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CA2573245A1 - Antagonistes multivalents de l'antigene vla-4 comportant des fractions polymeres - Google Patents

Antagonistes multivalents de l'antigene vla-4 comportant des fractions polymeres Download PDF

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Publication number
CA2573245A1
CA2573245A1 CA002573245A CA2573245A CA2573245A1 CA 2573245 A1 CA2573245 A1 CA 2573245A1 CA 002573245 A CA002573245 A CA 002573245A CA 2573245 A CA2573245 A CA 2573245A CA 2573245 A1 CA2573245 A1 CA 2573245A1
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substituted
group
alkyl
compound
polymer moiety
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CA2573245C (fr
Inventor
Andrei W. Konradi
Michael A. Pleiss
Christopher M. Semko
Theodore Yednock
Jenifer L. Smith
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Elan Pharmaceuticals LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
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  • Hematology (AREA)
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Abstract

L'invention concerne des conjugués qui se lient à l'antigène VLA-4. Certains de ces conjugués inhibent également l'adhérence des leucocytes, en particulier l'adhérence des leucocytes dont la médiation est assurée par VLA-4. Les conjugués selon l'invention peuvent servir à traiter des maladies inflammatoires chez un patient mammalien, par exemple un patient humain, ces maladies inflammatoires comprenant l'asthme, la maladie d'Alzheimer, l'athérosclérose, le syndrome démentiel lié au SIDA, le diabète, les maladies intestinales inflammables, l'arthrite rhumatoïde, la greffe de tissus, la métastase tumorale, et l'ischémie myocardique. Ces conjugués peuvent aussi être administrés pour traiter des maladies cérébrales inflammatoires telles que la sclérose en plaques.
CA2573245A 2004-07-08 2005-07-08 Antagonistes multivalents de l'antigene vla-4 comportant des fractions polymeres Expired - Fee Related CA2573245C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58697504P 2004-07-08 2004-07-08
US60/586,975 2004-07-08
PCT/US2005/024369 WO2006010054A2 (fr) 2004-07-08 2005-07-08 Antagonistes multivalents de l'antigene vla-4 comportant des fractions polymeres

Publications (2)

Publication Number Publication Date
CA2573245A1 true CA2573245A1 (fr) 2006-01-26
CA2573245C CA2573245C (fr) 2013-10-01

Family

ID=35501261

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2573245A Expired - Fee Related CA2573245C (fr) 2004-07-08 2005-07-08 Antagonistes multivalents de l'antigene vla-4 comportant des fractions polymeres

Country Status (19)

Country Link
US (4) US7794700B2 (fr)
EP (4) EP2298356A3 (fr)
JP (1) JP2008505927A (fr)
KR (1) KR101273614B1 (fr)
CN (1) CN101035563B (fr)
AR (1) AR050425A1 (fr)
AU (1) AU2005265316B2 (fr)
BR (1) BRPI0513143A (fr)
CA (1) CA2573245C (fr)
EA (1) EA012433B1 (fr)
EC (1) ECSP077231A (fr)
IL (1) IL180558A0 (fr)
MA (1) MA28786B1 (fr)
MX (1) MX2007000228A (fr)
NO (1) NO20070216L (fr)
NZ (1) NZ588839A (fr)
TW (1) TWI418346B (fr)
WO (1) WO2006010054A2 (fr)
ZA (1) ZA200700238B (fr)

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EP1706399A1 (fr) * 2004-01-23 2006-10-04 Elan Pharmaceuticals, Inc. Conjugues a base de polyethylene glycol d'acides heterocycloalkyl carboxamido propanoiques
AR050425A1 (es) 2004-07-08 2006-10-25 Elan Pharm Inc Antagonistas multivalentes de vla-4 que comprende fracciones polimericas. composiciones farmaceuticas
US8030328B2 (en) 2005-05-20 2011-10-04 Elan Pharmaceuticals, Inc. Imidazolone phenylalanine derivatives
NZ564836A (en) * 2005-07-08 2011-10-28 Elan Pharm Inc Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds
US7727996B2 (en) * 2005-09-29 2010-06-01 Elan Pharmaceuticals, Inc. Carbamate compounds which inhibit leukocyte adhesion mediated by VLA-4
CA2624450C (fr) * 2005-09-29 2014-02-04 Elan Pharmaceuticals, Inc. Composes de pyrimidinyl amide qui inhibent l'adherence leucocytaire a mediation par vla-4
EP1957476A1 (fr) * 2005-11-23 2008-08-20 AstraZeneca AB Derives de l-alanine
MY151045A (en) * 2006-02-27 2014-03-31 Elan Pharm Inc Pyrimidinyl sulfonamide compounds which inhibit leukocyte adhesion mediated by vla-4
US8410115B2 (en) * 2006-02-28 2013-04-02 Elan Pharmaceuticals, Inc. Methods of treating inflammatory and autoimmune diseases with alpha-4 inhibitory compounds
WO2007100770A2 (fr) * 2006-02-28 2007-09-07 Elan Pharmaceuticals, Inc. Méthodes pour traiter des maladies inflammatoires et auto-immunes avec du natalizumab
RS20080391A (sr) 2006-03-03 2009-07-15 Elan Pharmaceuticals Inc., Postupci lečenja zapaljenskih i autoimunih bolesti natalizumabom
TW200817369A (en) * 2006-05-22 2008-04-16 Elan Pharm Inc Preparation of polymer conjugates of therapeutic, agricultural and food additive compounds
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WO2008093065A1 (fr) * 2007-01-29 2008-08-07 Astrazeneca Ab Dérivés de l-alanine utilisés comme antagonistes d'alpha-5 bêta-l
US20100150915A1 (en) 2007-02-20 2010-06-17 Stewart Edward J Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist
WO2008125811A1 (fr) * 2007-04-11 2008-10-23 Astrazeneca Ab DÉRIVÉS DE N-[HÉTÉROARYLCARBONYL]-S-THIÉNYL-L-ALANINE EN TANT QU'ANTAGONISTES DE L'INTÉGRINE α5β1
WO2008153967A1 (fr) * 2007-06-08 2008-12-18 Contec Therapeutics, Inc. Conjugués antagonistes de bk1
CA2708262A1 (fr) * 2007-12-07 2009-06-18 Elan Pharmaceuticals, Inc. Procedes et compositions pour traiter des tumeurs liquides
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US20060013799A1 (en) 2006-01-19
HK1111674A1 (en) 2008-08-15
KR101273614B1 (ko) 2013-06-12
WO2006010054A2 (fr) 2006-01-26
TW200603788A (en) 2006-02-01
US20110002876A1 (en) 2011-01-06
EP1765412A2 (fr) 2007-03-28
EA200700212A1 (ru) 2007-08-31
CN101035563B (zh) 2012-03-28
EP2258400A3 (fr) 2011-08-10
BRPI0513143A (pt) 2008-04-29
ECSP077231A (es) 2007-03-29
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US8263063B2 (en) 2012-09-11
US7794700B2 (en) 2010-09-14
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