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CL2003002565A1 - Compuestos derivados de 3h-quinazolin-4-ona, su proceso de preparacion, composicion farmaceutica que los contiene, y uso en el tratamiento y prevencion de enfermedades mediadas por inhibidores de mao-b, tales como la enfermedad de alzheimer y demenci - Google Patents

Compuestos derivados de 3h-quinazolin-4-ona, su proceso de preparacion, composicion farmaceutica que los contiene, y uso en el tratamiento y prevencion de enfermedades mediadas por inhibidores de mao-b, tales como la enfermedad de alzheimer y demenci

Info

Publication number
CL2003002565A1
CL2003002565A1 CL200302565A CL2003002565A CL2003002565A1 CL 2003002565 A1 CL2003002565 A1 CL 2003002565A1 CL 200302565 A CL200302565 A CL 200302565A CL 2003002565 A CL2003002565 A CL 2003002565A CL 2003002565 A1 CL2003002565 A1 CL 2003002565A1
Authority
CL
Chile
Prior art keywords
quinazolin
ona
alzheimer
disease
inhibitors
Prior art date
Application number
CL200302565A
Other languages
English (en)
Inventor
Rosa Thomas Andrew Y Rodriguez
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CL2003002565A1 publication Critical patent/CL2003002565A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

DERIVADOS DE LA 3H-QUINAZOLIN-4-ONA DE FORMULA I, DONDE R1,R2,R3,R4 Y m SON COMO SE DEFINEN EN LA MEMORIA DESCRIPTIVA Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN, UTILES COMO INHIBIDORES SELECTIVOS DE LA MOAMINA-OXIDASA B, Y POR ELLO, ENFERMEDAD DE ALZHEIMER Y DEMENSCIA SENIL.
CL200302565A 2002-12-13 2003-12-10 Compuestos derivados de 3h-quinazolin-4-ona, su proceso de preparacion, composicion farmaceutica que los contiene, y uso en el tratamiento y prevencion de enfermedades mediadas por inhibidores de mao-b, tales como la enfermedad de alzheimer y demenci CL2003002565A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02027700 2002-12-13

Publications (1)

Publication Number Publication Date
CL2003002565A1 true CL2003002565A1 (es) 2005-01-07

Family

ID=32524001

Family Applications (1)

Application Number Title Priority Date Filing Date
CL200302565A CL2003002565A1 (es) 2002-12-13 2003-12-10 Compuestos derivados de 3h-quinazolin-4-ona, su proceso de preparacion, composicion farmaceutica que los contiene, y uso en el tratamiento y prevencion de enfermedades mediadas por inhibidores de mao-b, tales como la enfermedad de alzheimer y demenci

Country Status (23)

Country Link
US (1) US7087612B2 (es)
EP (1) EP1572666B1 (es)
JP (1) JP4384053B2 (es)
KR (1) KR100707532B1 (es)
CN (1) CN100418954C (es)
AR (1) AR042362A1 (es)
AT (1) ATE335729T1 (es)
AU (1) AU2003293798B8 (es)
BR (1) BR0317282A (es)
CA (1) CA2509633A1 (es)
CL (1) CL2003002565A1 (es)
DE (1) DE60307512T2 (es)
ES (1) ES2270154T3 (es)
GT (1) GT200300284A (es)
MX (1) MXPA05006124A (es)
MY (1) MY141743A (es)
PA (1) PA8591901A1 (es)
PE (1) PE20040911A1 (es)
PL (1) PL377474A1 (es)
RU (1) RU2340604C2 (es)
TW (1) TW200424180A (es)
UY (1) UY28120A1 (es)
WO (1) WO2004054985A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2584485C (en) 2004-10-20 2013-12-31 Resverlogix Corp. Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases
EP2281556A1 (en) 2005-02-25 2011-02-09 F. Hoffmann-La Roche AG Tablets with improved drugs substance dispersibility
CN101365446B (zh) 2005-07-29 2013-05-22 雷斯弗洛吉克斯公司 预防和治疗复杂疾病的药物组合物及其经由可植入医药装置的递送
GB0525068D0 (en) * 2005-12-08 2006-01-18 Novartis Ag Organic compounds
JP4876690B2 (ja) * 2006-04-21 2012-02-15 三菱瓦斯化学株式会社 キナゾリン−４−オン誘導体の製造法
WO2008087736A1 (ja) * 2007-01-19 2008-07-24 Ube Industries, Ltd. アラルキルオキシ又はヘテロアラルキルオキシ基を有する芳香族アミンの製法
DK2118074T3 (en) 2007-02-01 2014-03-10 Resverlogix Corp Compounds for the prevention and treatment of cardiovascular diseases
ES2532402T3 (es) 2008-06-26 2015-03-26 Resverlogix Corporation Métodos de preparación de derivados de quinazolinona
JP5635535B2 (ja) 2009-01-08 2014-12-03 レスバーロジックス コーポレイション 心血管疾患の予防および治療のための化合物
CN105859639A (zh) 2009-03-18 2016-08-17 雷斯韦洛吉克斯公司 新的抗炎剂
CN107252429B (zh) 2009-04-22 2023-06-16 雷斯韦洛吉克斯公司 新抗炎剂
JP5992049B2 (ja) 2011-11-01 2016-09-14 レスバーロジックス コーポレイション 置換されたキナゾリノンのための経口速放性製剤
WO2014080291A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Biaryl derivatives as bromodomain inhibitors
WO2014080290A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Cyclic amines as bromodomain inhibitors
AU2013365926B9 (en) 2012-12-21 2019-01-17 Zenith Epigenetics Ltd. Novel heterocyclic compounds as bromodomain inhibitors
CN114984016A (zh) 2015-03-13 2022-09-02 雷斯韦洛吉克斯公司 用于治疗补体相关疾病之组合物及治疗方法
CN106146410B (zh) * 2015-04-03 2018-10-12 中南大学 6-氨基-4(3h)-喹唑啉酮衍生物及其合成方法和用途
CN108191667B (zh) * 2018-01-04 2021-03-26 利尔化学股份有限公司 2-硝基-4-三氟甲基苯甲酸甲酯的制备方法
CN109553534A (zh) * 2018-11-27 2019-04-02 常州大学 一种2-硝基-4-甲氧基苯甲酸的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6136273A (ja) * 1984-07-26 1986-02-20 Mitsubishi Yuka Yakuhin Kk ２−フエニルアルキル−４（３ｈ）−キナゾリノン誘導体
RU2164224C2 (ru) * 1995-03-14 2001-03-20 Новартис Аг Трехзамещенные фенильные производные и фармацевтическая композиция
IL117659A (en) * 1995-04-13 2000-12-06 Dainippon Pharmaceutical Co Substituted 2-phenyl pyrimidino amino acetamide derivative process for preparing the same and a pharmaceutical composition containing same
US5679715A (en) 1995-06-07 1997-10-21 Harris; Richard Y. Method for treating multiple sclerosis
US5783577A (en) * 1995-09-15 1998-07-21 Trega Biosciences, Inc. Synthesis of quinazolinone libraries and derivatives thereof
CN1116870C (zh) 1996-03-15 2003-08-06 萨默塞特药品有限公司 司立吉林在制备用于预防或治疗外周神经病的药物中的应用
AU8816298A (en) * 1997-08-22 1999-03-16 Zeneca Limited Oxindolylquinazoline derivatives as angiogenesis inhibitors
US6890930B1 (en) * 1999-09-28 2005-05-10 3-Dimensional Pharmaceuticals, Inc. Quinazolinones
AU1359801A (en) 1999-11-05 2001-06-06 Vela Pharmaceuticals Inc. Methods and compositions for treating reward deficiency syndrome

Also Published As

Publication number Publication date
DE60307512T2 (de) 2007-02-08
AU2003293798B8 (en) 2009-02-12
DE60307512D1 (de) 2006-09-21
JP2006513177A (ja) 2006-04-20
ES2270154T3 (es) 2007-04-01
KR20050085587A (ko) 2005-08-29
US20040142951A1 (en) 2004-07-22
GT200300284A (es) 2004-07-14
MXPA05006124A (es) 2005-08-16
RU2340604C2 (ru) 2008-12-10
RU2005121908A (ru) 2006-01-27
PA8591901A1 (es) 2004-11-26
MY141743A (en) 2010-06-30
ATE335729T1 (de) 2006-09-15
WO2004054985A1 (en) 2004-07-01
UY28120A1 (es) 2004-06-30
KR100707532B1 (ko) 2007-04-12
CA2509633A1 (en) 2004-07-01
JP4384053B2 (ja) 2009-12-16
BR0317282A (pt) 2005-11-08
EP1572666B1 (en) 2006-08-09
AU2003293798A1 (en) 2004-07-09
CN100418954C (zh) 2008-09-17
PE20040911A1 (es) 2004-12-11
US7087612B2 (en) 2006-08-08
AR042362A1 (es) 2005-06-15
EP1572666A1 (en) 2005-09-14
PL377474A1 (pl) 2006-02-06
CN1720237A (zh) 2006-01-11
TW200424180A (en) 2004-11-16
AU2003293798B2 (en) 2009-01-15

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