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CY1114989T1 - ΠΑΡΑΓΩΓΑ ΤΗΣ ΠΥΡΙΔΟ[2,3-d]ΠΥΡΙΜΙΔΙΝΗΣ, Η ΠΑΡΑΣΚΕΥΗ ΤΟΥΣ ΚΑΙ Η ΕΦΑΡΜΟΓΗ ΤΟΥΣ ΣΕ ΘΕΡΑΠΕΥΤΙΚΕΣ ΑΓΩΓΕΣ - Google Patents

ΠΑΡΑΓΩΓΑ ΤΗΣ ΠΥΡΙΔΟ[2,3-d]ΠΥΡΙΜΙΔΙΝΗΣ, Η ΠΑΡΑΣΚΕΥΗ ΤΟΥΣ ΚΑΙ Η ΕΦΑΡΜΟΓΗ ΤΟΥΣ ΣΕ ΘΕΡΑΠΕΥΤΙΚΕΣ ΑΓΩΓΕΣ

Info

Publication number
CY1114989T1
CY1114989T1 CY20141100211T CY141100211T CY1114989T1 CY 1114989 T1 CY1114989 T1 CY 1114989T1 CY 20141100211 T CY20141100211 T CY 20141100211T CY 141100211 T CY141100211 T CY 141100211T CY 1114989 T1 CY1114989 T1 CY 1114989T1
Authority
CY
Cyprus
Prior art keywords
preparation
pyrimidine
pyridine
implementation
products
Prior art date
Application number
CY20141100211T
Other languages
English (en)
Inventor
Bernard Bourrie
Pierre Casellas
Samir Jegham
Claude Muneaux
Pierre Perreaut
Original Assignee
Sanofi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi filed Critical Sanofi
Publication of CY1114989T1 publication Critical patent/CY1114989T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Η παρούσα εφεύρεση έχει ως αντικείμενο παράγωγα της πυριδο[2,3-d]πυριμιδίνης, την παρασκευή τους και την εφαρμογή τους στις θεραπευτικές αγωγές. Οι ενώσεις της είναι ενδεχομένως χρήσιμες για την θεραπεία προβλημάτων που προκαλούνται από τον κυτταρικό πολλαπλασιασμό.
CY20141100211T 2005-07-01 2014-03-18 ΠΑΡΑΓΩΓΑ ΤΗΣ ΠΥΡΙΔΟ[2,3-d]ΠΥΡΙΜΙΔΙΝΗΣ, Η ΠΑΡΑΣΚΕΥΗ ΤΟΥΣ ΚΑΙ Η ΕΦΑΡΜΟΓΗ ΤΟΥΣ ΣΕ ΘΕΡΑΠΕΥΤΙΚΕΣ ΑΓΩΓΕΣ CY1114989T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0507032A FR2887882B1 (fr) 2005-07-01 2005-07-01 Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique
EP08017944.3A EP2020410B1 (fr) 2005-07-01 2006-06-29 Dérivés de pyrido[2,3-d] pyrimidine, leur préparation, leur application en thérapeutique

Publications (1)

Publication Number Publication Date
CY1114989T1 true CY1114989T1 (el) 2016-12-14

Family

ID=36096420

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20091100498T CY1110457T1 (el) 2005-07-01 2009-05-11 Παραγωγα της πυριδο[2,3-d]πυριμιδινης, η παρασκευη τους και η εφαρμογη τους σε θεραπευτικες αγωγες
CY20141100211T CY1114989T1 (el) 2005-07-01 2014-03-18 ΠΑΡΑΓΩΓΑ ΤΗΣ ΠΥΡΙΔΟ[2,3-d]ΠΥΡΙΜΙΔΙΝΗΣ, Η ΠΑΡΑΣΚΕΥΗ ΤΟΥΣ ΚΑΙ Η ΕΦΑΡΜΟΓΗ ΤΟΥΣ ΣΕ ΘΕΡΑΠΕΥΤΙΚΕΣ ΑΓΩΓΕΣ

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20091100498T CY1110457T1 (el) 2005-07-01 2009-05-11 Παραγωγα της πυριδο[2,3-d]πυριμιδινης, η παρασκευη τους και η εφαρμογη τους σε θεραπευτικες αγωγες

Country Status (40)

Country Link
US (2) US7504406B2 (el)
EP (2) EP1902054B1 (el)
JP (1) JP4472009B2 (el)
KR (1) KR101298344B1 (el)
CN (2) CN102260258B (el)
AR (1) AR054812A1 (el)
AT (1) ATE423119T1 (el)
AU (1) AU2006264801B2 (el)
BR (1) BRPI0613020A2 (el)
CA (1) CA2610794C (el)
CR (1) CR9568A (el)
CY (2) CY1110457T1 (el)
DE (1) DE602006005246D1 (el)
DK (2) DK1902054T3 (el)
DO (1) DOP2006000145A (el)
EA (1) EA014312B1 (el)
EC (1) ECSP078011A (el)
ES (2) ES2450067T3 (el)
FR (1) FR2887882B1 (el)
HR (2) HRP20090236T1 (el)
IL (1) IL187900A0 (el)
JO (1) JO2550B1 (el)
MA (1) MA29561B1 (el)
ME (1) ME01813B (el)
MX (1) MX2007016239A (el)
MY (1) MY143089A (el)
NO (1) NO20080418L (el)
NZ (1) NZ564072A (el)
PA (1) PA8684801A1 (el)
PE (1) PE20070139A1 (el)
PL (2) PL1902054T3 (el)
PT (2) PT2020410E (el)
RS (2) RS50781B (el)
SI (2) SI1902054T1 (el)
TN (1) TNSN07440A1 (el)
TW (1) TWI321566B (el)
UA (1) UA92021C2 (el)
UY (1) UY29645A1 (el)
WO (1) WO2007003765A1 (el)
ZA (1) ZA200711032B (el)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2873118B1 (fr) 2004-07-15 2007-11-23 Sanofi Synthelabo Derives de pyrido-pyrimidine, leur application en therapeutique
FR2887882B1 (fr) * 2005-07-01 2007-09-07 Sanofi Aventis Sa Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique
FR2896246B1 (fr) 2006-01-13 2008-08-15 Sanofi Aventis Sa Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique.
FR2910813B1 (fr) * 2006-12-28 2009-02-06 Sanofi Aventis Sa Nouvelle utilisation therapeutique pour le traitement des leucemies
CA2739901A1 (en) 2008-10-17 2010-04-22 Akaal Pharma Pty Ltd S1p receptors modulators
AU2009304598B2 (en) 2008-10-17 2015-01-29 Akaal Pharma Pty Ltd S1P receptors modulators and their use thereof
FR2948568B1 (fr) * 2009-07-30 2012-08-24 Sanofi Aventis Formulation pharmaceutique
CN103204827B (zh) * 2012-01-17 2014-12-03 上海科州药物研发有限公司 作为蛋白激酶抑制剂的苯并噻二唑化合物及其制备方法和用途
EP2638911A1 (en) 2012-03-14 2013-09-18 Sanofi Novel combinations for treating acute myeloid leukaemia or chronic myeloid leukaemia
CN103833771A (zh) * 2012-11-22 2014-06-04 天津滨江药物研发有限公司 作为蛋白激酶Mek抑制剂的苯并五元杂环化合物及其制备方法和用途

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GB1171218A (en) * 1967-11-09 1969-11-19 Parke Davis & Co New Heterocyclic Amine Compounds and Methods for their Production
JPH04128276A (ja) 1990-09-19 1992-04-28 Pfizer Pharmaceut Co Ltd アミノベンゾサルタム誘導体およびその用途
ES2146782T3 (es) * 1994-11-14 2000-08-16 Warner Lambert Co 6-aril-pirido(2,3-d)pirimidinas y naftiridinas para la inhibicion de la proliferacion celular inducida por la proteina tirosina quinasa.
IL115256A0 (en) 1994-11-14 1995-12-31 Warner Lambert Co 6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use
IL117923A (en) 1995-05-03 2000-06-01 Warner Lambert Co Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds
US5620981A (en) * 1995-05-03 1997-04-15 Warner-Lambert Company Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation
MXPA02007221A (es) * 2000-01-25 2002-11-29 Warner Lambert Co Inhibidores de pirido [2,3-d)pirimidin-2,7-diamina cinasa.
DZ3308A1 (fr) * 2000-03-06 2001-09-27 Warner Lambert Co Inhibiteurs de tyrosine kinase a base de 5-alkylpyrido [2,3-d] pyrimidines
JP2004519422A (ja) 2000-08-04 2004-07-02 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー ２−（４−ピリジル）アミノ−６−ジアルコキシフェニルピリド〔２，３−ｄ〕ピリミジン−７−オン
WO2003000011A2 (en) * 2001-06-21 2003-01-03 Ariad Pharmaceuticals, Inc. Novel pyridopyrimidines and uses thereof
AU2002952453A0 (en) * 2002-11-01 2002-11-21 Novogen Research Pty Ltd Aminated isoflavonoid derivatives and uses thereof
WO2004063195A1 (en) 2003-01-03 2004-07-29 Sloan-Kettering Institute For Cancer Research Pyridopyrimidine kinase inhibitors
TW200502236A (en) * 2003-03-28 2005-01-16 Hoffmann La Roche Novel pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents
WO2005105097A2 (en) 2004-04-28 2005-11-10 Gpc Biotech Ag Pyridopyrimidines for treating inflammatory and other diseases
FR2873118B1 (fr) * 2004-07-15 2007-11-23 Sanofi Synthelabo Derives de pyrido-pyrimidine, leur application en therapeutique
FR2887882B1 (fr) * 2005-07-01 2007-09-07 Sanofi Aventis Sa Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique
FR2896246B1 (fr) 2006-01-13 2008-08-15 Sanofi Aventis Sa Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique.
US8338435B2 (en) * 2006-07-20 2012-12-25 Gilead Sciences, Inc. Substituted pyrido(3,2-D) pyrimidines and pharmaceutical compositions for treating viral infections

Also Published As

Publication number Publication date
CN101213196B (zh) 2011-09-07
EP2020410B1 (fr) 2013-12-18
JP4472009B2 (ja) 2010-06-02
TW200745102A (en) 2007-12-16
CA2610794A1 (fr) 2007-01-11
MA29561B1 (fr) 2008-06-02
PT1902054E (pt) 2009-04-22
ZA200711032B (en) 2009-04-29
CN102260258B (zh) 2015-01-07
KR101298344B1 (ko) 2013-08-20
JO2550B1 (en) 2010-09-05
NZ564072A (en) 2012-02-24
FR2887882B1 (fr) 2007-09-07
HRP20090236T1 (hr) 2009-05-31
NO20080418L (no) 2008-03-28
EP1902054B1 (fr) 2009-02-18
KR20080021714A (ko) 2008-03-07
PL1902054T3 (pl) 2009-07-31
US20090163522A1 (en) 2009-06-25
PA8684801A1 (es) 2007-01-17
CN101213196A (zh) 2008-07-02
DE602006005246D1 (de) 2009-04-02
EA200800223A1 (ru) 2008-06-30
MY143089A (en) 2011-03-15
ES2450067T3 (es) 2014-03-21
ME01813B (me) 2014-09-20
US7504406B2 (en) 2009-03-17
MX2007016239A (es) 2008-03-06
IL187900A0 (en) 2008-03-20
CN102260258A (zh) 2011-11-30
WO2007003765A1 (fr) 2007-01-11
CY1110457T1 (el) 2015-04-29
RS50781B (sr) 2010-08-31
AR054812A1 (es) 2007-07-18
EP1902054A1 (fr) 2008-03-26
US8008310B2 (en) 2011-08-30
SI2020410T1 (sl) 2014-04-30
PE20070139A1 (es) 2007-03-07
TNSN07440A1 (en) 2009-03-17
ECSP078011A (es) 2008-01-23
BRPI0613020A2 (pt) 2010-12-14
ATE423119T1 (de) 2009-03-15
US20080176874A1 (en) 2008-07-24
DOP2006000145A (es) 2008-01-31
SI1902054T1 (sl) 2009-06-30
RS53211B (sr) 2014-08-29
HK1122797A1 (en) 2009-05-29
EA014312B1 (ru) 2010-10-29
TWI321566B (en) 2010-03-11
PL2020410T3 (pl) 2014-05-30
HRP20140246T1 (hr) 2014-06-20
DK2020410T3 (en) 2014-03-24
AU2006264801B2 (en) 2012-05-10
ES2322101T3 (es) 2009-06-16
EP2020410A1 (fr) 2009-02-04
JP2008544975A (ja) 2008-12-11
DK1902054T3 (da) 2009-06-15
CA2610794C (fr) 2012-02-21
CR9568A (es) 2008-02-20
UA92021C2 (ru) 2010-09-27
PT2020410E (pt) 2014-03-20
UY29645A1 (es) 2007-01-31
AU2006264801A1 (en) 2007-01-11
FR2887882A1 (fr) 2007-01-05

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