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CY1118879T1 - Ενωσεις τριαζινης ως αναστολεις κινασης ρ13 και mtor - Google Patents

Ενωσεις τριαζινης ως αναστολεις κινασης ρ13 και mtor

Info

Publication number
CY1118879T1
CY1118879T1 CY20171100482T CY171100482T CY1118879T1 CY 1118879 T1 CY1118879 T1 CY 1118879T1 CY 20171100482 T CY20171100482 T CY 20171100482T CY 171100482 T CY171100482 T CY 171100482T CY 1118879 T1 CY1118879 T1 CY 1118879T1
Authority
CY
Cyprus
Prior art keywords
mtor
compounds
modular
inhibitors
triazine compounds
Prior art date
Application number
CY20171100482T
Other languages
English (en)
Inventor
Aranapakam M Venkatesan
Zecheng Chen
Christoph M Dehnhardt
Santos Osvaldo Dos
Santos Efren Guillermo Delos
Arie Zask
Jeroen C Verheijen
Joshua Aaron Kaplan
David J Richard
Semiramis Ayral-Kaloustian
Tarek S Mansour
Ariamala Gopalsamy
Kevin J Curran
Mengxiao Shi
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40911929&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1118879(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of CY1118879T1 publication Critical patent/CY1118879T1/el

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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract

Ενώσεις του τύπου I (I) όπου: R1 είναι (II) ή (III)· και R2, R4, και R6-9 ορίζονται στο παρόν, και φαρμακευτικώς αποδεκτά άλατα και εστέρες αυτών. Αυτές οι ενώσεις παρεμποδίζουν ΡΙ3 κινάση και mTOR, και μπορεί να χρησιμοποιηθούν για να θεραπεύονται ασθένειες που προκαλούνται από ΡΙ3 κινάση και mTOR, όπως ποικιλία καρκίνων. Μέθοδοι για κατασκευή και χρήση των ενώσεων της εφεύρεσης αυτής αποκαλύπτονται. Αποκαλύπτονται επίσης διάφορες συνθέσεις που περιέχουν τις ενώσεις της εφεύρεσης αυτής.
CY20171100482T 2008-05-23 2017-05-03 Ενωσεις τριαζινης ως αναστολεις κινασης ρ13 και mtor CY1118879T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5566108P 2008-05-23 2008-05-23
PCT/US2009/044774 WO2009143313A1 (en) 2008-05-23 2009-05-21 Triazine compounds as p13 kinase and mtor inhibitors

Publications (1)

Publication Number Publication Date
CY1118879T1 true CY1118879T1 (el) 2018-01-10

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CY20171100482T CY1118879T1 (el) 2008-05-23 2017-05-03 Ενωσεις τριαζινης ως αναστολεις κινασης ρ13 και mtor
CY20191100421T CY1121699T1 (el) 2008-05-23 2019-04-16 Ενωσεις τριαζινης ως αναστολεις κινασης ρ13 και mtor

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Families Citing this family (59)

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RS55960B1 (sr) * 2008-05-23 2017-09-29 Wyeth Llc Triazinska jedinjenja kao inhibitori pi3 kinaze i mtor
BRPI0913031A2 (pt) 2008-05-23 2019-11-26 Novartis Ag derivados de quinolina e quinoxalinas como inibidores de proteína tirosina quinase, seus usos e processo de fabricação, bem como composições farmacêuticas e combinação que os compreende
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