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NO20070216L - Multivalente VLA-1 antagonister inneholdende polymerhalvdeler - Google Patents

Multivalente VLA-1 antagonister inneholdende polymerhalvdeler

Info

Publication number
NO20070216L
NO20070216L NO20070216A NO20070216A NO20070216L NO 20070216 L NO20070216 L NO 20070216L NO 20070216 A NO20070216 A NO 20070216A NO 20070216 A NO20070216 A NO 20070216A NO 20070216 L NO20070216 L NO 20070216L
Authority
NO
Norway
Prior art keywords
vla
conjugates
multivalent
containing polymer
inflammatory
Prior art date
Application number
NO20070216A
Other languages
English (en)
Inventor
Michael A Pleiss
Christopher M Semko
Andrei Konradi
Theodore Yednock
Original Assignee
Elan Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc filed Critical Elan Pharm Inc
Publication of NO20070216L publication Critical patent/NO20070216L/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
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  • Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • AIDS & HIV (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)

Abstract

Det beskrives konjugater som binder VLA-4. Noen av disse konjugater inhiberer også leukocyttadhesjon og særlig leukocyttadhesjon mediert av VLA-4. Slike konjugater er nyttige ved behandling av pattedyrpasienter som mennesker med inflammatoriske sykdommer som for eksempel astma, Alzheimers sykdom, aterosklerose, AIDS dementia, diabetes, inflammatorisk tarmsykdom, reumatoid artritt, vevtransplantasjon, tumormetastase og myokardial iskemi. Konjugatene kan også administreres for behandling av inflammatoriske hjernesykdommer som multippel sklerose.
NO20070216A 2004-07-08 2007-01-12 Multivalente VLA-1 antagonister inneholdende polymerhalvdeler NO20070216L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58697504P 2004-07-08 2004-07-08
PCT/US2005/024369 WO2006010054A2 (en) 2004-07-08 2005-07-08 Multivalent vla-4 antagonists comprising polyethylene glycol moieties

Publications (1)

Publication Number Publication Date
NO20070216L true NO20070216L (no) 2007-04-04

Family

ID=35501261

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20070216A NO20070216L (no) 2004-07-08 2007-01-12 Multivalente VLA-1 antagonister inneholdende polymerhalvdeler

Country Status (19)

Country Link
US (4) US7794700B2 (no)
EP (4) EP2298356A3 (no)
JP (1) JP2008505927A (no)
KR (1) KR101273614B1 (no)
CN (1) CN101035563B (no)
AR (1) AR050425A1 (no)
AU (1) AU2005265316B2 (no)
BR (1) BRPI0513143A (no)
CA (1) CA2573245C (no)
EA (1) EA012433B1 (no)
EC (1) ECSP077231A (no)
IL (1) IL180558A0 (no)
MA (1) MA28786B1 (no)
MX (1) MX2007000228A (no)
NO (1) NO20070216L (no)
NZ (1) NZ588839A (no)
TW (1) TWI418346B (no)
WO (1) WO2006010054A2 (no)
ZA (1) ZA200700238B (no)

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