CL2004000400A1 - Compuestos derivados de piridina sustituida con 1,3-oxazol y con isoxazol, composicion farmaceutica, procedimiento de preparacion, utiles como agentes antibacteriano, activo contra la bacteria gram negativa. - Google Patents
Compuestos derivados de piridina sustituida con 1,3-oxazol y con isoxazol, composicion farmaceutica, procedimiento de preparacion, utiles como agentes antibacteriano, activo contra la bacteria gram negativa.Info
- Publication number
- CL2004000400A1 CL2004000400A1 CL200400400A CL2004000400A CL2004000400A1 CL 2004000400 A1 CL2004000400 A1 CL 2004000400A1 CL 200400400 A CL200400400 A CL 200400400A CL 2004000400 A CL2004000400 A CL 2004000400A CL 2004000400 A1 CL2004000400 A1 CL 2004000400A1
- Authority
- CL
- Chile
- Prior art keywords
- sub
- useful
- antibacterial agents
- piridine
- isoxazol
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000003242 anti bacterial agent Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Chemical group 0.000 title abstract 2
- 241000894006 Bacteria Species 0.000 title 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical group C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 title 1
- AXLOCHLTNQDFFS-BESJYZOMSA-N azastene Chemical group C([C@H]1[C@@H]2CC[C@@]([C@]2(CC[C@@H]1[C@@]1(C)C2)C)(O)C)C=C1C(C)(C)C1=C2C=NO1 AXLOCHLTNQDFFS-BESJYZOMSA-N 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000003971 isoxazolinyl group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 2
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical group O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0304723A GB0304723D0 (en) | 2003-03-01 | 2003-03-01 | Chemical compounds |
| GB0318607A GB0318607D0 (en) | 2003-08-08 | 2003-08-08 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2004000400A1 true CL2004000400A1 (es) | 2005-04-22 |
Family
ID=32964061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL200400400A CL2004000400A1 (es) | 2003-03-01 | 2004-02-27 | Compuestos derivados de piridina sustituida con 1,3-oxazol y con isoxazol, composicion farmaceutica, procedimiento de preparacion, utiles como agentes antibacteriano, activo contra la bacteria gram negativa. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7192974B2 (es) |
| EP (1) | EP1599471B1 (es) |
| JP (1) | JP2006519247A (es) |
| KR (1) | KR20050106064A (es) |
| AT (1) | ATE396991T1 (es) |
| AU (1) | AU2004218206A1 (es) |
| BR (1) | BRPI0407835A (es) |
| CA (1) | CA2517706A1 (es) |
| CL (1) | CL2004000400A1 (es) |
| DE (1) | DE602004014107D1 (es) |
| ES (1) | ES2305732T3 (es) |
| MX (1) | MXPA05009205A (es) |
| NO (1) | NO20054523L (es) |
| TW (1) | TW200500360A (es) |
| UY (1) | UY28211A1 (es) |
| WO (1) | WO2004078753A1 (es) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60206154T2 (de) * | 2001-04-17 | 2006-06-29 | Merck & Co., Inc. | Bicyclo[3,1,0]hexan als strukturelement enthaltende oxazolidinon-antibiotika und deren derivate |
| JP2005524661A (ja) | 2002-02-28 | 2005-08-18 | アストラゼネカ アクチボラグ | ３−シクリル−５−（窒素含有５員環）メチル−オキサゾリジノン誘導体と抗菌剤としてのその使用 |
| KR20040086465A (ko) | 2002-02-28 | 2004-10-08 | 아스트라제네카 아베 | 화합물 |
| US8324398B2 (en) | 2003-06-03 | 2012-12-04 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of biaryl oxazolidinones |
| WO2005012271A2 (en) * | 2003-07-29 | 2005-02-10 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of biaryl oxazolidinones |
| MXPA05013132A (es) | 2003-06-03 | 2006-05-25 | Rib X Pharmaceuticals Inc | Compuestos heterociclicos de biarilo y metodos de produccion y su uso. |
| EP1654259A1 (en) * | 2003-07-02 | 2006-05-10 | Merck & Co., Inc. | Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof |
| US20060247286A1 (en) * | 2003-07-02 | 2006-11-02 | Milton Hammond | Oxazolidinone antibiotics and derivatives thereof |
| US20070293493A1 (en) * | 2003-07-02 | 2007-12-20 | Milton Hammond | Oxazolidinone antibiotics and derivatives thereof |
| JP4607107B2 (ja) * | 2003-07-02 | 2011-01-05 | メルク・シャープ・エンド・ドーム・コーポレイション | シクロプロピル基置換されたオキサゾリジノン抗生物質およびこれらの誘導体 |
| ES2536001T3 (es) * | 2003-07-29 | 2015-05-19 | Melinta Therapeutics, Inc. | Procedimiento para la síntesis de biariloxazolidinonas |
| US7932272B2 (en) | 2003-09-30 | 2011-04-26 | Eisai R&D Management Co., Ltd. | Antifungal agent containing heterocyclic compound |
| JP2007514782A (ja) | 2003-12-17 | 2007-06-07 | リブ−エックス ファーマシューティカルズ，インコーポレイテッド | ハロゲン化ビアリール複素環式化合物ならびにその作製方法および使用方法 |
| KR100854211B1 (ko) | 2003-12-18 | 2008-08-26 | 동아제약주식회사 | 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물 |
| US20050241110A1 (en) * | 2004-04-09 | 2005-11-03 | Bruce Baker | Ergonomic handles, especially for garden tools |
| WO2005116024A1 (en) * | 2004-05-25 | 2005-12-08 | Astrazeneca Ab | 3- (4- (2-dihydroisoxazol-3-ylpyridin-5-yl) phenyl) -5-triazol-1-ylmethyloxazolidin-2-one derivaives as mao inhibitors for the treatment of bacterial infections |
| US20080064689A1 (en) * | 2004-05-25 | 2008-03-13 | Astrazeneca Ab | 3-[4-(6-Pyridin-3-Yl)-3-Phenyl] -5-(1H-1,2,3-Triazol-1-Ylmethyl)-1,3-Oxazolidin-2-Ones as Antibacterial Agents |
| GB0411596D0 (en) * | 2004-05-25 | 2004-06-30 | Astrazeneca Ab | Chemical process |
| EP1799677A1 (en) * | 2004-10-08 | 2007-06-27 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
| WO2006106711A1 (ja) | 2005-03-30 | 2006-10-12 | Eisai R & D Management Co., Ltd. | ピリジン誘導体を含有する抗真菌剤 |
| JP5534497B2 (ja) | 2005-06-08 | 2014-07-02 | メリンタ セラピューティクス，インコーポレイテッド | トリアゾール類の合成方法 |
| TWI385169B (zh) | 2005-10-31 | 2013-02-11 | Eisai R&D Man Co Ltd | 經雜環取代之吡啶衍生物及含有彼之抗真菌劑 |
| JP5376805B2 (ja) * | 2005-11-04 | 2013-12-25 | 日本碍子株式会社 | ハニカム構造体及びハニカム触媒体 |
| US8119667B2 (en) * | 2005-12-29 | 2012-02-21 | Schering-Plough Animal Health Corporation | Carbonates of fenicol antibiotics |
| US8183264B2 (en) | 2006-09-21 | 2012-05-22 | Eisai R&D Managment Co., Ltd. | Pyridine derivative substituted by heteroaryl ring, and antifungal agent comprising the same |
| US20080190341A1 (en) * | 2007-02-08 | 2008-08-14 | Baruh Bradford G | System and method of adjusting the location and position of the foresail on a sailboat |
| US8258394B2 (en) * | 2007-02-08 | 2012-09-04 | Bradford G Baruh | Retractable solar panel system |
| US20100065104A1 (en) * | 2007-08-31 | 2010-03-18 | Baruh Bradford G | Retractable solar panel system |
| KR100848232B1 (ko) | 2007-04-12 | 2008-07-24 | 일동제약주식회사 | 신규 헤테로 고리 또는 알콕시아미노메틸 옥사졸리디논 및그 제조방법 |
| TW200841879A (en) * | 2007-04-27 | 2008-11-01 | Eisai R&D Man Co Ltd | Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same |
| AU2008246798A1 (en) | 2007-04-27 | 2008-11-13 | Eisai R&D Management Co., Ltd. | Salt of heterocycle-substituted pyridine derivative or crystal thereof |
| EP2166838B1 (en) * | 2007-06-01 | 2018-10-24 | CHX Technologies Inc. | Topical dental solution of chlorhexidine in sumatra benzoin bp/ep and methods of manufacturing and evaluating same |
| US8513287B2 (en) | 2007-12-27 | 2013-08-20 | Eisai R&D Management Co., Ltd. | Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same |
| US20100048524A1 (en) | 2008-03-14 | 2010-02-25 | Angela Brodie | Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity |
| GB2470700B (en) | 2008-03-25 | 2012-08-08 | Univ Maryland | C-17 heteroaryl steroidal CYP17 inhibitors |
| US7666864B2 (en) | 2008-03-26 | 2010-02-23 | Global Alliance For Tb Drug Development | Bicyclic nitroimidazole-substituted phenyl oxazolidinones |
| US8604209B2 (en) | 2008-10-10 | 2013-12-10 | Trius Therapeutics, Inc. | Methods for preparing oxazolidinones and compositions containing them |
| US8188119B2 (en) | 2008-10-24 | 2012-05-29 | Eisai R&D Management Co., Ltd | Pyridine derivatives substituted with heterocyclic ring and γ-glutamylamino group, and antifungal agents containing same |
| BRPI1008829A2 (pt) | 2009-02-03 | 2016-03-15 | Trius Therapeutics | forma cristalina de dihidrogenofosfato de (r)-3-(4-(2-(2-metiltetrazol-5-il) piridin-5-il)-3-fluorofenil)-5-hidroximetil oxazolidin-2-ona |
| CN102686600A (zh) | 2009-02-05 | 2012-09-19 | 托凯药业股份有限公司 | 甾体cyp17抑制剂/抗雄激素物质的新型药物前体 |
| US9428471B2 (en) | 2009-03-13 | 2016-08-30 | Sun Chemical B.V. | Cyclic carbamate compounds useful in energy-curable compositions |
| US8580767B2 (en) * | 2009-05-28 | 2013-11-12 | Trius Therapeutics, Inc. | Oxazolidinone containing dimer compounds, compositions and methods to make and use |
| KR101653570B1 (ko) * | 2011-03-30 | 2016-09-02 | 주식회사 레고켐 바이오사이언스 | 신규한 옥사졸리디논 유도체 및 이를 함유하는 의약 조성물 |
| EP2626356A1 (en) * | 2012-02-08 | 2013-08-14 | Rheinische Friedrich-Wilhelms-Universität Bonn | Thiamine analogues and their use as antibiotics |
| CA2904170A1 (en) | 2013-03-14 | 2014-09-25 | University Of Maryland, Baltimore | Androgen receptor down-regulating agents and uses thereof |
| JP2016528252A (ja) | 2013-08-12 | 2016-09-15 | トーカイ ファーマシューティカルズ， インコーポレイテッド | アンドロゲン標的治療を使用する新生物障害の処置のためのバイオマーカー |
| WO2021000297A1 (en) | 2019-07-03 | 2021-01-07 | Merck Sharp & Dohme Corp. | Compounds and methods of use thereof as antibacterial agents |
| CN112707779B (zh) * | 2020-12-26 | 2023-06-30 | 蚌埠中实化学技术有限公司 | 一种乙烯基环己烷的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4948801A (en) * | 1988-07-29 | 1990-08-14 | E. I. Du Pont De Nemours And Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
| CA2119556C (en) * | 1991-11-01 | 2004-07-06 | Michael Robert Barbachyn | Substituted aryl- and heteroaryl-phenyloxazolidinones |
| MXPA02012045A (es) | 2000-06-05 | 2003-10-15 | Dong A Pharm Co Ltd | Nuevos derivados de oxazolidinona y proceso para su preparacion. |
| US20020115669A1 (en) * | 2000-08-31 | 2002-08-22 | Wiedeman Paul E. | Oxazolidinone chemotherapeutic agents |
| RU2004111285A (ru) * | 2001-09-11 | 2005-10-10 | Астразенека Аб (Se) | Оксазолидинон и/или изоксазолин в качестве антибактериальных средств |
| KR20050085193A (ko) * | 2002-11-28 | 2005-08-29 | 아스트라제네카 아베 | 항균제로서의 옥사졸리디논 및(또는) 이속사졸린 유도체 |
| GB0227701D0 (en) * | 2002-11-28 | 2003-01-08 | Astrazeneca Ab | Chemical compounds |
| GB0229526D0 (en) * | 2002-12-19 | 2003-01-22 | Astrazeneca Ab | Chemical compounds |
-
2004
- 2004-02-23 TW TW093104447A patent/TW200500360A/zh unknown
- 2004-02-24 AT AT04713945T patent/ATE396991T1/de not_active IP Right Cessation
- 2004-02-24 CA CA002517706A patent/CA2517706A1/en not_active Abandoned
- 2004-02-24 BR BRPI0407835-7A patent/BRPI0407835A/pt not_active IP Right Cessation
- 2004-02-24 DE DE602004014107T patent/DE602004014107D1/de not_active Expired - Fee Related
- 2004-02-24 ES ES04713945T patent/ES2305732T3/es not_active Expired - Lifetime
- 2004-02-24 US US10/546,373 patent/US7192974B2/en not_active Expired - Fee Related
- 2004-02-24 WO PCT/GB2004/000730 patent/WO2004078753A1/en not_active Ceased
- 2004-02-24 AU AU2004218206A patent/AU2004218206A1/en not_active Abandoned
- 2004-02-24 EP EP04713945A patent/EP1599471B1/en not_active Expired - Lifetime
- 2004-02-24 JP JP2006505893A patent/JP2006519247A/ja active Pending
- 2004-02-24 KR KR1020057016202A patent/KR20050106064A/ko not_active Withdrawn
- 2004-02-24 MX MXPA05009205A patent/MXPA05009205A/es not_active Application Discontinuation
- 2004-02-27 CL CL200400400A patent/CL2004000400A1/es unknown
- 2004-02-27 UY UY28211A patent/UY28211A1/es not_active Application Discontinuation
-
2005
- 2005-09-30 NO NO20054523A patent/NO20054523L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004078753A1 (en) | 2004-09-16 |
| NO20054523D0 (no) | 2005-09-30 |
| CA2517706A1 (en) | 2004-09-16 |
| EP1599471B1 (en) | 2008-05-28 |
| EP1599471A1 (en) | 2005-11-30 |
| TW200500360A (en) | 2005-01-01 |
| ATE396991T1 (de) | 2008-06-15 |
| MXPA05009205A (es) | 2005-10-18 |
| HK1083097A1 (en) | 2006-06-23 |
| BRPI0407835A (pt) | 2006-02-14 |
| US7192974B2 (en) | 2007-03-20 |
| KR20050106064A (ko) | 2005-11-08 |
| ES2305732T3 (es) | 2008-11-01 |
| UY28211A1 (es) | 2004-09-30 |
| US20060270637A1 (en) | 2006-11-30 |
| AU2004218206A1 (en) | 2004-09-16 |
| DE602004014107D1 (de) | 2008-07-10 |
| NO20054523L (no) | 2005-12-01 |
| JP2006519247A (ja) | 2006-08-24 |
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