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CL2008000089A1 - Compuestos derivados de 2,4-pirimidinona condensada con un heterociclo, inhibidores de pde-4; composicion farmaceutica; combinacion farmaceutica; procedimiento de preparacion de los compuestos, utiles para tratar trastornos inmunes e inflamatorios. - Google Patents

Compuestos derivados de 2,4-pirimidinona condensada con un heterociclo, inhibidores de pde-4; composicion farmaceutica; combinacion farmaceutica; procedimiento de preparacion de los compuestos, utiles para tratar trastornos inmunes e inflamatorios.

Info

Publication number
CL2008000089A1
CL2008000089A1 CL2008000089A CL2008000089A CL2008000089A1 CL 2008000089 A1 CL2008000089 A1 CL 2008000089A1 CL 2008000089 A CL2008000089 A CL 2008000089A CL 2008000089 A CL2008000089 A CL 2008000089A CL 2008000089 A1 CL2008000089 A1 CL 2008000089A1
Authority
CL
Chile
Prior art keywords
condensed
pyrimidinone
pde
heterocycle
inhibitors
Prior art date
Application number
CL2008000089A
Other languages
English (en)
Inventor
Premji Meghani
Rhona Jane Cox
Roger Victor Bonnert
Sousa Simon De
Mark Dickinson
Simon Fraser Hunt
Aus Pimm
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CL2008000089A1 publication Critical patent/CL2008000089A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Abstract

Compuestos derivados de pirimidina condensada; proceso de preparación; composición farmacéutica; y uso en el tratamiento de una enfermedad mediada por pde4.
CL2008000089A 2007-01-11 2008-01-11 Compuestos derivados de 2,4-pirimidinona condensada con un heterociclo, inhibidores de pde-4; composicion farmaceutica; combinacion farmaceutica; procedimiento de preparacion de los compuestos, utiles para tratar trastornos inmunes e inflamatorios. CL2008000089A1 (es)

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ECSP099480A (es) 2009-08-28
AU2008204412A1 (en) 2008-07-17
EP2106396A2 (en) 2009-10-07
RU2009123930A (ru) 2011-02-20
US20090124596A1 (en) 2009-05-14
SA08280783B1 (ar) 2011-04-24
PE20121529A1 (es) 2012-12-16
CA2674647A1 (en) 2008-07-17
CO6210698A2 (es) 2010-10-20
US20100204203A1 (en) 2010-08-12
WO2008084223A3 (en) 2008-10-02
CN104147011A (zh) 2014-11-19
AR064889A1 (es) 2009-05-06
MY162022A (en) 2017-05-31
PE20090049A1 (es) 2009-03-21
EP2106396B1 (en) 2014-09-24
US20120077801A1 (en) 2012-03-29
JP5369302B2 (ja) 2013-12-18
CN102532135A (zh) 2012-07-04
KR20090101303A (ko) 2009-09-24
BRPI0806689A2 (pt) 2015-07-21
UY30863A1 (es) 2008-09-02
AU2008204412B2 (en) 2012-03-01
WO2008084223A2 (en) 2008-07-17
CN101636388B (zh) 2013-09-18
MX2009007231A (es) 2009-07-14
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RU2479584C2 (ru) 2013-04-20
TW200836745A (en) 2008-09-16

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