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NO20061345L - Interfererende RNA-duplekser med butte ender og 3'-modifiseringer - Google Patents

Interfererende RNA-duplekser med butte ender og 3'-modifiseringer

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Publication number
NO20061345L
NO20061345L NO20061345A NO20061345A NO20061345L NO 20061345 L NO20061345 L NO 20061345L NO 20061345 A NO20061345 A NO 20061345A NO 20061345 A NO20061345 A NO 20061345A NO 20061345 L NO20061345 L NO 20061345L
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Norway
Prior art keywords
aryl
alkyl
group
modifications
formula
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NO20061345A
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English (en)
Inventor
Jonathan Hall
Jean-Charles Bologna
Francois Jean-Charles Natt
Robert Haner
Jan Weiler
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Novartis Ag
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Publication of NO20061345L publication Critical patent/NO20061345L/no

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    • C12N2310/00—Structure or type of the nucleic acid
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Abstract

Oppfinnelsen angår dobbelttrådede RNA-forbindelser med minst en butt ende omfattende minst en Y-ende med formelen (I): der X er lik O eller S, R, og R2 er uavhengig OH, NH2, SH, alkyl, aryl, alkyl-aryl, aryl-alkyl, der alkyl, aryl, alkyl-aryl, aryl-alkyl kan være substituert med ytterligere heteroatomer og fimksjonelle grupper, fortrinnsvis et heteroatom utvalgt fra gruppen N, 0 eller S, eller en fimksjonell gruppe utvalgt fra gruppen OH, NH2, SH, karboksylsyre eller ester; eller R, og R2 kan ha formelen Y-Z der Y er O, N, S og Z er H, alkyl, aryl, alkyl-aryl, aryl-alkyl, der alkyl, aryl, alkyl-aryl, aryl-alkyl kan være substituert med ytterligere heteroatomer, fortrinnsvis et heteroatom utvalgt fra gruppen N, 0 eller S; og der nevnte dobbelttrådede RNA medierer RNA-interferens. Foretrukne Y-endemodifiseringer, fosfat, fosfortioat, abasisk ribonukleosid, hydroksyfopyl fosfodiester. Formel I: R1 ¦ 3`O-P-R2 ¦ X
NO20061345A 2003-08-28 2006-03-24 Interfererende RNA-duplekser med butte ender og 3'-modifiseringer NO20061345L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49851403P 2003-08-28 2003-08-28
PCT/EP2004/009599 WO2005021749A1 (en) 2003-08-28 2004-08-27 Interfering rna duplex having blunt-ends and 3’-modifications

Publications (1)

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NO20061345L true NO20061345L (no) 2006-05-29

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Country Status (21)

Country Link
US (2) US20070203084A1 (no)
EP (3) EP2489737A1 (no)
JP (2) JP2007503803A (no)
KR (3) KR20060087531A (no)
CN (2) CN101914533B (no)
AU (1) AU2004269150C1 (no)
BR (1) BRPI0413146A (no)
CA (1) CA2536333C (no)
CO (1) CO5680494A2 (no)
EC (1) ECSP066388A (no)
IL (1) IL173565A (no)
IS (1) IS8358A (no)
MA (1) MA28029A1 (no)
MX (1) MXPA06002216A (no)
NO (1) NO20061345L (no)
NZ (1) NZ545360A (no)
RU (2) RU2399671C2 (no)
SG (1) SG152279A1 (no)
TN (1) TNSN06065A1 (no)
WO (1) WO2005021749A1 (no)
ZA (1) ZA200601003B (no)

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