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CA2098989A1 - Methode et produits intermediaires pour la preparation d'azabicyclo¬2.2.2|octan-3-imines - Google Patents

Methode et produits intermediaires pour la preparation d'azabicyclo¬2.2.2|octan-3-imines

Info

Publication number
CA2098989A1
CA2098989A1 CA 2098989 CA2098989A CA2098989A1 CA 2098989 A1 CA2098989 A1 CA 2098989A1 CA 2098989 CA2098989 CA 2098989 CA 2098989 A CA2098989 A CA 2098989A CA 2098989 A1 CA2098989 A1 CA 2098989A1
Authority
CA
Canada
Prior art keywords
octan
imines
intermediates
azabicyclo
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2098989
Other languages
English (en)
Other versions
CA2098989C (fr
Inventor
Dennis M. Godek
Charles W. Murtiashaw
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd Great Britain
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CA002158130A priority Critical patent/CA2158130C/fr
Priority to CA002158131A priority patent/CA2158131C/fr
Publication of CA2098989A1 publication Critical patent/CA2098989A1/fr
Application granted granted Critical
Publication of CA2098989C publication Critical patent/CA2098989C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatuses For Bulk Treatment Of Fruits And Vegetables And Apparatuses For Preparing Feeds (AREA)

Abstract

(voir fig. I) (voir fig. II) (voir fig. III) Des azabicyclo[2.2.2]octan-3-imines de formule générale (I), où R1, R2 et R3 sont tels que définis dans la présente, sont préparées par réaction d'un composé de formule (II) avec un composé de formule (III), où A correspond à MgCl, MgBr ou Li.
CA002098989A 1991-01-03 1991-12-18 Methode et produits intermediaires pour la preparation d'azabicyclo¬2.2.2|octan-3-imines Expired - Fee Related CA2098989C (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA002158130A CA2158130C (fr) 1991-01-03 1991-12-18 Methode et produits intermediaires pour la preparation d'azabicyclo(2.2.2)octan-3-imines
CA002158131A CA2158131C (fr) 1991-12-18 1991-12-18 Production de dioxyde de soufre a partir d'une alimentation sulfuree, en grains ou sous forme d'emulsion

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US637,102 1991-01-03
US07/637,102 US5138060A (en) 1991-01-03 1991-01-03 Process and intermediates for preparing azabicyclo(2.2.2)octan-3-imines

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CA002158130A Division CA2158130C (fr) 1991-01-03 1991-12-18 Methode et produits intermediaires pour la preparation d'azabicyclo(2.2.2)octan-3-imines
CA002158131A Division CA2158131C (fr) 1991-12-18 1991-12-18 Production de dioxyde de soufre a partir d'une alimentation sulfuree, en grains ou sous forme d'emulsion

Publications (2)

Publication Number Publication Date
CA2098989A1 true CA2098989A1 (fr) 1992-07-04
CA2098989C CA2098989C (fr) 1998-02-03

Family

ID=24554545

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002158130A Expired - Fee Related CA2158130C (fr) 1991-01-03 1991-12-18 Methode et produits intermediaires pour la preparation d'azabicyclo(2.2.2)octan-3-imines
CA002098989A Expired - Fee Related CA2098989C (fr) 1991-01-03 1991-12-18 Methode et produits intermediaires pour la preparation d'azabicyclo¬2.2.2|octan-3-imines

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA002158130A Expired - Fee Related CA2158130C (fr) 1991-01-03 1991-12-18 Methode et produits intermediaires pour la preparation d'azabicyclo(2.2.2)octan-3-imines

Country Status (21)

Country Link
US (1) US5138060A (fr)
EP (1) EP0565558B1 (fr)
JP (5) JPH0768244B2 (fr)
KR (1) KR970001157B1 (fr)
AT (1) ATE115580T1 (fr)
AU (1) AU653380B2 (fr)
CA (2) CA2158130C (fr)
DE (1) DE69106003T2 (fr)
DK (1) DK0565558T3 (fr)
ES (1) ES2065161T3 (fr)
FI (3) FI933065A7 (fr)
GR (1) GR3015021T3 (fr)
HU (1) HU9301931D0 (fr)
IE (1) IE65005B1 (fr)
IL (1) IL100541A0 (fr)
MX (1) MX9200003A (fr)
NO (1) NO932431L (fr)
NZ (1) NZ241161A (fr)
PT (1) PT99970B (fr)
WO (1) WO1992012152A1 (fr)
ZA (1) ZA928B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5364943A (en) * 1991-11-27 1994-11-15 Pfizer Inc. Preparation of substituted piperidines
ES2092113T3 (es) * 1991-06-20 1996-11-16 Pfizer Derivados fluoroalcoxibencilamino de heterociclos que contienen nitrogeno.
HUT70741A (en) * 1991-11-12 1995-10-30 Pfizer Acyclic ethylenediamine derivatives as substance p receptor antagonists
EP0641328B1 (fr) * 1992-05-18 2001-11-21 Pfizer Inc. Derives aza-bicycliques en pont utiles comme antagonistes de la substance p
US6048859A (en) 1992-06-29 2000-04-11 Merck & Co., Inc. Morpholine and thiomorpholine tachykinin receptor antagonists
US5719147A (en) * 1992-06-29 1998-02-17 Merck & Co., Inc. Morpholine and thiomorpholine tachykinin receptor antagonists
US5637699A (en) * 1992-06-29 1997-06-10 Merck & Co., Inc. Process for preparing morpholine tachykinin receptor antagonists
JPH07506379A (ja) * 1992-08-04 1995-07-13 ファイザー・インコーポレーテッド 物質ｐ受容体アンタゴニストとしての３−ベンジルアミノ−２−フェニル−ピペリジン
US5387595A (en) * 1992-08-26 1995-02-07 Merck & Co., Inc. Alicyclic compounds as tachykinin receptor antagonists
US5518628A (en) * 1993-11-08 1996-05-21 Shipley Company Inc. Purification process
TW385308B (en) * 1994-03-04 2000-03-21 Merck & Co Inc Prodrugs of morpholine tachykinin receptor antagonists
US6861526B2 (en) 2002-10-16 2005-03-01 Pfizer Inc. Process for the preparation of (S,S)-cis-2-benzhydryl-3-benzylaminoquinuclidine
US20050136487A1 (en) * 2003-10-27 2005-06-23 Meyer Donald W. Transmissible spongiform encephalopathy detection in cervids, sheep and goats

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3560510A (en) * 1969-03-05 1971-02-02 Aldrich Chem Co Inc 2-benzhydrylquinuclidines
US3993652A (en) * 1973-07-09 1976-11-23 Air Products And Chemicals, Inc. Cyclic quaternary hydroxyalkyl phenoxide catalysts for isocyanate reactions
US4203990A (en) * 1979-04-30 1980-05-20 G. D. Searle & Co. Anti-diarrheal 2-substituted quinuclidines
FR2529548A1 (fr) * 1982-07-02 1984-01-06 Delalande Sa Nouveaux derives de l'amino-3 quinuclidine, leur procede et leur application en therapeutique
JPS59110656A (ja) * 1982-12-15 1984-06-26 Hiroyuki Nohira 光学活性な１―フェニル―２―（パラ―トリル）エチルアミンの製造方法
DE3604591A1 (de) * 1986-02-14 1987-08-20 Degussa Verfahren zur herstellung chiraler glycinderivate
JPS6354342A (ja) * 1986-08-26 1988-03-08 Daicel Chem Ind Ltd （±）−α−エチルベンジルアミンの光学分割方法
JPS63145256A (ja) * 1986-12-09 1988-06-17 Nippon Kayaku Co Ltd 光学活性ホモフエニルアラニンの製造法及び中間体
MX18467A (es) * 1988-11-23 1993-07-01 Pfizer Agentes terapeuticos de quinuclidinas
AU658898B2 (en) * 1991-05-22 1995-05-04 Pfizer Inc. Substituted 3-aminoquinuclidines

Also Published As

Publication number Publication date
FI933065A0 (fi) 1993-07-02
FI20001109A7 (fi) 2000-05-10
JPH07330766A (ja) 1995-12-19
FI20001109L (fi) 2000-05-10
IE65005B1 (en) 1995-10-04
JPH07316154A (ja) 1995-12-05
JP2845425B2 (ja) 1999-01-13
FI20001108A7 (fi) 2000-05-10
ES2065161T3 (es) 1995-02-01
US5138060A (en) 1992-08-11
JP2703193B2 (ja) 1998-01-26
JPH07316153A (ja) 1995-12-05
GR3015021T3 (en) 1995-05-31
JP2583026B2 (ja) 1997-02-19
WO1992012152A1 (fr) 1992-07-23
CA2098989C (fr) 1998-02-03
DE69106003T2 (de) 1995-04-27
ATE115580T1 (de) 1994-12-15
DE69106003D1 (de) 1995-01-26
PT99970B (pt) 1999-06-30
KR930703312A (ko) 1993-11-29
JPH0768244B1 (fr) 1995-07-26
CA2158130C (fr) 1998-07-14
DK0565558T3 (da) 1995-03-06
AU653380B2 (en) 1994-09-29
NZ241161A (en) 1994-10-26
FI20001108L (fi) 2000-05-10
NO932431D0 (no) 1993-07-02
KR970001157B1 (ko) 1997-01-29
MX9200003A (es) 1992-07-01
FI933065L (fi) 1993-07-02
PT99970A (pt) 1993-02-26
IL100541A0 (en) 1992-09-06
HU9301931D0 (en) 1993-12-28
EP0565558B1 (fr) 1994-12-14
JPH05508867A (ja) 1993-12-09
ZA928B (en) 1993-07-02
FI933065A7 (fi) 1993-07-02
AU9129891A (en) 1992-08-17
JPH0768244B2 (ja) 1995-07-26
IE920001A1 (en) 1992-07-15
EP0565558A1 (fr) 1993-10-20
CA2158130A1 (fr) 1992-07-04
NO932431L (no) 1993-07-02

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