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CO5700719A2 - Derivados de alcanos azaespiro como inhibidores de las metaloproteasas - Google Patents

Derivados de alcanos azaespiro como inhibidores de las metaloproteasas

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Publication number
CO5700719A2
CO5700719A2 CO05106414A CO05106414A CO5700719A2 CO 5700719 A2 CO5700719 A2 CO 5700719A2 CO 05106414 A CO05106414 A CO 05106414A CO 05106414 A CO05106414 A CO 05106414A CO 5700719 A2 CO5700719 A2 CO 5700719A2
Authority
CO
Colombia
Prior art keywords
crdrf
nrbc
nrb
nrbs
substituted
Prior art date
Application number
CO05106414A
Other languages
English (en)
Inventor
Yao Wenqing
Zhuo Jincong
Xu Meizhong
Zhang Fenglei
Metcalf Brian
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of CO5700719A2 publication Critical patent/CO5700719A2/es

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • C—CHEMISTRY; METALLURGY
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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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Abstract

1.- Un compuesto de Fórmula I o II: o un enantiómero, diaestereoisómero, prodroga, solvato, metabolito o sal farmacéuticamente aceptable del mismo, donde:A es CWOH, CWNHOH, CWNHOR5, N(OH)CHO, N(OH)CWR6, SH, SR7 o hidantoinilo;B es (CH2)n, (CH2)nC=W, (CRdRf)nNR8, NR8(CRdRf)n, (CRdRf)nO(CRdRf)r, (CRdRf)nS(CRdRf)r, O(C=W)NR8, O, N, NR8, S(O)m, S, C(O)NR8(CRdRf)n, C(O)(CRdRf)n o combinaciones de los mismos;G es (CH2)n, (CH2)nC=W, (CRdRf)nNR8, NR8(CRdRf)n, (CRdRf)nO(CRdRf)r, (CRdRf)nS(CRdRf)r, O(C=W)NR8, O, N, NR8, S(O)m, S, C(O)NR8(CRdRf)n, C(O)(CRdRf)n, o combinaciones de los mismos;D es oxígeno o azufre;X está ausente o es (CH2)j, alquileno C1-10 sustituido con 0 a 3 Ra, alquenileno C2-10 sustituido con 0 a 2 Ra, N, O, NRb, S(O)m, C=O, NRbC(O), NRbC(O)O, NRbC(O)NRb, C(O)O, OC(O), S(O)mNRb, NRbS(O)m, NRbS(O)mNRb, (CRdRf)jNRb, NRb(CRdRf)j o combinaciones de los mismos;Y está ausente o es (CH2)j, alquileno C1-10 sustituido con 0 a 3 Ra, alquenileno C2-10 sustituido, con 0 a 2 Ra, N, O, NRb, S(O)m, C=O, NRbC(O), NRbC(O)O, NRbC(O)NRb, C(O)O, OC(O), S(O)mNRb, NRbS(O)m, NRbS(O)mNRb, (CRdRf)jNRb, NRb(CRdRf)j o combinaciones de los mismos;M es CO o S(O)¡;U está ausente o es alquileno C1-10 sustituido con 0 a 5 Ra, alquenileno C2-10 sustituido con 0 a 2 Ra, N, O, NRb, NRbC(O), NRbC(O)O, NRbC(O)NRb, NRbS(O)m, NRbS(O)NRb o combinaciones de los mismos;V está ausente o es H, carbociclilo C3-13 sustituido con 0-5 Re o heterociclilo sustituido con 0-5 Re;U&#39 está ausente o es alquileno C1-10 sustituido con 0 a 5 Ra, alquenileno C2-10 sustituido con 0 a 2 Ra, N, O, NRbS(O)m, C=O, NRbC(O), NRbC(O)O, NRbC(O)NRb, C(O)O, OC(O), S(O)mNRb, NRbS(O)m, NRbS(O)NRb o combinaciones de los mismos; ...
CO05106414A 2003-04-24 2005-10-19 Derivados de alcanos azaespiro como inhibidores de las metaloproteasas CO5700719A2 (es)

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