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CN1093535C - 咪唑衍生物 - Google Patents

咪唑衍生物 Download PDF

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Publication number
CN1093535C
CN1093535C CN95195260A CN95195260A CN1093535C CN 1093535 C CN1093535 C CN 1093535C CN 95195260 A CN95195260 A CN 95195260A CN 95195260 A CN95195260 A CN 95195260A CN 1093535 C CN1093535 C CN 1093535C
Authority
CN
China
Prior art keywords
propyl
imidazoles
sec
sulfo
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN95195260A
Other languages
English (en)
Chinese (zh)
Other versions
CN1158609A (zh
Inventor
杉本裕彦
藤原民雄
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of CN1158609A publication Critical patent/CN1158609A/zh
Application granted granted Critical
Publication of CN1093535C publication Critical patent/CN1093535C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Dental Preparations (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
CN95195260A 1994-09-26 1995-09-25 咪唑衍生物 Expired - Fee Related CN1093535C (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP25749094 1994-09-26
JP257490/94 1994-09-26
JP8469095 1995-03-15
JP84690/95 1995-03-15
JP227205/95 1995-08-12
JP22720595 1995-08-12

Publications (2)

Publication Number Publication Date
CN1158609A CN1158609A (zh) 1997-09-03
CN1093535C true CN1093535C (zh) 2002-10-30

Family

ID=27304632

Family Applications (1)

Application Number Title Priority Date Filing Date
CN95195260A Expired - Fee Related CN1093535C (zh) 1994-09-26 1995-09-25 咪唑衍生物

Country Status (20)

Country Link
US (2) US5910506A (ja)
EP (1) EP0786455B1 (ja)
JP (1) JP3155009B2 (ja)
KR (1) KR100387157B1 (ja)
CN (1) CN1093535C (ja)
AT (1) ATE255564T1 (ja)
BR (1) BR9509024A (ja)
CA (1) CA2200316C (ja)
DE (1) DE69532245T2 (ja)
DK (1) DK0786455T3 (ja)
ES (1) ES2211917T3 (ja)
FI (1) FI971234A7 (ja)
HU (1) HUT77357A (ja)
MX (1) MX9702030A (ja)
NO (1) NO308739B1 (ja)
PL (1) PL183931B1 (ja)
PT (1) PT786455E (ja)
RU (1) RU2157368C2 (ja)
TW (1) TW401404B (ja)
WO (1) WO1996010019A1 (ja)

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RU2188638C2 (ru) * 1996-04-04 2002-09-10 Шионоги Энд Ко., Лтд. Анти-вич-композиция, содержащая имидазольные производные
US6018049A (en) * 1996-12-26 2000-01-25 Shionogi & Co., Ltd. Process for the preparation of carbamoylated imidazole derivatives
KR100399463B1 (ko) * 1996-12-26 2003-09-29 시오노기세이야쿠가부시키가이샤 이미다졸 유도체의 제조 방법
TWI232214B (en) 1998-04-16 2005-05-11 Shionogi & Co Preparation of aryl sulfenyl halide
WO2000061109A1 (fr) 1999-04-12 2000-10-19 Shionogi & Co., Ltd. Procede de production de composition medicamenteuse renfermant un compose medicamenteux hydrophobe basique
GB0016787D0 (en) 2000-07-07 2000-08-30 Pfizer Ltd Compounds useful in therapy
EP1377568A1 (en) 2001-01-31 2004-01-07 Warner-Lambert Company LLC Method for carbamoylating alcohols
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AU2002242926B2 (en) 2001-04-10 2007-10-11 Pfizer Inc. Pyrazole derivatives for treating HIV
GB0113524D0 (en) 2001-06-04 2001-07-25 Hoffmann La Roche Pyrazole derivatives
FR2825926A1 (fr) * 2001-06-14 2002-12-20 Sod Conseils Rech Applic Derives d'imidazoles modulant les canaux sodiques
KR100696561B1 (ko) * 2002-04-23 2007-03-19 에프. 호프만-라 로슈 아게 이미다졸린일메틸 아르알킬설폰아마이드
TWI332956B (en) 2002-04-26 2010-11-11 Gilead Sciences Inc Cellular accumulation of phosphonate analogs of hiv protease inhibitor compounds
TW200423930A (en) 2003-02-18 2004-11-16 Hoffmann La Roche Non-nucleoside reverse transcriptase inhibitors
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WO2004096285A2 (en) 2003-04-25 2004-11-11 Gilead Sciences, Inc. Anti-infective phosphonate conjugates
WO2005002626A2 (en) 2003-04-25 2005-01-13 Gilead Sciences, Inc. Therapeutic phosphonate compounds
US7427636B2 (en) 2003-04-25 2008-09-23 Gilead Sciences, Inc. Inosine monophosphate dehydrogenase inhibitory phosphonate compounds
US7407965B2 (en) 2003-04-25 2008-08-05 Gilead Sciences, Inc. Phosphonate analogs for treating metabolic diseases
US7432261B2 (en) 2003-04-25 2008-10-07 Gilead Sciences, Inc. Anti-inflammatory phosphonate compounds
US7452901B2 (en) 2003-04-25 2008-11-18 Gilead Sciences, Inc. Anti-cancer phosphonate analogs
AU2004233898B2 (en) 2003-04-25 2010-12-23 Gilead Sciences, Inc. Antiviral phosphonate analogs
EP1620109A2 (en) 2003-04-25 2006-02-01 Gilead Sciences, Inc. Kinase inhibitor phosphonate conjugates
US7470724B2 (en) 2003-04-25 2008-12-30 Gilead Sciences, Inc. Phosphonate compounds having immuno-modulatory activity
WO2005016912A1 (en) * 2003-08-19 2005-02-24 Pfizer Inc. An efficient microbial preparation of capravirine metabolites m4 and m5
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Citations (2)

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Publication number Priority date Publication date Assignee Title
EP0552060A1 (en) * 1992-01-16 1993-07-21 Shionogi & Co., Ltd. Imidazole derivatives having anti-HIV activity
JP4077791B2 (ja) * 2001-07-16 2008-04-23 ブラウン・ウント・ビュルフェレ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング・ウント・コンパニー 木製建築部品を接合するための固定ブラケット

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Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
EP0552060A1 (en) * 1992-01-16 1993-07-21 Shionogi & Co., Ltd. Imidazole derivatives having anti-HIV activity
JP4077791B2 (ja) * 2001-07-16 2008-04-23 ブラウン・ウント・ビュルフェレ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング・ウント・コンパニー 木製建築部品を接合するための固定ブラケット

Also Published As

Publication number Publication date
KR970706260A (ko) 1997-11-03
EP0786455A1 (en) 1997-07-30
AU4788896A (en) 1996-04-19
JP3155009B2 (ja) 2001-04-09
FI971234L (fi) 1997-05-23
HUT77357A (hu) 1998-03-30
NO971306D0 (no) 1997-03-20
NO308739B1 (no) 2000-10-23
AU706095B2 (en) 1999-06-10
FI971234A0 (fi) 1997-03-25
PL183931B1 (pl) 2002-08-30
BR9509024A (pt) 1997-09-30
MX9702030A (es) 1997-06-28
US6147097A (en) 2000-11-14
PT786455E (pt) 2004-02-27
EP0786455B1 (en) 2003-12-03
WO1996010019A1 (en) 1996-04-04
TW401404B (en) 2000-08-11
DK0786455T3 (da) 2004-03-29
CN1158609A (zh) 1997-09-03
PL320009A1 (en) 1997-09-01
KR100387157B1 (ko) 2003-09-29
ATE255564T1 (de) 2003-12-15
FI971234A7 (fi) 1997-05-23
DE69532245D1 (en) 2004-01-15
EP0786455A4 (en) 1998-12-30
ES2211917T3 (es) 2004-07-16
CA2200316A1 (en) 1996-04-04
US5910506A (en) 1999-06-08
CA2200316C (en) 2004-09-21
DE69532245T2 (de) 2004-09-16
RU2157368C2 (ru) 2000-10-10
NO971306L (no) 1997-05-21

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