BRPI0818618A2 - Compostos antimaláricos com cadeias laterais flexíveis e métodos de tratamento da malária. - Google Patents

Compostos antimaláricos com cadeias laterais flexíveis e métodos de tratamento da malária.

Info

Publication number: BRPI0818618A2
Authority: BR; Brazil
Prior art keywords: side chain; treatment methods; flexible side; malaria treatment; antimalarial compounds
Prior art date: 2007-10-08

Application number

BRPI0818618-9A

Other languages

English (en)

Inventor

Bongkoch Tarnchompoo

Yuthavong Yongyuth

Tirayut Vilaivan

Penchit Chitnumsub

Chawanee Thongpanchang

Sumalee Kamchonwongpaisan

David Matthews

Livia Vivas

Jirundon Yuvaniyama

Susan Charman

William Charman

Sanjay Babu Katiyar

Original Assignee

Medicines Malaria Venture Mmv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-10-08

Filing date

2008-10-08

Publication date

2015-08-04

2008-10-08 Application filed by Medicines Malaria Venture Mmv filed Critical Medicines Malaria Venture Mmv

2015-08-04 Publication of BRPI0818618A2 publication Critical patent/BRPI0818618A2/pt

2020-03-03 Publication of BRPI0818618B1 publication Critical patent/BRPI0818618B1/pt

2023-04-25 Publication of BRPI0818618B8 publication Critical patent/BRPI0818618B8/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Tropical Medicine & Parasitology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

BRPI0818618A 2007-10-08 2008-10-08 composto antimalárico, e, composição farmacêutica BRPI0818618B8 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US97837507P	2007-10-08	2007-10-08
US60/978,375		2007-10-08
PCT/US2008/079210 WO2009048957A1 (en)	2007-10-08	2008-10-08	Antimalarial compounds with flexible side-chains

Publications (3)

Publication Number	Publication Date
BRPI0818618A2 true BRPI0818618A2 (pt)	2015-08-04
BRPI0818618B1 BRPI0818618B1 (pt)	2020-03-03
BRPI0818618B8 BRPI0818618B8 (pt)	2023-04-25

Family

ID=40534843

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0818618A BRPI0818618B8 (pt)	2007-10-08	2008-10-08	composto antimalárico, e, composição farmacêutica

Country Status (22)

Country	Link
US (1)	US8530491B2 (pt)
EP (2)	EP2194985B1 (pt)
JP (1)	JP5603775B2 (pt)
KR (1)	KR101578949B1 (pt)
CN (1)	CN101820879B (pt)
AU (1)	AU2008310898B2 (pt)
BR (1)	BRPI0818618B8 (pt)
CA (1)	CA2700880C (pt)
CY (1)	CY1121598T1 (pt)
DK (1)	DK2194985T3 (pt)
ES (1)	ES2727015T3 (pt)
HR (1)	HRP20190589T1 (pt)
HU (1)	HUE044398T2 (pt)
LT (1)	LT2194985T (pt)
MX (1)	MX2010003739A (pt)
PL (1)	PL2194985T3 (pt)
PT (1)	PT2194985T (pt)
RU (1)	RU2485107C2 (pt)
SI (1)	SI2194985T1 (pt)
TR (1)	TR201904913T4 (pt)
UA (1)	UA105759C2 (pt)
WO (1)	WO2009048957A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9611503B2 (en)	2011-02-09	2017-04-04	National Science And Technology Development Agency	Escherichia coli cell line with thyA knockout and folA knockout
WO2012121682A2 (en) *	2011-03-10	2012-09-13	National Science And Technology Development Agency	Anti-folate antimalarials with dual-binding modes and their preparation
US10011842B2 (en)	2013-09-30	2018-07-03	National Science And Technology Development Agency	Escherichia coli cell line with thyA knockout, folA knockout, and one or both of folP knockout, and folK knockout
CN104593406A (zh) *	2015-01-08	2015-05-06	山西医科大学	pIRES/TgDHFR-TS真核表达重组质粒及其构建和应用
WO2017052479A1 (en) *	2015-09-23	2017-03-30	National Science And Technology Development Agency	2,4-diamino-6-ethylpyrimidine derivatives with antimalarial activities against plasmodium falciparum
CN106083742A (zh) *	2016-05-31	2016-11-09	广东工业大学	一种2,4‑二胺基喹唑啉衍生物及其制备方法和应用
AU2021215743B2 (en) *	2020-02-04	2024-06-13	Tsinghua University	Inhibitors of malarial and Plasmodium falciparum hexose transporter and uses thereof
CN112961106A (zh) *	2021-03-13	2021-06-15	德州学院	一种4-羟基-6氯喹啉合成新工艺
EP4438596A1 (en) *	2023-03-28	2024-10-02	Université de Lille	Diaminopyrimidine derivatives as hdac and dhfr dual-targeting inhibitors and use thereof in preventing and treating malaria
WO2025053796A1 (en) *	2023-09-04	2025-03-13	National Science And Technology Development Agency	Hybrid molecules between pyrimidine derivatives and idasanutlin

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4033962A (en)	1975-06-26	1977-07-05	Hoffman-La Roche Inc.	2,4-Diamino-pyrimidine derivatives and processes
GB1546937A (en) *	1976-07-29	1979-05-31	Beecham Group Ltd	2,4-diaminopyrimidine derivatives
FR2397407A2 (fr) *	1977-07-11	1979-02-09	Dick Pierre	Derives de 2,4-diamino pyrimidines et leur mise en solution en association avec des sulfamides
OA07362A (fr) *	1980-10-27	1984-06-30	May & Baker Ltd	Dérivés de la pyrimidine, leur procédé de préparation et les compositions les contenant.
GB2086386B (en) *	1980-10-27	1984-01-18	May & Baker Ltd	Pyrimidine derivatives
US5322858A (en)	1992-02-14	1994-06-21	Jacobus Pharmaceutical Co. Inc.	N,N'-substituted imidodicarbonimidic diamides derived from hydroxylamines
RU95113597A (ru) *	1992-12-02	1997-06-10	ФМК Корпорейшн (US)	Инсектицидная композиция, способы борьбы с насекомыми
CN1191861C (zh)	1999-05-24	2005-03-09	三共株式会社	含有抗Fas抗体的药物组合物
IT1317826B1 (it) *	2000-02-11	2003-07-15	Dompe Spa	Ammidi, utili nell'inibizione della chemiotassi dei neutrofiliindotta da il-8.
US7371758B2 (en) *	2003-03-13	2008-05-13	National Science & Technology Development Agency	Antimalarial pyrimidine derivatives and methods of making and using them

2008
- 2008-10-08 UA UAA201004117A patent/UA105759C2/uk unknown
- 2008-10-08 LT LTEP08837766.8T patent/LT2194985T/lt unknown
- 2008-10-08 US US12/247,953 patent/US8530491B2/en active Active
- 2008-10-08 EP EP08837766.8A patent/EP2194985B1/en active Active
- 2008-10-08 HR HRP20190589TT patent/HRP20190589T1/hr unknown
- 2008-10-08 BR BRPI0818618A patent/BRPI0818618B8/pt active IP Right Grant
- 2008-10-08 KR KR1020107010151A patent/KR101578949B1/ko active Active
- 2008-10-08 AU AU2008310898A patent/AU2008310898B2/en active Active
- 2008-10-08 CA CA2700880A patent/CA2700880C/en active Active
- 2008-10-08 PT PT08837766T patent/PT2194985T/pt unknown
- 2008-10-08 SI SI200832053T patent/SI2194985T1/sl unknown
- 2008-10-08 HU HUE08837766 patent/HUE044398T2/hu unknown
- 2008-10-08 DK DK08837766.8T patent/DK2194985T3/da active
- 2008-10-08 PL PL08837766T patent/PL2194985T3/pl unknown
- 2008-10-08 ES ES08837766T patent/ES2727015T3/es active Active
- 2008-10-08 EP EP19157867.3A patent/EP3546452A1/en not_active Withdrawn
- 2008-10-08 MX MX2010003739A patent/MX2010003739A/es active IP Right Grant
- 2008-10-08 RU RU2010117193/04A patent/RU2485107C2/ru active
- 2008-10-08 JP JP2010528223A patent/JP5603775B2/ja active Active
- 2008-10-08 WO PCT/US2008/079210 patent/WO2009048957A1/en not_active Ceased
- 2008-10-08 CN CN2008801106805A patent/CN101820879B/zh active Active
- 2008-10-08 TR TR2019/04913T patent/TR201904913T4/tr unknown
2019
- 2019-04-19 CY CY20191100432T patent/CY1121598T1/el unknown

Also Published As

Publication number	Publication date
RU2010117193A (ru)	2011-11-20
JP5603775B2 (ja)	2014-10-08
UA105759C2 (uk)	2014-06-25
EP2194985A1 (en)	2010-06-16
PT2194985T (pt)	2019-05-30
US8530491B2 (en)	2013-09-10
CA2700880C (en)	2016-03-08
EP2194985B1 (en)	2019-02-20
CY1121598T1 (el)	2020-07-31
CN101820879B (zh)	2013-01-02
EP3546452A1 (en)	2019-10-02
DK2194985T3 (da)	2019-05-20
CA2700880A1 (en)	2009-04-16
WO2009048957A1 (en)	2009-04-16
BRPI0818618B8 (pt)	2023-04-25
RU2485107C2 (ru)	2013-06-20
LT2194985T (lt)	2019-04-10
KR20100094459A (ko)	2010-08-26
HUE044398T2 (hu)	2019-10-28
JP2010540666A (ja)	2010-12-24
AU2008310898A1 (en)	2009-04-16
MX2010003739A (es)	2010-04-21
BRPI0818618B1 (pt)	2020-03-03
KR101578949B1 (ko)	2015-12-18
HRP20190589T1 (hr)	2019-05-31
EP2194985A4 (en)	2012-01-25
ES2727015T3 (es)	2019-10-11
SI2194985T1 (sl)	2019-04-30
WO2009048957A8 (en)	2010-04-22
AU2008310898B2 (en)	2014-05-08
CN101820879A (zh)	2010-09-01
TR201904913T4 (tr)	2019-05-21
US20090099220A1 (en)	2009-04-16
PL2194985T3 (pl)	2019-12-31

Publication	Publication Date	Title
BRPI0818618A2 (pt)	2015-08-04	Compostos antimaláricos com cadeias laterais flexíveis e métodos de tratamento da malária.
BRPI0814889A2 (pt)	2017-05-23	tratamento com ligantes alfa7-seletivos.
BRPI0906611A2 (pt)	2015-07-14	Produtos implantáveis compreendendo nanopartículas.
DE602006004866D1 (de)	2009-03-05	Katheter
DE602007004088D1 (de)	2010-02-11	Kettenförderer
BRPI0815773A2 (pt)	2019-09-24	composto, e, medicamento.
BRPI0717339A2 (pt)	2013-10-15	Reversor de empuxo e nacela de turboélice
EP1855738A4 (en)	2010-07-21	CATHETER CONNECTOR
DE112007003143A5 (de)	2009-09-24	Kettenverbindungsglied
DK2173831T3 (da)	2012-09-17	Brøndbehandling
BRPI0811870A2 (pt)	2014-10-21	Tratamento e prevenção de influenza
NL2002458A1 (nl)	2009-08-03	Transportband.
DE602006000045D1 (de)	2007-09-06	Förderkette
DE602006017356D1 (de)	2010-11-18	Kernlose gleiskette
BRPI0923796A2 (pt)	2018-05-29	compostos antivirais, tratamento e ensaio
EP2181946A4 (en)	2013-05-29	FÖRDERBAND
DE112007002789A5 (de)	2009-09-03	Laschenkette
BRPI0814935A2 (pt)	2015-02-03	Tratamento ou prevenção deinfecção por rotavírus
DK1981360T3 (da)	2010-04-26	Sensorisk prægning
BRPI0922477A2 (pt)	2015-12-15	transportador.
DE112008000219A5 (de)	2009-10-22	Laschenkette
NL2001852A1 (nl)	2009-01-29	Conveyor belt.
FR2915500B1 (fr)	2010-11-05	Garde-corps.
DE112008001185A5 (de)	2010-01-28	Laschenkette
EP1899623A4 (en)	2011-07-27	STAINABLE CHAIN

Legal Events

Date	Code	Title	Description
2015-08-04	B15I	Others concerning applications: loss of priority
2015-10-13	B12F	Other appeals [chapter 12.6 patent gazette]
2017-10-10	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
2018-04-17	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2019-02-12	B07E	Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]	Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI
2019-03-19	B07A	Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
2019-09-03	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2020-01-28	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2020-03-03	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 03/03/2020, OBSERVADAS AS CONDICOES LEGAIS.
2020-09-15	B25D	Requested change of name of applicant approved	Owner name: MMV MEDICINES FOR MALARIA VENTURE (CH)
2020-09-29	B25G	Requested change of headquarter approved	Owner name: MMV MEDICINES FOR MALARIA VENTURE (CH)
2021-05-25	B16C	Correction of notification of the grant [chapter 16.3 patent gazette]	Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 08/10/2008 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF
2023-04-25	B25A	Requested transfer of rights approved	Owner name: NATIONAL SCIENCE AND TECHNOLOGY DEVELOPMENT AGENCY (TH)