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CA2371633A1 - Derives de thio-oxindole - Google Patents

Derives de thio-oxindole Download PDF

Info

Publication number
CA2371633A1
CA2371633A1 CA002371633A CA2371633A CA2371633A1 CA 2371633 A1 CA2371633 A1 CA 2371633A1 CA 002371633 A CA002371633 A CA 002371633A CA 2371633 A CA2371633 A CA 2371633A CA 2371633 A1 CA2371633 A1 CA 2371633A1
Authority
CA
Canada
Prior art keywords
alkyl
substituted
aryl
heterocyclic
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002371633A
Other languages
English (en)
Inventor
Andrew Fensome
Puwen Zhang
Marci C. Koko
Lin Zhi
Todd K. Jones
Christopher M. Tegley
Jay E. Wrobel
James P. Edwards
Edward G. Melenski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/552,033 external-priority patent/US6355648B1/en
Application filed by Individual filed Critical Individual
Publication of CA2371633A1 publication Critical patent/CA2371633A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Cette invention se rapporte à des composés agonistes du récepteur de la progestérone, représentés par les structures générales (1) ou (2), où les substituants sont définis dans les pièces descriptives de la demande; ou à un sel de ces composés acceptable sur le plan pharmaceutique, ainsi qu'à des procédés d'utilisation de ces composés pour induire un effet contraceptif ou traiter les carcinomes et les adénocarcinomes associés à la progestérone.
CA002371633A 1999-05-04 2000-05-01 Derives de thio-oxindole Abandoned CA2371633A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US17225999P 1999-05-04 1999-05-04
US60/172,259 1999-05-04
US09/552,033 US6355648B1 (en) 1999-05-04 2000-04-19 Thio-oxindole derivatives
US09/552,033 2000-04-19
PCT/US2000/011630 WO2000066555A1 (fr) 1999-05-04 2000-05-01 Derives de thio-oxindole

Publications (1)

Publication Number Publication Date
CA2371633A1 true CA2371633A1 (fr) 2000-11-09

Family

ID=26867898

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002371633A Abandoned CA2371633A1 (fr) 1999-05-04 2000-05-01 Derives de thio-oxindole

Country Status (18)

Country Link
EP (1) EP1181275A1 (fr)
JP (1) JP2002543182A (fr)
KR (1) KR20020000636A (fr)
CN (1) CN1143847C (fr)
AU (1) AU767762B2 (fr)
BG (1) BG106078A (fr)
BR (1) BR0010216A (fr)
CA (1) CA2371633A1 (fr)
CZ (1) CZ20013950A3 (fr)
EA (1) EA005034B1 (fr)
GE (1) GEP20043266B (fr)
HU (1) HUP0200993A3 (fr)
MX (1) MXPA01011285A (fr)
NO (1) NO320912B1 (fr)
NZ (1) NZ515351A (fr)
PL (1) PL351407A1 (fr)
SK (1) SK15902001A3 (fr)
TR (1) TR200103288T2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1732921T3 (pl) * 2004-04-08 2009-04-30 Wyeth Corp Pochodne tioamidu jako modulatory receptora progesteronowego
PL1732922T3 (pl) * 2004-04-08 2009-03-31 Wyeth Corp Sposób minimalizowania zanieczyszczeń tioamidowych
GB201113538D0 (en) * 2011-08-04 2011-09-21 Karobio Ab Novel estrogen receptor ligands
EP2888268B1 (fr) * 2012-10-12 2018-08-22 Okinawa Institute of Science and Technology School Corporation Nouveau dérivé de spirooxindole et procédé pour la production de celui-ci
WO2016057931A1 (fr) 2014-10-10 2016-04-14 The Research Foundation For The State University Of New York Trifluorométhoxylation d'arènes via une migration intramoléculaire du groupe trifluorométhoxy
AU2017336074A1 (en) * 2016-09-30 2019-03-28 Epizyme, Inc. Substituted fused bi- or tri- heterocyclic compounds as ehmt2 inhibitors

Also Published As

Publication number Publication date
BR0010216A (pt) 2002-03-19
AU767762B2 (en) 2003-11-20
JP2002543182A (ja) 2002-12-17
SK15902001A3 (sk) 2002-11-06
PL351407A1 (en) 2003-04-22
EA200101180A1 (ru) 2002-04-25
NZ515351A (en) 2004-01-30
NO320912B1 (no) 2006-02-13
CZ20013950A3 (cs) 2002-06-12
EP1181275A1 (fr) 2002-02-27
NO20015380L (no) 2002-01-03
CN1349499A (zh) 2002-05-15
KR20020000636A (ko) 2002-01-05
MXPA01011285A (es) 2003-09-04
GEP20043266B (en) 2004-06-25
HUP0200993A3 (en) 2003-05-28
AU4681400A (en) 2000-11-17
HUP0200993A2 (hu) 2002-07-29
EA005034B1 (ru) 2004-10-28
NO20015380D0 (no) 2001-11-02
BG106078A (en) 2002-05-31
TR200103288T2 (tr) 2002-04-22
CN1143847C (zh) 2004-03-31

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued