CY1115820T1 - Ετεροαρυλo-κυκλοεξυλο-τετρααζαβενζο[ε]αζουλενια - Google Patents
Ετεροαρυλo-κυκλοεξυλο-τετρααζαβενζο[ε]αζουλενιαInfo
- Publication number
- CY1115820T1 CY1115820T1 CY20141101044T CY141101044T CY1115820T1 CY 1115820 T1 CY1115820 T1 CY 1115820T1 CY 20141101044 T CY20141101044 T CY 20141101044T CY 141101044 T CY141101044 T CY 141101044T CY 1115820 T1 CY1115820 T1 CY 1115820T1
- Authority
- CY
- Cyprus
- Prior art keywords
- nosepressin
- tetraazabenzo
- heteroaryl
- cyclohexyl
- nosopressin
- Prior art date
Links
- CUFNKYGDVFVPHO-UHFFFAOYSA-N azulene Chemical compound C1=CC=CC2=CC=CC2=C1 CUFNKYGDVFVPHO-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 230000028327 secretion Effects 0.000 abstract 2
- 206010001488 Aggression Diseases 0.000 abstract 1
- 208000005171 Dysmenorrhea Diseases 0.000 abstract 1
- 206010013935 Dysmenorrhoea Diseases 0.000 abstract 1
- 206010057671 Female sexual dysfunction Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 206010057672 Male sexual dysfunction Diseases 0.000 abstract 1
- 102100037505 Secretin Human genes 0.000 abstract 1
- 108010086019 Secretin Proteins 0.000 abstract 1
- 230000016571 aggressive behavior Effects 0.000 abstract 1
- 208000012761 aggressive behavior Diseases 0.000 abstract 1
- 208000029560 autism spectrum disease Diseases 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 229960002101 secretin Drugs 0.000 abstract 1
- OWMZNFCDEHGFEP-NFBCVYDUSA-N secretin human Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(N)=O)[C@@H](C)O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)C1=CC=CC=C1 OWMZNFCDEHGFEP-NFBCVYDUSA-N 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Gynecology & Obstetrics (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Η παρούσα εφεύρεση αφορά ετεροαρυλο-κυκλοεξυλο-τετρααζαβενζο[e]αζουλένια του τύπου (I), όπου οι R1, R2 και R3 είναι όπως περιγράφονται στο παρόν, στην παραγωγή τους, φαρμακευτικές συνθέσεις που τα περιέχουν και στη χρήση τους ως φάρμακα. Οι ενώσεις σύμφωνα με την εφεύρεση δρουν ως διαμορφωτές Via υποδοχέα, και ειδικότερα ως ανταγωνιστές Via υποδοχέα. Οι δραστικές ενώσεις της παρούσας εφεύρεσης είναι χρήσιμες ως θεραπευτικοί παράγοντες που δρουν περιφερικά και κεντρικά στις παθήσεις δυσμηνόρροιας, σεξουαλικής δυσλειτουργίας άρρενος ή θήλεος, υπέρτασης, χρόνιας καρδιακής ανεπάρκειας, απρόσφορης έκκρισης βασοπρεσίνης, κίρρωσης ήπατος, νεφρωσικού συνδρόμου, άγχους, διαταραχών κατάθλιψης, ιδεοψυχαναγκαστικής διαταραχής, διαταραχών αυτιστικού φάσματος, σχιζοφρένειας και επιθετικής συμπεριφοράς.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10162451 | 2010-05-10 | ||
| EP11718393.9A EP2569319B1 (en) | 2010-05-10 | 2011-05-09 | Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1115820T1 true CY1115820T1 (el) | 2017-01-25 |
Family
ID=44080459
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20141101044T CY1115820T1 (el) | 2010-05-10 | 2014-12-16 | Ετεροαρυλo-κυκλοεξυλο-τετρααζαβενζο[ε]αζουλενια |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US8513238B2 (el) |
| EP (1) | EP2569319B1 (el) |
| JP (1) | JP5868959B2 (el) |
| KR (1) | KR20130109958A (el) |
| CN (1) | CN102884065B (el) |
| AR (1) | AR081374A1 (el) |
| AU (1) | AU2011252116B2 (el) |
| BR (1) | BR112012028763A2 (el) |
| CA (1) | CA2797920A1 (el) |
| CL (1) | CL2012003132A1 (el) |
| CO (1) | CO6620058A2 (el) |
| CR (1) | CR20120542A (el) |
| CY (1) | CY1115820T1 (el) |
| DK (1) | DK2569319T3 (el) |
| EA (1) | EA021441B1 (el) |
| EC (1) | ECSP12012291A (el) |
| ES (1) | ES2523881T3 (el) |
| HR (1) | HRP20141250T1 (el) |
| IL (1) | IL222815A (el) |
| MA (1) | MA34252B1 (el) |
| MX (1) | MX2012012857A (el) |
| MY (1) | MY160517A (el) |
| NZ (1) | NZ603223A (el) |
| PE (1) | PE20130401A1 (el) |
| PH (1) | PH12012502174A1 (el) |
| PL (1) | PL2569319T3 (el) |
| PT (1) | PT2569319E (el) |
| RS (1) | RS53669B1 (el) |
| SG (1) | SG185484A1 (el) |
| SI (1) | SI2569319T1 (el) |
| TW (1) | TWI419892B (el) |
| UA (1) | UA110616C2 (el) |
| WO (1) | WO2011141396A1 (el) |
| ZA (1) | ZA201208317B (el) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2356123T3 (pl) | 2008-11-13 | 2013-03-29 | Hoffmann La Roche | Spiro-5,6-dihudro-4h-2,3,5,10b- tetraazabenzo[e]azuleny |
| MX2011005119A (es) | 2008-11-18 | 2011-05-30 | Hoffmann La Roche | Alquilciclohexileteres de dihidrotetraazabenzoazulenos. |
| JP5452608B2 (ja) | 2008-11-28 | 2014-03-26 | エフ．ホフマン−ラ ロシュ アーゲー | バソプレシン介在受容体アンタゴニストとしての使用のためのジヒドロテトラアザベンゾアズレンのアリールシクロヘキシルエーテル |
| US8420633B2 (en) | 2010-03-31 | 2013-04-16 | Hoffmann-La Roche Inc. | Aryl-cyclohexyl-tetraazabenzo[e]azulenes |
| US8461151B2 (en) | 2010-04-13 | 2013-06-11 | Hoffmann-La Roche Inc. | Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes |
| US8492376B2 (en) | 2010-04-21 | 2013-07-23 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes |
| US8481528B2 (en) | 2010-04-26 | 2013-07-09 | Hoffmann-La Roche Inc. | Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes |
| US8513238B2 (en) | 2010-05-10 | 2013-08-20 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes |
| WO2017191117A1 (en) | 2016-05-03 | 2017-11-09 | Bayer Pharma Aktiengesellschaft | V1a receptor antagonists for use in the treatment of renal diseases |
| AU2018207776B2 (en) | 2017-01-10 | 2021-06-17 | Bayer Aktiengesellschaft | Heterocyclene derivatives as pest control agents |
| UY37557A (es) | 2017-01-10 | 2018-07-31 | Bayer Ag | Derivados heterocíclicos como pesticidas |
| HU231206B1 (hu) | 2017-12-15 | 2021-10-28 | Richter Gedeon Nyrt. | Triazolobenzazepinek |
| TW201938171A (zh) | 2017-12-15 | 2019-10-01 | 匈牙利商羅特格登公司 | 作為血管升壓素Ｖ１ａ受體拮抗劑之三環化合物 |
| EP3935053B1 (en) | 2019-03-08 | 2023-06-07 | Syngenta Crop Protection AG | Pesticidally active azole-amide compounds |
| CN113597424B (zh) | 2019-03-20 | 2025-04-18 | 先正达农作物保护股份公司 | 杀有害生物活性的唑酰胺化合物 |
| CN114644635B (zh) * | 2020-12-21 | 2023-02-03 | 上海济煜医药科技有限公司 | 三氮唑类三并环衍生物及其制备方法和应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5428157A (en) | 1993-11-22 | 1995-06-27 | Merck & Co., Inc. | 3-acylaminobenzodiazepines |
| NL9401174A (nl) | 1994-07-15 | 1996-02-01 | A P I S Medical Bv | Inspuitsamenstel met opzuignaald en terugtrekbare inspuitnaald. |
| EP1000062B1 (en) * | 1997-07-30 | 2004-09-22 | Wyeth | Tricyclic vasopressin agonists |
| TR200102069T2 (tr) | 1999-01-19 | 2001-11-21 | Ortho-Mcneil Pharmaceutical, Inc. | Vasopresin reseptörü antagonistleri olarak trisiklik benzodiazepinler. |
| US7022699B2 (en) | 2001-04-12 | 2006-04-04 | Wyeth | Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators |
| US7109193B2 (en) | 2001-04-12 | 2006-09-19 | Wyeth | Tricyclic diazepines tocolytic oxytocin receptor antagonists |
| WO2003066634A1 (en) | 2002-02-07 | 2003-08-14 | Neurogen Corporation | Substituted fused pyrazolecarboxylic acid arylamides and related compounds |
| GB0303852D0 (en) * | 2003-02-19 | 2003-03-26 | Pfizer Ltd | Triazole compounds useful in therapy |
| GB0400700D0 (en) | 2004-01-13 | 2004-02-18 | Pfizer Ltd | Compounds useful in therapy |
| KR100840852B1 (ko) | 2004-05-25 | 2008-06-23 | 화이자 프로덕츠 인크. | 테트라아자벤조[ｅ]아줄렌 유도체 및 이의 유사체 |
| UA84208C2 (en) | 2004-05-25 | 2008-09-25 | Пфайзер Продактс Инк. | Tetraazabenzo(e)azulene derivatives and analogs thereof |
| EP1632494A1 (en) | 2004-08-24 | 2006-03-08 | Ferring B.V. | Vasopressin v1a antagonists |
| MX2007002248A (es) | 2004-08-25 | 2008-10-02 | Pfizer | Triazolobenzodiazepinas y su uso como antagonistas de vasopresina. |
| EA011725B1 (ru) * | 2004-08-26 | 2009-04-28 | Пфайзер Инк. | Пиразолзамещённые аминогетероарильные соединения в качестве ингибиторов протеинкиназы |
| JP2008539220A (ja) | 2005-04-26 | 2008-11-13 | ファイザー・リミテッド | バソプレシンアンタゴニストとしてのトリアゾール誘導体 |
| CA2608718A1 (en) | 2005-05-18 | 2006-11-23 | Pfizer Limited | 1, 2, 4-triazole derivatives as vasopressin antagonists |
| ES2376378T3 (es) | 2007-01-12 | 2012-03-13 | F. Hoffmann-La Roche Ag | Derivados de espiropiperidina-glicinamida. |
| MX2011005119A (es) | 2008-11-18 | 2011-05-30 | Hoffmann La Roche | Alquilciclohexileteres de dihidrotetraazabenzoazulenos. |
| US8420633B2 (en) | 2010-03-31 | 2013-04-16 | Hoffmann-La Roche Inc. | Aryl-cyclohexyl-tetraazabenzo[e]azulenes |
| US8461151B2 (en) | 2010-04-13 | 2013-06-11 | Hoffmann-La Roche Inc. | Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes |
| US8492376B2 (en) | 2010-04-21 | 2013-07-23 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes |
| US8481528B2 (en) * | 2010-04-26 | 2013-07-09 | Hoffmann-La Roche Inc. | Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes |
| US8513238B2 (en) | 2010-05-10 | 2013-08-20 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes |
-
2011
- 2011-05-05 US US13/101,173 patent/US8513238B2/en not_active Expired - Fee Related
- 2011-05-09 PE PE2012002147A patent/PE20130401A1/es not_active Application Discontinuation
- 2011-05-09 JP JP2013509524A patent/JP5868959B2/ja not_active Expired - Fee Related
- 2011-05-09 PH PH1/2012/502174A patent/PH12012502174A1/en unknown
- 2011-05-09 NZ NZ603223A patent/NZ603223A/en not_active IP Right Cessation
- 2011-05-09 CA CA2797920A patent/CA2797920A1/en not_active Abandoned
- 2011-05-09 PL PL11718393T patent/PL2569319T3/pl unknown
- 2011-05-09 EA EA201291187A patent/EA021441B1/ru not_active IP Right Cessation
- 2011-05-09 AR ARP110101587A patent/AR081374A1/es unknown
- 2011-05-09 EP EP11718393.9A patent/EP2569319B1/en not_active Not-in-force
- 2011-05-09 PT PT117183939T patent/PT2569319E/pt unknown
- 2011-05-09 KR KR1020127032241A patent/KR20130109958A/ko not_active Ceased
- 2011-05-09 MX MX2012012857A patent/MX2012012857A/es active IP Right Grant
- 2011-05-09 BR BR112012028763A patent/BR112012028763A2/pt not_active IP Right Cessation
- 2011-05-09 MY MYPI2012004887A patent/MY160517A/en unknown
- 2011-05-09 CN CN201180023289.3A patent/CN102884065B/zh not_active Expired - Fee Related
- 2011-05-09 ES ES11718393.9T patent/ES2523881T3/es active Active
- 2011-05-09 RS RS20140639A patent/RS53669B1/sr unknown
- 2011-05-09 WO PCT/EP2011/057368 patent/WO2011141396A1/en not_active Ceased
- 2011-05-09 TW TW100116207A patent/TWI419892B/zh not_active IP Right Cessation
- 2011-05-09 DK DK11718393.9T patent/DK2569319T3/da active
- 2011-05-09 AU AU2011252116A patent/AU2011252116B2/en not_active Ceased
- 2011-05-09 MA MA35399A patent/MA34252B1/fr unknown
- 2011-05-09 SI SI201130313T patent/SI2569319T1/sl unknown
- 2011-05-09 HR HRP20141250AT patent/HRP20141250T1/hr unknown
- 2011-05-09 SG SG2012082483A patent/SG185484A1/en unknown
- 2011-09-05 UA UAA201213888A patent/UA110616C2/uk unknown
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2012
- 2012-10-23 CR CR20120542A patent/CR20120542A/es unknown
- 2012-10-25 CO CO12191162A patent/CO6620058A2/es active IP Right Grant
- 2012-11-01 IL IL222815A patent/IL222815A/en active IP Right Grant
- 2012-11-05 ZA ZA2012/08317A patent/ZA201208317B/en unknown
- 2012-11-08 CL CL2012003132A patent/CL2012003132A1/es unknown
- 2012-11-09 EC ECSP12012291 patent/ECSP12012291A/es unknown
-
2014
- 2014-12-16 CY CY20141101044T patent/CY1115820T1/el unknown
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