CL2019002769A1 - Procesos para la producción de linfocitos infiltrantes de tumores y usos de ellos en inmunoterapia. - Google Patents
Procesos para la producción de linfocitos infiltrantes de tumores y usos de ellos en inmunoterapia.Info
- Publication number
- CL2019002769A1 CL2019002769A1 CL2019002769A CL2019002769A CL2019002769A1 CL 2019002769 A1 CL2019002769 A1 CL 2019002769A1 CL 2019002769 A CL2019002769 A CL 2019002769A CL 2019002769 A CL2019002769 A CL 2019002769A CL 2019002769 A1 CL2019002769 A1 CL 2019002769A1
- Authority
- CL
- Chile
- Prior art keywords
- tils
- closed
- immunotherapy
- processes
- production
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 238000009169 immunotherapy Methods 0.000 title 1
- 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- 238000011109 contamination Methods 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 238000001370 static light scattering Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/16—Physical preservation processes
- A01N1/162—Temperature processes, e.g. following predefined temperature changes over time
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- A61K2039/55511—Organic adjuvants
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61K40/50—Cellular immunotherapy characterised by the use of allogeneic cells
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
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- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- Dermatology (AREA)
- Dentistry (AREA)
- Environmental Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
LA PRESENTE INVENCIÓN PROPORCIONA MEJORES MÉTODOS Y/O MÉTODOS ACORTADOS PARA EXPANDIR TILS Y PRODUCIR POBLACIONES TERAPÉUTICAS DE TILS, INCLUYENDO NUEVOS MÉTODOS PARA EXPANDIR LAS POBLACIONES DE TILS EN UN SISTEMA CERRADO QUE LLEVAN A UNA MAYOR EFICACIA, MAYOR FENOTIPO Y MAYOR SALUD METABÓLICA DE LOS TILS EN UN PERÍODO DE TIEMPO MÁS CORTO, MIENTRAS PERMITE UNA CONTAMINACIÓN MICROBIANA REDUCIDA ASÍ COMO MENORES COSTOS. ESTOS TILS SE USAN EN REGÍMENES DE TRATAMIENTO TERAPÉUTICOS.
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762478506P | 2017-03-29 | 2017-03-29 | |
| US201762539410P | 2017-07-31 | 2017-07-31 | |
| US201762548306P | 2017-08-21 | 2017-08-21 | |
| US201762554538P | 2017-09-05 | 2017-09-05 | |
| US201762559374P | 2017-09-15 | 2017-09-15 | |
| US201762567121P | 2017-10-02 | 2017-10-02 | |
| US201762577655P | 2017-10-26 | 2017-10-26 | |
| US201762582874P | 2017-11-07 | 2017-11-07 | |
| US201762596374P | 2017-12-08 | 2017-12-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2019002769A1 true CL2019002769A1 (es) | 2020-05-08 |
Family
ID=61569356
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2019002769A CL2019002769A1 (es) | 2017-03-29 | 2019-09-27 | Procesos para la producción de linfocitos infiltrantes de tumores y usos de ellos en inmunoterapia. |
| CL2020002737A CL2020002737A1 (es) | 2017-03-29 | 2020-10-22 | Métodos para expandir linfocitos infiltrantes de tumores (divisional de la solicitud no. 201902769) |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2020002737A CL2020002737A1 (es) | 2017-03-29 | 2020-10-22 | Métodos para expandir linfocitos infiltrantes de tumores (divisional de la solicitud no. 201902769) |
Country Status (35)
| Country | Link |
|---|---|
| US (60) | US10894063B2 (es) |
| EP (6) | EP3601533B1 (es) |
| JP (6) | JP7169291B2 (es) |
| KR (2) | KR20240114787A (es) |
| CN (1) | CN110785486A (es) |
| AU (2) | AU2018243355B2 (es) |
| BR (1) | BR112019020326A2 (es) |
| CA (1) | CA3057975A1 (es) |
| CL (2) | CL2019002769A1 (es) |
| CO (1) | CO2019011995A2 (es) |
| CR (1) | CR20190487A (es) |
| CY (1) | CY1124136T1 (es) |
| DK (3) | DK3601533T3 (es) |
| EC (1) | ECSP19077884A (es) |
| ES (3) | ES3008832T3 (es) |
| FI (2) | FI3730608T3 (es) |
| HR (3) | HRP20250068T1 (es) |
| HU (3) | HUE070176T2 (es) |
| IL (2) | IL305198A (es) |
| JO (1) | JOP20190224A1 (es) |
| LT (3) | LT3601533T (es) |
| MA (2) | MA68598B1 (es) |
| MD (3) | MD3601533T2 (es) |
| MX (2) | MX2019011768A (es) |
| PE (1) | PE20191841A1 (es) |
| PH (1) | PH12019502247A1 (es) |
| PL (3) | PL3730608T3 (es) |
| PT (3) | PT3601533T (es) |
| RS (3) | RS66452B1 (es) |
| SG (1) | SG11201908994RA (es) |
| SI (3) | SI3730608T1 (es) |
| SM (3) | SMT202100298T1 (es) |
| TN (1) | TN2019000273A1 (es) |
| TW (1) | TWI799402B (es) |
| WO (1) | WO2018182817A1 (es) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11618878B2 (en) | 2017-01-13 | 2023-04-04 | Instil Bio (Uk) Limited | Aseptic tissue processing method, kit and device |
| US11767510B2 (en) | 2019-12-20 | 2023-09-26 | Instil Bio (Uk) Limited | Devices and methods for isolating tumor infiltrating lymphocytes and uses thereof |
Families Citing this family (117)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111643524B (zh) | 2013-03-01 | 2023-09-05 | 美国卫生和人力服务部 | 从外周血中产生肿瘤反应性t细胞富集群的方法 |
| GB201522097D0 (en) | 2015-12-15 | 2016-01-27 | Cellular Therapeutics Ltd | Cells |
| SMT202400133T1 (it) | 2016-10-26 | 2024-05-14 | Iovance Biotherapeutics Inc | Restimolazione di linfociti infiltranti il tumore crioconservati |
| US11332713B2 (en) | 2016-11-16 | 2022-05-17 | KSQ Therapeutics, Inc. | Gene-regulating compositions and methods for improved immunotherapy |
| EP3565586B1 (en) | 2017-01-06 | 2025-10-08 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes with potassium channel agonists and therapeutic uses thereof |
| AU2018234810B2 (en) | 2017-03-15 | 2023-05-11 | Pandion Operations, Inc. | Targeted immunotolerance |
| US11254913B1 (en) | 2017-03-29 | 2022-02-22 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11618878B2 (en) | 2017-01-13 | 2023-04-04 | Instil Bio (Uk) Limited | Aseptic tissue processing method, kit and device |
| US11618877B2 (en) | 2017-01-13 | 2023-04-04 | Instil Bio (Uk) Limited | Aseptic tissue processing method, kit and device |
| US11767510B2 (en) | 2019-12-20 | 2023-09-26 | Instil Bio (Uk) Limited | Devices and methods for isolating tumor infiltrating lymphocytes and uses thereof |
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