[go: up one dir, main page]

NO971306D0 - Imidazolderivater - Google Patents

Imidazolderivater

Info

Publication number
NO971306D0
NO971306D0 NO971306A NO971306A NO971306D0 NO 971306 D0 NO971306 D0 NO 971306D0 NO 971306 A NO971306 A NO 971306A NO 971306 A NO971306 A NO 971306A NO 971306 D0 NO971306 D0 NO 971306D0
Authority
NO
Norway
Prior art keywords
alkyl
halogeno
formula
imidazole
hydrogen
Prior art date
Application number
NO971306A
Other languages
English (en)
Other versions
NO308739B1 (no
NO971306L (no
Inventor
Hirohiko Sugimoto
Tamio Fujiwara
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of NO971306D0 publication Critical patent/NO971306D0/no
Publication of NO971306L publication Critical patent/NO971306L/no
Publication of NO308739B1 publication Critical patent/NO308739B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Dental Preparations (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO971306A 1994-09-26 1997-03-20 Imidazolderivater samt medisinsk sammensetning og anti-HIV- sammensetning omfattende samme NO308739B1 (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP25749094 1994-09-26
JP8469095 1995-03-15
JP22720595 1995-08-12
PCT/JP1995/001936 WO1996010019A1 (en) 1994-09-26 1995-09-25 Imidazole derivative

Publications (3)

Publication Number Publication Date
NO971306D0 true NO971306D0 (no) 1997-03-20
NO971306L NO971306L (no) 1997-05-21
NO308739B1 NO308739B1 (no) 2000-10-23

Family

ID=27304632

Family Applications (1)

Application Number Title Priority Date Filing Date
NO971306A NO308739B1 (no) 1994-09-26 1997-03-20 Imidazolderivater samt medisinsk sammensetning og anti-HIV- sammensetning omfattende samme

Country Status (20)

Country Link
US (2) US5910506A (no)
EP (1) EP0786455B1 (no)
JP (1) JP3155009B2 (no)
KR (1) KR100387157B1 (no)
CN (1) CN1093535C (no)
AT (1) ATE255564T1 (no)
BR (1) BR9509024A (no)
CA (1) CA2200316C (no)
DE (1) DE69532245T2 (no)
DK (1) DK0786455T3 (no)
ES (1) ES2211917T3 (no)
FI (1) FI971234L (no)
HU (1) HUT77357A (no)
MX (1) MX9702030A (no)
NO (1) NO308739B1 (no)
PL (1) PL183931B1 (no)
PT (1) PT786455E (no)
RU (1) RU2157368C2 (no)
TW (1) TW401404B (no)
WO (1) WO1996010019A1 (no)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69732230T2 (de) * 1996-03-28 2005-12-22 Shionogi & Co., Ltd. Durch lymphe absorbierbare imidazolderivate
RU2188638C2 (ru) * 1996-04-04 2002-09-10 Шионоги Энд Ко., Лтд. Анти-вич-композиция, содержащая имидазольные производные
WO1997037657A1 (en) * 1996-04-04 1997-10-16 Shionogi & Co., Ltd. Anti-hiv composition containing imidazole derivative
EP0949249B1 (en) * 1996-12-26 2005-07-13 Shionogi & Co., Ltd. Process for producing imidazole derivatives
EP0994106B1 (en) 1996-12-26 2004-03-17 Shionogi & Co., Ltd. Process for the preparation of carbamoylated imidazole derivatives
TWI232214B (en) * 1998-04-16 2005-05-11 Shionogi & Co Preparation of aryl sulfenyl halide
EP1172097B1 (en) 1999-04-12 2004-09-08 Shionogi & Co., Ltd. Process for producing medicinal composition of a basic hydrophobic medicinal compound
GB0016787D0 (en) * 2000-07-07 2000-08-30 Pfizer Ltd Compounds useful in therapy
CZ20032001A3 (en) 2001-01-31 2004-06-16 Warner-Lambert Company Llc Method for carbamoylating alcohols
TR200301890T2 (tr) * 2001-02-23 2004-12-21 K. U. Leuven Research & Development HIV-İnhibe edici N-Aminoimidazol türevleri.
BRPI0208811B8 (pt) 2001-04-10 2021-05-25 Pfizer derivados de pirazol, seu uso e processo de preparação, bem como composição farmacêutica compreendendo os mesmos
GB0113524D0 (en) 2001-06-04 2001-07-25 Hoffmann La Roche Pyrazole derivatives
FR2825926A1 (fr) * 2001-06-14 2002-12-20 Sod Conseils Rech Applic Derives d'imidazoles modulant les canaux sodiques
NZ535823A (en) * 2002-04-23 2007-07-27 Hoffmann La Roche Imidazolin-2-ylmethyl substituted aralkylsulfonamides
NZ535828A (en) 2002-04-26 2007-10-26 Gilead Sciences Inc Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds and the compounds as such
TW200423930A (en) 2003-02-18 2004-11-16 Hoffmann La Roche Non-nucleoside reverse transcriptase inhibitors
MXPA05010081A (es) 2003-03-24 2005-11-23 Hoffmann La Roche Bencil-piridazinonas como inhibidores de transcriptasa inversa.
DK1628685T3 (da) 2003-04-25 2011-03-21 Gilead Sciences Inc Antivirale phosphonatanaloge
WO2004096287A2 (en) 2003-04-25 2004-11-11 Gilead Sciences, Inc. Inosine monophosphate dehydrogenase inhibitory phosphonate compounds
US7470724B2 (en) 2003-04-25 2008-12-30 Gilead Sciences, Inc. Phosphonate compounds having immuno-modulatory activity
WO2004096285A2 (en) 2003-04-25 2004-11-11 Gilead Sciences, Inc. Anti-infective phosphonate conjugates
US7452901B2 (en) 2003-04-25 2008-11-18 Gilead Sciences, Inc. Anti-cancer phosphonate analogs
WO2005002626A2 (en) 2003-04-25 2005-01-13 Gilead Sciences, Inc. Therapeutic phosphonate compounds
EA200501676A1 (ru) 2003-04-25 2006-04-28 Джилид Сайэнс, Инк. Фосфонатсодержащие ингибиторы киназы (варианты), способ их получения, фармацевтическая композиция, лекарственная форма на их основе и способ ингибирования киназы у млекопитающего (варианты)
US7407965B2 (en) 2003-04-25 2008-08-05 Gilead Sciences, Inc. Phosphonate analogs for treating metabolic diseases
US7432261B2 (en) 2003-04-25 2008-10-07 Gilead Sciences, Inc. Anti-inflammatory phosphonate compounds
WO2005016912A1 (en) * 2003-08-19 2005-02-24 Pfizer Inc. An efficient microbial preparation of capravirine metabolites m4 and m5
CA2543142A1 (en) 2003-10-24 2005-05-12 Gilead Sciences, Inc. Methods and compositions for identifying therapeutic compounds
US7432273B2 (en) 2003-10-24 2008-10-07 Gilead Sciences, Inc. Phosphonate analogs of antimetabolites
US7427624B2 (en) 2003-10-24 2008-09-23 Gilead Sciences, Inc. Purine nucleoside phosphorylase inhibitory phosphonate compounds
EP2153832B1 (en) * 2003-12-15 2016-03-09 Merck Sharp & Dohme Corp. Heterocyclic aspartyl protease inhibitors
CN1906196A (zh) 2003-12-22 2007-01-31 吉里德科学公司 具有hiv和hcv抗病毒活性的4'-取代的卡波韦-和阿巴卡韦-衍生物以及相关化合物
US20080132549A1 (en) * 2004-04-14 2008-06-05 Pfizer Inc. Sulphur-Linked Imidazone Compounds for the Treatment of Hiv/Aids
KR100749566B1 (ko) * 2004-04-21 2007-08-16 이화여자대학교 산학협력단 Alk5 및/또는 alk4 억제제로 유효한 2-피리딜이치환된 이미다졸 유도체
US7893278B2 (en) * 2004-06-17 2011-02-22 Hoffman-La Roche Inc. CIS-imidazolines
AU2005330489B2 (en) 2004-07-27 2011-08-25 Gilead Sciences, Inc. Nucleoside phosphonate conjugates as anti HIV agents
WO2006013948A1 (ja) 2004-08-04 2006-02-09 Taisho Pharmaceutical Co., Ltd. トリアゾール誘導体
JP2008526828A (ja) * 2005-01-06 2008-07-24 ファイザー・リミテッド 逆転写酵素モジュレーターとしてのイミダゾール誘導体
US7579368B2 (en) * 2005-03-16 2009-08-25 Hoffman-La Roche Inc. Cis-imidazolines
EP2130822A1 (en) * 2005-12-01 2009-12-09 F. Hoffmann-La Roche AG 2,4,5-triphenyl imidazoline derivatives as inhibitors of the interaction between p53 and mdm2 proteins for use as anticancer agents
CN101415691B (zh) 2006-02-03 2011-12-14 大正制药株式会社 三唑衍生物
JP5218737B2 (ja) * 2006-02-06 2013-06-26 大正製薬株式会社 スフィンゴシン−1−リン酸結合阻害物質
US7649098B2 (en) * 2006-02-24 2010-01-19 Lexicon Pharmaceuticals, Inc. Imidazole-based compounds, compositions comprising them and methods of their use
JP5207964B2 (ja) 2006-03-31 2013-06-12 武田薬品工業株式会社 酸分泌抑制薬
PE20080948A1 (es) * 2006-07-25 2008-09-10 Irm Llc Derivados de imidazol como moduladores de la senda de hedgehog
CN101501002B (zh) 2006-08-16 2012-06-27 弗·哈夫曼-拉罗切有限公司 非核苷逆转录酶抑制剂
RU2468009C2 (ru) 2007-08-01 2012-11-27 Тайсо Фармасьютикал Ко., Лтд. Ингибитор связывания s1p1
TW200920355A (en) * 2007-09-06 2009-05-16 Lexicon Pharmaceuticals Inc Compositions and methods for treating immunological and inflammatory diseases and disorders
AR068538A1 (es) * 2007-09-28 2009-11-18 Takeda Pharmaceutical Compuesto heterociclico de 5 miembros con actividad supresora de la secrecion de acido
BRPI0821349A2 (pt) 2007-12-21 2019-09-24 Hoffmann La Roche compostos antivirais heterocíclicos
PE20110219A1 (es) 2008-07-08 2011-03-31 Gilead Sciences Inc Sales del compuesto n-[(s)({[(2r,5r)-5-(6-amino-9h-purin-9-il)-4-fluoro-2,5-dihidrofuran-2-il]oxi}metil)fenoxifosfinoil]-l-alaninato de etilo como inhibidores de vih
AR075255A1 (es) 2009-02-12 2011-03-16 Exelixis Inc Derivados diazolicos y/o triazolicos agonistas de receptores tgr5 acoplado a proteina g, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de la obesidad, diabetes y otros trastornos metabolicos.
EP2412713B1 (en) 2009-03-26 2016-11-30 Takeda Pharmaceutical Company Limited Pyrazole compound
EP2508511A1 (en) 2011-04-07 2012-10-10 Laboratoire Biodim Inhibitors of viral replication, their process of preparation and their therapeutical uses
HRP20180543T1 (hr) * 2012-07-24 2018-06-29 Bial-Portela & Ca, S.A. Spojevi uree i njihova upotreba kao inhibitora enzima
EP2716639A1 (en) 2012-10-05 2014-04-09 Laboratoire Biodim Inhibitors of viral replication, their process of preparation and their therapeutical uses
EP2716632A1 (en) 2012-10-05 2014-04-09 Laboratoire Biodim Inhibitors of viral replication, their process of preparation and their therapeutical uses
GB201602934D0 (en) 2016-02-19 2016-04-06 Cancer Res Inst Royal Compounds
EP3381905A1 (en) * 2017-03-30 2018-10-03 Institut National de la Sante et de la Recherche Medicale (INSERM) Novel antiviral compounds
ES2969496T3 (es) 2017-08-01 2024-05-20 Gilead Sciences Inc Formas cristalinas de ((S)-((((2R,5R)-5-(6-amino-9H-purin-9-il)-4-fluoro-2,5-dihidrofuran-2- il)oxi)metil)(fenoxi)fosforil)-L-alaninato de etilo para tratar infecciones virales

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE428686B (sv) * 1975-08-11 1983-07-18 Du Pont Forfarande for framstellning av antiinflammatoriskt aktiva imidazoler
JPS63150266A (ja) * 1986-12-12 1988-06-22 Mitsui Petrochem Ind Ltd ベンジルイミダゾ−ル誘導体
JPH0283373A (ja) * 1988-05-19 1990-03-23 Nippon Soda Co Ltd 5員環の複素環化合物及びその製造方法
IL98319A (en) * 1990-07-05 1997-04-15 Roussel Uclaf Sulphurous derivatives of imidazole, their preparation process, and pharmaceutical compositions containing them
TW235963B (no) * 1992-01-16 1994-12-11 Shionogi & Co
DE10230797C2 (de) * 2001-07-16 2003-09-25 Dieter Reif Befestigungsklammer zur Verbindung von Holzbauteilen

Also Published As

Publication number Publication date
BR9509024A (pt) 1997-09-30
KR100387157B1 (ko) 2003-09-29
CN1158609A (zh) 1997-09-03
DE69532245T2 (de) 2004-09-16
AU4788896A (en) 1996-04-19
NO308739B1 (no) 2000-10-23
PL320009A1 (en) 1997-09-01
CA2200316A1 (en) 1996-04-04
PL183931B1 (pl) 2002-08-30
CA2200316C (en) 2004-09-21
ES2211917T3 (es) 2004-07-16
FI971234A7 (fi) 1997-05-23
DK0786455T3 (da) 2004-03-29
RU2157368C2 (ru) 2000-10-10
DE69532245D1 (en) 2004-01-15
US5910506A (en) 1999-06-08
EP0786455B1 (en) 2003-12-03
EP0786455A1 (en) 1997-07-30
MX9702030A (es) 1997-06-28
PT786455E (pt) 2004-02-27
FI971234A0 (fi) 1997-03-25
NO971306L (no) 1997-05-21
US6147097A (en) 2000-11-14
TW401404B (en) 2000-08-11
HUT77357A (hu) 1998-03-30
KR970706260A (ko) 1997-11-03
JP3155009B2 (ja) 2001-04-09
CN1093535C (zh) 2002-10-30
AU706095B2 (en) 1999-06-10
EP0786455A4 (en) 1998-12-30
ATE255564T1 (de) 2003-12-15
WO1996010019A1 (en) 1996-04-04
FI971234L (fi) 1997-05-23

Similar Documents

Publication Publication Date Title
ATE255564T1 (de) Imidazolderivat
NO179142C (no) 3-benzyliden-1-karbamoyl-2-pyrrolidon-analoger
EP0742216A3 (en) Ringamide derivatives
DE69129611D1 (de) Sulfonamid-Derivate
ID29452A (id) 4-okso-1,4-dihidro-3-quinolinkarboksamida sebagai agen-agen antivirus
PT732928E (pt) Metodo para a reducao dos niveis de colesterol serico com 2,6-dialquil-4-sililfenois
ATE152444T1 (de) N,n-disubstituierte amidsäuren, ihre ammoniumsalze sowie verwendung als emulgator
ES2093091T3 (es) Derivado de glutation.
ATE113030T1 (de) Hydroxyalkancarbonsäure-derivate und deren verwendung.
ATE176906T1 (de) Benzolactam-derivate
DK0601191T3 (da) Hidtil ukendt tetracyklisk forbindelse
DK0594329T3 (da) Antimikrobielle midler, der omfatter polykvaternære ammoniumforbindelser
MY116103A (en) Pyridine-2, 3-dicarboxylic acid diamide derivatives and herbicides comprising said derivatives as active ingredient
ATE184605T1 (de) Methotrexat-derivate
ATE318265T1 (de) Amidin-derivate, ihre herstellung und verwendung als medikamenten
EP1112998A4 (en) Amine derivatives
BR9305092A (pt) Processo para a preparação de derivados de 5-pirazolmercáptan, composto ditiocarbazato de etilideno, processo para a preparação de derivados do mesmo
ES2077697T3 (es) Derivados de 1-fenoxicarbonil-2-pirrolidinona y agentes nootropicos.