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BG106078A - Thio-oxindole derivatives - Google Patents

Thio-oxindole derivatives

Info

Publication number
BG106078A
BG106078A BG106078A BG10607801A BG106078A BG 106078 A BG106078 A BG 106078A BG 106078 A BG106078 A BG 106078A BG 10607801 A BG10607801 A BG 10607801A BG 106078 A BG106078 A BG 106078A
Authority
BG
Bulgaria
Prior art keywords
thio
oxindole derivatives
compounds
progesterone
adenocacinomas
Prior art date
Application number
BG106078A
Other languages
Bulgarian (bg)
Inventor
Andrew Fensome
Puwen Zhang
Marci KOKO
Jay Wrobel
James Edwards
Todd Jones
Christopher Tegley
Lin Zhi
Edward MELENSKI
Original Assignee
Ligand Pharmaceuticals, Inc.
Wyeth
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/552,033 external-priority patent/US6355648B1/en
Application filed by Ligand Pharmaceuticals, Inc., Wyeth filed Critical Ligand Pharmaceuticals, Inc.
Publication of BG106078A publication Critical patent/BG106078A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

The invention relates to compounds which are agonists of the progesterone receptor, which have the general structures or wherein their substituents have the meanings listed in the description, or a pharmaceutically acceptable salt thereof, as well as methods of using these compounds to induce contraception or treat progesterone-related carcinomas and adenocacinomas. 18 claims
BG106078A 1999-05-04 2001-11-02 Thio-oxindole derivatives BG106078A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17225999P 1999-05-04 1999-05-04
US09/552,033 US6355648B1 (en) 1999-05-04 2000-04-19 Thio-oxindole derivatives
PCT/US2000/011630 WO2000066555A1 (en) 1999-05-04 2000-05-01 Thio-oxindole derivatives

Publications (1)

Publication Number Publication Date
BG106078A true BG106078A (en) 2002-05-31

Family

ID=26867898

Family Applications (1)

Application Number Title Priority Date Filing Date
BG106078A BG106078A (en) 1999-05-04 2001-11-02 Thio-oxindole derivatives

Country Status (18)

Country Link
EP (1) EP1181275A1 (en)
JP (1) JP2002543182A (en)
KR (1) KR20020000636A (en)
CN (1) CN1143847C (en)
AU (1) AU767762B2 (en)
BG (1) BG106078A (en)
BR (1) BR0010216A (en)
CA (1) CA2371633A1 (en)
CZ (1) CZ20013950A3 (en)
EA (1) EA005034B1 (en)
GE (1) GEP20043266B (en)
HU (1) HUP0200993A3 (en)
MX (1) MXPA01011285A (en)
NO (1) NO320912B1 (en)
NZ (1) NZ515351A (en)
PL (1) PL351407A1 (en)
SK (1) SK15902001A3 (en)
TR (1) TR200103288T2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1732921T3 (en) * 2004-04-08 2009-04-30 Wyeth Corp Thioamide derivatives as progesterone receptor modulators
PL1732922T3 (en) * 2004-04-08 2009-03-31 Wyeth Corp Methods for minimizing thioamide impurities
GB201113538D0 (en) * 2011-08-04 2011-09-21 Karobio Ab Novel estrogen receptor ligands
EP2888268B1 (en) * 2012-10-12 2018-08-22 Okinawa Institute of Science and Technology School Corporation Novel spirooxindole derivative and process for producing the same
WO2016057931A1 (en) 2014-10-10 2016-04-14 The Research Foundation For The State University Of New York Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration
AU2017336074A1 (en) * 2016-09-30 2019-03-28 Epizyme, Inc. Substituted fused bi- or tri- heterocyclic compounds as ehmt2 inhibitors

Also Published As

Publication number Publication date
BR0010216A (en) 2002-03-19
AU767762B2 (en) 2003-11-20
JP2002543182A (en) 2002-12-17
SK15902001A3 (en) 2002-11-06
PL351407A1 (en) 2003-04-22
CA2371633A1 (en) 2000-11-09
EA200101180A1 (en) 2002-04-25
NZ515351A (en) 2004-01-30
NO320912B1 (en) 2006-02-13
CZ20013950A3 (en) 2002-06-12
EP1181275A1 (en) 2002-02-27
NO20015380L (en) 2002-01-03
CN1349499A (en) 2002-05-15
KR20020000636A (en) 2002-01-05
MXPA01011285A (en) 2003-09-04
GEP20043266B (en) 2004-06-25
HUP0200993A3 (en) 2003-05-28
AU4681400A (en) 2000-11-17
HUP0200993A2 (en) 2002-07-29
EA005034B1 (en) 2004-10-28
NO20015380D0 (en) 2001-11-02
TR200103288T2 (en) 2002-04-22
CN1143847C (en) 2004-03-31

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