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CO5680494A2 - Interferencia de arn doble que tiene extremos romos y modificaciones 3 - Google Patents

Interferencia de arn doble que tiene extremos romos y modificaciones 3

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Publication number
CO5680494A2
CO5680494A2 CO06027688A CO06027688A CO5680494A2 CO 5680494 A2 CO5680494 A2 CO 5680494A2 CO 06027688 A CO06027688 A CO 06027688A CO 06027688 A CO06027688 A CO 06027688A CO 5680494 A2 CO5680494 A2 CO 5680494A2
Authority
CO
Colombia
Prior art keywords
aryl
alkyl
rna interference
romes
extreme
Prior art date
Application number
CO06027688A
Other languages
English (en)
Inventor
Jan Weiler
Jonathan Hall
Jean Charles Bologna
Francois Jean-Charles Natt
Robert Haner
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CO5680494A2 publication Critical patent/CO5680494A2/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/311—Phosphotriesters
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/33—Chemical structure of the base
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    • C12N2320/00—Applications; Uses
    • C12N2320/50—Methods for regulating/modulating their activity
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    • C12N2330/00—Production
    • C12N2330/30—Production chemically synthesised

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • Organic Chemistry (AREA)
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  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
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  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
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  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1.- ARN de estructura de cadena doble con por lo menos un extremo romo que comprende por lo menos un extremo 3AND#39 de la fórmula: en donde X es O o S R1 y R2 son independientemente OH, NH2, SH, alquilo, arilo, alquilarilo, aril-alquilo, en donde el alquilo, arilo, alquil-arilo, aril-alquilo pueden estar substituidos por átomos heterogéneos adicionales y grupos funcionales, preferiblemente un átomo heterogéneo seleccionado del grupo que consiste de N, O, o S o un grupo funcional seleccionado del grupo OH, NH2, SH, ácido o éster carboxílico;o, R1 y R2 pueden ser de la fórmula Y-Z en donde Y es O, N, S y Z es H, alquilo, arilo, alquil-arilo, aril- alquilo, en donde eI alquilo, arilo, alquilariIo, aril-aIquiIo pueden estar substituidos por átomos heterogéneos adicionales, preferiblemente un átomo heterogéneo seleccionado del grupo de N, O, o S;y en donde dicho ARN de estructura de cadena doble media la interferencia de ARN.
CO06027688A 2003-08-28 2006-03-21 Interferencia de arn doble que tiene extremos romos y modificaciones 3 CO5680494A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49851403P 2003-08-28 2003-08-28

Publications (1)

Publication Number Publication Date
CO5680494A2 true CO5680494A2 (es) 2006-09-29

Family

ID=34272687

Family Applications (1)

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CO06027688A CO5680494A2 (es) 2003-08-28 2006-03-21 Interferencia de arn doble que tiene extremos romos y modificaciones 3

Country Status (21)

Country Link
US (2) US20070203084A1 (es)
EP (3) EP2338995A3 (es)
JP (2) JP2007503803A (es)
KR (3) KR101059315B1 (es)
CN (2) CN1845993B (es)
AU (1) AU2004269150C1 (es)
BR (1) BRPI0413146A (es)
CA (1) CA2536333C (es)
CO (1) CO5680494A2 (es)
EC (1) ECSP066388A (es)
IL (1) IL173565A (es)
IS (1) IS8358A (es)
MA (1) MA28029A1 (es)
MX (1) MXPA06002216A (es)
NO (1) NO20061345L (es)
NZ (1) NZ545360A (es)
RU (2) RU2399671C2 (es)
SG (1) SG152279A1 (es)
TN (1) TNSN06065A1 (es)
WO (1) WO2005021749A1 (es)
ZA (1) ZA200601003B (es)

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AU2004269150A1 (en) 2005-03-10
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MXPA06002216A (es) 2006-04-27
KR20060087531A (ko) 2006-08-02
SG152279A1 (en) 2009-05-29
US20070203084A1 (en) 2007-08-30
ECSP066388A (es) 2006-08-30
EP1660657A1 (en) 2006-05-31
JP2011160796A (ja) 2011-08-25
KR20080034046A (ko) 2008-04-17
IL173565A (en) 2012-07-31
WO2005021749A1 (en) 2005-03-10
CN101914533A (zh) 2010-12-15
KR20110007263A (ko) 2011-01-21
RU2399671C2 (ru) 2010-09-20
CN1845993A (zh) 2006-10-11
TNSN06065A1 (en) 2007-10-03
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CA2536333C (en) 2013-01-08
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AU2004269150C1 (en) 2010-11-18
US20090192113A1 (en) 2009-07-30
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