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CN109661395A - Pde4抑制剂 - Google Patents

Pde4抑制剂 Download PDF

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Publication number
CN109661395A
CN109661395A CN201780051434.6A CN201780051434A CN109661395A CN 109661395 A CN109661395 A CN 109661395A CN 201780051434 A CN201780051434 A CN 201780051434A CN 109661395 A CN109661395 A CN 109661395A
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China
Prior art keywords
compound
pharmaceutically acceptable
room temperature
acceptable salt
alkyl
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Application number
CN201780051434.6A
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English (en)
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CN109661395B (zh
Inventor
罗云富
杨纯道
雷茂义
刘玲
胡国平
黎健
陈曙辉
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Medshine Discovery Inc
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Medshine Discovery Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

提供一种PDE4抑制剂，及其在制备治疗与PDE4相关疾病的药物中的应用。具体公开了式(Ⅰ)所示化合物及其药学上可接受的盐。

Description

PCT国内申请，说明书已公开。

Claims (26)

  1. PCT国内申请，权利要求书已公开。
CN201780051434.6A 2016-08-22 2017-08-22 Pde4抑制剂 Active CN109661395B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201610700714 2016-08-22
CN2016107007142 2016-08-22
PCT/CN2017/098461 WO2018036469A1 (zh) 2016-08-22 2017-08-22 Pde4抑制剂

Publications (2)

Publication Number Publication Date
CN109661395A true CN109661395A (zh) 2019-04-19
CN109661395B CN109661395B (zh) 2020-09-01

Family

ID=61246401

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780051434.6A Active CN109661395B (zh) 2016-08-22 2017-08-22 Pde4抑制剂

Country Status (9)

Country Link
US (1) US10662189B2 (zh)
EP (1) EP3502111B1 (zh)
JP (1) JP7029444B2 (zh)
CN (1) CN109661395B (zh)
AU (1) AU2017317123B9 (zh)
CA (1) CA3034785C (zh)
RU (1) RU2743126C9 (zh)
WO (1) WO2018036469A1 (zh)
ZA (1) ZA201901773B (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111683949A (zh) * 2018-01-29 2020-09-18 石家庄智康弘仁新药开发有限公司 一种1H-咪唑并[4,5-b]吡啶-2(3H)-酮类化合物的晶型及其制备方法

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY207239A (en) * 2018-09-13 2025-02-08 Kissei Pharmaceutical Imidazopyridinone compound
WO2021169913A1 (zh) 2020-02-24 2021-09-02 苏州隆博泰药业有限公司 Pde4抑制剂化合物及其医药用途
JP7504822B2 (ja) * 2020-03-12 2024-06-24 キッセイ薬品工業株式会社 イミダゾピリジノン化合物を含む医薬組成物
CN112876403B (zh) * 2021-01-27 2022-10-21 成都摩尔生物医药有限公司 一种阿普斯特杂质的制备方法
US20240208969A1 (en) * 2021-04-12 2024-06-27 Impact Therapeutics (Shanghai), Inc. Substituted fused bicyclic compounds as parp inhibitors and the use thereof
CN119161297A (zh) * 2024-09-18 2024-12-20 浙江工业大学 一种4-溴-6-氯烟酸甲酯的制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101119996A (zh) * 2005-02-16 2008-02-06 阿斯利康(瑞典)有限公司 化学化合物
CN101573360A (zh) * 2006-10-19 2009-11-04 西格诺药品有限公司 杂芳基化合物、其组合物以及它们作为蛋白激酶抑制剂的用途
WO2010030500A1 (en) * 2008-09-09 2010-03-18 Boehringer Ingelheim International Gmbh Aza-benzimidazolone chymase inhibitors
WO2011021678A1 (ja) * 2009-08-21 2011-02-24 武田薬品工業株式会社 縮合複素環化合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6667316B1 (en) * 1999-11-12 2003-12-23 Celgene Corporation Pharmaceutically active isoindoline derivatives
BRPI0519030A2 (pt) * 2004-12-13 2008-12-23 Celgene Corp mÉtodos de tratamento, prevenÇço, ou controle de inflamaÇço das vias aÉreas e de uma doenÇa ou distérbio das vias aÉreas ou pulmonar, e, composiÇço farmacÊutica
WO2006087538A1 (en) 2005-02-16 2006-08-24 Astrazeneca Ab Chemical compounds
GB0525143D0 (en) * 2005-12-09 2006-01-18 Novartis Ag Organic compounds
EP3142663A1 (en) * 2014-05-16 2017-03-22 Celgene Corporation Compositions and methods for the treatment of atherosclerotic cardiovascular diseases with pde4 modulators

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101119996A (zh) * 2005-02-16 2008-02-06 阿斯利康(瑞典)有限公司 化学化合物
CN101573360A (zh) * 2006-10-19 2009-11-04 西格诺药品有限公司 杂芳基化合物、其组合物以及它们作为蛋白激酶抑制剂的用途
WO2010030500A1 (en) * 2008-09-09 2010-03-18 Boehringer Ingelheim International Gmbh Aza-benzimidazolone chymase inhibitors
WO2011021678A1 (ja) * 2009-08-21 2011-02-24 武田薬品工業株式会社 縮合複素環化合物

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DAY,JONATHAN P.等: ""Elucidation of a Structural Basis for the Inhibitor-Driven,p62(SQSTM1)-Dependent Intracellular Redistribution of cAMP Phosphodiesterase-4A4(PDE4A4)"", 《JOURNAL OF MEDICINAL CHEMISTRY》 *
RAEWYN M. POOLE等: ""Apremilast: First Global Approval"", 《DRUGS》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111683949A (zh) * 2018-01-29 2020-09-18 石家庄智康弘仁新药开发有限公司 一种1H-咪唑并[4,5-b]吡啶-2(3H)-酮类化合物的晶型及其制备方法
CN111683949B (zh) * 2018-01-29 2023-03-21 南京明德新药研发有限公司 一种1H-咪唑并[4,5-b]吡啶-2(3H)-酮类化合物的晶型及其制备方法

Also Published As

Publication number Publication date
AU2017317123B9 (en) 2021-11-25
CN109661395B (zh) 2020-09-01
EP3502111A4 (en) 2020-05-20
US10662189B2 (en) 2020-05-26
RU2743126C9 (ru) 2021-04-27
EP3502111A1 (en) 2019-06-26
RU2019108189A (ru) 2020-09-22
WO2018036469A1 (zh) 2018-03-01
RU2019108189A3 (zh) 2020-09-22
CA3034785A1 (en) 2018-03-01
EP3502111B1 (en) 2022-07-27
JP7029444B2 (ja) 2022-04-07
JP2019528298A (ja) 2019-10-10
CA3034785C (en) 2022-11-15
US20190177318A1 (en) 2019-06-13
AU2017317123B2 (en) 2021-07-29
ZA201901773B (en) 2021-08-25
RU2743126C2 (ru) 2021-02-15
AU2017317123A1 (en) 2019-04-11

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