CY1121598T1 - Ανθελονοσιακες ενωσεις με ευελικτες πλευρικες αλυσιδες - Google Patents
Ανθελονοσιακες ενωσεις με ευελικτες πλευρικες αλυσιδεςInfo
- Publication number
- CY1121598T1 CY1121598T1 CY20191100432T CY191100432T CY1121598T1 CY 1121598 T1 CY1121598 T1 CY 1121598T1 CY 20191100432 T CY20191100432 T CY 20191100432T CY 191100432 T CY191100432 T CY 191100432T CY 1121598 T1 CY1121598 T1 CY 1121598T1
- Authority
- CY
- Cyprus
- Prior art keywords
- compounds
- antifinal
- side chains
- flexible side
- present
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 108010022394 Threonine synthase Proteins 0.000 abstract 2
- 102000004419 dihydrofolate reductase Human genes 0.000 abstract 2
- 201000004792 malaria Diseases 0.000 abstract 2
- 241000223960 Plasmodium falciparum Species 0.000 abstract 1
- 230000000078 anti-malarial effect Effects 0.000 abstract 1
- 239000003430 antimalarial agent Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 244000045947 parasite Species 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Η παρούσα εφεύρεση σχετίζεται με νέες ενώσεις που είναι αναστολείς άγριου τύπου και μεταλλαγμένης διυδροφολικής αναγωγάσης (DHFR) του Πλασμωδίου του ημισεληνοειδούς (Plasmodium falciparum), οι οποίες είναι χρήσιμες για τη θεραπεία της ελονοσίας. Επίσης αναφέρεται σε διεργασίες παρασκευής και χρήσης τέτοιων ενώσεων. Οι ανθελονοσιακές ενώσεις της παρούσας εφεύρεσης έχουν χαμηλή τοξικότητα σε έναν ξενιστή που έχει μολυνθεί με το ελονοσιακό παράσιτο και είναι ισχυροί όταν χορηγούνται σε φαρμακευτικές συνθέσεις.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97837507P | 2007-10-08 | 2007-10-08 | |
| PCT/US2008/079210 WO2009048957A1 (en) | 2007-10-08 | 2008-10-08 | Antimalarial compounds with flexible side-chains |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1121598T1 true CY1121598T1 (el) | 2020-07-31 |
Family
ID=40534843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20191100432T CY1121598T1 (el) | 2007-10-08 | 2019-04-19 | Ανθελονοσιακες ενωσεις με ευελικτες πλευρικες αλυσιδες |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US8530491B2 (el) |
| EP (2) | EP2194985B1 (el) |
| JP (1) | JP5603775B2 (el) |
| KR (1) | KR101578949B1 (el) |
| CN (1) | CN101820879B (el) |
| AU (1) | AU2008310898B2 (el) |
| BR (1) | BRPI0818618B8 (el) |
| CA (1) | CA2700880C (el) |
| CY (1) | CY1121598T1 (el) |
| DK (1) | DK2194985T3 (el) |
| ES (1) | ES2727015T3 (el) |
| HR (1) | HRP20190589T1 (el) |
| HU (1) | HUE044398T2 (el) |
| LT (1) | LT2194985T (el) |
| MX (1) | MX2010003739A (el) |
| PL (1) | PL2194985T3 (el) |
| PT (1) | PT2194985T (el) |
| RU (1) | RU2485107C2 (el) |
| SI (1) | SI2194985T1 (el) |
| TR (1) | TR201904913T4 (el) |
| UA (1) | UA105759C2 (el) |
| WO (1) | WO2009048957A1 (el) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012108845A1 (en) * | 2011-02-09 | 2012-08-16 | National Science And Technology Development Agency | A bacterial surrogate for testing of antimalarials: thya knockout and fola knockout bacteria for testing of inhibition of malarial dihydrofolate reductase-thymidylate synthase |
| WO2012121682A2 (en) * | 2011-03-10 | 2012-09-13 | National Science And Technology Development Agency | Anti-folate antimalarials with dual-binding modes and their preparation |
| US10011842B2 (en) | 2013-09-30 | 2018-07-03 | National Science And Technology Development Agency | Escherichia coli cell line with thyA knockout, folA knockout, and one or both of folP knockout, and folK knockout |
| CN104593406A (zh) * | 2015-01-08 | 2015-05-06 | 山西医科大学 | pIRES/TgDHFR-TS真核表达重组质粒及其构建和应用 |
| US11028072B2 (en) | 2015-09-23 | 2021-06-08 | National Science And Technology Development Agency | 2,4-diamino-6-ethylpyrimidine derivatives with antimalarial activities against Plasmodium falciparum |
| CN106083742A (zh) * | 2016-05-31 | 2016-11-09 | 广东工业大学 | 一种2,4‑二胺基喹唑啉衍生物及其制备方法和应用 |
| CN115427049B (zh) * | 2020-02-04 | 2024-09-06 | 清华大学 | 疟疾和恶性疟原虫己糖转运蛋白的抑制剂及其用途 |
| CN112961106A (zh) * | 2021-03-13 | 2021-06-15 | 德州学院 | 一种4-羟基-6氯喹啉合成新工艺 |
| EP4438596A1 (en) * | 2023-03-28 | 2024-10-02 | Université de Lille | Diaminopyrimidine derivatives as hdac and dhfr dual-targeting inhibitors and use thereof in preventing and treating malaria |
| WO2025053796A1 (en) * | 2023-09-04 | 2025-03-13 | National Science And Technology Development Agency | Hybrid molecules between pyrimidine derivatives and idasanutlin |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4033962A (en) * | 1975-06-26 | 1977-07-05 | Hoffman-La Roche Inc. | 2,4-Diamino-pyrimidine derivatives and processes |
| GB1546937A (en) * | 1976-07-29 | 1979-05-31 | Beecham Group Ltd | 2,4-diaminopyrimidine derivatives |
| FR2397407A2 (fr) * | 1977-07-11 | 1979-02-09 | Dick Pierre | Derives de 2,4-diamino pyrimidines et leur mise en solution en association avec des sulfamides |
| OA07362A (fr) * | 1980-10-27 | 1984-06-30 | May & Baker Ltd | Dérivés de la pyrimidine, leur procédé de préparation et les compositions les contenant. |
| GB2086386B (en) * | 1980-10-27 | 1984-01-18 | May & Baker Ltd | Pyrimidine derivatives |
| US5322858A (en) | 1992-02-14 | 1994-06-21 | Jacobus Pharmaceutical Co. Inc. | N,N'-substituted imidodicarbonimidic diamides derived from hydroxylamines |
| RU95113597A (ru) * | 1992-12-02 | 1997-06-10 | ФМК Корпорейшн (US) | Инсектицидная композиция, способы борьбы с насекомыми |
| BR0010909A (pt) * | 1999-05-24 | 2002-02-19 | Sankyo Co | Composição farmacêutica, agente que tem atividade indutora de apoptose, e, uso de um anticorpo fas anti-humano |
| IT1317826B1 (it) * | 2000-02-11 | 2003-07-15 | Dompe Spa | Ammidi, utili nell'inibizione della chemiotassi dei neutrofiliindotta da il-8. |
| US7371758B2 (en) * | 2003-03-13 | 2008-05-13 | National Science & Technology Development Agency | Antimalarial pyrimidine derivatives and methods of making and using them |
-
2008
- 2008-10-08 MX MX2010003739A patent/MX2010003739A/es active IP Right Grant
- 2008-10-08 RU RU2010117193/04A patent/RU2485107C2/ru active
- 2008-10-08 TR TR2019/04913T patent/TR201904913T4/tr unknown
- 2008-10-08 SI SI200832053T patent/SI2194985T1/sl unknown
- 2008-10-08 DK DK08837766.8T patent/DK2194985T3/da active
- 2008-10-08 AU AU2008310898A patent/AU2008310898B2/en active Active
- 2008-10-08 US US12/247,953 patent/US8530491B2/en active Active
- 2008-10-08 LT LTEP08837766.8T patent/LT2194985T/lt unknown
- 2008-10-08 PT PT08837766T patent/PT2194985T/pt unknown
- 2008-10-08 KR KR1020107010151A patent/KR101578949B1/ko active Active
- 2008-10-08 HR HRP20190589TT patent/HRP20190589T1/hr unknown
- 2008-10-08 EP EP08837766.8A patent/EP2194985B1/en active Active
- 2008-10-08 EP EP19157867.3A patent/EP3546452A1/en not_active Withdrawn
- 2008-10-08 HU HUE08837766 patent/HUE044398T2/hu unknown
- 2008-10-08 JP JP2010528223A patent/JP5603775B2/ja active Active
- 2008-10-08 ES ES08837766T patent/ES2727015T3/es active Active
- 2008-10-08 WO PCT/US2008/079210 patent/WO2009048957A1/en not_active Ceased
- 2008-10-08 PL PL08837766T patent/PL2194985T3/pl unknown
- 2008-10-08 CN CN2008801106805A patent/CN101820879B/zh active Active
- 2008-10-08 UA UAA201004117A patent/UA105759C2/uk unknown
- 2008-10-08 BR BRPI0818618A patent/BRPI0818618B8/pt active IP Right Grant
- 2008-10-08 CA CA2700880A patent/CA2700880C/en active Active
-
2019
- 2019-04-19 CY CY20191100432T patent/CY1121598T1/el unknown
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