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NO308739B1 - Imidazolderivater samt medisinsk sammensetning og anti-HIV- sammensetning omfattende samme - Google Patents

Imidazolderivater samt medisinsk sammensetning og anti-HIV- sammensetning omfattende samme

Info

Publication number
NO308739B1
NO308739B1 NO971306A NO971306A NO308739B1 NO 308739 B1 NO308739 B1 NO 308739B1 NO 971306 A NO971306 A NO 971306A NO 971306 A NO971306 A NO 971306A NO 308739 B1 NO308739 B1 NO 308739B1
Authority
NO
Norway
Prior art keywords
composition
alkyl
hiv
well
same
Prior art date
Application number
NO971306A
Other languages
English (en)
Norwegian (no)
Other versions
NO971306L (no
NO971306D0 (no
Inventor
Hirohiko Sugimoto
Tamio Fujiwara
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of NO971306D0 publication Critical patent/NO971306D0/no
Publication of NO971306L publication Critical patent/NO971306L/no
Publication of NO308739B1 publication Critical patent/NO308739B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Dental Preparations (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
NO971306A 1994-09-26 1997-03-20 Imidazolderivater samt medisinsk sammensetning og anti-HIV- sammensetning omfattende samme NO308739B1 (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP25749094 1994-09-26
JP8469095 1995-03-15
JP22720595 1995-08-12
PCT/JP1995/001936 WO1996010019A1 (en) 1994-09-26 1995-09-25 Imidazole derivative

Publications (3)

Publication Number Publication Date
NO971306D0 NO971306D0 (no) 1997-03-20
NO971306L NO971306L (no) 1997-05-21
NO308739B1 true NO308739B1 (no) 2000-10-23

Family

ID=27304632

Family Applications (1)

Application Number Title Priority Date Filing Date
NO971306A NO308739B1 (no) 1994-09-26 1997-03-20 Imidazolderivater samt medisinsk sammensetning og anti-HIV- sammensetning omfattende samme

Country Status (20)

Country Link
US (2) US5910506A (ja)
EP (1) EP0786455B1 (ja)
JP (1) JP3155009B2 (ja)
KR (1) KR100387157B1 (ja)
CN (1) CN1093535C (ja)
AT (1) ATE255564T1 (ja)
BR (1) BR9509024A (ja)
CA (1) CA2200316C (ja)
DE (1) DE69532245T2 (ja)
DK (1) DK0786455T3 (ja)
ES (1) ES2211917T3 (ja)
FI (1) FI971234L (ja)
HU (1) HUT77357A (ja)
MX (1) MX9702030A (ja)
NO (1) NO308739B1 (ja)
PL (1) PL183931B1 (ja)
PT (1) PT786455E (ja)
RU (1) RU2157368C2 (ja)
TW (1) TW401404B (ja)
WO (1) WO1996010019A1 (ja)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
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WO1997035843A1 (en) * 1996-03-28 1997-10-02 Shionogi & Co., Ltd. Lymph-absorbable imidazole derivatives
PL187925B1 (pl) * 1996-04-04 2004-11-30 Shionogi & Co Kompozycja farmaceutyczna przeciw HIV
RU2188638C2 (ru) * 1996-04-04 2002-09-10 Шионоги Энд Ко., Лтд. Анти-вич-композиция, содержащая имидазольные производные
ATE299498T1 (de) * 1996-12-26 2005-07-15 Shionogi & Co Verfahren zur herstellung von imidazolderivaten
DE69728180T2 (de) 1996-12-26 2005-03-17 Shionogi & Co., Ltd. Verfahren zur herstellung von carbamoylsubstituierten imidazolderivaten
TWI232214B (en) 1998-04-16 2005-05-11 Shionogi & Co Preparation of aryl sulfenyl halide
WO2000061109A1 (fr) 1999-04-12 2000-10-19 Shionogi & Co., Ltd. Procede de production de composition medicamenteuse renfermant un compose medicamenteux hydrophobe basique
GB0016787D0 (en) * 2000-07-07 2000-08-30 Pfizer Ltd Compounds useful in therapy
BR0206806A (pt) 2001-01-31 2004-02-03 Warner Lambert Co Método para carbamoilação de álcoois
KR100732581B1 (ko) 2001-02-23 2007-06-27 케이.유.루벤 리서치 앤드 디벨럽먼트 Hiv 억제 n-아미노이미다졸 유도체
PT1377556E (pt) 2001-04-10 2007-06-06 Pfizer Ltd Derivados de pirazole para tratamento do hiv
GB0113524D0 (en) * 2001-06-04 2001-07-25 Hoffmann La Roche Pyrazole derivatives
FR2825926A1 (fr) * 2001-06-14 2002-12-20 Sod Conseils Rech Applic Derives d'imidazoles modulant les canaux sodiques
RU2318814C2 (ru) * 2002-04-23 2008-03-10 Ф.Хоффманн-Ля Рош Аг Имидазолинилметиларалкилсульфонамиды
EA008775B1 (ru) 2002-04-26 2007-08-31 Джилид Сайэнс, Инк. Ингибиторы протеазы вич для лечения инфекции вич и фармацевтическая композиция
TW200423930A (en) 2003-02-18 2004-11-16 Hoffmann La Roche Non-nucleoside reverse transcriptase inhibitors
CA2518823A1 (en) 2003-03-24 2004-10-07 F.Hoffmann-La Roche Ag Benzyl-pyridazinons as reverse transcriptase inhibitors
US7470724B2 (en) 2003-04-25 2008-12-30 Gilead Sciences, Inc. Phosphonate compounds having immuno-modulatory activity
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US7427636B2 (en) 2003-04-25 2008-09-23 Gilead Sciences, Inc. Inosine monophosphate dehydrogenase inhibitory phosphonate compounds
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US7407965B2 (en) 2003-04-25 2008-08-05 Gilead Sciences, Inc. Phosphonate analogs for treating metabolic diseases
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KR100749566B1 (ko) * 2004-04-21 2007-08-16 이화여자대학교 산학협력단 Alk5 및/또는 alk4 억제제로 유효한 2-피리딜이치환된 이미다졸 유도체
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DE10230797C2 (de) * 2001-07-16 2003-09-25 Dieter Reif Befestigungsklammer zur Verbindung von Holzbauteilen

Also Published As

Publication number Publication date
DE69532245D1 (en) 2004-01-15
MX9702030A (es) 1997-06-28
NO971306L (no) 1997-05-21
TW401404B (en) 2000-08-11
FI971234A0 (fi) 1997-03-25
BR9509024A (pt) 1997-09-30
EP0786455A1 (en) 1997-07-30
EP0786455A4 (en) 1998-12-30
CA2200316C (en) 2004-09-21
PL320009A1 (en) 1997-09-01
RU2157368C2 (ru) 2000-10-10
EP0786455B1 (en) 2003-12-03
PL183931B1 (pl) 2002-08-30
HUT77357A (hu) 1998-03-30
DE69532245T2 (de) 2004-09-16
FI971234A7 (fi) 1997-05-23
AU4788896A (en) 1996-04-19
KR100387157B1 (ko) 2003-09-29
US6147097A (en) 2000-11-14
US5910506A (en) 1999-06-08
JP3155009B2 (ja) 2001-04-09
KR970706260A (ko) 1997-11-03
AU706095B2 (en) 1999-06-10
ATE255564T1 (de) 2003-12-15
PT786455E (pt) 2004-02-27
WO1996010019A1 (en) 1996-04-04
NO971306D0 (no) 1997-03-20
CN1093535C (zh) 2002-10-30
FI971234L (fi) 1997-05-23
CN1158609A (zh) 1997-09-03
CA2200316A1 (en) 1996-04-04
ES2211917T3 (es) 2004-07-16
DK0786455T3 (da) 2004-03-29

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