CL2012002422A1 - Método para tratar artritis por lupus activo que comprende administrar al paciente laquinimod o su sal sódica por vía oral. - Google Patents
Método para tratar artritis por lupus activo que comprende administrar al paciente laquinimod o su sal sódica por vía oral.Info
- Publication number
- CL2012002422A1 CL2012002422A1 CL2012002422A CL2012002422A CL2012002422A1 CL 2012002422 A1 CL2012002422 A1 CL 2012002422A1 CL 2012002422 A CL2012002422 A CL 2012002422A CL 2012002422 A CL2012002422 A CL 2012002422A CL 2012002422 A1 CL2012002422 A1 CL 2012002422A1
- Authority
- CL
- Chile
- Prior art keywords
- sodium salt
- comprises administering
- active lupus
- treating active
- lupus arthritis
- Prior art date
Links
- 206010003246 arthritis Diseases 0.000 title abstract 2
- GKWPCEFFIHSJOE-UHFFFAOYSA-N laquinimod Chemical compound OC=1C2=C(Cl)C=CC=C2N(C)C(=O)C=1C(=O)N(CC)C1=CC=CC=C1 GKWPCEFFIHSJOE-UHFFFAOYSA-N 0.000 title abstract 2
- 229960004577 laquinimod Drugs 0.000 title abstract 2
- 206010025135 lupus erythematosus Diseases 0.000 title abstract 2
- 159000000000 sodium salts Chemical class 0.000 title abstract 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Método para tratar artritis por lupus activo que comprende administrar al paciente laquinimod o su sal sódica por vía oral.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33935510P | 2010-03-03 | 2010-03-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2012002422A1 true CL2012002422A1 (es) | 2012-12-21 |
Family
ID=44531530
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2012002422A CL2012002422A1 (es) | 2010-03-03 | 2012-08-31 | Método para tratar artritis por lupus activo que comprende administrar al paciente laquinimod o su sal sódica por vía oral. |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US20110217295A1 (es) |
| EP (1) | EP2542080B1 (es) |
| JP (2) | JP2013521305A (es) |
| KR (1) | KR20130036217A (es) |
| CN (1) | CN102781239B (es) |
| AU (1) | AU2011223702B2 (es) |
| BR (1) | BR112012022064A2 (es) |
| CA (1) | CA2791711A1 (es) |
| CL (1) | CL2012002422A1 (es) |
| CO (1) | CO6630086A2 (es) |
| EA (1) | EA201290859A1 (es) |
| ES (1) | ES2601819T3 (es) |
| MX (1) | MX342001B (es) |
| NZ (1) | NZ602512A (es) |
| PE (1) | PE20130496A1 (es) |
| PH (1) | PH12012501741A1 (es) |
| PL (1) | PL2542080T3 (es) |
| PT (1) | PT2542080T (es) |
| SG (2) | SG183515A1 (es) |
| WO (1) | WO2011109536A1 (es) |
| ZA (1) | ZA201207125B (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107176923A (zh) * | 2005-10-19 | 2017-09-19 | 泰华制药工业有限公司 | 拉奎尼莫钠晶体及其制备方法 |
| KR101495327B1 (ko) | 2006-06-12 | 2015-02-24 | 테바 파마슈티컬 인더스트리즈 리미티드 | 안정한 라퀴니모드 제제 |
| US8178127B2 (en) | 2007-12-20 | 2012-05-15 | Teva Pharmaceuticals Industries, Ltd. | Stable laquinimod preparations |
| CA2736091A1 (en) * | 2008-09-03 | 2010-03-11 | Teva Pharmaceutical Industries Ltd. | 2-oxo-1,2-dihydro-quinoline modulators of immune function |
| HUE026406T2 (en) * | 2009-06-19 | 2016-06-28 | Teva Pharma | Treatment of multiple sclerosis with laquinimod |
| CN105616410A (zh) * | 2009-07-30 | 2016-06-01 | 泰华制药工业有限公司 | 利用拉喹莫德治疗克隆氏病 |
| ES2731052T3 (es) | 2009-08-10 | 2019-11-13 | Active Biotech Ab | Tratamiento de la enfermedad de Huntington usando laquinimod |
| KR20150135552A (ko) * | 2010-03-03 | 2015-12-02 | 테바 파마슈티컬 인더스트리즈 리미티드 | 라퀴니모드를 이용한 루푸스 신장염의 치료 |
| SG183515A1 (en) * | 2010-03-03 | 2012-10-30 | Teva Pharma | Treatment of lupus arthritis using laquinimod |
| WO2011109531A1 (en) * | 2010-03-03 | 2011-09-09 | Teva Pharmaceutical Industries Ltd. | Treatment of rheumatoid arthritis with a combination of laquinimod and methotrexate |
| JP2013535437A (ja) | 2010-07-09 | 2013-09-12 | テバ ファーマシューティカル インダストリーズ リミティド | 重水素化されたn−エチル−n−フェニル−1,2−ジヒドロ−4−ヒドロキシ−5−クロロ−1−メチル−2−オキソキノリン−3−カルボキサミド、その塩および使用 |
| SG11201401330YA (en) | 2011-10-12 | 2014-05-29 | Teva Pharma | Treatment of multiple sclerosis with combination of laquinimod and fingolimod |
| US9161935B2 (en) | 2012-02-03 | 2015-10-20 | Teva Pharmaceutical Industries, Ltd. | Use of laquinimod for treating Crohn's disease patients who failed first-line anti-TNF therapy |
| AR090073A1 (es) | 2012-02-16 | 2014-10-15 | Teva Pharma | N-etil-n-fenil-1,2-dihidro-4,5-di-hidroxi-1-metil-2-oxo-3-quinolinacarboxamida, su preparacion y usos |
| TW201350467A (zh) | 2012-05-08 | 2013-12-16 | Teva Pharma | N-乙基-4-羥基-1-甲基-5-(甲基(2,3,4,5,6-五羥基己基)胺基)-2-側氧-n-苯基-1,2-二氫喹啉-3-甲醯胺 |
| TW201400117A (zh) | 2012-06-05 | 2014-01-01 | Teva Pharma | 使用拉喹莫德治療眼發炎疾病 |
| TW201410244A (zh) | 2012-08-13 | 2014-03-16 | Teva Pharma | 用於治療gaba媒介之疾病之拉喹莫德(laquinimod) |
| CA2890194A1 (en) | 2012-11-07 | 2014-05-15 | Teva Pharmaceutical Industries Ltd. | Amine salts of laquinimod |
| WO2014153145A2 (en) | 2013-03-14 | 2014-09-25 | Teva Pharmaceutical Industries Ltd. | Crystals of laquinimod sodium and improved process for the manufacture thereof |
| HK1220125A1 (zh) | 2013-03-14 | 2017-04-28 | Teva Pharmaceutical Industries Ltd. | 拉喹莫德的透皮配方 |
| UY36099A (es) | 2014-04-29 | 2016-02-29 | Teva Pharma | Laquinimod para el tratamiento de pacientes con esclerosis múltiple remitente recurrente (rrms) con un alto grado de discapacidad |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| FR2340735A1 (fr) * | 1976-02-11 | 1977-09-09 | Roussel Uclaf | Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament |
| IE52670B1 (en) * | 1981-03-03 | 1988-01-20 | Leo Ab | Heterocyclic carboxamides,compositions containing such compounds,and processes for their preparation |
| US5540934A (en) * | 1994-06-22 | 1996-07-30 | Touitou; Elka | Compositions for applying active substances to or through the skin |
| US5912349A (en) * | 1997-01-31 | 1999-06-15 | Pharmacia & Upjohn Company | Process for the preparation of roquinimex |
| US6696407B1 (en) * | 1997-03-21 | 2004-02-24 | The Regents Of The University Of California | Huntington's disease treatment comprising administering aldose reductase inhibitors to increase striatal CNTF |
| SE9801474D0 (sv) * | 1998-04-27 | 1998-04-27 | Active Biotech Ab | Quinoline Derivatives |
| US6077851A (en) * | 1998-04-27 | 2000-06-20 | Active Biotech Ab | Quinoline derivatives |
| US6133285A (en) * | 1998-07-15 | 2000-10-17 | Active Biotech Ab | Quinoline derivatives |
| US6121287A (en) * | 1998-07-15 | 2000-09-19 | Active Biotech Ab | Quinoline derivatives |
| US6395750B1 (en) * | 1999-10-25 | 2002-05-28 | Active Biotech Ab | Drugs for the treatment of malignant tumors |
| EP1365794A2 (en) * | 2000-07-21 | 2003-12-03 | Lue, Tom | Prevention and treatment of sexual arousal disorders |
| US6307050B1 (en) * | 2000-08-29 | 2001-10-23 | R. T. Alamo Venture I Llc | Method of synthesizing flosequinan from 4-fluoroanthranilic acid |
| US7560557B2 (en) * | 2002-06-12 | 2009-07-14 | Active Biotech Ag | Process for the manufacture of quinoline derivatives |
| US6875869B2 (en) * | 2002-06-12 | 2005-04-05 | Active Biotech Ab | Process for the manufacture of quinoline derivatives |
| US20070292461A1 (en) * | 2003-08-04 | 2007-12-20 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
| WO2005000244A2 (en) * | 2003-06-25 | 2005-01-06 | Elan Pharmaceuticals, Inc. | Methods and compositions for treating rheumatoid arthritis |
| US8795693B2 (en) * | 2003-08-04 | 2014-08-05 | Foamix Ltd. | Compositions with modulating agents |
| SE0400235D0 (sv) * | 2004-02-06 | 2004-02-06 | Active Biotech Ab | New composition containing quinoline compounds |
| US8314124B2 (en) * | 2004-02-06 | 2012-11-20 | Active Biotech Ab | Crystalline salts of quinoline compounds and methods for preparing them |
| EP1763361A2 (en) * | 2004-04-01 | 2007-03-21 | Elan Pharmaceuticals, Inc. | Steroid sparing agents and their use |
| EP1796710A4 (en) * | 2004-09-02 | 2010-05-26 | Teva Pharma | THERAPY COMBINED WITH GLATIRAMER ACETATE AND N-ACETYLCYSTEINE TO TREAT MULTIPLE SCLEROSIS |
| EA015860B1 (ru) * | 2005-10-13 | 2011-12-30 | Хьюман Дженом Сайенсиз, Инк. | Способы лечения аутоиммунных заболеваний при использовании антагониста нейтрокина-альфа |
| CN107176923A (zh) * | 2005-10-19 | 2017-09-19 | 泰华制药工业有限公司 | 拉奎尼莫钠晶体及其制备方法 |
| ATE534630T1 (de) * | 2005-10-26 | 2011-12-15 | Merck Serono Sa | Sulfonamidderivate und deren verwendung zur modulation von metalloproteinasen |
| US20080108641A1 (en) * | 2006-02-08 | 2008-05-08 | Ajami Alfred M | Compounds for treating inflammatory disorders, demyelinating disdorders and cancers |
| US8367629B2 (en) * | 2006-02-14 | 2013-02-05 | Noxxon Pharma Ag | MCP-1 binding nucleic acids and use thereof |
| US8410115B2 (en) * | 2006-02-28 | 2013-04-02 | Elan Pharmaceuticals, Inc. | Methods of treating inflammatory and autoimmune diseases with alpha-4 inhibitory compounds |
| WO2007100770A2 (en) * | 2006-02-28 | 2007-09-07 | Elan Pharmaceuticals, Inc. | Methods of treating inflammatory and autoimmune diseases with natalizumab |
| RS20080391A (sr) * | 2006-03-03 | 2009-07-15 | Elan Pharmaceuticals Inc., | Postupci lečenja zapaljenskih i autoimunih bolesti natalizumabom |
| US9399061B2 (en) * | 2006-04-10 | 2016-07-26 | Abbvie Biotechnology Ltd | Methods for determining efficacy of TNF-α inhibitors for treatment of rheumatoid arthritis |
| WO2007139887A2 (en) * | 2006-05-22 | 2007-12-06 | Cargill, Incorporated | Methods for treating bone or joint inflammation |
| WO2007146331A1 (en) * | 2006-06-12 | 2007-12-21 | Teva Pharmaceutical Industries, Ltd. | Tannate salt form of polypeptide mixtures, their preparation and use |
| KR101495327B1 (ko) * | 2006-06-12 | 2015-02-24 | 테바 파마슈티컬 인더스트리즈 리미티드 | 안정한 라퀴니모드 제제 |
| EP2056818B1 (en) * | 2006-08-11 | 2011-05-25 | The Johns Hopkins University | Compositions and methods for neuroprotection |
| CA2970273C (en) * | 2007-07-11 | 2020-04-14 | Medicinova, Inc. | Treatment of progressive neurodegenerative disease with ibudilast |
| US8178127B2 (en) * | 2007-12-20 | 2012-05-15 | Teva Pharmaceuticals Industries, Ltd. | Stable laquinimod preparations |
| CA2736091A1 (en) * | 2008-09-03 | 2010-03-11 | Teva Pharmaceutical Industries Ltd. | 2-oxo-1,2-dihydro-quinoline modulators of immune function |
| HUE026406T2 (en) * | 2009-06-19 | 2016-06-28 | Teva Pharma | Treatment of multiple sclerosis with laquinimod |
| CN105616410A (zh) * | 2009-07-30 | 2016-06-01 | 泰华制药工业有限公司 | 利用拉喹莫德治疗克隆氏病 |
| ES2731052T3 (es) * | 2009-08-10 | 2019-11-13 | Active Biotech Ab | Tratamiento de la enfermedad de Huntington usando laquinimod |
| SG183515A1 (en) * | 2010-03-03 | 2012-10-30 | Teva Pharma | Treatment of lupus arthritis using laquinimod |
| JP2013535437A (ja) * | 2010-07-09 | 2013-09-12 | テバ ファーマシューティカル インダストリーズ リミティド | 重水素化されたn−エチル−n−フェニル−1,2−ジヒドロ−4−ヒドロキシ−5−クロロ−1−メチル−2−オキソキノリン−3−カルボキサミド、その塩および使用 |
| WO2014153145A2 (en) * | 2013-03-14 | 2014-09-25 | Teva Pharmaceutical Industries Ltd. | Crystals of laquinimod sodium and improved process for the manufacture thereof |
-
2011
- 2011-03-02 SG SG2012063517A patent/SG183515A1/en unknown
- 2011-03-02 SG SG10201501539SA patent/SG10201501539SA/en unknown
- 2011-03-02 NZ NZ602512A patent/NZ602512A/en not_active IP Right Cessation
- 2011-03-02 JP JP2012556214A patent/JP2013521305A/ja not_active Withdrawn
- 2011-03-02 CN CN201180012107.2A patent/CN102781239B/zh not_active Expired - Fee Related
- 2011-03-02 PL PL11751305T patent/PL2542080T3/pl unknown
- 2011-03-02 AU AU2011223702A patent/AU2011223702B2/en not_active Ceased
- 2011-03-02 PE PE2012001382A patent/PE20130496A1/es not_active Application Discontinuation
- 2011-03-02 EP EP11751305.1A patent/EP2542080B1/en not_active Not-in-force
- 2011-03-02 KR KR1020127025805A patent/KR20130036217A/ko not_active Ceased
- 2011-03-02 ES ES11751305.1T patent/ES2601819T3/es active Active
- 2011-03-02 MX MX2012010071A patent/MX342001B/es active IP Right Grant
- 2011-03-02 EA EA201290859A patent/EA201290859A1/ru unknown
- 2011-03-02 PH PH1/2012/501741A patent/PH12012501741A1/en unknown
- 2011-03-02 US US13/039,194 patent/US20110217295A1/en not_active Abandoned
- 2011-03-02 WO PCT/US2011/026891 patent/WO2011109536A1/en not_active Ceased
- 2011-03-02 PT PT117513051T patent/PT2542080T/pt unknown
- 2011-03-02 CA CA2791711A patent/CA2791711A1/en not_active Abandoned
- 2011-03-02 BR BR112012022064A patent/BR112012022064A2/pt not_active IP Right Cessation
-
2012
- 2012-08-31 CL CL2012002422A patent/CL2012002422A1/es unknown
- 2012-09-18 CO CO12160941A patent/CO6630086A2/es unknown
- 2012-09-21 ZA ZA2012/07125A patent/ZA201207125B/en unknown
-
2013
- 2013-03-05 US US13/785,511 patent/US20130184310A1/en not_active Abandoned
-
2014
- 2014-12-01 US US14/556,321 patent/US20150086549A1/en not_active Abandoned
-
2016
- 2016-04-04 US US15/089,792 patent/US20160213663A1/en not_active Abandoned
- 2016-05-25 JP JP2016104447A patent/JP2016196473A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| MX342001B (es) | 2016-09-09 |
| CN102781239B (zh) | 2015-01-21 |
| EP2542080A1 (en) | 2013-01-09 |
| WO2011109536A1 (en) | 2011-09-09 |
| PT2542080T (pt) | 2016-11-16 |
| PL2542080T3 (pl) | 2017-02-28 |
| KR20130036217A (ko) | 2013-04-11 |
| BR112012022064A2 (pt) | 2015-09-08 |
| AU2011223702A1 (en) | 2012-10-25 |
| CN102781239A (zh) | 2012-11-14 |
| HK1177876A1 (zh) | 2013-08-30 |
| EP2542080A4 (en) | 2013-07-17 |
| US20150086549A1 (en) | 2015-03-26 |
| SG10201501539SA (en) | 2015-04-29 |
| JP2013521305A (ja) | 2013-06-10 |
| CA2791711A1 (en) | 2011-09-09 |
| SG183515A1 (en) | 2012-10-30 |
| NZ602512A (en) | 2014-07-25 |
| ZA201207125B (en) | 2014-06-25 |
| EA201290859A1 (ru) | 2013-04-30 |
| AU2011223702B2 (en) | 2016-07-14 |
| MX2012010071A (es) | 2012-10-03 |
| ES2601819T3 (es) | 2017-02-16 |
| PE20130496A1 (es) | 2013-05-08 |
| US20160213663A1 (en) | 2016-07-28 |
| PH12012501741A1 (en) | 2012-11-12 |
| US20110217295A1 (en) | 2011-09-08 |
| EP2542080B1 (en) | 2016-08-31 |
| JP2016196473A (ja) | 2016-11-24 |
| US20130184310A1 (en) | 2013-07-18 |
| CO6630086A2 (es) | 2013-03-01 |
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