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CU20130107A7 - IMIDAZO[5,1-f][1,2,4] TRIAZINAS PARA EL TRATAMIENTO DE TRASTORNOS NEUROLÓGICOS - Google Patents

IMIDAZO[5,1-f][1,2,4] TRIAZINAS PARA EL TRATAMIENTO DE TRASTORNOS NEUROLÓGICOS

Info

Publication number
CU20130107A7
CU20130107A7 CU2013000107A CU20130107A CU20130107A7 CU 20130107 A7 CU20130107 A7 CU 20130107A7 CU 2013000107 A CU2013000107 A CU 2013000107A CU 20130107 A CU20130107 A CU 20130107A CU 20130107 A7 CU20130107 A7 CU 20130107A7
Authority
CU
Cuba
Prior art keywords
treatment
triazins
imidazo
neurological disorders
compounds
Prior art date
Application number
CU2013000107A
Other languages
English (en)
Inventor
Thomas Allen Chappie
John Michael Humphrey
Patrick Robert Verhoest
Eddie Yang
Christopher John Helal
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45755439&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU20130107(A7) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of CU20130107A7 publication Critical patent/CU20130107A7/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a compuestos de Fórmula y a sales de los mismos farmacéuticamente aceptables, a procedimientos para la preparación de, a intermedios usados en la preparación de, y composiciones que contienen dichos compuestos y a los usos de dichos compuestos como un porcedimiento para el tratamiento, de una enfermedad o afección seleccionada del grupo que consiste en trastornos del sistema nervioso central, trastornos cognitivos, esquizofrenia, demencia y otros trastornos, en un mamífero.
CU2013000107A 2011-02-23 2013-07-30 IMIDAZO[5,1-f][1,2,4] TRIAZINAS PARA EL TRATAMIENTO DE TRASTORNOS NEUROLÓGICOS CU20130107A7 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161445617P 2011-02-23 2011-02-23
PCT/IB2012/050589 WO2012114222A1 (en) 2011-02-23 2012-02-09 IMIDAZO[5,1-f][1,2,4]TRIAZINES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS

Publications (1)

Publication Number Publication Date
CU20130107A7 true CU20130107A7 (es) 2013-09-27

Family

ID=45755439

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2013000107A CU20130107A7 (es) 2011-02-23 2013-07-30 IMIDAZO[5,1-f][1,2,4] TRIAZINAS PARA EL TRATAMIENTO DE TRASTORNOS NEUROLÓGICOS

Country Status (31)

Country Link
US (2) US8598155B2 (es)
EP (1) EP2681218A1 (es)
JP (1) JP5543039B2 (es)
KR (1) KR101548443B1 (es)
CN (1) CN103391941A (es)
AP (1) AP2013007070A0 (es)
AR (1) AR085304A1 (es)
AU (1) AU2012221828C1 (es)
BR (1) BR112013021366A2 (es)
CA (1) CA2825699A1 (es)
CL (1) CL2013002125A1 (es)
CO (1) CO6751271A2 (es)
CR (1) CR20130371A (es)
CU (1) CU20130107A7 (es)
DO (1) DOP2013000194A (es)
EA (1) EA022586B1 (es)
EC (1) ECSP13012892A (es)
GT (1) GT201300206A (es)
IL (1) IL227716A0 (es)
MA (1) MA34922B1 (es)
MX (1) MX2013009684A (es)
NI (1) NI201300071A (es)
PE (1) PE20140236A1 (es)
PH (1) PH12013501556A1 (es)
SG (1) SG192576A1 (es)
TN (1) TN2013000349A1 (es)
TW (1) TWI469983B (es)
UA (1) UA106692C2 (es)
UY (1) UY33916A (es)
WO (1) WO2012114222A1 (es)
ZA (1) ZA201306348B (es)

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JP6626449B2 (ja) * 2014-04-23 2019-12-25 ダート・ニューロサイエンス・（ケイマン）・リミテッド ＰＤＥ２阻害剤としての置換［１，２，４］トリアゾロ［１，５−ａ］ピリミジン−７−イル化合物
TWI568737B (zh) 2014-11-05 2017-02-01 達特神經科學（開曼）有限責任公司 作為ｐｄｅ２抑制劑之經取代的５－甲基－［１，２，４］三唑并［１，５－ａ］嘧啶－２－胺化合物
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HK1243935A1 (zh) 2014-12-06 2018-07-27 Intra-Cellular Therapies, Inc. 有机化合物
CN104525240A (zh) * 2014-12-10 2015-04-22 河北工业大学 硝酸铁作为催化剂在苯与羟胺盐反应一步法制苯胺反应中的应用方法
WO2016103097A1 (en) 2014-12-22 2016-06-30 Pfizer Inc. Antagonists of prostaglandin ep3 receptor
TWI713497B (zh) * 2015-02-26 2020-12-21 南韓商愛思開生物製藥股份有限公司 咪唑并嘧啶及咪唑并三衍生物及包含該衍生物之醫藥組成物
WO2016145614A1 (en) 2015-03-17 2016-09-22 Merck Sharp & Dohme Corp. Triazolyl pyrimidinone compounds as pde2 inhibitors
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WO2016179059A1 (en) 2015-05-05 2016-11-10 Merck Sharp & Dohme Corp. Heteroaryl-pyrimidinone compounds as pde2 inhibitors
WO2016183741A1 (en) 2015-05-15 2016-11-24 Merck Sharp & Dohme Corp. Pyrimidinone amide compounds as pde2 inhibitors
WO2016191935A1 (en) 2015-05-29 2016-12-08 Merck Sharp & Dohme Corp. 6-alkyl dihydropyrazolopyrimidinone compounds as pde2 inhibitors
WO2016192083A1 (en) 2015-06-04 2016-12-08 Merck Sharp & Dohme Corp. Dihydropyrazolopyrimidinone compounds as pde2 inhibitors
EP3313852B1 (en) 2015-06-25 2021-01-20 Merck Sharp & Dohme Corp. Substituted pyrazolo/imidazolo bicyclic compounds as pde2 inhibitors
WO2017004134A1 (en) * 2015-06-29 2017-01-05 Nimbus Iris, Inc. Irak inhibitors and uses thereof
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HK1256751A1 (zh) 2015-11-02 2019-10-04 Janssen Pharmaceutica Nv [1，2，4]三唑并[1，5-a]嘧啶-7-基化合物
CN105669680B (zh) * 2016-03-24 2018-02-23 南京药捷安康生物科技有限公司 吡咯并[2,1‑f][1,2,4]三嗪‑4(1H)‑酮衍生物类PDE9A抑制剂
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Also Published As

Publication number Publication date
EA201390971A1 (ru) 2014-02-28
KR20130132612A (ko) 2013-12-04
NZ613373A (en) 2015-04-24
ZA201306348B (en) 2014-04-30
DOP2013000194A (es) 2014-01-31
WO2012114222A1 (en) 2012-08-30
TWI469983B (zh) 2015-01-21
CL2013002125A1 (es) 2013-12-20
NI201300071A (es) 2014-02-12
PH12013501556A1 (en) 2017-10-25
TW201247673A (en) 2012-12-01
MA34922B1 (fr) 2014-02-01
TN2013000349A1 (fr) 2015-01-20
MX2013009684A (es) 2013-10-28
EP2681218A1 (en) 2014-01-08
SG192576A1 (en) 2013-09-30
US20140066622A1 (en) 2014-03-06
AP2013007070A0 (en) 2013-08-31
US20120214791A1 (en) 2012-08-23
KR101548443B1 (ko) 2015-08-28
CA2825699A1 (en) 2012-08-30
CN103391941A (zh) 2013-11-13
JP2014506589A (ja) 2014-03-17
EA022586B1 (ru) 2016-01-29
CR20130371A (es) 2013-09-18
ECSP13012892A (es) 2013-10-31
GT201300206A (es) 2015-02-19
CO6751271A2 (es) 2013-09-16
UA106692C2 (uk) 2014-09-25
AR085304A1 (es) 2013-09-18
JP5543039B2 (ja) 2014-07-09
IL227716A0 (en) 2013-09-30
AU2012221828B2 (en) 2015-05-28
US8598155B2 (en) 2013-12-03
AU2012221828C1 (en) 2015-10-01
UY33916A (es) 2012-09-28
US9200000B2 (en) 2015-12-01
PE20140236A1 (es) 2014-03-14
BR112013021366A2 (pt) 2016-09-13

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