CY1112655T1 - Γλυκοζυλιωμενη ιl-7, παρασκευη και χρησεις - Google Patents
Γλυκοζυλιωμενη ιl-7, παρασκευη και χρησειςInfo
- Publication number
- CY1112655T1 CY1112655T1 CY20121100161T CY121100161T CY1112655T1 CY 1112655 T1 CY1112655 T1 CY 1112655T1 CY 20121100161 T CY20121100161 T CY 20121100161T CY 121100161 T CY121100161 T CY 121100161T CY 1112655 T1 CY1112655 T1 CY 1112655T1
- Authority
- CY
- Cyprus
- Prior art keywords
- polypeptides
- well
- relates
- preparation
- cells
- Prior art date
Links
- 108010002586 Interleukin-7 Proteins 0.000 title abstract 4
- 102000000704 Interleukin-7 Human genes 0.000 abstract 3
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical class 0.000 abstract 1
- 230000013595 glycosylation Effects 0.000 abstract 1
- 238000006206 glycosylation reaction Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5418—IL-7
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Transplantation (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05291556A EP1746161A1 (fr) | 2005-07-20 | 2005-07-20 | IL-7 glycosylée, préparation et utilisations |
| EP06795556A EP1904635B1 (fr) | 2005-07-20 | 2006-07-19 | Il-7 glycosylee, preparation et utilisations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1112655T1 true CY1112655T1 (el) | 2016-02-10 |
Family
ID=35385570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20121100161T CY1112655T1 (el) | 2005-07-20 | 2012-02-16 | Γλυκοζυλιωμενη ιl-7, παρασκευη και χρησεις |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US7708985B2 (fr) |
| EP (2) | EP1746161A1 (fr) |
| JP (2) | JP5685363B2 (fr) |
| CN (2) | CN105647939A (fr) |
| AT (1) | ATE542901T1 (fr) |
| AU (1) | AU2006271315B2 (fr) |
| CA (2) | CA2615562C (fr) |
| CY (1) | CY1112655T1 (fr) |
| DK (1) | DK1904635T3 (fr) |
| EA (1) | EA012802B1 (fr) |
| ES (1) | ES2379732T3 (fr) |
| IL (1) | IL188480A0 (fr) |
| NO (1) | NO344802B1 (fr) |
| NZ (1) | NZ564907A (fr) |
| PL (1) | PL1904635T3 (fr) |
| PT (1) | PT1904635E (fr) |
| SI (1) | SI1904635T1 (fr) |
| WO (1) | WO2007010401A2 (fr) |
| ZA (1) | ZA200800533B (fr) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2367891T3 (es) | 2000-09-29 | 2011-11-10 | Schering Corporation | Interleucina-10 pegilada. |
| EP1391513A1 (fr) | 2002-08-08 | 2004-02-25 | Cytheris | Substance médicamenteuse IL-7, composition comprenant IL-7, procédé de sa préparation et ses utilisations |
| DK1699822T3 (da) | 2003-12-30 | 2008-08-04 | Merck Patent Gmbh | IL-7-fusionsproteiner med antistofdele, fremstilling deraf og anvendelse deraf |
| EP2066336B1 (fr) | 2006-09-28 | 2012-09-19 | Merck Sharp & Dohme Corp. | Utilisation d'il-10 pégilée pour traiter un cancer |
| CL2007003411A1 (es) * | 2006-11-28 | 2008-07-04 | Centelion | Proteina fusion que consiste en una region fc de una inmunoglobulina con un fragmento o dominio soluble de un receptor para fgf; polinucleotido que la codifica y vector y celula que lo comprenden; composicion farmaceutica que comprende la proteina fu |
| CN101943688B (zh) * | 2009-07-10 | 2013-01-02 | 复旦大学 | 一种利用质谱靶板富集糖基化肽段的方法 |
| EP2808344A1 (fr) | 2010-06-01 | 2014-12-03 | Monash University | Anticorps dirigés contre le récepteur tyrosine kinase c-Met |
| NZ707637A (en) * | 2010-07-19 | 2016-09-30 | Otago Innovation Ltd | Signal biomarkers |
| AU2011325871B2 (en) | 2010-11-05 | 2016-02-04 | Medvet Science Pty Ltd | Markers of endothelial progenitor cells and uses thereof |
| CA2820956C (fr) * | 2010-12-10 | 2016-05-03 | University Of Central Florida Research Foundation, Inc. | Methodes et compositions comprenant des ligands du recepteur a l'il-7 |
| EP2739301B1 (fr) | 2011-08-03 | 2016-01-20 | Cytheris | Immunothérapie contre le vhc |
| RU2679889C2 (ru) | 2013-04-18 | 2019-02-14 | Армо Байосайенсиз, Инк. | Способы применения интерлейкина-10 для лечения заболеваний и расстройств |
| US9823255B2 (en) | 2013-06-17 | 2017-11-21 | Armo Biosciences, Inc. | Method for assessing protein identity and stability |
| CN105848674A (zh) | 2013-11-11 | 2016-08-10 | 阿尔莫生物科技股份有限公司 | 将白细胞介素-10用于治疗疾病和病症的方法 |
| CN104725484B (zh) * | 2013-12-19 | 2018-03-13 | 中国科学院微生物研究所 | 一种糖基化多肽及其制备方法和其应用 |
| EP3119412A1 (fr) | 2014-03-21 | 2017-01-25 | Boreal Invest | Nanofiltration finale de compositions de protéines solubilisées en vue de l'élimination d'agrégats immunogènes |
| CN106573072A (zh) | 2014-06-02 | 2017-04-19 | 阿尔莫生物科技股份有限公司 | 降低血清胆固醇的方法 |
| MX2017004983A (es) | 2014-10-22 | 2017-11-13 | Armo Biosciences Inc | Metodos para usar interleucina 10 para tratar enfermedades y trastornos. |
| CN104372021A (zh) * | 2014-11-05 | 2015-02-25 | 太仓思源生物医药有限公司 | 人白细胞介素-2蛋白质的制备方法 |
| WO2016126615A1 (fr) | 2015-02-03 | 2016-08-11 | Armo Biosciences, Inc. | Procédés d'utilisation de l'interleukine-10 pour le traitement de maladies et de troubles |
| JP7121496B2 (ja) | 2015-05-28 | 2022-08-18 | アルモ・バイオサイエンシーズ・インコーポレイテッド | 癌治療で使用するためのペグ化インターロイキン-10 |
| CN114853873B (zh) | 2015-06-11 | 2025-01-28 | 格纳西尼有限公司 | 经修饰的白细胞介素-7蛋白及其用途 |
| AU2016341402B2 (en) | 2015-10-23 | 2020-08-27 | Apogenix Ag | Single-chain GITR-receptor agonist proteins |
| KR102386735B1 (ko) | 2015-11-06 | 2022-04-14 | 주식회사 제넥신 | 변형된 인터루킨-7 융합 단백질의 제형 |
| WO2017095191A1 (fr) * | 2015-12-04 | 2017-06-08 | 주식회사 제넥신 | Composition pharmaceutique comprenant une protéine de fusion d'interleukine 7 fusionnés avec fc d'immunoglobuline pour la prévention ou le traitement de maladies causées par le papillomavirus humain |
| US11357827B2 (en) | 2015-12-04 | 2022-06-14 | Genexine, Inc. | Method for preventing or treating influenza virus infection using pharmaceutical composition comprising immunoglobulin Fc-fused interleukin-7 fusion protein |
| CN107759697B (zh) * | 2016-08-19 | 2023-03-24 | 安源医药科技(上海)有限公司 | 制备融合蛋白的方法 |
| IL273202B2 (en) | 2017-09-11 | 2024-08-01 | Univ Monash | Binding proteins to the human thrombin receptor, par4 |
| WO2019144945A1 (fr) | 2018-01-25 | 2019-08-01 | I-Mab | Anticorps anti-pd-l1 et fusions d'il-7 |
| CA3119341A1 (fr) | 2018-11-16 | 2020-05-22 | Neoimmunetech, Inc. | Methode de traitement d'une tumeur au moyen de l'association de la proteine il-7 et d'un inhibiteur de point de controle immunitaire |
| CN113614109A (zh) | 2018-12-21 | 2021-11-05 | Ose免疫疗法公司 | 双功能抗pd-1/il-7分子 |
| AU2020334924A1 (en) * | 2019-08-22 | 2022-04-07 | The Regents Of The University Of California | UBE3A for the treatment of Angelman syndrome |
| AU2020383176B2 (en) * | 2019-11-15 | 2023-10-19 | Genexine, Inc. | Fusion protein including modified interleukin-7 and TGF beta receptor II and use thereof |
| JP2023512456A (ja) | 2020-01-13 | 2023-03-27 | ネオイミューンテック, インコーポレイテッド | Il-7タンパク質と二重特異性抗体の組み合わせで腫瘍を治療する方法 |
| JP2023512657A (ja) | 2020-02-05 | 2023-03-28 | ワシントン・ユニバーシティ | Il-7タンパク質とcar保有免疫細胞の組み合わせで固形腫瘍を治療する方法 |
| US20230398184A1 (en) | 2020-10-26 | 2023-12-14 | Neoimmunetech, Inc. | Methods of inducing stem cell mobilization |
| WO2022094475A1 (fr) | 2020-11-02 | 2022-05-05 | Neoimmunetech, Inc. | Utilisation de l'interleukine-7 pour le traitement du coronavirus |
| IL302482A (en) | 2020-11-05 | 2023-06-01 | Neoimmunetech Inc | Method of treating a tumor with a combination of an il-7 protein and a nucleotide vaccine |
| WO2022117569A1 (fr) | 2020-12-02 | 2022-06-09 | Oncurious Nv | Anticorps antagoniste de ccr8 en combinaison avec un anticorps agoniste du récepteur bêta de la lymphotoxine en thérapie contre le cancer |
| CN113817043B (zh) * | 2021-09-22 | 2023-07-25 | 清华大学 | 制备活性铁调节激素的方法 |
| JP2025501238A (ja) | 2021-12-30 | 2025-01-17 | ネオイミューンテック, インコーポレイテッド | Il-7タンパク質とvegfアンタゴニストの併用による腫瘍の治療方法 |
| WO2023133595A2 (fr) | 2022-01-10 | 2023-07-13 | Sana Biotechnology, Inc. | Méthodes de dosage et d'administration ex vivo de particules lipidiques ou de vecteurs viraux ainsi que systèmes et utilisations associés |
| US20250222027A1 (en) | 2022-04-01 | 2025-07-10 | Sana Biotechnology, Inc. | Cytokine receptor agonist and viral vector combination therapies |
| KR20250089492A (ko) | 2022-11-07 | 2025-06-18 | 네오이뮨텍, 인코퍼레이티드 | 비메틸화된 mgmt 프로모터를 갖는 종양의 치료 방법 |
| WO2024150158A1 (fr) | 2023-01-11 | 2024-07-18 | Bright Peak Therapeutics Ag | Polypeptides il-7, immunocytokines les comprenant et leurs utilisations |
| WO2024261027A1 (fr) | 2023-06-19 | 2024-12-26 | Vector Biopharma Ag | Reciblage d'il-7 d'adénovirus pour une infection spécifique d'une cellule |
| CN117050178B (zh) * | 2023-10-13 | 2024-01-12 | 北京百普赛斯生物科技股份有限公司 | 特异性检测il-7的抗体及应用 |
| WO2025093541A1 (fr) | 2023-10-31 | 2025-05-08 | Ose Immunotherapeutics | Combinaison d'interleukine 7 et de vaccin antigénique associé à une tumeur |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA887773B (en) * | 1987-10-26 | 1989-07-26 | Immunex Corp | Interleukin-7 |
| US5714585A (en) * | 1987-10-26 | 1998-02-03 | Sterling Winthrop, Inc. | Antibodies that are immunoreactive with interleukin-7 |
| US4965195A (en) | 1987-10-26 | 1990-10-23 | Immunex Corp. | Interleukin-7 |
| US5328988A (en) * | 1987-10-26 | 1994-07-12 | Immunex Corporation | Interleukin-7 |
| US5153310A (en) * | 1989-02-28 | 1992-10-06 | Du Pont Merck Pharmaceutical Company | Il-2 analogs containing n-linked glycosylation sites |
| JP2004504016A (ja) * | 2000-06-30 | 2004-02-12 | マキシゲン・エイピーエス | ペプチド拡張されたグリコシル化ポリペプチド |
| EP1391513A1 (fr) | 2002-08-08 | 2004-02-25 | Cytheris | Substance médicamenteuse IL-7, composition comprenant IL-7, procédé de sa préparation et ses utilisations |
-
2005
- 2005-07-20 EP EP05291556A patent/EP1746161A1/fr not_active Withdrawn
-
2006
- 2006-07-19 EP EP06795556A patent/EP1904635B1/fr active Active
- 2006-07-19 PT PT06795556T patent/PT1904635E/pt unknown
- 2006-07-19 EA EA200800368A patent/EA012802B1/ru not_active IP Right Cessation
- 2006-07-19 JP JP2008522097A patent/JP5685363B2/ja active Active
- 2006-07-19 US US11/996,176 patent/US7708985B2/en active Active
- 2006-07-19 CA CA2615562A patent/CA2615562C/fr active Active
- 2006-07-19 CN CN201610038940.9A patent/CN105647939A/zh active Pending
- 2006-07-19 CA CA2859145A patent/CA2859145C/fr active Active
- 2006-07-19 SI SI200631263T patent/SI1904635T1/sl unknown
- 2006-07-19 PL PL06795556T patent/PL1904635T3/pl unknown
- 2006-07-19 AT AT06795556T patent/ATE542901T1/de active
- 2006-07-19 NZ NZ564907A patent/NZ564907A/en not_active IP Right Cessation
- 2006-07-19 AU AU2006271315A patent/AU2006271315B2/en active Active
- 2006-07-19 WO PCT/IB2006/002663 patent/WO2007010401A2/fr not_active Ceased
- 2006-07-19 ES ES06795556T patent/ES2379732T3/es active Active
- 2006-07-19 DK DK06795556.7T patent/DK1904635T3/da active
- 2006-07-19 CN CN200680026503.XA patent/CN101228275B/zh not_active Expired - Fee Related
-
2007
- 2007-12-27 IL IL188480A patent/IL188480A0/en active IP Right Grant
-
2008
- 2008-01-03 NO NO20080045A patent/NO344802B1/no not_active IP Right Cessation
- 2008-01-18 ZA ZA200800533A patent/ZA200800533B/xx unknown
-
2010
- 2010-02-24 US US12/711,675 patent/US8034327B2/en active Active
-
2011
- 2011-08-24 US US13/216,331 patent/US8153114B2/en active Active
-
2012
- 2012-02-16 CY CY20121100161T patent/CY1112655T1/el unknown
-
2014
- 2014-10-01 JP JP2014202828A patent/JP2015057392A/ja active Pending
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