[go: up one dir, main page]

CL2007001498A1 - Metodo para la preparacion de 2-(3-(hidroximetil)-6-nitro- 2,3-dihidrobenzo[b][1,4]dioxin-5-il)acetonitrilo. - Google Patents

Metodo para la preparacion de 2-(3-(hidroximetil)-6-nitro- 2,3-dihidrobenzo[b][1,4]dioxin-5-il)acetonitrilo.

Info

Publication number
CL2007001498A1
CL2007001498A1 CL2007001498A CL2007001498A CL2007001498A1 CL 2007001498 A1 CL2007001498 A1 CL 2007001498A1 CL 2007001498 A CL2007001498 A CL 2007001498A CL 2007001498 A CL2007001498 A CL 2007001498A CL 2007001498 A1 CL2007001498 A1 CL 2007001498A1
Authority
CL
Chile
Prior art keywords
dihydrobenzo
dioxin
hydroxymethyl
acetonitrile
nitro
Prior art date
Application number
CL2007001498A
Other languages
English (en)
Inventor
Rocco J Galante
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CL2007001498A1 publication Critical patent/CL2007001498A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Método para preparar un compuesto 2-(3-(hidroximetil)-6-nitro-2,3-dihidrobenzo[b][1,4]dioxin-5-il)acetonitrilo, que tienen actividad como agonistas de los autoreceptores de la dopamina y agonistas parciales en el receptor de la dopamina d2postsinaptica.
CL2007001498A 2006-05-25 2007-05-24 Metodo para la preparacion de 2-(3-(hidroximetil)-6-nitro- 2,3-dihidrobenzo[b][1,4]dioxin-5-il)acetonitrilo. CL2007001498A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80839406P 2006-05-25 2006-05-25

Publications (1)

Publication Number Publication Date
CL2007001498A1 true CL2007001498A1 (es) 2008-01-18

Family

ID=38569786

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2007001498A CL2007001498A1 (es) 2006-05-25 2007-05-24 Metodo para la preparacion de 2-(3-(hidroximetil)-6-nitro- 2,3-dihidrobenzo[b][1,4]dioxin-5-il)acetonitrilo.

Country Status (16)

Country Link
US (1) US7662979B2 (es)
EP (1) EP2046771B1 (es)
JP (1) JP5295103B2 (es)
CN (1) CN101448814B (es)
AR (1) AR061125A1 (es)
AU (1) AU2007267799B2 (es)
BR (1) BRPI0712608B8 (es)
CA (1) CA2652800C (es)
CL (1) CL2007001498A1 (es)
ES (1) ES2387901T3 (es)
IL (1) IL195226A0 (es)
MX (1) MX2008014789A (es)
PE (1) PE20080178A1 (es)
TW (1) TW200811182A (es)
WO (1) WO2007139998A2 (es)
ZA (1) ZA200809966B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0415953B8 (pt) 2003-10-29 2021-05-25 Wyeth Corp formulação de dosagem de liberação controlada e conjunto de formas de dosagem de liberação controlada
WO2008118935A1 (en) * 2007-03-26 2008-10-02 Neurogen Corporation Compounds and processes for preparing substituted aminomethyl-2,3,8,9-tetrahydro-7h-1,4-dioxino[2,3-e]indol-8-ones

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4314944A (en) * 1980-08-22 1982-02-09 Smithkline Corporation 4-Aminoalkyl-7-hydroxy-2(3H)-indolones
EP0594593A1 (en) 1990-03-15 1994-05-04 PHARMACIA & UPJOHN COMPANY Therapeutically useful heterocyclic indole compounds
US5126366A (en) * 1991-06-21 1992-06-30 American Home Products Corporation Aminophenoxyalkyl derivatives of benzodioxan
US5166367A (en) * 1991-06-21 1992-11-24 American Home Products Corporation Antipsychotic benzodioxan derivatives
US5189171A (en) * 1991-06-21 1993-02-23 American Home Products Corporation Antipsychotic benzodioxan derivatives
DE4135474A1 (de) 1991-10-28 1993-04-29 Bayer Ag 2-aminomethyl-chromane
DE4140540A1 (de) * 1991-12-09 1993-06-17 Bayer Ag Neue azaheterocyclylmethyl-chromane
US5235055A (en) * 1992-09-02 1993-08-10 American Home Products Corporation Antipsychotic quinoline derivatives of benzodioxanmethylamine
US5245051A (en) * 1992-09-03 1993-09-14 American Home Products Corporation Antipsychotic chroman derivatives of benzodioxanmethylamine
EP0605033B1 (en) * 1992-12-21 1999-07-21 Duphar International Research B.V Enzymatic process for the stereoselective preparation of a hetero-bicyclic alcohol enantiomer
PT707007E (pt) 1994-10-14 2002-06-28 Merck Patent Gmbh Derivados amino(tio)eter como agentes activos no snc
AR004523A1 (es) 1995-11-06 1998-12-16 American Home Prod 2-(AMINOMETIL)-3,4,7,9-TETRAHIDRO-2H-PIRANO-[2,3e] INDOL-8-ONAS Y COMPOSICIONES FARMACEUTICAS QUE LAS COMPRENDEN
US5756532A (en) * 1995-11-06 1998-05-26 American Home Products Corporation Aminomethyl-2 3 8 9-tetrahydro-7H-1 4-dioxino 2 3-E!-indol-8-ones and derivatives
US5869490A (en) * 1996-10-15 1999-02-09 American Home Products Corporation Azaheterocyclymethyl derivatives of 2,3,8,9-tetrahydro-7h-1,4-dioxino (2,3-e) indol-8-one
US5750556A (en) * 1996-10-30 1998-05-12 American Home Products Corporation 2-(aminomethyl)-3,4,7,9-tetrahydro-2H-pyrano- 2,3-E!indol-8-ones and derivatives
WO2003031428A1 (en) * 2001-10-05 2003-04-17 Wyeth Stereospecific process for the synthesis of 2-yl chroman derivatives
MXPA04003086A (es) * 2001-10-05 2004-09-06 Wyeth Corp Proceso para sintesis estereoselectiva de 2-hidroximetil-cromanos.
US7135479B2 (en) * 2002-09-12 2006-11-14 Wyeth Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans
ES2277546B1 (es) 2005-11-21 2008-06-16 Natraceutical, S.A. Procedimiento microbiano de produccion de isomeros especificos de acidos linoleicos conjugados.

Also Published As

Publication number Publication date
CN101448814A (zh) 2009-06-03
BRPI0712608B8 (pt) 2021-05-25
TW200811182A (en) 2008-03-01
CA2652800A1 (en) 2007-12-06
EP2046771B1 (en) 2012-07-11
AU2007267799B2 (en) 2013-09-12
JP2009538324A (ja) 2009-11-05
AR061125A1 (es) 2008-08-06
BRPI0712608A2 (pt) 2012-08-14
JP5295103B2 (ja) 2013-09-18
US7662979B2 (en) 2010-02-16
AU2007267799A1 (en) 2007-12-06
WO2007139998A3 (en) 2008-01-31
ZA200809966B (en) 2009-09-30
ES2387901T3 (es) 2012-10-03
IL195226A0 (en) 2009-08-03
BRPI0712608B1 (pt) 2020-09-08
WO2007139998A2 (en) 2007-12-06
EP2046771A2 (en) 2009-04-15
CN101448814B (zh) 2013-04-24
US20070293686A1 (en) 2007-12-20
MX2008014789A (es) 2008-11-28
CA2652800C (en) 2014-05-13
BRPI0712608A8 (pt) 2018-12-11
PE20080178A1 (es) 2008-04-16

Similar Documents

Publication Publication Date Title
SV2011003894A (es) Nuevos compuestos halosustituidos
WO2007098474A8 (en) Phenyl-cycloalkyl and phenyl-heterocyclic derivatives as s1p receptor agonists
ECSP11011098A (es) Nuevas pirazol-4-n-alcoxicarboxamidas cómo microbicidas.
BRPI0907364A2 (pt) Antagonistas aminoalquilbifenil n,n-disubstituídos de receptores d2 de prostaglandina
HRP20120129T1 (hr) Hidroksimetil pirolidini kao agonisti beta 3 adrenergičkog receptora
ECSP088210A (es) Bencimidazoles sustituidos y métodos de preparación
CR10872A (es) Compuestos agonistas y antagonistas del receptor de esfingosina-1-fosfato
PT2435023T (pt) Composições para a administração, por via pulmonar de antagonistas muscarínicos de acção prolongada, e agonistas de receptores adrenérgicos beta 2 de acção prolongada e métodos e sistemas associados
CR20110250A (es) Antagonistas de los receptores de la melacortina
CO6440523A2 (es) Análogos de esfingosina-1-fosfato de arilo bicíclico
CR20140316A (es) Derivados de indol como antagonistas receptores de s1p1 (divisional 10922)
CR11264A (es) Compuestos de 5-(4-halo-alcoxi)-fenil)-pirimidin-2-amina y composiciones como inhibidores de cinasa
CL2009000707A1 (es) Composicion controladora de enfermedades de plantas que comprende un compuesto derivado de pirazolinona y al menos otros fungicidas derivados de estrobirulina como dimoxiestrobina; y metodo para controlar una enfermedad en planta mediante el uso de la composicion.
WO2008064337A3 (en) Benzocycloheptyl analogs having sphingosine 1-phosphate receptor activity
HN2010000352A (es) Derivados de ciclopropilamida 978
DK2235007T3 (da) Ikke-steroide mineralocorticoid-receptorantagonister af 6h-dibenz0 [b,e] oxepin
BRPI0608221A2 (pt) métodos para preparação de um composto, e para preparar seletivamente um composto de nitrila, e, composto
CR11098A (es) Compuestos de pirido [2,3-d] pirimidina-7-ona como inhibidores de p13k-alfa para el tratamiento del cancer
CL2008000222A1 (es) Procedimiento para la preparacion de compuestos derivados de 2h-1,4-benzoxazin-3(4h)-ona.
CR7717A (es) Nuevos inhibidores biciclicos de hormona sensitiva a la lipasa
GT200900026A (es) Derivados de 5,6 -bisaril-2-piridin-carboxamida, su preparacion y su aplicacion en terapeutica como antagonistas de los receptores de urotensina ii
BR112012004173A2 (pt) "composto, composição, método para preparar uma composição, e, uso de um composto"
ECSP088700A (es) Acidos 4-fenil-tiazol-5-carboxilicos y amidas de acidos 4-fenil-tiazol-5-carboxilicos como inhibidores de la plk1
ECSP088740A (es) Derivados de tetrahidronaftalina, procedimientos para prepararlos y su uso como antiinflamatorios
SE0800742L (sv) Vikttäcke