CN1195531A - Drug for curing diabetes and its preparing method - Google Patents
Drug for curing diabetes and its preparing method Download PDFInfo
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- CN1195531A CN1195531A CN97103536A CN97103536A CN1195531A CN 1195531 A CN1195531 A CN 1195531A CN 97103536 A CN97103536 A CN 97103536A CN 97103536 A CN97103536 A CN 97103536A CN 1195531 A CN1195531 A CN 1195531A
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- gliquidone
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- glycosuria
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- 239000003814 drug Substances 0.000 title claims abstract description 28
- 206010012601 diabetes mellitus Diseases 0.000 title claims abstract description 13
- 229940079593 drug Drugs 0.000 title claims abstract description 10
- 238000000034 method Methods 0.000 title claims description 4
- 150000001875 compounds Chemical class 0.000 claims abstract description 15
- 238000002360 preparation method Methods 0.000 claims abstract description 9
- LLJFMFZYVVLQKT-UHFFFAOYSA-N 1-cyclohexyl-3-[4-[2-(7-methoxy-4,4-dimethyl-1,3-dioxo-2-isoquinolinyl)ethyl]phenyl]sulfonylurea Chemical compound C=1C(OC)=CC=C(C(C2=O)(C)C)C=1C(=O)N2CCC(C=C1)=CC=C1S(=O)(=O)NC(=O)NC1CCCCC1 LLJFMFZYVVLQKT-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229960003468 gliquidone Drugs 0.000 claims abstract description 8
- 241000222640 Polyporus Species 0.000 claims abstract description 5
- 235000007164 Oryza sativa Nutrition 0.000 claims description 10
- 235000013339 cereals Nutrition 0.000 claims description 9
- 206010018473 Glycosuria Diseases 0.000 claims description 8
- 240000007594 Oryza sativa Species 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 8
- 241000208340 Araliaceae Species 0.000 claims description 7
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 7
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 7
- 239000002775 capsule Substances 0.000 claims description 7
- 235000008434 ginseng Nutrition 0.000 claims description 7
- 229960003105 metformin Drugs 0.000 claims description 7
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims description 7
- 241000903946 Clematidis Species 0.000 claims description 6
- 229940104771 gliquidone 30 mg Drugs 0.000 claims description 6
- 229940093462 metformin hydrochloride 250 mg Drugs 0.000 claims description 6
- 235000021419 vinegar Nutrition 0.000 claims description 6
- 239000000052 vinegar Substances 0.000 claims description 6
- 240000000920 Typhonium flagelliforme Species 0.000 claims description 5
- 235000009566 rice Nutrition 0.000 claims description 4
- 238000009313 farming Methods 0.000 claims description 2
- 239000000796 flavoring agent Substances 0.000 claims description 2
- 235000019634 flavors Nutrition 0.000 claims description 2
- 239000010903 husk Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 238000012856 packing Methods 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 230000029058 respiratory gaseous exchange Effects 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- 241000209094 Oryza Species 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 17
- 230000001225 therapeutic effect Effects 0.000 abstract description 5
- 230000007774 longterm Effects 0.000 abstract description 4
- 239000000463 material Substances 0.000 abstract description 2
- 241000748223 Alisma Species 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 241000972673 Phellodendron amurense Species 0.000 abstract 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 description 16
- 239000008280 blood Substances 0.000 description 16
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 12
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 8
- 239000008103 glucose Substances 0.000 description 8
- 230000003907 kidney function Effects 0.000 description 8
- 102000004877 Insulin Human genes 0.000 description 6
- 108090001061 Insulin Proteins 0.000 description 6
- 230000003203 everyday effect Effects 0.000 description 6
- 230000006870 function Effects 0.000 description 6
- 229940125396 insulin Drugs 0.000 description 6
- 238000002347 injection Methods 0.000 description 5
- 239000007924 injection Substances 0.000 description 5
- 230000003908 liver function Effects 0.000 description 5
- 210000003734 kidney Anatomy 0.000 description 3
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 3
- BOVGTQGAOIONJV-BETUJISGSA-N 1-[(3ar,6as)-3,3a,4,5,6,6a-hexahydro-1h-cyclopenta[c]pyrrol-2-yl]-3-(4-methylphenyl)sulfonylurea Chemical compound C1=CC(C)=CC=C1S(=O)(=O)NC(=O)NN1C[C@H]2CCC[C@H]2C1 BOVGTQGAOIONJV-BETUJISGSA-N 0.000 description 2
- 229960004580 glibenclamide Drugs 0.000 description 2
- ZNNLBTZKUZBEKO-UHFFFAOYSA-N glyburide Chemical compound COC1=CC=C(Cl)C=C1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCCCC2)C=C1 ZNNLBTZKUZBEKO-UHFFFAOYSA-N 0.000 description 2
- 230000002218 hypoglycaemic effect Effects 0.000 description 2
- ICFJFFQQTFMIBG-UHFFFAOYSA-N phenformin Chemical compound NC(=N)NC(=N)NCCC1=CC=CC=C1 ICFJFFQQTFMIBG-UHFFFAOYSA-N 0.000 description 2
- 229960003243 phenformin Drugs 0.000 description 2
- 210000000582 semen Anatomy 0.000 description 2
- 229940123208 Biguanide Drugs 0.000 description 1
- 240000002791 Brassica napus Species 0.000 description 1
- 235000011293 Brassica napus Nutrition 0.000 description 1
- 235000000540 Brassica rapa subsp rapa Nutrition 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 208000013016 Hypoglycemia Diseases 0.000 description 1
- 206010023379 Ketoacidosis Diseases 0.000 description 1
- 208000007976 Ketosis Diseases 0.000 description 1
- 208000035286 Spontaneous Remission Diseases 0.000 description 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 150000004283 biguanides Chemical class 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 210000004211 gastric acid Anatomy 0.000 description 1
- 150000002333 glycines Chemical class 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 210000003677 hemocyte Anatomy 0.000 description 1
- 229940000351 hemocyte Drugs 0.000 description 1
- 230000010224 hepatic metabolism Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 210000004153 islets of langerhan Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a series of drugs for curing diabetes and its preparation method. It is characterized by that it uses several Chinese medicinal materials, such as polyporus, alisma tuber and phellodendron bark, etc. and adds dimethyl biguanidium hydrochloride and gliquidone to form the invented series drugs for curing diabetes, including compound tangniao No.1.A, compound tangniao No.1.B and compound tangniao No.1.C. Said invented drugs possess strong therapeutic action, curative effect is stable, and has a little side effect, can be taken in for a long term.
Description
The invention belongs to medicinal preparation.Be to contain the medicinal preparation that raw material is mainly derived from the material of plant.
The treatment diabetes use for a long time medicine that sulphanylureas (suitable flat, the Gliguidone of D860, glyburide, diamicron, Mei Bida, Tang etc.) and biguanides medicines such as (phenformin, metformin etc.) are arranged.These medicines are the strongest with the effect of glyburide, phenformin, but side effect is also more obvious, as to the human liver renal damage.Because these medicines are at liver metabolism, through renal excretion mostly, so hepatic and kidney function obstacle, the ketoacidosis person uses and is restricted.Though the side effect of diamicron, gliquidone, Gliguidone etc. is lighter, its blood sugar reducing function again a little less than, clinical Chang Buneng is blood sugar control satisfactorily, causes the morbidity risk rate of patient's complication to increase.Insulin is the specific medicament of treatment diabetes, no matter be I type or type ii diabetes, except that the insulin resistant phenomenon occurring, its hypoglycemic effect is all fabulous, but because it is inactivated in gastric acid, so can only be made into injection when using, three times on the one insulin injection makes patient often be difficult to stand the misery of adhering to long term injections.The someone uses the islets of langerhans rifle in the recent period, i.e. fast injection method, though can alleviate patient some miseries, but will inject, also be afraid of unclean infection. everydayFor the therapeutical effect that solves diabetes medicament and the contradiction of side effect, many diabetes scholars have done number of research projects, have invented the compound recipe of some treatment diabetes.Pure Chinese medicine preparation is arranged, as applicator etc.; The Chinese medicine and western medicine compound recipe is also arranged, as sugared prestige capsule etc.Though these medicines have reduced the side effect of diabetes medicament to a certain extent, its therapeutic effect is also good inadequately.
The object of the present invention is to provide a kind of therapeutical effect take by force, for many years effect stability, side effect minimum, can grow its treatment diabetes medicine series that continues to take and preparation method thereof.
The present invention realizes with following mode: it is characterized in that pharmaceutical formulation is as follows:
Compound recipe glycosuria I A prescription:
Rhizoma Imperatae 80g Radix Clematidis 60g Cortex Phellodendri 30g Rhizoma Anemarrhenae 30g
Radix Ginseng 50g Oryza sativa L. var. glutinosa Matsum. bud point 20g metformin hydrochloride 250mg * 200
Gliquidone 30mg * 100 slice;
Compound recipe glycosuria I B prescription:
Rhizoma Imperatae 80g Typhonium flagelliforme (Lodd.) Blume 60g Cortex Phellodendri 30g Rhizoma Anemarrhenae 30g
Radix Ginseng 50g Oryza sativa L. var. glutinosa Matsum. bud point 20g metformin hydrochloride 250mg * 180
Gliquidone 30mg * 100 slice;
Compound recipe glycosuria I C prescription:
Rhizoma Imperatae 80g Typhonium flagelliforme (Lodd.) Blume 30g Cortex Phellodendri 30g Rhizoma Alismatis 30g
Polyporus 30g Radix Ginseng 50g Oryza sativa L. var. glutinosa Matsum. bud point 20g
Gliquidone 30mg * 150, metformin hydrochloride 250mg * 150 slice;
Preparation method is as follows:
1., with glutinous rice by the farming method 1.5-2cm long time of waiting to germinate of sprouting, remove empty rice husk after, pure Fructus Setariae Germinatus is dried, stir to yellow with white vinegar again, can not be sallow, the white vinegar consumption is that 100g gulch bud is converted white vinegar 5g;
2., with the Chinese medicine oven dry of respectively distinguishing the flavor of of said medicine prescription, grind the powder packing respectively;
3., the Radix Clematidis that will grind powder converts with Sal again, consumption is that every 100g Radix Clematidis is converted Sal 6g, is neither big nor small light the stir-fry to little yellow of firewood with mild and heavy respiration;
4., metformin and gliquidone are ground powder respectively;
5., above all grind powder and make after the former medicines of prescription mix thoroughly respectively by above-mentioned compound recipe glycosuria I A, B, C formula proportion, encapsulate with No. 0 capsule shells; It is 44g that per 100 capsules contain the compound recipe grain weight; Every capsules ball contains metformin 71.42mg, about three/a slice; Contain gliquidone 4.28mg, about seven/a slice.
Function of the present invention: QI invigorating the moon, let out that kidney is turbid, clots absorbing blood.Cure mainly slight, the moderate of I type, type ii diabetes, than the severe patient.Light moderate infringement is arranged renal function but the twenty-four-hour urine amount all can courageously be used more than 800ml patient.Therapeutical effect of the present invention is strong, and side effect is minimum; The type ii diabetes patient is acted on better, and the patient has certain effect to type i diabetes; The light moderate infringement of hepatic and renal function patient can use; Blood circulation promoting and blood stasis dispelling is arranged, prevent the hardened function of blood capillary; There is consolidating YIN to let out that kidney is turbid, the effect of renal function protecting; Blood sugar reducing function is stablized soon; Blood fat reducing and the effect that improves blood supply of cardiac muscle are arranged.
Usage of the present invention and consumption: be grown up three times on the one, a 1-4 grain, take 20 minutes ante cibum, preferably according to the blood glucose regulation survival dose.
BS (blood glucose) 〉=14mmol/L obeys the 9-12 grain every day;
BS (blood glucose) ≈ 10mmol/L obeys the 7-9 grain every day;
BS (blood glucose) ≈ 8.3mmol/L obeys the 6-8 grain every day;
BS (blood glucose) ≈ 7.8mmol/L obeys the 5-6 grain every day;
BS (blood glucose) ≈ 5-6.7mmol/L obeys the 4-6 grain every day.
The effect of blood sugar lowering of the present invention is obvious, should just regulate dosage according to blood glucose, in order to avoid cause hypoglycemia.Diet white turnip, Folium Camelliae sinensis, Semen arachidis hypogaeae, Semen Glycines when taking medicine.Side effect of the present invention is minimum.Spontaneous remission after taking medicine 2 days when idol has nauseating phenomenon to occur.Because the characteristics on the prescription; not only the content of metformin, gliquidone is few; little to hepatic and renal function influence, and Rhizoma Alismatis, Polyporus, Cortex Phellodendri have on the one hand and rush down that kidney is turbid, the function of renal function protecting, and medicine such as Rhizoma Alismatis, Polyporus has the function of antagonism metformin, gliquidone side effect on the other hand.So the light moderate of hepatic and renal function infull person still can use.Clinical practice effective percentage 96.4% of the present invention, obvious effective rate 79.8%.Obvious effective rate is meant that clinical symptoms is clearly better, and BS is controlled at about 7.8mmol/L, is no more than 8.3mmol/L.To the patient of long term injections insulin, after using the present invention, obviously reduce insulin dosage, the part patient is arranged even broken away from the treatment of insulin.The present invention of patient's life-time service does not find side effect.Check patient's liver function repeatedly, renal function is not seen harmful effect, hemocyte does not have downward trend, can make rate and blood-lipid decreased, and the ECG change of diabetes patient's ischemia is improved, this be because of the synergism of Typhonium flagelliforme (Lodd.) Blume, Radix Ginseng institute extremely.The long-term prescription patient does not see Drug resistance more than 3 years.Having the part patient to take 3-6 grain medicine every day can make blood glucose for a long time continually and steadily in the absolute normal district of 4.5-6.7mmol/L.
Claims (1)
1, a kind of medicine for the treatment of diabetes and preparation method thereof is characterized in that pharmaceutical formulation is as follows:
Compound recipe glycosuria I A prescription:
Rhizoma Imperatae 80g Radix Clematidis 60g Cortex Phellodendri 30g Rhizoma Anemarrhenae 30g
Radix Ginseng 50g Oryza sativa L. var. glutinosa Matsum. bud point 20g metformin hydrochloride 250mg * 200
Gliquidone 30mg * 100 slice;
Compound recipe glycosuria I B prescription:
Rhizoma Imperatae 80g Typhonium flagelliforme (Lodd.) Blume 60g Cortex Phellodendri 30g Rhizoma Anemarrhenae 30g
Radix Ginseng 50g Oryza sativa L. var. glutinosa Matsum. bud point 20g metformin hydrochloride 250mg * 180
Gliquidone 30mg * 100 slice;
Compound recipe glycosuria I C prescription:
Rhizoma Imperatae 80g Typhonium flagelliforme (Lodd.) Blume 30g Cortex Phellodendri 30g Rhizoma Alismatis 30g
Polyporus 30g Radix Ginseng 50g Oryza sativa L. var. glutinosa Matsum. bud point 20g
Gliquidone 30mg * 150, metformin hydrochloride 250mg * 150 slice;
Preparation method is as follows:
1., with glutinous rice by the farming method 1.5-2cm long time of waiting to germinate of sprouting, remove empty rice husk after, pure Fructus Setariae Germinatus is dried, stir to yellow with white vinegar again, can not be sallow, the white vinegar consumption is that every 100g gulch bud is converted white vinegar 5g;
2., with the Chinese medicine oven dry of respectively distinguishing the flavor of of said medicine prescription, grind the powder packing respectively;
3., the Radix Clematidis that will grind powder converts with Sal again, consumption is that every 100g Radix Clematidis is converted Sal 6g, is neither big nor small light the stir-fry to little yellow of firewood with mild and heavy respiration;
4., metformin and gliquidone are ground powder respectively;
5., above all grind powder and make after the former medicines of prescription mix thoroughly respectively by above-mentioned compound recipe glycosuria I A, B, C formula proportion, encapsulate with No. 0 capsule shells; It is 44g that per 100 capsules contain the compound recipe grain weight; Every capsules ball contains metformin 71.42mg, about three/a slice; Contain gliquidone 4.28mg, about seven/a slice.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97103536A CN1060373C (en) | 1997-04-05 | 1997-04-05 | Drug for curing diabetes and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97103536A CN1060373C (en) | 1997-04-05 | 1997-04-05 | Drug for curing diabetes and its preparing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1195531A true CN1195531A (en) | 1998-10-14 |
| CN1060373C CN1060373C (en) | 2001-01-10 |
Family
ID=5166712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN97103536A Expired - Fee Related CN1060373C (en) | 1997-04-05 | 1997-04-05 | Drug for curing diabetes and its preparing method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1060373C (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1069050C (en) * | 1998-12-01 | 2001-08-01 | 周旭生 | Compound Chinese medicine for treating diabetes |
| CN100362988C (en) * | 2006-09-01 | 2008-01-23 | 胡可丁 | Chinese and western medicine composition contg. metformin |
| CN101194998B (en) * | 2007-11-28 | 2011-05-25 | 韩曙光 | Chinese medicine for treating diabetes |
| CN105640976A (en) * | 2016-03-04 | 2016-06-08 | 广东药学院 | Application of total saponins of anemarrhena combined with metformin in the preparation of medicines for treating diabetes or hyperlipidemia |
-
1997
- 1997-04-05 CN CN97103536A patent/CN1060373C/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1069050C (en) * | 1998-12-01 | 2001-08-01 | 周旭生 | Compound Chinese medicine for treating diabetes |
| CN100362988C (en) * | 2006-09-01 | 2008-01-23 | 胡可丁 | Chinese and western medicine composition contg. metformin |
| CN101194998B (en) * | 2007-11-28 | 2011-05-25 | 韩曙光 | Chinese medicine for treating diabetes |
| CN105640976A (en) * | 2016-03-04 | 2016-06-08 | 广东药学院 | Application of total saponins of anemarrhena combined with metformin in the preparation of medicines for treating diabetes or hyperlipidemia |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1060373C (en) | 2001-01-10 |
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