CN118766650A - A one-time implantable artificial cornea imitating human eyes and its use method - Google Patents

Abstract

The present invention discloses an artificial cornea that can be implanted once and imitates a human eye, and belongs to the technical field of in vivo prosthesis implantation. At least the problem that the existing artificial cornea cannot simulate the appearance of a real eye is solved. The artificial cornea includes a mirror column, a bracket and a cosmetic tray; wherein the mirror column includes a mirror column body and a rear tray coaxially arranged at a position close to the rear end face of the mirror column body; the cosmetic tray is coaxially arranged at the front end of the mirror column body; the bracket is coaxially and movably arranged on the mirror column body between the rear tray and the cosmetic tray; in the use state, the bracket and the rear tray clamp the cornea one after the other; the cosmetic tray has a hole in the center and has an iris texture area and a sclera texture area; the iris texture area is formed with an iris texture layer, and the sclera texture area is formed with a texture layer that imitates the bulbar conjunctiva blood vessels. The present invention also provides a method for using an artificial cornea that can be implanted once and imitates a human eye.

Description

A one-time implantable artificial cornea imitating human eyes and its use method

Technical Field

The invention belongs to the technical field of in vivo prosthesis implantation, and in particular relates to a one-time implantation artificial cornea imitating a human eye and a use method thereof.

Background Art

An artificial cornea refers to a special refractive device made of artificial materials, which is used to replace the cloudy cornea that blocks the optical pathway of the eye after a disease, so that the patient can regain a certain degree of vision.

Iris texture is determined by genetic genes. Each person's iris texture is unique and has a stable physiological structure. These texture features include radial stripes, spots, filaments, coronal shapes, crypts and other shapes. The cosmetic piece with iris texture pattern is placed on the patient's eye surface mainly to simulate the appearance of a real eye. However, the artificial cornea provided by the prior art only has the function of refraction and does not simulate the appearance of a real eye. The artificial cornea provided by the prior art is prone to postoperative complications such as artificial corneal anterior membrane.

In view of this, it is urgent to propose an artificial cornea that can be implanted once and imitates the human eye and a method of using the same.

Summary of the invention

The purpose of the present invention is to provide a one-time implantable artificial cornea imitating a human eye and a method of using the same, so as to simulate the appearance of a real eye and reduce postoperative complications such as anterior membrane.

In order to achieve the above object, the present invention provides the following technical solutions:

In a first aspect, the present invention provides a one-time implantable artificial cornea that imitates a human eye, comprising a lens column, a bracket and a cosmetic tray; wherein the lens column comprises a lens column body and a rear tray coaxially arranged at a position near the rear end face of the lens column body; the cosmetic tray is coaxially arranged at the front end of the lens column body; the bracket is coaxially and movably arranged on the lens column body between the rear tray and the cosmetic tray; in a state of use, the bracket and the rear tray clamp the cornea in front and back; the cosmetic tray has a hole in the center and has an iris texture area and a sclera texture area; the iris texture area forms an iris texture layer, and the sclera texture area forms a vascular texture layer that imitates the bulbar conjunctiva.

As a possible implementation method, the iris texture layer and the conjunctiva-like blood vessel texture layer are formed by image processing and 3D printing.

As a possible implementation, the iris texture layer and the conjunctival vascular texture layer are any one of a corneal contact lens, a contact lens, an iris cover lens or a cosmetic contact lens attached to a cosmetic tray.

As a possible implementation, the beauty tray is oval in shape, with a major axis of 11 mm to 26 mm and a minor axis of 5.5 mm to 11 mm.

As a possible implementation, the curvature radius of the beauty tray is 12 mm ± 3.0 mm.

As a possible implementation method, the beauty tray has a structure that is thick in the middle and thin on both sides, is made of resin, and has a maximum thickness of 0.05 to 0.5 mm.

As a possible implementation, the beauty tray is a resin beauty tray, and a notch is provided on the edge of the resin beauty tray for easy clamping.

As a possible implementation method, the beauty tray is a resin beauty tray, and the position of the mirror column body for installing the beauty tray is provided with an external thread, and the diameter is smaller than the diameter at other positions to form a limiting step; the inner wall of the central hole of the beauty tray is provided with an internal thread therewith.

As a possible implementation method, the beauty tray is made of silicone hydrogel, hydrogel ionic material, or non-ionic material, and is sleeved on the front end of the mirror column body.

As a possible implementation manner, the front end surface of the mirror column body is flush with or protrudes from the central opening of the beauty tray.

In a second aspect, the present invention further provides a method for using a human eye-like one-time implanted artificial cornea, comprising the following steps:

S10. Insert the rear end of the artificial cornea column together with the rear disc into the anterior chamber;

S11. Slide the rear plate of the bracket to the posterior surface of the cornea so that the lens column is located in the center of the corneal hole;

S12. Suture the radial lateral corneal incision until it is watertight;

S13. Rotate the bracket until it fits the anterior surface of the cornea;

S14. Suturing and fixing the stent to the anterior surface of the cornea, at this time, the posterior disc and the stent clamp the cornea front and back;

S15. Biological tissue or artificial synthetic material reinforced scaffold.

Compared with the prior art, the present invention has the following effects:

1. A beauty tray is added to the artificial cornea, and a hole is opened in the center of the beauty tray. The beauty tray has an iris texture area of the same size as the cornea. On the one hand, it will not affect the refractive function that the artificial cornea must have. On the other hand, an iris texture layer and a sclera texture layer are formed in the iris texture area, which can simulate the appearance of a real eye;

2. The cosmetic tray of the present invention can prevent biological tissue from growing into the front end surface of the lens column body, reducing the occurrence of complications such as posterior membrane;

3. Reduce tear evaporation, reduce the degree of postoperative dry eyes, and reduce medication;

4. No donor cornea is needed, and a single implantation operation can complete the treatment of corneal blindness and restoration of vision;

5. The stent is located on the outer surface of the cornea, which makes the operation less difficult, less traumatic, has a short healing period and good healing effect.

BRIEF DESCRIPTION OF THE DRAWINGS

The drawings described herein are used to provide further understanding of the present invention and constitute a part of the present invention. The exemplary embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute improper limitations on the present invention.

FIG1 is a schematic diagram of the overall structure of an artificial cornea provided by an embodiment of the present invention;

FIG2 is a schematic diagram of the structure of a mirror column provided in an embodiment of the present invention;

FIG3 is a schematic diagram of the structure of a bracket provided in an embodiment of the present invention;

FIG4 is a schematic structural diagram of a connection for a bracket provided in an embodiment of the present invention;

FIG. 5 is a schematic diagram of the structure of another bracket provided in an embodiment of the present invention.

Reference numerals:

1-mirror column, 10-mirror column body, 11-rear plate;

2-bracket, 20-bracket body, 21-connecting ring, 210-internal thread, 211-annular groove, 212-notch, 213-pinhole;

3-Beauty tray.

DETAILED DESCRIPTION

In order to clearly describe the technical solutions of the embodiments of the present invention, in the embodiments of the present invention, words such as "first" and "second" are used to distinguish the same items or similar items with basically the same functions and effects. For example, the first threshold and the second threshold are only used to distinguish different thresholds, and their order is not limited. Those skilled in the art can understand that words such as "first" and "second" do not limit the quantity and execution order, and words such as "first" and "second" do not necessarily limit them to be different.

It should be noted that, in the present invention, words such as "exemplary" or "for example" are used to indicate examples, illustrations or descriptions. Any embodiment or design described as "exemplary" or "for example" in the present invention should not be interpreted as being more preferred or more advantageous than other embodiments or designs. Specifically, the use of words such as "exemplary" or "for example" is intended to present related concepts in a specific way.

In the present invention, "at least one" means one or more, and "plurality" means two or more. "And/or" describes the association relationship of associated objects, indicating that three relationships may exist. For example, A and/or B can mean: A exists alone, A and B exist at the same time, and B exists alone, where A and B can be singular or plural. The character "/" generally indicates that the associated objects before and after are in an "or" relationship. "At least one of the following" or similar expressions refers to any combination of these items, including any combination of single or plural items. For example, at least one of a, b or c can mean: a, b, c, the combination of a and b, the combination of a and c, the combination of b and c, or the combination of a, b and c, where a, b, c can be single or multiple.

Referring to Fig. 1 and Fig. 2, an embodiment of the present invention provides a one-time implantable artificial cornea that simulates a human eye, comprising a lens column 1, a bracket 2 and a cosmetic tray 3. The lens column 1 comprises a lens column body 10 and a rear tray 11 coaxially arranged at a position close to the rear end face of the lens column body 10; the cosmetic tray 3 is coaxially arranged at the front end of the lens column body 10; the bracket 2 is coaxially and movably arranged on the lens column body 10 between the rear tray 11 and the cosmetic tray 3; in the use state, the bracket 2 and the rear tray 11 clamp the cornea in front and back; the cosmetic tray 3 has a central opening and has an iris texture area and a sclera texture area; the iris texture area is formed with an iris texture layer, and the sclera texture area is formed with a bulbar conjunctival vascular texture layer.

A cosmetic tray 3 is coaxially arranged at the front end of the lens column 1, and a texture imitating a human eye is formed on the cosmetic tray 3, so that the artificial cornea is closer to a real human eye and the aesthetics are improved. Moreover, the refractive function that the artificial cornea must have will not be affected. The cosmetic tray 3 provided in the embodiment of the present invention can prevent biological tissue from growing into the front end surface of the lens column body 10, reduce the occurrence of complications such as posterior membrane, that is, reduce the adverse effect on the refractive power of the lens column 1. The cosmetic tray 3 is equivalent to a barrier on the ocular surface and is placed outside the ocular surface, which can reduce tear evaporation, that is, it can reduce the degree of postoperative dry eyes and reduce medication.

The iris texture layer and the imitation bulbar conjunctiva blood vessel texture layer are formed by image processing and 3D printing. That is, the image processing technology is used to extract features to generate images of the iris texture layer and the imitation bulbar conjunctiva blood vessel texture layer. Then, 3D printing is used to form the iris texture layer and the imitation bulbar conjunctiva blood vessel texture layer in the corresponding area of the beauty tray 3. For example, a high molecular density resin can be formed on the front surface of the beauty tray 3 by spraying or printing.

The iris texture layer and the imitation bulbar conjunctiva blood vessel texture layer are any one of a corneal contact lens, a contact lens, an iris cover lens or a cosmetic contact lens attached to the beauty tray 3 .

The size of the cosmetic tray 3 is adapted to the size of the conjunctival sac. The cosmetic tray 3 may be an elliptical sheet structure with a certain curvature. Its major axis is 11 mm to 26 mm, and its minor axis is 5.5 mm to 11 mm. For example, the major axis is 11 mm and the minor axis is 5.5 mm, or the major axis is 26 mm and the minor axis is 11 mm.

The curvature radius of the beauty tray 3 is 12 mm ± 3.0 mm, for example, specifically 9 mm, 10 mm, 11 mm, 12 mm, 13 mm, 14 mm or 15 mm.

The beauty tray 3 is thick in the middle and thin at both sides, and is made of resin with a thickness of 0.05 to 0.5 mm. For example, the beauty tray 3 is thickest near the central hole, and its thickness is 0.05 mm, 0.06 mm, 0.07 mm, 0.08 mm, 0.09 mm, 0.1 mm, 0.2 mm, 0.3 mm, 0.4 mm or 0.5 mm.

In order to facilitate the installation of the resin beauty tray and the mirror column body 10, a notch (not shown in the figure) for easy clamping can be opened on the edge of the resin beauty tray. The notches can be spaced and evenly distributed along the circumference of the resin beauty tray.

The beauty tray 3 is a resin beauty tray. The mirror column body 10 is provided with an external thread at the position for installing the resin beauty tray, and the diameter is smaller than the diameter at other positions to form a limiting step; the inner wall of the central hole of the beauty tray 3 is provided with an internal thread therewith.

The pitch of the threaded section at the resin beauty tray installation position is different from the pitch of the threaded section at the bracket installation position, so that the resin beauty tray will not continue to rotate downward after being installed in place. That is, the threaded sections with different pitches can play a role of limiting.

The beauty tray 3 is made of silicone hydrogel, hydrogel ionic material, or non-ionic material, and is sleeved on the front end of the mirror column body 10. That is, the beauty tray 3 is a non-rigid beauty tray, in other words, the beauty tray 3 has a certain elasticity, and the diameter of the central opening of the beauty tray 3 is smaller than the diameter of the mirror column body 10 for installing the beauty tray. By using its own elasticity, the beauty tray 3 is tightly wrapped around the front end of the mirror column body. Such a setting is not only convenient for assembly, but also does not affect the refractive field of the mirror column body 10.

The front end surface of the lens column body 10 is flush with or protrudes from the central opening of the beauty tray 3 to minimize the adverse effect of the beauty tray 3 on the refractive field of the lens column body 10.

In the assembled state, the bracket 2 and the mirror column 1 can be screwed together.

The mirror column body 10 and the rear plate 11 are made of the same material and can be integrally formed, or the mirror column body 10 and the rear plate 11 can be manufactured separately and then coaxially fastened together in any manner.

The portion of the mirror column body 10 located in front of the rear plate 11 can be a cylindrical structure with equal diameters from top to bottom, and the position screwed to the bracket 2 is provided with an external thread section matching the internal thread 210 of the bracket 2 from top to bottom.

The diameter of the mirror column body 10 is smaller than that of the rear plate 11. Specifically, the diameter of the mirror column body 10 is 2.0-3.5 mm. The diameter of the rear plate 11 is 2-4 mm larger than that of the mirror column body 10, that is, the diameter of the rear plate 11 is 4-7.5 mm. For example, the diameter of the mirror column body 10 is 2 mm, and the diameter of the rear plate 11 is 4 mm; the diameter of the mirror column body 10 is 3 mm, and the diameter of the rear plate 11 is 5 mm; the diameter of the mirror column body 10 is 3.5 mm, and the diameter of the rear plate 11 is 7.5 mm.

In practical applications, the diameter of the cornea is 11 mm, the diameter of the drill hole is 2.5 mm, and the diameter of the rear plate 11 is less than or equal to the sum of the radius of the cornea and the radius of the lens column body 10.

The total length of the mirror column body 10 is 4.5-8.5 mm, of which the length from the rear disc 11 to the rear end face is 1-2 mm, the length of the optical axis from the rear disc 11 to the end of the threaded section is 0.2-0.5 mm, the length of the rear disc 11 is 0.3-0.5 mm, and the length of the threaded section is 3-5.5 mm.

The refractive power of the lens column 1 is 42-62D, for example, 42D, 45D, 50D, 55D, 60D or 62D.

The side bottom end to the rear end face of the mirror column body 10 behind the rear plate 11 is a square edge. In this way, it is difficult for biological tissues around the square edge to grow over the square edge to the rear end face, that is, it can prevent the growing biological tissues from covering the rear end face of the mirror column 1, thereby effectively avoiding the problem that the mirror column 1 cannot transmit light due to being covered by the growing biological tissues.

The square edge is one of a right angle edge, an obtuse angle edge or an acute angle edge. The mirror column body 10 behind the rear plate 11 is one of a constant diameter structure, a structure with a gradually decreasing diameter or a structure with a gradually increasing diameter.

The mirror column body 10 behind the rear plate 11 is one of a structure with a constant diameter, a structure with a gradually decreasing diameter, or a structure with a gradually increasing diameter.

The non-threaded section of the mirror column body 10 is coated with a hydroxyapatite film. When atmospheric plasma spraying is used, the coating thickness is 30 to 150 microns and the bonding strength is at least 10 MPa.

The mirror column body 10 constitutes an optical device for replacing the optical path of the eye, that is, light is imaged on the retina after passing through the mirror column body 10 .

The outer periphery of the rear disc 11 is provided with an annular outer edge forwardly, which seals the rear disc 11 and the rear surface of the cornea to prevent water leakage and infection.

The mirror column 1 is made of at least one of poly(hydroxyethyl methacrylate), poly(methyl methacrylate), bioceramics or optical glass.

3 to 5 , the bracket 2 may be a metal bracket, such as a medical titanium bracket, or a PMMA bracket, that is, the material of the bracket 2 is the same as or similar to that of the mirror column 1 .

When the bracket 2 is a metal bracket, in order to shorten the healing period between the bracket 2 and the cornea and improve the healing effect, a layer of hydroxyapatite can be plated on the surface of the bracket 2.

When the bracket 2 is a metal bracket, the one-time implantation of the artificial cornea further includes a hollow stepped shaft-shaped connecting ring 21, the material of which is the same or similar to that of the lens column 1. The inner wall of the connecting ring 21 is provided with an internal thread 210, and the front section of the lens column 1 is provided with an external thread section matching the internal thread 210. An annular groove 211 is provided at the shoulder of the outer wall of the hollow stepped shaft, and the inner wall of the central mounting hole of the bracket 2 is inserted into the annular groove 211 in an interference fit assembly manner; and the connecting ring 21 is inserted into the central mounting hole of the bracket from front to back.

When the bracket 2 and the lens column 1 are made of different materials but need to move relative to each other in a threaded connection, the metal bracket 2 will damage the threads of the lens column 1. The internal and external thread segments of the same material minimize the damage to each other caused by the rotational movement when the two undergo relative displacement changes. In addition, the connecting ring 21 is inserted into the central mounting hole of the bracket from front to back. When the bracket 2 is rotated to approach the ocular surface during surgery, the connecting ring 21 will not fall off from the central mounting hole into the eye.

When the bracket 2 and the mirror column 1 are both made of PMMA, the bracket 2 and the mirror column 1 can be directly connected without the connecting ring 21. That is, an internal thread 210 matching the external thread segment can be directly provided on the inner wall of the central mounting hole of the bracket 2.

Structurally, the support 2 can be a butterfly support, a single ring support, a double ring support (with a grid connecting piece between the outer ring and the inner ring) or a mesh support. Among them, the mesh support is convenient for the nutrient exchange of the front and back tissues.

Since the bracket 2 needs to fit the front surface of the cornea, it needs to have a certain curvature to ensure that the bracket 2 can completely fit the front surface of the cornea. In addition, the bracket 2 needs to have a certain rigidity, that is, after the bracket 2 is attached to the front surface of the cornea, it is not easy to deform or warp under force. The bracket 2 also needs to have a certain flexibility. Since the curvature of the cornea varies from patient to patient, the bracket 2 with a certain flexibility can have a certain deformation space to adapt to corneas with different curvatures.

The bracket 2 is provided with a notch 212 or a pinhole 213 for suturing and fixing. This arrangement facilitates the bracket 2 to be sutured and fixed to the ocular surface. After the radial side incision of the cornea is sutured, the human cornea is fixed to the posterior surface of the cornea, and after the bracket 2 is moved to fit the anterior surface of the cornea, the notch 212 or the pinhole 213 is used to suture the bracket 2 and the cornea.

Biological tissue or artificial synthetic material for reinforcing the bracket 2 is also sutured outside the cornea. The biological tissue covers the bracket 2 and surrounds the lens column 1. It plays the role of reinforcing the bracket 2 and the lens column 1 at the same time. The tissues are ear cartilage, Tenon's capsule and epithelial tissue from back to front. The artificial synthetic material can be hydroxyapatite or artificial bone.

In specific applications, the patient's own ear cartilage can be taken, a hole is drilled in the ear cartilage corresponding to the position of the mirror column 1, and the ear cartilage is sutured to the cornea, wrapping around the mirror column 1 and covering the bracket 2. The secondary reinforcement of the artificial cornea is achieved, making the artificial cornea more stable and not easy to dislocate. In addition, after the cornea is covered with ear cartilage, it is equivalent to covering it with a barrier, which not only plays a protective role, but also can prevent the cornea from dissolving.

The front surface of the ear cartilage is further covered with a Tenon's capsule, which is a biomass capsule on the surface of the eye and has a certain degree of flexibility and elasticity. The Tenon's capsule can be used to achieve three reinforcements of the artificial cornea.

The outer circumference size of the bracket 2 is 8.5 mm to 10 mm. For example, the outer circumference size of the bracket 2 is 8.5 mm, 9.0 mm, 9.5 mm or 10 mm.

The curvature radius of the bracket 2 is 7.8 mm ± 2.0 mm. For example, the curvature radius of the bracket 2 is 5.8 mm, 6.8 mm, 7.8 mm, 8.8 mm or 9.8 mm.

The artificial cornea provided by the present invention is implanted into the eyes of patients with severe corneal blindness in the following manner to achieve the purpose of restoring sight: a hole is drilled in the center of the patient's cornea, and a side cut is made on one side of the hole to form a radial side incision of the cornea, thereby improving the surgical field of view, facilitating the complete removal of the lens, or solving the problem of residual lens cortex in the prior art.

After the lens is removed and the anterior vitreous body is removed, the posterior disc 11 included in the artificial cornea is implanted into the above-mentioned drilled hole, that is, the posterior disc 11 enters the cornea through the radial side incision of the cornea and fits with its rear surface. At this time, the radial side incision of the cornea can be sutured to preliminarily fix the lens column 1. On this basis, the bracket 2 is rotated to move the bracket 2 backward. When the bracket 2 fits with the front surface of the cornea, the bracket 2 and the posterior disc 11 are clamped on the cornea one after the other, and the bracket 2 and the cornea are sutured together to achieve the fixation of the bracket 2 on the ocular surface.

From the above application process, it can be known that the artificial cornea provided by the present invention only requires one operation to complete the treatment of corneal blindness and restoration of vision, shortening the operation period, and reducing the patient's anxiety of waiting and the pain of multiple operations. Moreover, the initial fixation of the bracket 2 is achieved by using the patient's own cornea, without the need for a donor cornea, which can completely avoid the lack of donor corneas and rejection of allogeneic corneal transplants. In addition, the bracket 2 is located on the front surface of the cornea. Compared with the bracket provided by the prior art that is implanted in the corneal lamella, the difficulty and risk of the operation are greatly reduced, the trauma is small, the healing period is short, and the healing effect is good.

In practical applications, when the rear disc 11 and the mirror column body 10 are integrally formed, they are assembled together in the following manner:

a. Insert the connecting ring 21 into the center mounting hole of the bracket 2 from top to bottom;

b. The front end of the mirror column body 10 penetrates the internal thread 210 of the connecting ring 21 (or the internal thread hole of the central mounting hole), and the mirror column body 20 and the bracket 2 are rotated in opposite directions to move the bracket 2 along the axial direction of the mirror column body 10 toward the direction close to the rear plate 11;

c. A beauty tray is coaxially mounted at the front end of the mirror column body 10.

When the material of the bracket is the same as that of the mirror column, the connecting ring is omitted, and the bracket with internal threads is directly connected to the mirror column body.

In a second aspect, the embodiment of the present invention also provides a method for using an artificial cornea that is implanted once. Before using the artificial cornea provided by the embodiment of the present invention, it is first necessary to determine that the implantation position is located in the center of the cornea, drill a hole in the center of the cornea with a trephine, and make a radial side incision of the cornea. The method of use comprises the following steps:

S10. Implant the rear end of the artificial cornea column together with the posterior disc into the anterior chamber;

S11. Slide the rear disc of the bracket to the rear surface of the center of the cornea;

S12. Suture the radial lateral corneal incision until it is watertight;

S13. Rotate the bracket until it fits against the anterior surface of the cornea;

S14. Suture and fix the stent to the anterior surface of the eyeball. At this time, the posterior disc and the stent clamp the cornea front and back;

S15. Biological tissue or artificial material reinforced scaffold.

As an example, S15 specifically includes:

S150. Take the patient's ear cartilage, and drill a hole in the ear cartilage corresponding to the mirror column body. Pass the ear cartilage through the hole to wrap around the mirror column body and cover the bracket, and suture the ear cartilage and cornea at the same time.

S151. Flatten the Tenon's capsule and cover it on the surface of the ear cartilage, and sew it together with the ear cartilage.

Although the present invention is described herein in conjunction with various embodiments, in the process of implementing the claimed invention, those skilled in the art may understand and implement other variations of the disclosed embodiments by viewing the drawings, the disclosure, and the drawings, etc. In the specification, the word "comprising" does not exclude other components or steps, and "one" or "an" does not exclude multiple situations. A single processor or other unit can implement several functions listed in the specification. Certain measures are recorded in different embodiments, but this does not mean that these measures cannot be combined to produce good results.

Although the present invention has been described in conjunction with specific features and embodiments thereof, it is apparent that various modifications and combinations may be made thereto without departing from the spirit and scope of the present invention. Accordingly, this specification and the accompanying drawings are merely exemplary illustrations of the present invention and are deemed to cover any and all modifications, variations, combinations or equivalents within the scope of the present invention. Obviously, those skilled in the art may make various modifications and variations to the present invention without departing from the spirit and scope of the present invention. Thus, the present invention is intended to include such modifications and variations if they fall within the scope of the present invention and its equivalents.

Claims (10)

1. The artificial cornea is implanted once by imitating human eyes and is characterized by comprising a lens column, a bracket and a cosmetic disc; the lens column comprises a lens column body and a rear disc coaxially arranged at the position, close to the rear end face, of the lens column body; the cosmetic disc is coaxially arranged at the front end of the mirror column body; the support is coaxially and movably arranged on the lens column body between the rear disc and the cosmetic disc; in the use state, the cornea is clamped by the bracket and the rear disc in tandem; the beauty disc is provided with a central opening and an iris texture area and a texture area; the iris texture region is formed with an iris texture layer, and the scleral texture region is formed with a bulbar conjunctiva blood vessel imitation texture layer.

2. The one-time human eye-simulated artificial cornea of claim 1, wherein the iris texture layer and the bulbar conjunctiva blood vessel texture layer are formed by image processing and 3D printing; or alternatively, the first and second heat exchangers may be,

The iris texture layer and the bulbar conjunctiva blood vessel imitation texture layer are at least one of a cornea contact lens, a contact lens, an iris shading plate or a pupil beauty attached to the cosmetic disc.

3. The one-time implantation artificial cornea of human eye according to claim 1, wherein said cosmetic disc is elliptical, has a major axis of 11mm to 26mm and a minor axis of 5.5mm to 11mm.

4. The human-simulated eye one-time implantation keratoprosthesis of claim 1, wherein the cosmetic disc has a radius of curvature of 12mm ± 3.0mm.

5. The artificial cornea of claim 1, wherein the cosmetic disc has a structure with a thick middle and two thin sides, is made of resin, and has a maximum thickness of 0.05-0.5 mm.

6. The artificial cornea of claim 1, wherein the cosmetic disc is a resin cosmetic disc, and the edge of the resin cosmetic disc is provided with a notch for facilitating clamping.

7. The artificial cornea of claim 1, wherein the cosmetic disc is a resin cosmetic disc, and the position of the lens column body for installing the cosmetic disc is provided with external threads, and the diameter of the lens column body is smaller than that of other positions, so as to form a limit step; the inner wall of the central hole of the cosmetic disc is provided with an internal thread.

8. The one-time implantation artificial cornea for a human eye according to claim 1, wherein the cosmetic disc is made of silicon hydrogel, hydrogel ionic material and nonionic material, and is sleeved on the front end of the lens column body.

9. The artificial cornea of claim 1, wherein the front face of the lens post body is flush with or protrudes from the central opening of the cosmetic disc.

10. The application method of the artificial cornea for one-time implantation of the human-simulated eye is characterized by comprising the following steps:

s10, the rear end of the artificial cornea mirror column and the rear disc enter an anterior chamber;

S11, sliding and moving a rear disc of the bracket to the rear surface of the cornea, so that the lens column is positioned in the center of the cornea drilling hole;

s12, suturing the radial side incision of the cornea to be watertight;

S13, rotating the bracket until the bracket is attached to the front surface of the cornea;

S14, suturing and fixing the bracket on the front surface of the cornea, and clamping the cornea front and back by the rear disc and the bracket at the moment;

s15, reinforcing the bracket by biological tissues or artificial synthetic materials.