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CL2023003518A1 - Nuevas sales y formas cristalinas de sales de n,n-dimetiltriptamina - Google Patents

Nuevas sales y formas cristalinas de sales de n,n-dimetiltriptamina

Info

Publication number
CL2023003518A1
CL2023003518A1 CL2023003518A CL2023003518A CL2023003518A1 CL 2023003518 A1 CL2023003518 A1 CL 2023003518A1 CL 2023003518 A CL2023003518 A CL 2023003518A CL 2023003518 A CL2023003518 A CL 2023003518A CL 2023003518 A1 CL2023003518 A1 CL 2023003518A1
Authority
CL
Chile
Prior art keywords
salts
crystalline forms
dimethyltryptamine
new
new salts
Prior art date
Application number
CL2023003518A
Other languages
English (en)
Inventor
Fawaz Majed
KASERA Setu
Morra Nicholas
Original Assignee
Atai Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Atai Therapeutics Inc filed Critical Atai Therapeutics Inc
Publication of CL2023003518A1 publication Critical patent/CL2023003518A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/06—Oxalic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/08—Malonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/10—Succinic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/15—Fumaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Photoreceptors In Electrophotography (AREA)

Abstract

Esta divulgación proporciona sales y formas cristalinas de sales de N,N-dimetiltriptamina, su preparación, composiciones farmacéuticas que comprenden dichas sales y formas cristalinas de sales, y su uso en el tratamiento de enfermedades y afecciones neurológicas.
CL2023003518A 2021-05-25 2023-11-24 Nuevas sales y formas cristalinas de sales de n,n-dimetiltriptamina CL2023003518A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US202163192938P 2021-05-25 2021-05-25

Publications (1)

Publication Number Publication Date
CL2023003518A1 true CL2023003518A1 (es) 2024-05-03

Family

ID=84230260

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2023003518A CL2023003518A1 (es) 2021-05-25 2023-11-24 Nuevas sales y formas cristalinas de sales de n,n-dimetiltriptamina

Country Status (12)

Country Link
US (1) US12378194B2 (es)
EP (1) EP4347562A4 (es)
JP (1) JP2024521747A (es)
KR (1) KR20240013170A (es)
CN (1) CN117545739A (es)
AU (1) AU2022281358A1 (es)
BR (1) BR112023024550A2 (es)
CA (1) CA3218110A1 (es)
CL (1) CL2023003518A1 (es)
IL (1) IL308816A (es)
MX (1) MX2023013928A (es)
WO (1) WO2022251351A1 (es)

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MX2023013928A (es) 2021-05-25 2023-12-08 Atai Therapeutics Inc Nuevas sales y formas cristalinas de sales de n,n-dimetiltriptamina.
JP2024522174A (ja) 2021-06-09 2024-06-11 アタイ セラピューティクス， インコーポレイテッド ジメチルトリプタミンの新規プロドラッグおよびコンジュゲート
US12012381B2 (en) 2021-12-30 2024-06-18 Atai Therapeutics, Inc. Dimethyltryptamine analogues as nitric oxide delivery drugs
JP2025525090A (ja) * 2022-07-27 2025-08-01 リコネクト ラブズ アーゲー ハルミンの高溶解度製剤

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Also Published As

Publication number Publication date
US20220388956A1 (en) 2022-12-08
EP4347562A1 (en) 2024-04-10
MX2023013928A (es) 2023-12-08
WO2022251351A4 (en) 2022-12-29
CN117545739A (zh) 2024-02-09
KR20240013170A (ko) 2024-01-30
JP2024521747A (ja) 2024-06-04
BR112023024550A2 (pt) 2024-02-06
CA3218110A1 (en) 2022-12-01
US12378194B2 (en) 2025-08-05
AU2022281358A1 (en) 2023-11-23
WO2022251351A1 (en) 2022-12-01
EP4347562A4 (en) 2025-04-30
IL308816A (en) 2024-01-01

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