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CY1124571T1 - Ενεσιμες μικροπορωδεις υδροπηκτες - Google Patents

Ενεσιμες μικροπορωδεις υδροπηκτες

Info

Publication number
CY1124571T1
CY1124571T1 CY20211100738T CY211100738T CY1124571T1 CY 1124571 T1 CY1124571 T1 CY 1124571T1 CY 20211100738 T CY20211100738 T CY 20211100738T CY 211100738 T CY211100738 T CY 211100738T CY 1124571 T1 CY1124571 T1 CY 1124571T1
Authority
CY
Cyprus
Prior art keywords
cross
hydrogel
macroporous hydrogel
polymer
macroporous
Prior art date
Application number
CY20211100738T
Other languages
English (en)
Inventor
Nicolas BROGUIERE
Marcy Zenobi-Wong
Original Assignee
ETH Zürich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ETH Zürich filed Critical ETH Zürich
Publication of CY1124571T1 publication Critical patent/CY1124571T1/el

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    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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    • A—HUMAN NECESSITIES
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    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
    • C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
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    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/28—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof by elimination of a liquid phase from a macromolecular composition or article, e.g. drying of coagulum
    • C08J9/286—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof by elimination of a liquid phase from a macromolecular composition or article, e.g. drying of coagulum the liquid phase being a solvent for the monomers but not for the resulting macromolecular composition, i.e. macroporous or macroreticular polymers
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Abstract

Η εφεύρεση σχετίζεται με μια μέθοδο για την παραγωγή μιας μακροπορώδους υδροπηκτής. Σε ένα πρώτο στάδιο, ένα υδατικό διάλυμα δύο διαλυμένων ουσιών παράγεται. Η πρώτη διαλυμένη ουσία είναι ένα πολυμερές που μπορεί να συνδεθεί με σταυροειδείς δεσμούς και είναι ένα παράγωγο πολυαιθυλενογλυκόλης (PEG) ή πολυοξαζολίνης (ΡΟx) και η δεύτερη διαλυμένη ουσία είναι ένας κοσμοτροπικός παράγοντας. Σε ένα δεύτερο στάδιο, ένα παράγοντας σύνδεσης με σταυροειδείς δεσμούς προστίθεται στο διάλυμα. Αυτό ξεκινά ταυτόχρονα την πηκτωμάτωση του πολυμερούς και το διαχωρισμό των φάσεων, δημιουργώντας έτσι μια μακροπορώδη υδροπηκτή. Η εφεύρεση σχετίζεται περαιτέρω με μια μακροπορώδη υδροπηκτή, η οποία μπορεί να ληφθεί με την εφευρετική μέθοδο. Αυτή η μακροπορώδης υδροπηκτή αποτελείται από ένα συνδεδεμένο με σταυροειδείς δεσμούς πολυμερές, το οποίο είναι ένα παράγωγο πολυαιθυλενογλυκόλης (PEG) ή πολυοξαζολίνης (ΡΟx). Η υδροπηκτή παρουσιάζει διασυνδεδεμένους μακροπόρους με μέγεθος από 200 nm έως 1000 μm, συγκεκριμένα 500 nm έως 100 μm και χαρακτηρίζεται από ένα pΗ του 7,0 έως 8,0, συγκεκριμένα περίπου 7,4.
CY20211100738T 2015-09-09 2021-08-18 Ενεσιμες μικροπορωδεις υδροπηκτες CY1124571T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15184552 2015-09-09
PCT/EP2016/071238 WO2017042301A1 (en) 2015-09-09 2016-09-08 Injectable macroporous hydrogels

Publications (1)

Publication Number Publication Date
CY1124571T1 true CY1124571T1 (el) 2022-07-22

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US (1) US20180264176A1 (el)
EP (2) EP3868416B1 (el)
JP (1) JP6829898B2 (el)
CN (2) CN108025110B (el)
AU (1) AU2016320395B2 (el)
CA (1) CA2992692C (el)
CY (1) CY1124571T1 (el)
DK (2) DK3868416T3 (el)
ES (1) ES2883235T3 (el)
HR (1) HRP20211306T1 (el)
HU (1) HUE055937T2 (el)
IL (1) IL257024B (el)
LT (1) LT3347061T (el)
PL (1) PL3347061T3 (el)
PT (1) PT3347061T (el)
RS (1) RS62239B1 (el)
SI (1) SI3347061T1 (el)
SM (1) SMT202100470T1 (el)
WO (1) WO2017042301A1 (el)

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