CN118845297A - One-time implantation of artificial cornea and method of use thereof - Google Patents

Abstract

The present invention discloses a one-time implantable artificial cornea, belonging to the technical field of in vivo prosthesis implantation. At least the problems existing in the prior art, such as the need for a donor cornea, multiple surgeries, large trauma, and not suitable for patients with severe corneal blindness, are solved. The one-time implantable artificial cornea includes a bracket and a mirror column, the mirror column includes a mirror column body and a rear disc coaxially arranged at the rear end surface of the mirror column body; the mirror column and the bracket are coaxially detachably connected; in the use state, the rear end of the mirror column body located behind the rear disc protrudes into the eye, the rear disc fits the rear surface of the cornea and the bracket fits the front surface of the cornea, the bracket is fixed to the corneal surface by a suturing method, and at the same time, the bracket and the rear disc clamp the cornea one after the other. The present invention also provides a method for using the one-time implantable artificial cornea. It has the advantages of one-time implantation, no need for a donor cornea, small trauma, and being suitable for patients with severe corneal blindness, and has broad application prospects.

Description

One-time implantation of artificial cornea and method of use thereof

Technical Field

The invention belongs to the technical field of in vivo prosthesis implantation, and in particular relates to a one-time implantation artificial cornea and a use method thereof.

Background Art

An artificial cornea refers to a special refractive device made of biomedical materials, which is used to replace the cloudy cornea that blocks the optical pathway of the eye after a disease, so that the patient can regain a certain degree of vision.

The prior art provides an artificial cornea with a blindness-free rate of up to 79.9%, which is currently the most widely used artificial cornea in the world. The artificial cornea not only requires general anesthesia during the treatment process, but also requires the use of a trephine to remove the large-diameter full-thickness cornea during the operation, and the risk of serious complications during the operation is high. In particular, a donor corneal graft is required as a carrier, and the severe shortage of donor corneas is a problem that is difficult to solve in my country at present. Therefore, the artificial cornea cannot be transplanted on a large scale. In addition, the artificial cornea requires long-term local use of hormones or immunosuppressants after surgery, and the incidence of infection and glaucoma is high, and it is difficult to maintain long-term vision. In addition, due to the large-diameter posterior disc, the incidence of posterior membrane of the artificial cornea is high, which not only seriously threatens vision, but also has a high incidence of complications of corneal graft dissolution. At the same time, the risk of glaucoma is increased. In addition, the artificial cornea has high requirements for ocular surface conditions, that is, it requires good tear function and requires the eyelids and conjunctival sac to have good integrity, especially for dry eyes caused by autoimmune diseases. The recovery is extremely poor. Furthermore, if perforation and leakage occur, a new artificial cornea needs to be replaced urgently, but if there is no donor corneal graft, emergency rescue cannot be performed.

The existing technology also provides another artificial cornea with a blindness-free rate of 86.6%. It can also be used for patients with bilateral blindness such as severe ocular surface diseases, chemical injuries, thermal burns, blast injuries, eyelid closure, and terminal dry eyes. However, two-stage surgery is required, namely, stage I surgery for stent implantation and stage II surgery for lens column implantation. The difficulty in promoting surgical technology is mainly due to the difficulty in separating the corneal lamellae, which is prone to corneal perforation during surgery and leads to failure of stent implantation. The surgical field is small during stage II surgery, and lens removal is extremely difficult. The incidence of residual lens cortex is high, which can cause lens-derived inflammatory response and threaten visual function. For this type of surgery, the surgical learning curve is long and requires the surgeon to have comprehensive surgical skills. Therefore, it is difficult to master and widely promote. In addition, the lens column is fixed in a screw buckle manner, which is easy to fall off, and once it falls off, it will lead to serious consequences. The connector between the stent and the lens column is inserted from back to front, and the stage II lens column is implanted from front to back. During the implantation process, the force applied to the stent may cause the connector to fall off, resulting in the dilemma of being unable to implant the lens column.

In view of this, it is urgent to propose an artificial cornea that can overcome the above-mentioned technical problems and complete corneal blindness restoration treatment with a single implant.

Summary of the invention

The purpose of the present invention is to provide a one-time implantation artificial cornea and a method of using the same, which can effectively solve the problems existing in the prior art, such as the need for a donor cornea, multiple surgeries to implant the stent and lens column separately, difficulty in lens removal, high incidence of cortical residues, and unsuitability for patients with severe ocular surface diseases.

In order to achieve the above object, the present invention provides the following technical solutions:

In the first aspect, the present invention provides a one-time implantable artificial cornea, comprising a bracket and a lens column, the lens column comprising a lens column body and a rear disk coaxially arranged at the rear end surface of the lens column body; the lens column and the bracket are coaxially detachably connected; in the use state, the rear end of the lens column body located behind the rear disk protrudes into the eye, the rear disk fits the rear surface of the cornea and the bracket fits the front surface of the cornea, the bracket is fixed to the corneal surface by a suturing method, and at the same time, the bracket and the rear disk clamp the cornea front and back.

When the above technical solution is adopted, the artificial cornea provided by the present invention is implanted into the eyes of patients with severe corneal blindness in the following manner to achieve the purpose of restoring sight: a hole is drilled in the center of the patient's cornea, and a side cut is made on one side of the hole to form a radial side incision of the cornea, thereby improving the surgical field of view, facilitating the complete removal of the lens, and solving the problem of residual lens cortex in the prior art.

After removing the lens and removing the anterior vitreous body, the posterior disc included in the artificial cornea is implanted into the above-mentioned drill hole, that is, the posterior disc enters the cornea through the radial side incision of the cornea and fits with its posterior surface. At this time, the radial side incision of the cornea can be sutured to initially fix the lens column. On this basis, the bracket is rotated to move the bracket backward. When the bracket fits with the anterior surface of the cornea, the bracket and the posterior disc are clamped on the cornea one after the other, and the bracket and the cornea are sutured together to achieve the fixation of the bracket on the ocular surface.

From the above application process, it can be seen that the artificial cornea provided by the present invention only requires one operation to complete the implantation, and the operation cycle is short, which can reduce the patient's anxiety of waiting and the pain of multiple operations. Moreover, the initial fixation of the stent is achieved by using the patient's own cornea, without the need for a donor cornea, which can completely avoid the problems of donor cornea shortage and allogeneic corneal transplant rejection. In addition, the stent is located on the front surface of the cornea, and compared with the stent provided by the prior art that is implanted in the corneal lamella, the difficulty and risk of the operation are greatly reduced, the trauma is small, the healing cycle is short, and the healing effect is good.

As a possible implementation method, the side bottom end to the rear end face of the lens column body behind the rear disc is a square edge. In this way, it is difficult for biological tissue on the side wall of the lens column to grow beyond the square edge to the rear end face of the lens column, which can effectively prevent the formation of the posterior membrane of the artificial cornea, thereby avoiding the problem that the lens column cannot transmit light.

As a possible implementation, an annular outer edge is provided forwardly on the periphery of the posterior disc to seal the posterior disc and the posterior surface of the cornea.

As a possible implementation manner, the square edge is one of a right-angled edge, an obtuse-angled edge, or an acute-angled edge.

As a possible implementation manner, the mirror column body behind the rear disc is one of a structure with a constant diameter, a structure with a gradually decreasing diameter, or a structure with a gradually increasing diameter.

As a possible implementation method, the front surface of the cornea is sutured with biological tissue or artificial synthetic material for reinforcing the bracket. The biological tissue includes ear cartilage and Tenon's capsule from the inside to the outside; the artificial synthetic material is hydroxyapatite and artificial bone.

In actual application, the ear cartilage is taken from the patient, a hole is made in the center of the ear cartilage, and the lens column is inserted so that the ear cartilage surrounds the lens column and covers the bracket, and is sutured and fixed to the eye surface to reinforce the artificial cornea, making the artificial cornea more stable and less likely to dislocate. In addition, after the cornea is covered with ear cartilage, it is equivalent to covering it with a barrier, which not only plays a protective role, but also can prevent the cornea from dissolving.

The front surface of the ear cartilage is further covered with Tenon's capsule to fix the ear cartilage and provide nutrition to the ear cartilage, so that the tissue can heal better. The surface of Tenon's capsule is covered with conjunctiva, oral mucosa or eyelid skin to achieve surface epithelialization, which can effectively resist tissue dissolution and infection.

As a possible implementation, the bracket is a metal bracket, and the lens column is at least one of poly(hydroxyethyl methacrylate), poly(methyl methacrylate), bioceramics or optical glass. The one-time implanted artificial cornea also includes a hollow stepped shaft-shaped connecting ring, and the material of the connecting ring is the same as or similar to that of the lens column. The inner wall of the connecting ring is provided with an internal thread, and the front section of the lens column is provided with an external thread section matching the internal thread; an annular groove is provided at the shoulder of the outer wall of the hollow stepped shaft, and the inner wall of the central mounting hole of the bracket is inserted into the annular groove in an interference fit assembly manner; and the connecting ring is inserted into the central mounting hole of the bracket from front to back.

As a possible implementation manner, the material of the bracket is the same as or similar to that of the mirror column, and the mirror column is directly connected to the center of the bracket.

As a possible implementation method, a notch or a needle hole is provided on the bracket to facilitate suturing and fixation.

As a possible implementation manner, the non-threaded parts of the metal bracket and the mirror column body are provided with a hydroxyapatite coating layer.

In a second aspect, the present invention further provides a method for using a one-time implanted artificial cornea, comprising the following steps:

S10. Insert the rear end of the artificial cornea column together with the rear disc into the anterior chamber;

S11. Slide the rear plate of the bracket to the posterior surface of the cornea so that the lens column is located on the posterior surface of the center of the corneal drilling hole;

S12. Suture the radial lateral corneal incision until it is watertight;

S13. Rotate the bracket until it fits the anterior surface of the cornea;

S14. Suturing and fixing the stent to the anterior surface of the cornea, at this time, the posterior disc and the stent clamp the cornea front and back;

S15. Biological tissue or artificial synthetic material reinforced scaffold.

Compared with the prior art, the present invention has the following effects:

1. No donor cornea is needed, and a single implantation operation can complete the treatment of corneal blindness and restore vision, shortening the operation period;

2. The stent is located on the anterior surface of the cornea, reducing the difficulty and risk of surgery;

3. Use biological tissue or artificial synthetic materials to effectively reinforce the artificial cornea, making it more stable and improving the in-situ rate;

4. When the cornea is covered with biological tissue or artificial synthetic materials, it is equivalent to being covered with a barrier, which not only plays a protective role but also can prevent corneal dissolution;

5. The square edge design at the rear end of the lens column can effectively prevent the occurrence of posterior corneal membrane;

6. Use a connecting ring with the same material as the mirror column and with internal threads on the inner wall, or use a bracket and mirror column with the same material to avoid damage to the mirror column during rotation;

7. The connecting ring is inserted into the central mounting hole of the metal bracket from front to back, and the hollow stepped shaft-shaped outer wall shoulder is provided with an annular groove to prevent the connecting ring from falling off. At the same time, after the bracket is rotated into place, the connecting ring and the metal bracket are not easy to separate, which can completely prevent the connecting ring from falling into the eyeball during surgery.

8. The non-threaded section of the metal bracket and the side wall of the mirror column is coated with hydroxyapatite to improve the healing property.

BRIEF DESCRIPTION OF THE DRAWINGS

The drawings described herein are used to provide further understanding of the present invention and constitute a part of the present invention. The exemplary embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute improper limitations on the present invention.

FIG1 is a schematic diagram of the overall structure of an artificial cornea provided by an embodiment of the present invention;

FIG2 is a schematic diagram of the structure of a mirror column provided in an embodiment of the present invention;

FIG3 is a schematic diagram of the structure of a bracket provided in an embodiment of the present invention;

FIG4 is a schematic structural diagram of a connecting ring for a stent provided in an embodiment of the present invention;

FIG. 5 is a schematic structural diagram of another bracket provided in an embodiment of the present invention.

Reference numerals:

1-mirror column, 10-mirror column body, 11-rear plate;

2-bracket, 20-bracket body, 21-connecting ring, 210-internal thread, 211-annular groove, 212-notch, 213-pinhole.

DETAILED DESCRIPTION

In order to clearly describe the technical solutions of the embodiments of the present invention, in the embodiments of the present invention, words such as "first" and "second" are used to distinguish the same items or similar items with basically the same functions and effects. For example, the first threshold and the second threshold are only used to distinguish different thresholds, and their order is not limited. Those skilled in the art can understand that words such as "first" and "second" do not limit the quantity and execution order, and words such as "first" and "second" do not necessarily limit them to be different.

It should be noted that, in the present invention, words such as "exemplary" or "for example" are used to indicate examples, illustrations or descriptions. Any embodiment or design described as "exemplary" or "for example" in the present invention should not be interpreted as being more preferred or more advantageous than other embodiments or designs. Specifically, the use of words such as "exemplary" or "for example" is intended to present related concepts in a specific way.

In the present invention, "at least one" means one or more, and "plurality" means two or more. "And/or" describes the association relationship of associated objects, indicating that three relationships may exist. For example, A and/or B can mean: A exists alone, A and B exist at the same time, and B exists alone, where A and B can be singular or plural. The character "/" generally indicates that the associated objects before and after are in an "or" relationship. "At least one of the following" or similar expressions refers to any combination of these items, including any combination of single or plural items. For example, at least one of a, b or c can mean: a, b, c, the combination of a and b, the combination of a and c, the combination of b and c, or the combination of a, b and c, where a, b, c can be single or multiple.

1 and 2 , an embodiment of the present invention provides a one-time implant artificial cornea, including a lens column 1 and a bracket 2 .

The mirror column 1 includes a mirror column body 10 and a rear plate 11 coaxially arranged near the rear end surface of the mirror column body 10; the mirror column 1 is coaxially detachably connected to the bracket 2. In the use state, the rear end of the mirror column body 10 located behind the rear plate 11 protrudes into the eye, the rear plate 11 fits the rear surface of the cornea and the bracket 2 fits the front surface of the cornea, and the bracket 2 is fixed to the corneal surface by suturing. At the same time, the rear plate 11 and the bracket 2 clamp the cornea.

In the assembled state, the bracket 2 and the mirror column 1 can be screwed together.

The mirror column body 10 and the rear plate 11 are made of the same material and can be integrally formed, or the mirror column body 10 and the rear plate 11 can be manufactured separately and then coaxially fastened together in any manner.

The portion of the mirror column body 10 located in front of the rear plate 11 can be a cylindrical structure with equal diameters from top to bottom, and the position screwed to the bracket 2 is provided with an external thread section matching the internal thread 210 of the bracket 2 from top to bottom.

The diameter of the mirror column body 10 is smaller than that of the rear plate 11. Specifically, the diameter of the mirror column body 10 is 2.0-3.5 mm. The diameter of the rear plate 11 is 2-4 mm larger than that of the mirror column body 10, that is, the diameter of the rear plate 11 is 4-7.5 mm. For example, the diameter of the mirror column body 10 is 2 mm, and the diameter of the rear plate 11 is 4 mm; the diameter of the mirror column body 10 is 3 mm, and the diameter of the rear plate 11 is 5 mm; the diameter of the mirror column body 10 is 3.5 mm, and the diameter of the rear plate 11 is 7.5 mm.

In practical applications, the diameter of the cornea is 11 mm, the diameter of the drill hole is 2.5 mm, and the diameter of the rear plate 11 is less than or equal to the sum of the radius of the cornea and the radius of the lens column body 10.

The total length of the mirror column body 10 is 4.5-8.5 mm, of which the length from the rear disc 11 to the rear end face is 1-2 mm, the length of the optical axis from the rear disc 11 to the end of the threaded section is 0.2-0.5 mm, the length of the rear disc 11 is 0.3-0.5 mm, and the length of the threaded section is 3-5.5 mm.

The refractive power of the lens column 1 is 42-62D, for example, 42D, 45D, 50D, 55D, 60D or 62D.

The side bottom end to the rear end face of the mirror column body 10 behind the rear plate 11 is a square edge. In this way, it is difficult for biological tissues around the square edge to grow over the square edge to the rear end face, that is, it can prevent the growing biological tissues from covering the rear end face of the mirror column 1, thereby effectively avoiding the problem that the mirror column 1 cannot transmit light due to being covered by the growing biological tissues.

The square edge is one of a right angle edge, an obtuse angle edge or an acute angle edge. The mirror column body 10 behind the rear plate 11 is one of a constant diameter structure, a structure with a gradually decreasing diameter or a structure with a gradually increasing diameter.

The mirror column body 10 behind the rear plate 11 is one of a structure with a constant diameter, a structure with a gradually decreasing diameter, or a structure with a gradually increasing diameter.

The non-threaded section of the mirror column body 10 is coated with a hydroxyapatite film. When atmospheric plasma spraying is used, the coating thickness is 30 to 150 microns and the bonding strength is at least 10 MPa.

The mirror column body 10 constitutes an optical device for replacing the optical path of the eye, that is, light is imaged on the retina after passing through the mirror column body 10 .

The outer periphery of the rear disc 11 is provided with an annular outer edge forwardly, which seals the rear disc 11 and the rear surface of the cornea to prevent water leakage and infection.

The mirror column 1 is made of at least one of poly(hydroxyethyl methacrylate), poly(methyl methacrylate), bioceramics or optical glass.

3 to 5 , the bracket 2 may be a metal bracket, such as a medical titanium bracket, or a PMMA bracket, that is, the material of the bracket 2 is the same as or similar to that of the mirror column 1 .

When the bracket 2 is a metal bracket, in order to shorten the healing period between the bracket 2 and the cornea and improve the healing effect, a layer of hydroxyapatite can be plated on the surface of the bracket 2.

When the bracket 2 is a metal bracket, the one-time implantation of the artificial cornea further includes a hollow stepped shaft-shaped connecting ring 21, the material of which is the same or similar to that of the lens column 1. The inner wall of the connecting ring 21 is provided with an internal thread 210, and the front section of the lens column 1 is provided with an external thread section matching the internal thread 210. An annular groove 211 is provided at the shoulder of the outer wall of the hollow stepped shaft, and the inner wall of the central mounting hole of the bracket 2 is inserted into the annular groove 211 in an interference fit assembly manner; and the connecting ring 21 is inserted into the central mounting hole of the bracket from front to back.

When the bracket 2 and the lens column 1 are made of different materials but need to move relative to each other in a threaded connection, the metal bracket 2 will damage the threads of the lens column 1. The internal and external thread segments of the same material minimize the damage to each other caused by the rotational movement when the two undergo relative displacement changes. In addition, the connecting ring 21 is inserted into the central mounting hole of the bracket from front to back. When the bracket 2 is rotated to approach the ocular surface during surgery, the connecting ring 21 will not fall off from the central mounting hole into the eye.

When the bracket 2 and the mirror column 1 are both made of PMMA, the bracket 2 and the mirror column 1 can be directly connected without the connecting ring 21. That is, an internal thread 210 matching the external thread segment can be directly provided on the inner wall of the central mounting hole of the bracket 2.

Structurally, the support 2 can be a butterfly support, a single ring support, a double ring support (with a grid connecting piece between the outer ring and the inner ring) or a mesh support. Among them, the mesh support is convenient for the nutrient exchange of the front and back tissues.

Since the bracket 2 needs to fit the front surface of the cornea, it needs to have a certain curvature to ensure that the bracket 2 can completely fit the front surface of the cornea. In addition, the bracket 2 needs to have a certain rigidity, that is, after the bracket 2 is attached to the front surface of the cornea, it is not easy to deform or warp under force. The bracket 2 also needs to have a certain flexibility. Since the curvature of the cornea varies from patient to patient, the bracket 2 with a certain flexibility can have a certain deformation space to adapt to corneas with different curvatures.

The bracket 2 is provided with a notch 212 or a pinhole 213 for suturing and fixing. This arrangement facilitates the bracket 2 to be sutured and fixed to the ocular surface. After the radial side incision of the cornea is sutured, the human cornea is fixed to the posterior surface of the cornea, and after the bracket 2 is moved to fit the anterior surface of the cornea, the notch 212 or the pinhole 213 is used to suture the bracket 2 and the cornea.

Biological tissue or artificial synthetic material for reinforcing the bracket 2 is also sutured outside the cornea. The biological tissue covers the bracket 2 and surrounds the lens column 1. It plays the role of reinforcing the bracket 2 and the lens column 1 at the same time. The tissues are ear cartilage, Tenon's capsule and epithelial tissue from back to front. The artificial synthetic material can be hydroxyapatite or artificial bone.

In specific applications, the patient's own ear cartilage can be taken, a hole is drilled in the ear cartilage corresponding to the position of the mirror column 1, and the ear cartilage is sutured to the cornea, wrapping around the mirror column 1 and covering the bracket 2. The secondary reinforcement of the artificial cornea is achieved, making the artificial cornea more stable and not easy to dislocate. In addition, after the cornea is covered with ear cartilage, it is equivalent to covering it with a barrier, which not only plays a protective role, but also can prevent the cornea from dissolving.

The front surface of the ear cartilage is further covered with a Tenon's capsule, which is a biomass capsule on the surface of the eye and has a certain degree of flexibility and elasticity. The Tenon's capsule can be used to achieve three reinforcements of the artificial cornea.

The outer circumference size of the bracket 2 is 8.5 mm to 10 mm. For example, the outer circumference size of the bracket 2 is 8.5 mm, 9.0 mm, 9.5 mm or 10 mm.

The curvature radius of the bracket 2 is 7.8 mm ± 2.0 mm. For example, the curvature radius of the bracket 2 is 5.8 mm, 6.8 mm, 7.8 mm, 8.8 mm or 9.8 mm.

The artificial cornea provided by the present invention is implanted into the eyes of patients with severe corneal blindness in the following manner to achieve the purpose of restoring sight: a hole is drilled in the center of the patient's cornea, and a side cut is made on one side of the hole to form a radial side incision of the cornea, thereby improving the surgical field of view, facilitating the complete removal of the lens, or solving the problem of residual lens cortex in the prior art.

After the lens is removed and the anterior vitreous body is removed, the posterior disc 11 included in the artificial cornea is implanted into the above-mentioned drilled hole, that is, the posterior disc 11 enters the cornea through the radial side incision of the cornea and fits with its rear surface. At this time, the radial side incision of the cornea can be sutured to preliminarily fix the lens column 1. On this basis, the bracket 2 is rotated to move the bracket 2 backward. When the bracket 2 fits with the front surface of the cornea, the bracket 2 and the posterior disc 11 are clamped on the cornea one after the other, and the bracket 2 and the cornea are sutured together to achieve the fixation of the bracket 2 on the ocular surface.

From the above application process, it can be known that the artificial cornea provided by the present invention only requires one operation to complete the treatment of corneal blindness and restoration of vision, shortening the operation period, and reducing the patient's anxiety of waiting and the pain of multiple operations. Moreover, the initial fixation of the bracket 2 is achieved by using the patient's own cornea, without the need for a donor cornea, which can completely avoid the lack of donor corneas and rejection of allogeneic corneal transplants. In addition, the bracket 2 is located on the front surface of the cornea. Compared with the bracket provided by the prior art that is implanted in the corneal lamella, the difficulty and risk of the operation are greatly reduced, the trauma is small, the healing period is short, and the healing effect is good.

In practical applications, when the rear disc 11 and the mirror column body 10 are integrally formed, they are assembled together in the following manner:

a. Insert the connecting ring 21 into the center mounting hole of the bracket 2 from top to bottom;

b. The front end of the mirror column body 10 passes through the internal thread 210 of the connecting ring 21 (or the internal thread hole of the center mounting hole), and the mirror column body 20 and the bracket 2 are rotated in opposite directions to move the bracket 2 along the axial direction of the mirror column body 10 toward the rear disk 11.

In a second aspect, the embodiment of the present invention also provides a method for using an artificial cornea that is implanted once. Before using the artificial cornea provided by the embodiment of the present invention, it is first necessary to determine that the implantation position is located in the center of the cornea, drill a hole in the center of the cornea with a trephine, and make a radial side incision of the cornea. The method of use comprises the following steps:

S10. Implant the rear end of the artificial cornea column together with the posterior disc into the anterior chamber;

S11. Slide the rear disc of the bracket to the rear surface of the center of the cornea;

S12. Suture the radial lateral corneal incision until it is watertight;

S13. Rotate the bracket until it fits the anterior surface of the cornea;

S14. Suture and fix the stent to the anterior surface of the eyeball. At this time, the posterior disc and the stent clamp the cornea front and back;

S15. Biological tissue or artificial material reinforced scaffold.

As an example, S15 specifically includes:

S150. Take the patient's ear cartilage, and drill a hole in the ear cartilage corresponding to the mirror column body. Pass the ear cartilage through the hole to wrap around the mirror column body and cover the bracket, and suture the ear cartilage and cornea at the same time.

S151. Flatten the Tenon's capsule and cover it on the surface of the ear cartilage, and sew it together with the ear cartilage.

Although the present invention is described herein in conjunction with various embodiments, in the process of implementing the claimed invention, those skilled in the art may understand and implement other variations of the disclosed embodiments by viewing the drawings, the disclosure, and the drawings, etc. In the specification, the word "comprising" does not exclude other components or steps, and "one" or "an" does not exclude multiple situations. A single processor or other unit can implement several functions listed in the specification. Certain measures are recorded in different embodiments, but this does not mean that these measures cannot be combined to produce good results.

Although the present invention has been described in conjunction with specific features and embodiments thereof, it is apparent that various modifications and combinations may be made thereto without departing from the spirit and scope of the present invention. Accordingly, this specification and the accompanying drawings are merely exemplary illustrations of the present invention and are deemed to cover any and all modifications, variations, combinations or equivalents within the scope of the present invention. Obviously, those skilled in the art may make various modifications and variations to the present invention without departing from the spirit and scope of the present invention. Thus, the present invention is intended to include such modifications and variations if they fall within the scope of the present invention and its equivalents.

Claims (10)

1. A one-time implantable artificial cornea, comprising a bracket and a lens column, characterized in that the lens column comprises a lens column body and a rear disc coaxially arranged at the rear end surface of the lens column body; the lens column and the bracket are coaxially detachably connected; in a use state, the rear end of the lens column body located behind the rear disc protrudes into the eye, the rear disc fits the rear surface of the cornea and the bracket fits the front surface of the cornea, and the bracket is fixed to the front surface of the cornea by a suturing method, so that the bracket and the rear disc clamp the cornea front and back. 2. The one-time implantable artificial cornea according to claim 1 is characterized in that the side bottom end to the rear end face of the lens column body behind the rear disc is a square edge; and/or, the outer periphery of the rear disc is provided with an annular outer edge forward to seal the rear disc and the rear surface of the cornea. 3. The one-time implant artificial cornea according to claim 2, characterized in that the square edge is one of a right-angled edge, an obtuse-angled edge or an acute-angled edge. 4. The one-time implantable artificial cornea according to claim 3 is characterized in that the lens column body behind the posterior disc is one of an equal-diameter structure, a structure with a gradually decreasing diameter, or a structure with a gradually increasing diameter. 5. The one-time implant artificial cornea according to claim 1 is characterized in that biological tissue or artificial synthetic material for reinforcing the support is sutured on the front surface of the cornea. 6. The one-time implant artificial cornea according to claim 5, characterized in that the biological tissues include ear cartilage and Tenon's capsule from inside to outside; The artificial synthetic materials are hydroxyapatite and artificial bone. 7. The one-time implant artificial cornea according to claim 1, characterized in that the bracket is a metal bracket, and the mirror column is at least one of polyhydroxyethyl methacrylate, polymethyl methacrylate, bioceramics or optical glass; The one-time implanted artificial cornea also includes a hollow stepped shaft-shaped connecting ring, the material of the connecting ring is the same as or similar to the material of the mirror column; the inner wall of the connecting ring is provided with an internal thread, and the front section of the mirror column body is provided with an external thread matching the internal thread; the outer wall shoulder of the hollow stepped shaft is provided with an annular groove, and the inner wall of the central mounting hole of the bracket is inserted into the annular groove in an interference fit assembly manner; and the connecting ring is inserted into the central mounting hole of the bracket from front to back. 8. The one-time implantable artificial cornea according to claim 1 is characterized in that the material of the bracket is the same as or similar to the material of the lens column, and the lens column is directly connected to the central mounting hole of the bracket. 9. The one-time implant artificial cornea according to claim 1 is characterized in that a notch or a pinhole is provided on the bracket for suturing and fixation; and/or the non-threaded parts of the metal bracket and the lens column body have a hydroxyapatite coating layer. 10. A method for using a one-time implanted artificial cornea, characterized in that it comprises the following steps: S10. Insert the rear end of the artificial cornea column together with the rear disc into the anterior chamber; S11. Slide the rear plate of the bracket to the posterior surface of the cornea so that the lens column is located in the center of the corneal hole; S12. Suture the radial lateral corneal incision until it is watertight; S13. Rotate the bracket until it fits the anterior surface of the cornea; S14. Suturing and fixing the stent to the anterior surface of the cornea, at this time, the posterior disc and the stent clamp the cornea front and back; S15. Biological tissue or artificial material reinforced scaffold.