CN1069050C - Compound Chinese medicine for treating diabetes - Google Patents
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Abstract
The present invention relates to a compound Chinese medicine preparation for treating diabetes, which belongs to the technical field of medicine. The present invention is mainly characterized in that the present invention is prepared from borneol, benzoin, stir-fried fankincense, pearl, natural indigo, snakegourd root, coptis, ophiopogon root, ginseng and clematis root according to a certain proportion. Compared with the existing Chinese medicine for treating diabetes, the present invention uses medicines with an aromatic resuscitation function, and stresses detoxification and heat discharge. The present invention has the advantages of long medicine effect, high durability, small toxic and side effect, rapid and obvious effect, etc., and can be used for preventing complications.
Description
The invention belongs to medical technical field, is a kind of compound Chinese medicinal preparation for the treatment of diabetes.
This invention is mainly used in the treatment diabetes.Diabetes are a kind of owing to insulin secretion lacks or the effect obstacle causes the chronic general metabolic disease of hyperglycemia.According to World Health Organization's 1997 annual reports, the diabetes patient that the whole world has been diagnosed is about 1.35 hundred million, and sickness rate is progressively rising.China's diabetes prevalence by 1980 0.67% rise to 1996 3.2%.Its case fatality rate and disability rate are only second to blood official disease and tumor.Diabetes mainly are divided into I type and II type, and II type patient accounts for sum more than 90%.
The pathogeny of diabetes is not illustrated as yet fully.In recent years research is thought, the morbidity of type i diabetes belongs to the susceptible individual on the hereditism, because virus or other factors cause autoimmune response, damages due to the beta Cell of islet; The morbidity of type ii diabetes then is genetic predisposition and the coefficient result of acquired environment factor, relates to a plurality of links of multiple factor of the whole process of human body metabolism.For example the type ii diabetes people just insulin resistant can occur in 10 years at premorbid, insulin is low anti-receptor arranged again before, receptor, the difference of level behind the receptor has only just found that at acceptor levels the gene point-like sudden change more than 30 kinds lacks with fragment.To thoroughly understand the complicated relation of each link of onset diabetes mechanism, also need for a long time.
The diabetes basically identical of diabetes and Chinese medicine.Pathogenic factor has diet, feelings will, exhaustion due to sexual indulgence, aspect such as congenital, and for the traditional understanding of pathogenesis, mainly is YIN fluid deficiency, production of dryness-heat in the interior.The thick impairing the spleen and stomach of surfeit delicious food and pure wine, fortuneization mistake department amasss and lead to interior-heat in stomach; Excessive direct stimulation, five excessive emotions converting into internal fire, hyperactivity of hesrt-fire and liver-fire, stomach Tianjin consumption kidney liquid down upward burns; Exhaustion due to sexual indulgence does not save, deficiency of the kidney, and deficiency-fire produced in the interior is gradually all existing to the stomach-heat due to lung-dryness of suffering from a deficiency of the kidney; Or because of the natural endowment deficiency, the five internal organs weakness, insufficiency of vital energy and blood exhausts to damage of essence liquid eventually, also can send out to quenching one's thirst.The various causes of disease cause quenching one's thirst, all not from YIN fluid deficiency, and scorching inclined to one side Sheng, and both reciprocal causations.The scorching more Sheng of cloudy more void, the scorching more void of the moon of more containing.
In recent ten years, the etiology and pathogenesis theory of diabetes mainly contains following several aspect: 1, deficiency-weakness of spleen-QI also in the development of enriching constantly.Spleen is the body of the day after tomorrow, the source of QI and bloodization life, and insufficiency of the spleen mistake fortune, then gas Tianjin does not rise, clear QI being mixed up with turbid QI, precise and tiny making a bet goes out from urine.2, stagnation of blood stasis.Body fluid deficiency heat is burnt all can cause the stasis of blood, and blood stasis is interior, and the moon is held back QI and blood and caused to quench one's thirst and prolongedly do not heal again.3, stagnation of QI due to depression of the liver.Feelings will impairing the liver, stagnated QI transforming into fire, lung stomach, the consumption the moon that is impairment of the kidney that burns disappears.4, phlegm-damp turbid pathogen.Spleen is transported and is good for, sick turbid interior giving birth to, and the moon is held back mechanism of qi, or strongly fragrant and living hot, or phlegm and blood stasis, influences lysis and causes complication to take place.
Modern medicine treatment diabetes comprise diet control, exercise therapy, pharmacotherapy, aspects such as diabetes education, pharmacotherapy comprises injection of insulin and oral medicine, oral medicine mainly contains iodine ureas and biguanides, and there have alpha-glucosidase inhibitor and euglycemic agent to drop in recent years again to be clinical.
TCM treatment of diabetes is principle of treatment traditionally with the replenishing YIN and removing heat.
In the present age, different doctors are tame to be familiar with and to know from experience according to oneself, also emphasizes particularly on different fields in treatment.Wish that as Beijing it is main very giving professor's supplementing QI and nourishing YIN, pay attention to blood circulation promoting and blood stasis dispelling, initiative blood sugar lowering blood circulation promoting recipe; Beijing professor Lv Renhe advocates differentiation of symptoms and signs for classification of syndrome and executes and control, and proposes five phases 16 pattern of syndrome of diabetes; Guangzhou Traditional Chinese Medicine College adds flavor based on the Taoren Chengqi Tang of the catharsis of invigorating blood circulation; No.1 Military Medical Univ. pays attention to the smart ball of nourishing kidney Rong of kidney tonifying, essence replenishing; Xiyuan, Beijing hospital supplementing QI and nourishing YIN is main manna diabetes capsule; Shandong College of Traditional Chinese Medicine's invigorating the spleen and benefiting QI is the main plain film of quenching one's thirst; And depressed liver-energy dispersing and QI regulating, eliminating phlegm and removing dampness, various theory of temperature male wind-supplying kidney or the like and school are advocated by other doctor families.
YUQUAN WAN is the representative prescription of the traditional method of treatment by Chinese herbs diabetes, and effect is more sure, now still extensively sells in both at home and abroad.This side comes from Qing Dynasty's " miscellaneous diseases source and course rhinoceros candle ": each two halves of Radix Trichosanthis, Radix Puerariae, Radix Ophiopogonis, Radix Ginseng, Poria, Fructus Mume, Radix Glycyrrhizae each one or two, Radix Astragali, each five money of Radix Astragali Preparata are smalls, practicing honey is ball, big every clothes one ball of pellet shot from a slingshot, warm water is chewed down.Clearing away heat and promoting production of body fluid is arranged, the effect of Replenishing QI and nourishing YIN.
Diabetes treatment by western medicine, the blood sugar lowering effect is rapid, and the problem of existence mainly is: 1, drug effect is of short duration.The human body metabolism is complicated process, and Western medicine only acts on wherein a certain link, discharges human body after drug metabolism, and drug effect promptly comes to an end, must long-term SM.2, the anti-property done.Chemical drugs acts on human body and produces drug resistance gradually, causes dosage cumulative big, in addition reach maximum dose can not disease controlling.3, toxic and side effects.4, be combined the control shortage effective means of disease.
The treatment by Chinese herbs diabetes are being improved condition of illness, health invigorating, and often there is better effects prevention complication aspect, but to the recovery of lab index, it is slower to take effect, and also needs to further develop raising.
The Chinese medicine of this medicine and existing treatment diabetes relatively, the main innovation part: the one, being suitable for of causing resuscitation with aromatic drugs medicine, the 2nd, emphasis is conceived to detoxifcation and expels the heat-evil.Drug effect is long, the anti-property done is strong, toxic and side effects is little to reach, prevention complication, quick result and purpose such as obvious.
The causing resuscitation with aromatic drugs medicine is an important composition part of motherland's medicine, and long history is arranged.It is top grade to classify Shennong's Herbal as Moschus, and it is top grade that Styrax, Olibanum are classified " Mingyi Bielu " as, and Borneolum Syntheticum, Benzoinum etc. are written into the Tang Dynasty " Newly Revised Canon of Materia Medica ".But since modern, this class medicine are used for the treatment of epidemic febrile disease unconsciousness and delirium and some surgical diseasess mostly, and less utilization does not appear in the newspapers in diabetes especially in other internal medical diseases.
The generation pathogeny of diabetes, a little less than the deficiency of YIN, scorching, spleen or the like, the evil dark volt of poison must not leak, and also is an importance.
The notion of " poison " is used very extensive in Chinese medicine, relates to many fields such as the cause of disease, pathogenesis, the rule of treatment, method of treatment, medicine.Poison as etiology and pathogenesis is evil, to ancient Chinese medicine doctor later age, argumentation is arranged from Huangdi's Internal Classics, Zhang Zhongjing " Treatise on Febrile and Miscellaneous Disease ", Chao Shi " source of disease " more, especially occupies critical role in the theory of epidemic febrile disease of the Qing Dynasty.In general, malicious heresy can be come the ruthless and tyrannical cruel gas of comfortable occurring in nature, also can be accumulate strongly fragrant accumulating day by day and be transformed by intravital pathogen.Can grasp and be subjected in congenital, also can heredity in the offspring.Poison is evil to cause a disease, and patient's condition is heavier mostly, hurts sb.'s feelings more very, obstinate and touching, is easy to the folder fire, holds the stasis of blood under the arm.Very grave according to the diabetes calorific potential, touching difficulty more, deteriorated case is numerous and diverse, and clinical manifestations such as heritability are arranged, we think and quite meet with the motherland medical science evil characteristics of poisoning.Dark volt of evil poison and scorching mutual knot pine for holding under the arm poison, and the poison residence is pined for, and poison does not go then hot difficulty to remove.It is of a specified duration to soak day of year, and healthy energy is gradually decreased, cloudy Tianjin is gradually consumed, disorder of movement of QI blood vessels stasis of blood the moon, and produce all deteriorated cases, harmful to human.
Though pathology of Diabetes Mellitus mechanism has the weak one side of deficiency of YIN gas, deficiency of YIN gas is weak many because of pyretic toxicity for a long time due to the bridle.The so-called ineffectual remedy not as removing burning wood away under the boiler, heresy is gone then peace just certainly, and pyretic toxicity one is dispelled, and gas the moon is expected to day by day recover, and pyretic toxicity does not remove, then disease undirected prestige of healing eventually.
The method for detoxification of getting rid of evils; though capture, removing summer-heat, Tuoli or the like be multiple, and being suitable for of causing resuscitation with aromatic drugs usually can be played other method of treatment; irreplaceable effect; receive accident effect rapidly, for example warm seriously ill card pyretic toxicity highest, interior slow nutrient blood; injuring YIN due to production of dryness; hold the stasis of blood under the arm and hold up expectorant, so that the coma convulsion faints, all methods are deceived and are imitated; must use anti-pestilence and fever powder this moment; though often can difference be arranged, there is a common ground side such as Zhibao Dan, cow-bezoar bolus for resurrection; promptly be that fragrance is walked to scurry medicine and heat and toxic materials clearing away medicine share; to reach all keys, get rid of evils and go out, greatly strengthened the effect of heat-clearing and toxic substances removing.
Someone thinks that the causing resuscitation with aromatic drugs method only is only applicable to delirious patient, and this is a kind of misunderstanding in fact.For multiple difficult disease, use properly, good effect is all arranged, modern age, one of Beijing four big well-known doctors Mr. Kong Baihua promptly was good at using this type of medicine in other internal medical diseases, in 42 kinds of internal diseases recording in " Kong Baihua cures collection ", these side's medicines of 24 kinds of diseases are just arranged, and often As the medicine took effect, the symptoms lessened.
Its reason is, the refreshment of not only can having one's ideas straightened out of causing resuscitation with aromatic drugs medicine still has dredging the meridian in addition, and popular QI and blood is dispersed effects such as stagnated fire.As Compendium of Material Medica Moschus bar: " can lead to the unfavorable of all keys, open the heap soil or fertilizer over and around the roots of meridians and hold back, if all wind, clearing heat in QI system; all blood, all pains; the frightened all diseases of abdominal mass, the meridians scheme is closed, the empty unfavorable person in hole; pacify need not for guiding open logical? " " herbal classic is met former " Styrax bar,: " can saturating all keys dirty, ward off all not just gas, all accumulation of phlegm are lost consciousness; must convince by patient analysis with this earlier, control expectorant and to regulate the flow of vital energy serve as this also." " medical center is usurped and wanted " Borneolum Syntheticum bar: " the main stagnated fire of loosing can deep heat extraction." people all over the body, QI and blood nothing but.Stagnation of QI-blood, meridians are jammed, and then pyretic toxicity is cohesion, and all kinds of diseases and ailments are by life; QI and blood and smooth, channels and collaterals dredging then heresy has the outlet, and pyretic toxicity easily removes.
Because diabetic duration is very long, touching difficulty heals, and there is functional activity of QI being not smooth to some extent in most patients, and the blood vessels stasis of blood stagnates, pathological changes such as the turbid cohesion of expectorant, also will cause the generation of decline of people's body constitution and various complication gradually, causing resuscitation with aromatic drugs medicine dredging the meridian, popular QI and blood, not only can go out healing rapidly, and, improve patient's life quality for preventing and delaying to merge developing of card, very important effect is also arranged.Hinder vigour for preventing that the hot product that loose from consuming, can noted aspect consumption and the compatibility.Consumption should strictly be grasped, and having should be excessive, and is aided with the medicine of QI invigorating the moon in the side.By clinical observation, effect is satisfied.
Provide the formulation ratio of the compound Chinese medicinal preparation of these treatment diabetes below, adjustable extent (proportioning employing percentage by weight)
Ice fragrant Ganlu pill
Borneolum Syntheticum 0.5-1.2% Benzoinum 4-12%
Olibanum (processed) 6-15% Margarita 0.8-3%
Indigo Naturalis 5-15% Radix Trichosanthis 10-20%
Rhizoma Coptidis 10-25% 10-20% Radix Ophiopogonis
Radix Ginseng 10-20% Radix Clematidis 5-15%
Wherein Benzoinum can be substituted by Styrax.
Its optimum ratio is as follows:
Borneolum Syntheticum 0.8% Benzoinum 8%
Olibanum (processed) 8% Margarita 1.6%
Indigo Naturalis 9.6% Radix Trichosanthis 16%
16% Radix Ophiopogonis 16% of Rhizoma Coptidis
Radix Ginseng 16% Radix Clematidis 8%
Compatibility is analyzed
Borneolum Syntheticum leads to all keys, the stagnated fire of loosing, and Benzoinum is had one's ideas straightened out, qi and blood circulation promotion; Indigo Naturalis, clearing away heat,cooling blood and removing toxin again can " eliminating pathogen in the liver gallbladder, loose stagnated fire " (" herbal classic be met former "), and the Rhizoma Coptidis eliminating fire and detoxication is again to control the key medicine of quenching one's thirst at all times.Four medicines share, and drive away scorching malicious heresy and go out the Main Ingredients and Appearance in the side of being.
The Olibanum regulating qi and activating blood chases after poison, to help Borneolum Syntheticum, the power that Benzoinum is had one's ideas straightened out; The Radix Trichosanthis promoting the production of body fluid to quench thirst, pathogenic fire reducing is moisturized, and the sweet saltiness of Margarita is cold, the detoxifcation heat clearing away, Gu promptly is used for " closing Rhizoma Anemarrhenae treatment dysphoria with smothery sensation quenches one's thirst " (" Haiyao Bencao, Oversea Materia Medica "), to help Indigo Naturalis, the merit of Rhizoma Coptidis heat-clearing and toxic substances removing.Be auxiliary composition in the side.
The Radix Ginseng supplementing QI for promoting the production of body fluid, support stomach reinforcing Radix Ophiopogonis, and in order to reinforcing body resistance, eliminating evil going out can prevent the hot consumption gas that looses again, the fraud of bitter cold dryness-transformation.Radix Clematidis " the logical twelve channels and collaterals of a surname ".For Fang Zhongzuo makes composition.
All medicines are shared, cooperatively interact, and play the logical all keys of a surname, the pathogenic fire reducing that heals, the effect of supplementing QI for promoting the production of body fluid.
Dosage form, method for making, usage, consumption
The watered pill.Also can be made as dosage forms such as water-honeyed pill, honeyed pill, concentrated pill, extractum sheet, capsule.
Margarita is put and boils 2-3 hour in the bean curd, and taking-up is dried, and grinds impalpable powder, crosses 200 mesh sieves.All the other medicine pulverize separately or porphyrizes are crossed 100 mesh sieves.Except that Radix Clematidis, all the other medicine mixings are made as the watered pill according to well-established law, hang clothing with the Radix Clematidis powder.
Every clothes 6-10 gram, each group component multiplies each other every day 2-3 time by proportioning and total amount, warm water delivery service.30-60 days is a course of treatment, the careful usefulness of Deficiency and coldness of spleen and stomach disease and anemia of pregnant woman.
Clinical data " icing fragrant Ganlu pill treatment diabetes clinical summary " portion provides in the lump as adnexa.
Do following pluses and minuses relative analysis in conjunction with adnexa
1, therapeutic effect significantly improves than matched group, and treatment group total effective rate 92.7%, matched group are 58%; Obvious effective rate treatment group 68.7%, matched group only 10%.
2, obviously shorten the course of treatment.One month curative effect of treatment group is higher than being to shine two months curative effect of group, and it is over half to illustrate that can shorten the course of treatment.
3, observing in the case approximately 60%, is to take the patient that the blood sugar lowering Western medicine still can not disease controlling for a long time, is also taken a turn for the better rapidly after treating with we, illustrates that this medicine has positive effect to the drug resistance problem of Western medicine.
4, observe in the case, the curative effect between doctor's pattern of syndrome, statistical analysis does not have significant difference through the position, and we's treatment diabetes patient adaptability more widely is described.
5, follow up a case by regular visits to situation explanation we reliable late result is arranged.
6, in recent years, medical circle expert's common recognition, the prevention target of diabetes not only is confined to separate X/W (Ex-warrants) shape and blood sugar control glucose in urine, also comprises the raising life quality, the aspects such as development of preventing and delaying and issuing licence.This group case is when the state of an illness is improved, also observing body weight develops to the standard weight direction, the blood fat trend that raises normally waits variation, illustrate that this law is to treatment of diabetes, by eliminating pathogenic factor for supporting vital QI, promoting flow of QI and blood makes the E﹠M function gradually normal from disorder, stable curative effect and lasting has demonstrated fully Chinese medicine organic conception and the dialectical advantage place of controlling of executing.
7, weak point, for the patient of weakness of the spleen and stomach or kidney yang deficiency, taking originally to have stomachache, side effect such as diarrhoea.
8, the overwhelming majority is the type ii diabetes people in this group observation case, and I type patient only has 3 examples, though for I type patient the symptom of improvement is arranged also, reduces effects such as insulin dosage, and total curative effect is not ideal enough.
List of references
1, Zhong Xueli: clinical diabetes is learned.Shanghai science tech publishing house 1989.10 front pages.
2, yellow star wall etc.: " poison " meaning in epidemic febrile disease is sent out.Journal of Traditional Chinese Medicine 1991. (1), 4-11
3, Wei Junping: the progress of Chinese patent medicine and single medicinal material treatment diabetes.Jilin Chinese medicine 1993; (5); 44
4, Wang Hongman etc., diabetes Chinese medicine research therapeutic situation.Chinese medicine information 1994; (3): 3-5.
Claims (1)
1, a kind of compound Chinese medicinal preparation for the treatment of diabetes is characterized in that being made up of following proportioning, and wherein proportioning adopts percentage by weight:
Borneolum Syntheticum 0.5-1.2% Benzoinum 4-12%
Olibanum (processed) 6-15% Margarita 0.8-3%
Indigo Naturalis 6-15% Radix Trichosanthis 1020%
Rhizoma Coptidis 10-25% 10-20% Radix Ophiopogonis
Radix Ginseng 10-20% Radix Clematidis 5-15%
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| CN1870992A (en) | 2003-10-03 | 2006-11-29 | 维伊林股份有限公司 | Animal feed composition |
| CN101194998B (en) * | 2007-11-28 | 2011-05-25 | 韩曙光 | Chinese medicine for treating diabetes |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1174043A (en) * | 1996-06-26 | 1998-02-25 | 麻凯 | Chinese medicine for diabetes |
| CN1195531A (en) * | 1997-04-05 | 1998-10-14 | 姚远林 | Drug for curing diabetes and its preparing method |
| CN1196941A (en) * | 1997-11-18 | 1998-10-28 | 陈金燕 | Compound Chinese and western medicinal compsn. for treating 'medium elimination' diabetes |
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| CN1174043A (en) * | 1996-06-26 | 1998-02-25 | 麻凯 | Chinese medicine for diabetes |
| CN1195531A (en) * | 1997-04-05 | 1998-10-14 | 姚远林 | Drug for curing diabetes and its preparing method |
| CN1196941A (en) * | 1997-11-18 | 1998-10-28 | 陈金燕 | Compound Chinese and western medicinal compsn. for treating 'medium elimination' diabetes |
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| Title |
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| 《中成药》1993，15(8) 2093.9.1 张军，"安宫牛黄丸的演化制剂及应用进展" * |
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