[go: up one dir, main page]

CY1107274T1 - Παραγωγα αλφα-αμινοαμιδιου χρησιμα σαν παραγοντες κατα της ημικρανιας - Google Patents

Παραγωγα αλφα-αμινοαμιδιου χρησιμα σαν παραγοντες κατα της ημικρανιας

Info

Publication number
CY1107274T1
CY1107274T1 CY20081100099T CY081100099T CY1107274T1 CY 1107274 T1 CY1107274 T1 CY 1107274T1 CY 20081100099 T CY20081100099 T CY 20081100099T CY 081100099 T CY081100099 T CY 081100099T CY 1107274 T1 CY1107274 T1 CY 1107274T1
Authority
CY
Cyprus
Prior art keywords
alpha
derivatives useful
aminoamide derivatives
migraine agents
migraine
Prior art date
Application number
CY20081100099T
Other languages
English (en)
Inventor
Patricia Salvati
Marcello Calabresi
Luciano Dho
Orietta Veneroni
Piero Melloni
Original Assignee
Newron Pharmaceuticals S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Newron Pharmaceuticals S.P.A. filed Critical Newron Pharmaceuticals S.P.A.
Publication of CY1107274T1 publication Critical patent/CY1107274T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

Αποκαλύπτονται παράγωγα α-αμινοαμιδίου χρήσιμα σαν παράγοντες κατά της ημικρανίας, ιδιαιτέρως για τη θεραπεία καταστάσεων κεφαλαλγίας, όπως ημικρανίας, εντοπισμένης κεφαλαλγίας ή άλλης σοβαρής κεφαλαλγίας Οι παράγοντες κατά της ημικρανίας της εφεύρεσης είναι ικανοί να μειώσουν ή ακόμη και να σταματήσουν τον πόνο που προέρχεται από τέτοιες καταστάσεις χωρίς σχεδόν οποιεσδήποτε παρενέργειες.
CY20081100099T 2003-01-16 2008-01-28 Παραγωγα αλφα-αμινοαμιδιου χρησιμα σαν παραγοντες κατα της ημικρανιας CY1107274T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03000921A EP1438956A1 (en) 2003-01-16 2003-01-16 Alpha-aminoamide derivatives useful as antimigraine agents
EP03772344A EP1585510B1 (en) 2003-01-16 2003-11-18 Alpha-aminoamide derivatives useful as antimigraine agents

Publications (1)

Publication Number Publication Date
CY1107274T1 true CY1107274T1 (el) 2012-11-21

Family

ID=32524140

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081100099T CY1107274T1 (el) 2003-01-16 2008-01-28 Παραγωγα αλφα-αμινοαμιδιου χρησιμα σαν παραγοντες κατα της ημικρανιας

Country Status (20)

Country Link
US (2) US7709523B2 (el)
EP (2) EP1438956A1 (el)
JP (1) JP4885455B2 (el)
KR (1) KR101049694B1 (el)
CN (1) CN100418517C (el)
AT (1) ATE380026T1 (el)
AU (1) AU2003279399B8 (el)
BR (1) BRPI0317795B8 (el)
CA (1) CA2510514C (el)
CY (1) CY1107274T1 (el)
DE (1) DE60317935T2 (el)
DK (1) DK1585510T3 (el)
ES (1) ES2295658T3 (el)
MX (1) MXPA05007339A (el)
NO (1) NO333610B1 (el)
NZ (1) NZ541117A (el)
PT (1) PT1585510E (el)
RU (1) RU2336077C2 (el)
SI (1) SI1585510T1 (el)
WO (1) WO2004062655A1 (el)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9727523D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
IL160523A0 (en) 2001-09-03 2004-07-25 Newron Pharm Spa PHARMACEUTICAL COMPOSITION COMPRISING GABAPENTIN OR AN ANALOGUE THEREOF AND AN alpha-AMINOAMIDE AND ITS ANALGESIC USE
BRPI0413982A (pt) * 2003-08-25 2006-11-07 Newron Pharm Spa derivados de alfa-aminoamida úteis como agentes anti-inflamatórios
KR101277520B1 (ko) * 2004-09-10 2013-06-21 뉴론 파마슈티칼즈 에스. 피. 에이. （할로벤질옥시）벤질아미노－프로판아미드를 포함하는 선택적 나트륨 및／또는 칼슘 채널 조절제로서 유용한 약제학적 조성물
HRP20160005T1 (hr) 2005-12-22 2016-02-12 Newron Pharmaceuticals S.P.A. 2-feniletilamono derivati kao modulatori kalcijskih i/ili natrijskih kanala
JP5240476B2 (ja) 2006-06-19 2013-07-17 ニユーロン・フアーマシユーテイカルズ・エツセ・ピー・アー ２−［４−（３−及び２−フルオロベンジルオキシ）ベンジルアミノ］プロパンアミドの製造方法
FR2903985B1 (fr) 2006-07-24 2008-09-05 Sanofi Aventis Sa Derives de n-(amino-heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
RS56780B1 (sr) 2007-06-15 2018-04-30 Newron Pharm Spa Substituisani derivati 2-[2-(fenil) etilamino]alkanamida i njihova upotreba kao modulatora kanala za natrijum i/ili kalcijum
DK2229351T3 (en) 2007-12-11 2018-01-22 Newron Pharm Spa PROCEDURE FOR THE PREPARATION OF 2- [4- (3- OR 2-FLUORBENZYLOXY) BENZYLAMINO] PROPANAMIDS WITH HIGH PURITY
EP2314569A1 (en) 2009-10-22 2011-04-27 Merck Patent GmbH Novel polymorphic forms of (S)-2-[4-(3-Fluoro-benzyloxy)-benzylamino]-propionamide mesylate salt and processes of manufacturing thereof
SI2563355T1 (sl) 2010-04-27 2016-10-28 Newron Pharmaceuticals S.P.A. Postopek za izdelavo metansulfonatnih soli ralfinamida ali njihovih R-enantiomerov
KR101705718B1 (ko) * 2013-12-30 2017-02-14 이화여자대학교 산학협력단 신규한 아미드 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 포함하는 통증의 예방 또는 치료용 약학적 조성물
CN107522654B (zh) * 2016-06-21 2020-09-01 中国人民解放军军事医学科学院毒物药物研究所 新的α-氨基酰胺衍生物及其医药用途
CN112041296B (zh) * 2018-04-28 2023-12-29 上海璃道医药科技有限公司 包含苯并含氧脂肪环结构的氨基乙酰胺类化合物及其用途
CN112716927B (zh) * 2020-10-12 2022-10-14 复旦大学 α-氨基酰胺类化合物及其制备方法与应用

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3658967A (en) * 1966-06-23 1972-04-25 Ici Ltd Carboxylic acid derivatives for lowering the concentration of triglycerides in the blood
GB1140748A (en) * 1966-06-23 1969-01-22 Ici Ltd New carboxylic acid derivatives
CH480308A (de) * 1966-08-11 1969-10-31 Ciba Geigy Verfahren zur Herstellung von Thiosemicarbazid-Verbindungen
US4049663A (en) * 1972-06-06 1977-09-20 Allen & Hanburys Limited Ethylene diamine derivatives
US4311853A (en) * 1979-02-06 1982-01-19 The Radiochemical Centre Limited Selenium derivatives of thyroxine and tri-iodothyronine
DE3050800C2 (el) * 1979-03-22 1989-06-22 Continental Pharma Inc., Bruessel/Bruxelles, Be
US4267354A (en) * 1979-04-25 1981-05-12 E. R. Squibb & Sons, Inc. Substituted amides having antiinflammatory activity and intermediates
ZA805476B (en) 1979-09-26 1981-11-25 Robins Co Inc A H 2-amino-3-benzoyl-phenylacetamides and cyclic homologues
FR2480747A1 (fr) * 1980-04-17 1981-10-23 Roques Bernard Derives d'acides amines et leur application therapeutique
DE3483308D1 (de) * 1983-11-21 1990-10-31 Fujisawa Pharmaceutical Co Semicarbazid-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
US4839369A (en) * 1985-04-16 1989-06-13 Rorer Pharmaceutical Corporation Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4631287A (en) * 1985-04-16 1986-12-23 Usv Pharmaceutical Corp. Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4725619A (en) * 1985-04-16 1988-02-16 Usv Pharmaceutical Corporation Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
GB8714901D0 (en) * 1986-07-23 1987-07-29 Ici Plc Amide derivatives
GB2216515A (en) * 1988-03-04 1989-10-11 Nippon Shinyaku Co Ltd Acylphenol derivatives
IL94466A (en) * 1989-05-25 1995-01-24 Erba Carlo Spa Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
DE3928488A1 (de) 1989-08-29 1991-03-07 Standard Elektrik Lorenz Ag Interferometrisches messsystem
DE69224861T2 (de) 1991-07-30 1998-08-06 Korea Res Inst Chem Tech Neue Phenylacetamidderivate und Verfahren zu ihrer Herstellung
US5498610A (en) * 1992-11-06 1996-03-12 Pfizer Inc. Neuroprotective indolone and related derivatives
GB9306899D0 (en) * 1993-04-01 1993-05-26 Erba Carlo Spa Substituted (arylalkylaminobenzyl) aminopropionamide derivatives and process for their preparation
GB9306886D0 (en) 1993-04-01 1993-05-26 Erba Carlo Spa Substituted (arylakoxybenzyl) aminopropanamide derivatives and process for their preparation
US5475007A (en) * 1993-05-28 1995-12-12 The Regents Of The University Of California 1,2,3,4-tetrahydroquinoline-2,3,4-trione-3 or 4-oximes and the use thereof
US5482964A (en) * 1994-10-11 1996-01-09 Warner-Lambert Company Substituted phenoxyhydroxypropyl amines as central nervous system agents
US5541204A (en) * 1994-12-02 1996-07-30 Bristol-Myers Squibb Company Aryloxypropanolamine β 3 adrenergic agonists
KR0147963B1 (ko) * 1995-01-10 1998-08-17 강박광 엔-아릴알킬페닐아세트아미드 유도체와 그의 제조방법
US5849737A (en) * 1995-04-14 1998-12-15 The Regents Of The University Of California Compositions and methods for treating pain
US5741818A (en) * 1995-06-07 1998-04-21 University Of Saskatchewan Semicarbazones having CNS activity and pharmaceutical preparations containing same
GB9515411D0 (en) 1995-07-27 1995-09-27 Pharmacia Spa N-(4-substituted-benzyl)-2-aminolactam derivatives
GB9515412D0 (en) * 1995-07-27 1995-09-27 Pharmacia Spa 2-(4-substituted)-benzylamino-2-methyl-propanamide derivatives
US5688830A (en) * 1996-01-25 1997-11-18 Syntex (U.S.A.) Inc. Treatment of neuropathic pain
JP4160136B2 (ja) * 1996-08-29 2008-10-01 武田薬品工業株式会社 縮合環状エーテル類、その製造法および剤
TW492957B (en) 1996-11-07 2002-07-01 Novartis Ag N-substituted 2-cyanopyrrolidnes
GB9625795D0 (en) 1996-12-12 1997-01-29 Smithkline Beecham Plc Novel treatment
GB9706730D0 (en) 1997-04-03 1997-05-21 Pharmacia & Upjohn Spa 2-[(3-substituted)-5-Isoxazolymethylaminojalkanamid derivatives
BR9809288A (pt) 1997-04-22 2001-08-07 Cocensys Inc Semicarbazonas e tiosemicarbazonas substituìdas carbocìclicas e heterocìclicas e utilização das mesmas
MXPA00004919A (es) * 1997-11-21 2002-10-17 Euro Celtique Sa 2-aminoacetamidas sustituidas y uso de las mismas.
GB9727521D0 (en) * 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Substituted 2-benzylamino-2-phenyl-acetamide compounds
GB9727523D0 (en) * 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
MXPA00007585A (es) 1998-02-04 2002-10-17 Euro Celtique Sa Semicarbazidas substituidas y el uso de las mismas.
JP2000191533A (ja) * 1998-10-19 2000-07-11 Eisai Co Ltd 鎮痛剤
KR20010103583A (ko) * 1998-10-19 2001-11-23 다니구치 미즈오 진통제
US6281211B1 (en) * 1999-02-04 2001-08-28 Euro-Celtique S.A. Substituted semicarbazides and the use thereof
RU2001129155A (ru) * 1999-03-26 2003-08-10 Еро-Сельтик С.А. (Lu) Соединения с арильными заместителями (варианты), фармацевтическая композиция и способ лечения расстройства, чувствительного к блокаде натриевых каналов у млекопитающего, способ лечения, профилактики различных заболеваний или уменьшения интенсивности гибели или потери нейронов (варианты), способ облегчения или предупреждения эпилептических припадков у животного (варианты), соединение - радиоактивный лиганд для участка связывания в натриевом канале
DK1169060T3 (da) * 1999-04-09 2006-01-16 Euro Celtique Sa Natriumkanalblokkerpræparater og anvendelse deraf
IL160523A0 (en) * 2001-09-03 2004-07-25 Newron Pharm Spa PHARMACEUTICAL COMPOSITION COMPRISING GABAPENTIN OR AN ANALOGUE THEREOF AND AN alpha-AMINOAMIDE AND ITS ANALGESIC USE
AR044007A1 (es) * 2003-04-11 2005-08-24 Newron Pharmaceuticals Inc Metodos para el tratamiento de la enfermedad de parkinson
EP1588704A1 (en) * 2004-04-22 2005-10-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders
KR101277520B1 (ko) * 2004-09-10 2013-06-21 뉴론 파마슈티칼즈 에스. 피. 에이. （할로벤질옥시）벤질아미노－프로판아미드를 포함하는 선택적 나트륨 및／또는 칼슘 채널 조절제로서 유용한 약제학적 조성물

Also Published As

Publication number Publication date
SI1585510T1 (sl) 2008-04-30
ES2295658T3 (es) 2008-04-16
PT1585510E (pt) 2008-02-28
AU2003279399B8 (en) 2009-01-29
WO2004062655A1 (en) 2004-07-29
BR0317795A (pt) 2005-11-22
JP4885455B2 (ja) 2012-02-29
US7709523B2 (en) 2010-05-04
JP2006514060A (ja) 2006-04-27
ATE380026T1 (de) 2007-12-15
DE60317935D1 (de) 2008-01-17
AU2003279399B2 (en) 2008-11-27
EP1585510B1 (en) 2007-12-05
MXPA05007339A (es) 2005-09-30
KR20050094852A (ko) 2005-09-28
AU2003279399A1 (en) 2004-08-10
US20060079570A1 (en) 2006-04-13
KR101049694B1 (ko) 2011-07-19
EP1585510A1 (en) 2005-10-19
RU2336077C2 (ru) 2008-10-20
NO20053780D0 (no) 2005-08-09
BRPI0317795B1 (pt) 2019-04-02
BRPI0317795B8 (pt) 2021-05-25
CN100418517C (zh) 2008-09-17
NZ541117A (en) 2008-02-29
DE60317935T2 (de) 2008-11-27
RU2005125919A (ru) 2006-01-10
US20100267835A1 (en) 2010-10-21
CN1738611A (zh) 2006-02-22
CA2510514A1 (en) 2004-07-29
NO333610B1 (no) 2013-07-22
DK1585510T3 (da) 2008-02-25
NO20053780L (no) 2005-10-13
HK1086487A1 (zh) 2006-09-22
CA2510514C (en) 2011-07-26
EP1438956A1 (en) 2004-07-21

Similar Documents

Publication Publication Date Title
CY1107274T1 (el) Παραγωγα αλφα-αμινοαμιδιου χρησιμα σαν παραγοντες κατα της ημικρανιας
SE0202241D0 (sv) Novel Compounds
TW200510301A (en) Novel compounds
TW200510303A (en) Novel compounds
TW200407305A (en) Novel compounds
SE0303180D0 (sv) Novel compounds
NO20082136L (no) 1,5-substituerte indol-2-yl-amidderivater
EP1606286A4 (en) BENZODIAZEPINE SPIROHYDANTOINES AS CGRP RECEPTOR ANTAGONISTS
DE602004013563D1 (de) Rantagonisten
TNSN05045A1 (en) Indole or benzimidazole derivatives for modulating ikappab kinase
NO20082096L (no) Azaindol-2-karboksamidderivativer
ATE516803T1 (de) Aryl-spirohydantoin-cgrp-rezeptor-antagonisten
MX2008013196A (es) 5-amido-2-carboxiamida-indoles.
TW200736229A (en) Substituted 1H-benzimidazole-4-carboxamides are potent PARP inhibitors
ATE494890T1 (de) Alpha-aminoamid-derivate zur behandlung von suchtstörungen
NO20082214L (no) 1,1-Diokso-tiomorfolinyl-indolyl-metanonderivater for anvendelse som H3-modulatorer
EA200801734A1 (ru) Производные n-тиазол-2-илбензамида
DE602006010738D1 (de) Pyrroloä2,3-cüpyridinderivate
ATE467632T1 (de) Pyrroloä2,3-büpyridinderivate als modulatoren des h3-rezeptors
IL173886A0 (en) Alpha-aminoamide derivatives useful as anti-inflammatory agents
DE602005014632D1 (de) Pyrrol- bzw. imidazolamide zur behandlung von obesitas
EA200602081A1 (ru) Пиридиновые производные алкилоксиндолов в качестве агентов, активных в отношении рецептора 5-нт7
ATE289510T1 (de) Sulfonylpyridazinone derivate zur behandlung von ischämischem gewebeschaden
ATE479691T1 (de) 4,5,6,7-tetrahydrothienoä2,3-cüpyridine als h3- modulatoren
ATE502947T1 (de) 4,5,6,7-tetrahydrothienoä3,2-cüpyridinderivate als h3-modulatoren