CY1110434T1 - Παραγωγα ν-πυρρολιδιν-3-υλ-αμιδιου ως αναστολεις επαναπροσληψεως σεροτονινης και νοραδρεναλινης - Google Patents
Παραγωγα ν-πυρρολιδιν-3-υλ-αμιδιου ως αναστολεις επαναπροσληψεως σεροτονινης και νοραδρεναλινηςInfo
- Publication number
- CY1110434T1 CY1110434T1 CY20081100869T CY081100869T CY1110434T1 CY 1110434 T1 CY1110434 T1 CY 1110434T1 CY 20081100869 T CY20081100869 T CY 20081100869T CY 081100869 T CY081100869 T CY 081100869T CY 1110434 T1 CY1110434 T1 CY 1110434T1
- Authority
- CY
- Cyprus
- Prior art keywords
- alkyl
- aryl
- alkoxy
- heterocyclic
- heterocyclo
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Reproductive Health (AREA)
- Psychology (AREA)
- Endocrinology (AREA)
- Addiction (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Rheumatology (AREA)
- Gynecology & Obstetrics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Μία ένωση του Τύπου (I) και φαρμακευτικά και/ή κτηνιατρικά αποδεκτά παράγωγα της, όπου το R1 είναι Η, C1-6αλκύλιο, -C(X)Y, C3-8κυκλοαλκύλιο, αρύλιο, ετεροκυκλική ομάδα, άρυλο-C1-4 αλκύλιο ή ετερόκυκλο-C1-4αλκύλιο, όπου οι κυκλο-αλκυλικές, αρυλικές ή ετεροκυκλικές ομάδες είναι προαιρετικά υποκατεστημένες με τουλάχιστον έναν υποκατάστατη που επιλέγεται ανεξάρτητα από τους C1-8αλκύλιο, C1-8αλκοξύλιο, ΟΗ, αλογονο-ομάδα, CF3, OCF3, SCF3, υδρόξυ-C1-6αλκύλιο, C1-4αλκόξυ-C1-6αλκύλιο και C1-4αλκύλιο-S-C1-4αλκύλιο. To R2 είναι αρύλιο ή ετεροαρύλιο το καθένα από τα οποία είναι προαιρετικά υποκατεστημένο με τουλάχιστον έναν υποκατάστατη που επιλέγεται ανεξάρτητα από τους C1-8αλκύλιο, C1-8αλκοξύλιο, ΟΗ, αλογονο-ομάδα, CF3, OCF3, SCF3, υδρόξυ-C1-6αλκύλιο, C1-4αλκόξυ-C1-6αλκύλιο και C1-4αλκύλιο-S-C1-4αλκύλιο. To R3 είναι C1-6αλκύλιο, C3-8κύκλοαλκύλιο, C3-8κύκλοαλκύλιο-C1-6αλκύλιο, αρύλιο, ετεροκυκλική ομάδα, άρυλο-C1-4αλκύλιο ή ετερόκυκλο-C1-4αλκύλιο, όπου οι κυκλοαλκυλικές, αρυλικές ή ετεροκυκλικές ομάδες είναι προαιρετικά υποκατεστημένες με τουλάχιστον έναν υποκατάστατη που επιλέγεται ανεξάρτητα από τους C1-6αλκύλιο, C1-6αλκοξύλιο, ΟΗ, αλογονο-ομάδα, CF3, OCF3, SCF3, υδρόξυ-C1-6αλκύλιο, C1-4αλκόξυ-C1-6αλκύλιο και C1-4αλκύλιο-S-C1-4αλκύλιο. To Χ είναι S ή Ο. Το Υ είναι Η, C1-6αλκύλιο, αρύλιο, ετεροκυκλική ομάδα, άρυλο-C1-4αλκύλιο ή ετερόκυκλο –C1-4αλκύλιο. Και το n είναι 1 ή 2, υπό την προϋπόθεση ότι όταν το n είναι 1, το m είναι 0 ή 1, και όταν το n είναι 2, το m είναι 0, όπου όταν το m είναι 0 τότε το * απεικονίζει ένα χειρόμορφο κέντρο. Οι ενώσεις της εφευρέσεως επιδεικνύουν δραστικότητα ως αναστολείς επαναπροσλήψεως τόσο της σεροτονίνης όσο και της νοραδρεναλίνης και επομένως έχουν χρησιμότητα σε μία ποικιλία θεραπευτικών πεδίων, όπως για παράδειγμα η ακράτεια ούρων.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0314048.0A GB0314048D0 (en) | 2003-06-17 | 2003-06-17 | Novel compounds |
| US49312603P | 2003-08-06 | 2003-08-06 | |
| EP04736241A EP1638933B1 (en) | 2003-06-17 | 2004-06-07 | N-pyrrolidin-3-yl-amide derivatives as serotonin and noradrenaline re-uptake inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1110434T1 true CY1110434T1 (el) | 2015-04-29 |
Family
ID=33554153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20081100869T CY1110434T1 (el) | 2003-06-17 | 2008-08-14 | Παραγωγα ν-πυρρολιδιν-3-υλ-αμιδιου ως αναστολεις επαναπροσληψεως σεροτονινης και νοραδρεναλινης |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US7378436B2 (el) |
| EP (1) | EP1638933B1 (el) |
| JP (1) | JP4137159B2 (el) |
| KR (1) | KR100803796B1 (el) |
| AP (1) | AP2005003467A0 (el) |
| AR (1) | AR044715A1 (el) |
| AT (1) | ATE398107T1 (el) |
| AU (1) | AU2004247487B2 (el) |
| BR (1) | BRPI0411594A (el) |
| CA (1) | CA2530159C (el) |
| CY (1) | CY1110434T1 (el) |
| DE (1) | DE602004014372D1 (el) |
| DK (1) | DK1638933T3 (el) |
| EA (1) | EA009881B1 (el) |
| EC (1) | ECSP056232A (el) |
| ES (1) | ES2305776T3 (el) |
| HR (2) | HRP20050993A2 (el) |
| IL (1) | IL172063A0 (el) |
| IS (1) | IS8136A (el) |
| MA (1) | MA27885A1 (el) |
| MX (1) | MXPA05013960A (el) |
| NL (1) | NL1026438C2 (el) |
| NZ (1) | NZ544046A (el) |
| PA (1) | PA8605301A1 (el) |
| PE (1) | PE20050631A1 (el) |
| PL (1) | PL1638933T3 (el) |
| PT (1) | PT1638933E (el) |
| SI (1) | SI1638933T1 (el) |
| TW (1) | TW200505852A (el) |
| UY (1) | UY28360A1 (el) |
| WO (1) | WO2004110995A1 (el) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8017627B2 (en) * | 2000-07-31 | 2011-09-13 | Nycomed Danmark Aps | Fentanyl composition for nasal administration |
| ES2305776T3 (es) * | 2003-06-17 | 2008-11-01 | Pfizer Inc. | Derivados de n-pirrolidin-3-il-amida como inhibidores de la re-captacion de serotonina y noradrenalina. |
| ATE452130T1 (de) | 2004-10-18 | 2010-01-15 | Lilly Co Eli | 1-(hetero)aryl-3-aminopyrrolidinderivate zur verwendung als antagonisten des mglur3-rezeptors |
| US7122683B2 (en) | 2004-11-23 | 2006-10-17 | Pfizer Inc. | Amides useful as monoamine re-uptake inhibitors |
| GB0425766D0 (en) * | 2004-11-23 | 2004-12-22 | Pfizer Ltd | Novel compounds |
| EP1828119A1 (en) * | 2004-12-14 | 2007-09-05 | Pfizer Limited | N-pyrrolidin-3-yl-amide derivatives as serotonin and noradrenalin re-uptake inhibitors |
| CA2590229A1 (en) * | 2004-12-14 | 2006-06-22 | Pfizer Limited | N-pyrrolidin-3-yl-amide derivatives as serotonin and noradrenalin re-uptake inhibitors |
| TWI439452B (zh) | 2005-05-13 | 2014-06-01 | Otsuka Pharma Co Ltd | 吡咯烷化合物（二） |
| PT1893603E (pt) | 2005-06-02 | 2009-11-24 | Hoffmann La Roche | Derivados de piperidin-4-il-amida e a sua utilização como antagonistas do receptor de sst do subtipo 5 |
| WO2007135530A2 (en) * | 2006-05-22 | 2007-11-29 | Pfizer Limited | Pharmaceutically & veterinarily suitable salt |
| US20080014152A1 (en) * | 2006-07-13 | 2008-01-17 | Di Mauro Thomas M | Intranasal delivery of clenbuterol across the cribriform plate and into the brain |
| JP5219465B2 (ja) * | 2006-11-10 | 2013-06-26 | 大塚製薬株式会社 | 医薬 |
| US20100056497A1 (en) * | 2007-01-31 | 2010-03-04 | Dainippon Sumitomo Pharma Co., Ltd | Amide derivative |
| JP2010189275A (ja) * | 2007-06-14 | 2010-09-02 | Dainippon Sumitomo Pharma Co Ltd | ナフタレン誘導体 |
| US8263652B2 (en) | 2007-10-31 | 2012-09-11 | Sk Biopharmaceuticals Co., Ltd. | Stabilized pediatric suspension of carisbamate |
| JP5484069B2 (ja) * | 2007-12-19 | 2014-05-07 | 大日本住友製薬株式会社 | 二環性へテロ環誘導体 |
| ES2434250T3 (es) | 2008-07-24 | 2013-12-16 | Theravance, Inc. | Compuestos de 3-(fenoxifenilmetil)pirrolidina |
| PL2358674T3 (pl) * | 2008-11-14 | 2013-06-28 | Theravance Inc | Sposób otrzymywania związków 4-[2-(2-fluorofenoksymetylo)fenylo]piperydyny |
| US20100267743A1 (en) * | 2009-04-15 | 2010-10-21 | Stangeland Eric L | 3-(phenoxypyrrolidin-3-yl-methyl)heteroaryl, 3-(phenylpyrrolidin-3-ylmethoxy)heteroaryl, and 3-(heteroarylpyrrolidin-3-ylmethoxy)heteroaryl compounds |
| TWI461422B (zh) | 2009-06-24 | 2014-11-21 | Sumitomo Dainippon Pharma Co Ltd | Ｎ－取代－環狀胺基衍生物 |
| CN102471258A (zh) | 2009-07-13 | 2012-05-23 | 施万制药 | 3-苯氧基甲基吡咯烷化合物 |
| ES2495366T3 (es) | 2009-07-21 | 2014-09-17 | Theravance, Inc. | Compuestos de 3-fenoximetilpirrolidina |
| US8778949B2 (en) | 2010-01-11 | 2014-07-15 | Theravance Biopharma R&D Ip, Llc | 1-(2-phenoxymethylphenyl)piperazine compounds |
| EP2550252B1 (en) * | 2010-03-22 | 2015-05-06 | Theravance Biopharma R&D IP, LLC | 1-(2-phenoxymethylheteroaryl)piperidine and piperazine compounds |
| ES2533434T3 (es) | 2010-10-11 | 2015-04-10 | Theravance Biopharma R&D Ip, Llc | Inhibidores de la captación de la serotonina |
| WO2012075239A1 (en) | 2010-12-03 | 2012-06-07 | Theravance, Inc. | Serotonin reuptake inhibitors |
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| DE138773C (el) | ||||
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| US4002757A (en) * | 1974-12-26 | 1977-01-11 | A. H. Robins Company, Incorporated | N-(1-substituted-3-pyrrolidinyl)-4-quinolinecarboxamides |
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| GB1574419A (en) * | 1977-11-11 | 1980-09-03 | Anphar Sa | Piperidine compounds |
| CH628885A5 (en) * | 1978-01-01 | 1982-03-31 | Anphar Sa | Piperidine derivative |
| US5130312A (en) * | 1987-07-17 | 1992-07-14 | Janssen Pharmaceutica N.V. | Substituted N-(3-hydroxy-4-piperidinyl)benzamides |
| FR2642069B1 (fr) * | 1989-01-20 | 1991-04-12 | Rhone Poulenc Sante | Nouveaux derives du benzopyranne, leur preparation et les compositions pharmaceutiques qui les contiennent |
| EP0862435A4 (en) | 1995-11-22 | 1999-02-03 | Merck & Co Inc | Inhibitors of farnesyl-protein transferase |
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| DE60237528D1 (de) | 2001-09-14 | 2010-10-14 | High Point Pharmaceuticals Llc | Neue aminoazetidin-, aminopyrrolidin- und aminopiperidinderivative |
| CA2468761A1 (en) | 2001-10-31 | 2003-05-08 | Morphochem Aktiengesellschaft Fuer Kombinatorische Chemie | Novel anticancer compounds |
| GB0128287D0 (en) | 2001-11-26 | 2002-01-16 | Smithkline Beecham Plc | Novel method and compounds |
| AU2003247615B2 (en) * | 2002-06-24 | 2007-08-09 | Acadia Pharmaceuticals Inc. | N-substituted piperidine derivatives as serotonin receptor agents |
| WO2004009549A2 (en) | 2002-07-18 | 2004-01-29 | Actelion Pharmaceuticals Ltd | Piperidines useful for the treatment of central nervous system disorders |
| WO2004022536A1 (en) | 2002-09-04 | 2004-03-18 | Glenmark Pharmaceuticals Limited | New heterocyclic amide compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them |
| ES2323528T3 (es) | 2002-12-20 | 2009-07-20 | Chemocentryx, Inc. | Inhibidores de la union de la quimiokina sdf-o i-tac al receptor ccxckr2. |
| ES2305776T3 (es) * | 2003-06-17 | 2008-11-01 | Pfizer Inc. | Derivados de n-pirrolidin-3-il-amida como inhibidores de la re-captacion de serotonina y noradrenalina. |
-
2004
- 2004-06-07 ES ES04736241T patent/ES2305776T3/es not_active Expired - Lifetime
- 2004-06-07 EA EA200501730A patent/EA009881B1/ru not_active IP Right Cessation
- 2004-06-07 AT AT04736241T patent/ATE398107T1/de not_active IP Right Cessation
- 2004-06-07 HR HR20050993A patent/HRP20050993A2/hr not_active Application Discontinuation
- 2004-06-07 JP JP2006516540A patent/JP4137159B2/ja not_active Expired - Fee Related
- 2004-06-07 PL PL04736241T patent/PL1638933T3/pl unknown
- 2004-06-07 HR HR20080339T patent/HRP20080339T3/xx unknown
- 2004-06-07 PT PT04736241T patent/PT1638933E/pt unknown
- 2004-06-07 KR KR1020057024147A patent/KR100803796B1/ko not_active Expired - Fee Related
- 2004-06-07 SI SI200430767T patent/SI1638933T1/sl unknown
- 2004-06-07 AP AP2005003467A patent/AP2005003467A0/xx unknown
- 2004-06-07 NZ NZ544046A patent/NZ544046A/en unknown
- 2004-06-07 MX MXPA05013960A patent/MXPA05013960A/es active IP Right Grant
- 2004-06-07 CA CA002530159A patent/CA2530159C/en not_active Expired - Fee Related
- 2004-06-07 EP EP04736241A patent/EP1638933B1/en not_active Expired - Lifetime
- 2004-06-07 BR BRPI0411594-5A patent/BRPI0411594A/pt not_active IP Right Cessation
- 2004-06-07 WO PCT/IB2004/001943 patent/WO2004110995A1/en not_active Ceased
- 2004-06-07 DE DE602004014372T patent/DE602004014372D1/de not_active Expired - Lifetime
- 2004-06-07 DK DK04736241T patent/DK1638933T3/da active
- 2004-06-07 AU AU2004247487A patent/AU2004247487B2/en not_active Expired - Fee Related
- 2004-06-14 UY UY28360A patent/UY28360A1/es not_active Application Discontinuation
- 2004-06-14 PE PE2004000590A patent/PE20050631A1/es not_active Application Discontinuation
- 2004-06-16 PA PA20048605301A patent/PA8605301A1/es unknown
- 2004-06-16 AR ARP040102082A patent/AR044715A1/es not_active Application Discontinuation
- 2004-06-16 TW TW093117317A patent/TW200505852A/zh unknown
- 2004-06-17 US US10/872,160 patent/US7378436B2/en not_active Expired - Fee Related
- 2004-06-17 NL NL1026438A patent/NL1026438C2/nl not_active IP Right Cessation
-
2005
- 2005-11-20 IL IL172063A patent/IL172063A0/en unknown
- 2005-11-21 IS IS8136A patent/IS8136A/is unknown
- 2005-12-16 EC EC2005006232A patent/ECSP056232A/es unknown
- 2005-12-16 MA MA28674A patent/MA27885A1/fr unknown
-
2008
- 2008-05-21 US US12/124,755 patent/US20080306123A1/en not_active Abandoned
- 2008-08-14 CY CY20081100869T patent/CY1110434T1/el unknown
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