170B1/fr unknown
- 2011-03-28 RS RS20150340A patent/RS54017B1/sr unknown
- 2011-03-28 SI SI201131054A patent/SI2924034T1/sl unknown
- 2011-03-28 EP EP15157348.2A patent/EP2924034B1/en active Active
- 2011-03-28 GE GEAP201112882A patent/GEP20156368B/en unknown
- 2011-03-28 AU AU2011235568A patent/AU2011235568B2/en active Active
- 2011-03-28 MY MYPI2012004342A patent/MY163979A/en unknown
- 2011-03-28 PL PL15157348T patent/PL2924034T3/pl unknown
- 2011-03-28 EP EP11761856.1A patent/EP2552902B1/en active Active
- 2011-03-28 DK DK11761856.1T patent/DK2552902T3/en active
- 2011-03-28 WO PCT/CA2011/000320 patent/WO2011120133A1/en not_active Ceased
- 2011-03-28 HU HUE15157348A patent/HUE031785T2/en unknown
- 2011-03-28 PL PL11761856T patent/PL2552902T3/pl unknown
- 2011-03-28 PT PT117618561T patent/PT2552902E/pt unknown
- 2011-03-28 HR HRP20150427TT patent/HRP20150427T1/hr unknown
- 2011-03-28 BR BR112012024691-7A patent/BR112012024691B1/pt active IP Right Grant
- 2011-03-28 PH PH1/2012/501923A patent/PH12012501923A1/en unknown
- 2011-03-29 AR ARP110101028A patent/AR080859A1/es active IP Right Grant
- 2011-03-29 TW TW100110833A patent/TWI458719B/zh active
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2012
- 2012-09-20 IL IL222030A patent/IL222030A/en active Protection Beyond IP Right Term
- 2012-09-20 TN TNP2012000455A patent/TN2012000455A1/en unknown
- 2012-09-27 HN HN2012002039A patent/HN2012002039A/es unknown
- 2012-09-28 CL CL2012002744A patent/CL2012002744A1/es unknown
- 2012-09-28 DO DO2012000256A patent/DOP2012000256A/es unknown
- 2012-09-28 NI NI201200146A patent/NI201200146A/es unknown
- 2012-10-01 CR CR20120503A patent/CR20120503A/es unknown
- 2012-10-01 EC ECSP12012201 patent/ECSP12012201A/es unknown
- 2012-10-01 CO CO12171897A patent/CO6630126A2/es active IP Right Grant
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2013
- 2013-05-23 JP JP2013108533A patent/JP5886790B2/ja not_active Expired - Fee Related
- 2013-07-03 US US13/934,633 patent/US20130296382A1/en not_active Abandoned
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2014
- 2014-06-23 IL IL233334A patent/IL233334A/en active IP Right Grant
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2016
- 2016-12-09 HR HRP20161680TT patent/HRP20161680T1/hr unknown
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2017
- 2017-01-25 CY CY20171100114T patent/CY1118774T1/el unknown
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2019
- 2019-04-09 HU HUS1900022C patent/HUS1900022I1/hu unknown
- 2019-04-09 HU HUS1900021C patent/HUS1900021I1/hu unknown
- 2019-04-11 LT LTPA2019507C patent/LTC2924034I2/lt unknown
- 2019-04-11 LT LTPA2019506 patent/LTC2552902I2/lt unknown
- 2019-04-16 NL NL300980C patent/NL300980I2/nl unknown
- 2019-04-17 LU LU00114C patent/LUC00114I2/fr unknown
- 2019-04-17 FI FIC20190021C patent/FIC20190021I1/fi unknown
- 2019-04-17 LU LU00113C patent/LUC00113I9/fr unknown
- 2019-04-24 NO NO2019019C patent/NO2019019I1/no unknown
- 2019-04-24 NO NO2019018C patent/NO2019018I1/no unknown
- 2019-05-16 CY CY2019025C patent/CY2019025I1/el unknown
- 2019-05-16 CY CY2019026C patent/CY2019026I2/el unknown
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