NO20080045L - Glykosylert UL-7, fremstilling og anvendelse av samme - Google Patents
Glykosylert UL-7, fremstilling og anvendelse av sammeInfo
- Publication number
- NO20080045L NO20080045L NO20080045A NO20080045A NO20080045L NO 20080045 L NO20080045 L NO 20080045L NO 20080045 A NO20080045 A NO 20080045A NO 20080045 A NO20080045 A NO 20080045A NO 20080045 L NO20080045 L NO 20080045L
- Authority
- NO
- Norway
- Prior art keywords
- polypeptides
- well
- relates
- preparation
- same
- Prior art date
Links
- 102000000704 Interleukin-7 Human genes 0.000 abstract 3
- 108010002586 Interleukin-7 Proteins 0.000 abstract 3
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical class 0.000 abstract 1
- 230000013595 glycosylation Effects 0.000 abstract 1
- 238000006206 glycosylation reaction Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5418—IL-7
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Sammendrag Det beskrives nye og forbedrete interl eukin-7 polypeptider, og likeledes sammensetninger omfattende samme, deres framstilling og anvendelser. Nærmere bestemt vedrører oppfinnelsen hyperglykosylerte IL-7 polypeptider som har forbedrete egenskaper, og likeledes framstilling og terapeutiske anvendelser av disse. Oppfinnelsen beskriver også nye IL-7 polypeptider som har modifiserte aminosyresekvenser inne- holdende artifisielt etablerte glykosyleringssete(r), og likeledes korresponderende nukleinsyremolekyler, vektorer og rekombinante vertsceller. Oppfinnelsen vedrører også anvendelse av slike polypeptider, celler eller nukleinsyrer for helbredende eller preventiv behandling av mammaiske individer, inkluderende mennesker.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05291556A EP1746161A1 (en) | 2005-07-20 | 2005-07-20 | Glycosylated IL-7, preparation and uses |
| PCT/IB2006/002663 WO2007010401A2 (en) | 2005-07-20 | 2006-07-19 | Glycosylated il-7, preparation and uses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20080045L true NO20080045L (no) | 2008-04-21 |
| NO344802B1 NO344802B1 (no) | 2020-05-04 |
Family
ID=35385570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20080045A NO344802B1 (no) | 2005-07-20 | 2008-01-03 | Glykosylert UL-7, fremstilling og anvendelse av samme. |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US7708985B2 (no) |
| EP (2) | EP1746161A1 (no) |
| JP (2) | JP5685363B2 (no) |
| CN (2) | CN101228275B (no) |
| AT (1) | ATE542901T1 (no) |
| AU (1) | AU2006271315B2 (no) |
| CA (2) | CA2859145C (no) |
| CY (1) | CY1112655T1 (no) |
| DK (1) | DK1904635T3 (no) |
| EA (1) | EA012802B1 (no) |
| ES (1) | ES2379732T3 (no) |
| IL (1) | IL188480A0 (no) |
| NO (1) | NO344802B1 (no) |
| NZ (1) | NZ564907A (no) |
| PL (1) | PL1904635T3 (no) |
| PT (1) | PT1904635E (no) |
| SI (1) | SI1904635T1 (no) |
| WO (1) | WO2007010401A2 (no) |
| ZA (1) | ZA200800533B (no) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1324779B1 (en) | 2000-09-29 | 2011-07-20 | Schering Corporation | Pegylated interleukin-10 |
| EP1391513A1 (en) * | 2002-08-08 | 2004-02-25 | Cytheris | IL-7 drug substance, IL-7 comprising composition, preparation and uses thereof |
| AU2004309050B2 (en) | 2003-12-30 | 2010-10-14 | Merck Patent Gmbh | IL-7 fusion proteins |
| EP2468293B1 (en) | 2006-09-28 | 2014-10-22 | Merck Sharp & Dohme Corp. | Use of pegylated il-10 to prevent metastasis of a cancer or tumor to the lung |
| PE20081250A1 (es) * | 2006-11-28 | 2008-10-07 | Centelion | FUSIONES Fc CON RECEPTOR PARA FGF SOLUBLE MODIFICADAS, CON ACTIVIDAD BIOLOGICA MEJORADA |
| CN101943688B (zh) * | 2009-07-10 | 2013-01-02 | 复旦大学 | 一种利用质谱靶板富集糖基化肽段的方法 |
| JP2013534515A (ja) | 2010-06-01 | 2013-09-05 | モナシュ ユニバーシティ | プロセシングされていない受容体型チロシンキナーゼc−METに対する抗体 |
| ES2629850T3 (es) * | 2010-07-19 | 2017-08-16 | Otago Innovation Limited | Biomarcadores de señal |
| NZ609567A (en) | 2010-11-05 | 2015-05-29 | Transbio Ltd | Markers of endothelial progenitor cells and uses thereof |
| CA2820956C (en) | 2010-12-10 | 2016-05-03 | University Of Central Florida Research Foundation, Inc. | Methods and compositions comprising il-7 receptor ligands |
| US20140377218A1 (en) | 2011-08-03 | 2014-12-25 | Cytheris | Hcv immunotherapy |
| CN105209054A (zh) | 2013-04-18 | 2015-12-30 | 阿尔莫生物科技股份有限公司 | 使用白细胞介素-10治疗疾病和病症的方法 |
| EP3434277A1 (en) | 2013-06-17 | 2019-01-30 | Armo Biosciences, Inc. | Method for assessing protein identity and stability |
| EP3068425B1 (en) | 2013-11-11 | 2021-01-27 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
| CN104725484B (zh) * | 2013-12-19 | 2018-03-13 | 中国科学院微生物研究所 | 一种糖基化多肽及其制备方法和其应用 |
| US20180028593A1 (en) | 2014-03-21 | 2018-02-01 | Boreal Invest | Terminal nanofiltration of solubilized protein compositions for removal of immunogenic aggregates |
| US10293043B2 (en) | 2014-06-02 | 2019-05-21 | Armo Biosciences, Inc. | Methods of lowering serum cholesterol |
| EP3209320B1 (en) | 2014-10-22 | 2023-03-08 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
| CN104372021A (zh) * | 2014-11-05 | 2015-02-25 | 太仓思源生物医药有限公司 | 人白细胞介素-2蛋白质的制备方法 |
| WO2016126615A1 (en) | 2015-02-03 | 2016-08-11 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
| HK1246201A1 (zh) | 2015-05-28 | 2018-09-07 | Armo Biosciences, Inc. | 用於治疗癌症的聚乙二醇化白细胞介素-10 |
| HK1256149A1 (zh) * | 2015-06-11 | 2019-09-13 | 格纳西尼有限公司 | 经修饰的白细胞介素-7蛋白及其用途 |
| EP3365363A1 (en) | 2015-10-23 | 2018-08-29 | Apogenix AG | Single-chain gitr-receptor agonist proteins |
| KR102386735B1 (ko) | 2015-11-06 | 2022-04-14 | 주식회사 제넥신 | 변형된 인터루킨-7 융합 단백질의 제형 |
| TWI774651B (zh) * | 2015-12-04 | 2022-08-21 | 南韓商吉耐森股份有限公司 | 包含融合有免疫球蛋白Fc之介白素-7的用於預防或治療人類乳頭狀瘤病毒相關疾病的藥學組成物 |
| CN108697764A (zh) | 2015-12-04 | 2018-10-23 | 格纳西尼有限公司 | 含有免疫球蛋白fc融合白细胞介素-7融合蛋白的用于预防或治疗流感病毒感染的药物组合物 |
| CN107759697B (zh) * | 2016-08-19 | 2023-03-24 | 安源医药科技(上海)有限公司 | 制备融合蛋白的方法 |
| EP4512469A3 (en) | 2017-09-11 | 2025-05-21 | Monash University | Binding proteins to the human thrombin receptor, par4 |
| CN110352202A (zh) * | 2018-01-25 | 2019-10-18 | 天境生物 | 抗pd-l1抗体和il-7融合蛋白 |
| EP3880231A1 (en) | 2018-11-16 | 2021-09-22 | NeoImmuneTech, Inc. | Method of treating a tumor with a combination of il-7 protein and an immune checkpoint inhibitor |
| US20230071889A1 (en) | 2018-12-21 | 2023-03-09 | Ose Immunotherapeutics | Bifunctional anti-pd-1/il-7 molecule |
| JP2022545184A (ja) * | 2019-08-22 | 2022-10-26 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | アンジェルマン症候群の処置のためのube3a |
| KR102402276B1 (ko) * | 2019-11-15 | 2022-05-26 | 주식회사 제넥신 | 변형된 인터루킨-7 및 tgf 베타 수용체 ii를 포함하는 융합단백질 및 이의 용도 |
| AU2021207586A1 (en) | 2020-01-13 | 2022-07-21 | Neoimmunetech, Inc. | Method of treating a tumor with a combination of IL-7 protein and a bispecific antibody |
| KR20220137630A (ko) | 2020-02-05 | 2022-10-12 | 워싱턴 유니버시티 | Il-7 단백질과 car-보유 면역 세포의 조합물로 고형 종양을 치료하는 방법 |
| US20230398184A1 (en) | 2020-10-26 | 2023-12-14 | Neoimmunetech, Inc. | Methods of inducing stem cell mobilization |
| WO2022094475A1 (en) | 2020-11-02 | 2022-05-05 | Neoimmunetech, Inc. | Use of interleukin-7 for the treatment of coronavirus |
| IL302482A (en) | 2020-11-05 | 2023-06-01 | Neoimmunetech Inc | Method of treating a tumor with a combination of an il-7 protein and a nucleotide vaccine |
| WO2022117569A1 (en) | 2020-12-02 | 2022-06-09 | Oncurious Nv | A ccr8 antagonist antibody in combination with a lymphotoxin beta receptor agonist antibody in therapy against cancer |
| CN113817043B (zh) * | 2021-09-22 | 2023-07-25 | 清华大学 | 制备活性铁调节激素的方法 |
| US20250099542A1 (en) | 2021-12-30 | 2025-03-27 | Neoimmunetech, Inc. | Method of treating a tumor with a combination of il-7 protein and vegf antagonist |
| WO2023133595A2 (en) | 2022-01-10 | 2023-07-13 | Sana Biotechnology, Inc. | Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses |
| WO2023193015A1 (en) | 2022-04-01 | 2023-10-05 | Sana Biotechnology, Inc. | Cytokine receptor agonist and viral vector combination therapies |
| WO2024102722A1 (en) | 2022-11-07 | 2024-05-16 | Neoimmunetech, Inc. | Methods of treating a tumor with an unmethylated mgmt promoter |
| US20240424127A1 (en) | 2023-01-11 | 2024-12-26 | Bright Peak Therapeutics Ag | Il-7 polypeptides, immunocytokines comprising same, and uses thereof |
| WO2024261027A1 (en) | 2023-06-19 | 2024-12-26 | Vector Biopharma Ag | Il-7-retargeting of adenoviruses for cell specific infection |
| CN117050178B (zh) * | 2023-10-13 | 2024-01-12 | 北京百普赛斯生物科技股份有限公司 | 特异性检测il-7的抗体及应用 |
| WO2025093541A1 (en) | 2023-10-31 | 2025-05-08 | Ose Immunotherapeutics | Combination of interleukin 7 and tumour associated antigen vaccine |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA887773B (en) | 1987-10-26 | 1989-07-26 | Immunex Corp | Interleukin-7 |
| US4965195A (en) | 1987-10-26 | 1990-10-23 | Immunex Corp. | Interleukin-7 |
| US5714585A (en) * | 1987-10-26 | 1998-02-03 | Sterling Winthrop, Inc. | Antibodies that are immunoreactive with interleukin-7 |
| US5328988A (en) * | 1987-10-26 | 1994-07-12 | Immunex Corporation | Interleukin-7 |
| US5153310A (en) * | 1989-02-28 | 1992-10-06 | Du Pont Merck Pharmaceutical Company | Il-2 analogs containing n-linked glycosylation sites |
| AU2001267337A1 (en) * | 2000-06-30 | 2002-01-14 | Maxygen Aps | Peptide extended glycosylated polypeptides |
| EP1391513A1 (en) * | 2002-08-08 | 2004-02-25 | Cytheris | IL-7 drug substance, IL-7 comprising composition, preparation and uses thereof |
-
2005
- 2005-07-20 EP EP05291556A patent/EP1746161A1/en not_active Withdrawn
-
2006
- 2006-07-19 EA EA200800368A patent/EA012802B1/ru not_active IP Right Cessation
- 2006-07-19 ES ES06795556T patent/ES2379732T3/es active Active
- 2006-07-19 PT PT06795556T patent/PT1904635E/pt unknown
- 2006-07-19 JP JP2008522097A patent/JP5685363B2/ja active Active
- 2006-07-19 CA CA2859145A patent/CA2859145C/en active Active
- 2006-07-19 NZ NZ564907A patent/NZ564907A/en not_active IP Right Cessation
- 2006-07-19 CN CN200680026503.XA patent/CN101228275B/zh not_active Expired - Fee Related
- 2006-07-19 CN CN201610038940.9A patent/CN105647939A/zh active Pending
- 2006-07-19 SI SI200631263T patent/SI1904635T1/sl unknown
- 2006-07-19 CA CA2615562A patent/CA2615562C/en active Active
- 2006-07-19 EP EP06795556A patent/EP1904635B1/en active Active
- 2006-07-19 WO PCT/IB2006/002663 patent/WO2007010401A2/en not_active Ceased
- 2006-07-19 PL PL06795556T patent/PL1904635T3/pl unknown
- 2006-07-19 AU AU2006271315A patent/AU2006271315B2/en active Active
- 2006-07-19 AT AT06795556T patent/ATE542901T1/de active
- 2006-07-19 DK DK06795556.7T patent/DK1904635T3/da active
- 2006-07-19 US US11/996,176 patent/US7708985B2/en active Active
-
2007
- 2007-12-27 IL IL188480A patent/IL188480A0/en active IP Right Grant
-
2008
- 2008-01-03 NO NO20080045A patent/NO344802B1/no not_active IP Right Cessation
- 2008-01-18 ZA ZA200800533A patent/ZA200800533B/xx unknown
-
2010
- 2010-02-24 US US12/711,675 patent/US8034327B2/en active Active
-
2011
- 2011-08-24 US US13/216,331 patent/US8153114B2/en active Active
-
2012
- 2012-02-16 CY CY20121100161T patent/CY1112655T1/el unknown
-
2014
- 2014-10-01 JP JP2014202828A patent/JP2015057392A/ja active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |