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BRPI0407679A - sulfamatos de estra-1,3,5(10)-trien-3-ila 2-substituìdos ativos antitumor - Google Patents

sulfamatos de estra-1,3,5(10)-trien-3-ila 2-substituìdos ativos antitumor

Info

Publication number
BRPI0407679A
BRPI0407679A BRPI0407679-6A BRPI0407679A BRPI0407679A BR PI0407679 A BRPI0407679 A BR PI0407679A BR PI0407679 A BRPI0407679 A BR PI0407679A BR PI0407679 A BRPI0407679 A BR PI0407679A
Authority
BR
Brazil
Prior art keywords
estra
substituted
trien
sulfite
sulfates
Prior art date
Application number
BRPI0407679-6A
Other languages
English (en)
Inventor
Alexander Hillisch
Olaf Peters
Christian Gege
Wilko Regenhardt
Dirk Kosemund
Gerhard Siemeister
Eberhard Unger
Ulrich Bothe
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of BRPI0407679A publication Critical patent/BRPI0407679A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"SULFAMATOS DE ESTRA-1,3,5(10)-TRIEN-3-ILA 2SUBSTITUìDOS ATIVOS ANTITUMOR". A invenção refere-se ao uso de sulfamatos de estra-1,3,5(10)trien-3-ila 2-substituídos de fórmula geral I, além de seus sais farmaceuticamente aceitáveis para a produção de um medicamento. Os referidos compostos têm uma ação antitumoral.
BRPI0407679-6A 2003-02-19 2004-02-19 sulfamatos de estra-1,3,5(10)-trien-3-ila 2-substituìdos ativos antitumor BRPI0407679A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10307104A DE10307104A1 (de) 2003-02-19 2003-02-19 Antitumor wirksame 2-substituierte Estra-1,3,5(10)-trien-3-yl sulfamate
PCT/EP2004/001606 WO2004074307A1 (de) 2003-02-19 2004-02-19 Antitumor wirksame 2-substituierte estra-1,3,5(10)-trien-3-yl sulfamate

Publications (1)

Publication Number Publication Date
BRPI0407679A true BRPI0407679A (pt) 2006-03-01

Family

ID=32891761

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0407679-6A BRPI0407679A (pt) 2003-02-19 2004-02-19 sulfamatos de estra-1,3,5(10)-trien-3-ila 2-substituìdos ativos antitumor

Country Status (13)

Country Link
US (2) US7427610B2 (pt)
EP (1) EP1599493B1 (pt)
JP (1) JP4933250B2 (pt)
CN (1) CN1751059A (pt)
AT (1) ATE489399T1 (pt)
AU (1) AU2004213146A1 (pt)
BR (1) BRPI0407679A (pt)
CA (1) CA2516177A1 (pt)
DE (2) DE10307104A1 (pt)
ES (1) ES2355379T3 (pt)
MX (1) MXPA05008906A (pt)
RU (1) RU2005128831A (pt)
WO (1) WO2004074307A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10307104A1 (de) 2003-02-19 2004-09-23 Schering Ag Antitumor wirksame 2-substituierte Estra-1,3,5(10)-trien-3-yl sulfamate
DE10307105A1 (de) * 2003-02-19 2004-09-09 Schering Ag Antitumor wirksame 2-substituierte 18a-Homoestra-1,3,5(10)-trien-3-yl sulfamate
DE10307103A1 (de) 2003-02-19 2004-09-09 Schering Ag Antitumor wirksame 2-substituierte D-Homostra-1,3,5(10)-trien-3-yl sulfamate
WO2005020928A2 (en) 2003-08-29 2005-03-10 The Regents Of The University Of California Agents and methods for enhancing bone formation by oxysterols in combination with bone morphogenic proteins
JP2007529426A (ja) * 2004-03-12 2007-10-25 エントレメッド インコーポレイテッド 抗血管新生薬
GB0421106D0 (en) * 2004-09-22 2004-10-27 Sterix Ltd Compound
JP2009528291A (ja) 2006-02-27 2009-08-06 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア オキシステロール化合物及びヘッジホッグ経路
AU2007227256B2 (en) 2006-03-20 2012-10-04 Entremed, Inc. Disease modifying anti-arthritic activity of 2-methoxyestradiol
AU2008331808B2 (en) 2007-03-16 2014-08-21 The Regents Of The University Of California Oxysterols for activation of hedgehog signaling, osteoinduction, antiadipogenesis, and Wnt signaling
KR20150013232A (ko) 2012-05-07 2015-02-04 더 리전트 오브 더 유니버시티 오브 캘리포니아 골형성 및 헤지호그 신호전달을 유도하고 지방생성을 억제하는 옥시스테롤 유사체 oxy133
CN105263500A (zh) 2013-05-02 2016-01-20 加利福尼亚大学董事会 骨选择性成骨性氧固醇-骨靶向剂

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2006A (en) * 1841-03-16 Clamp for crimping leather
US6011024A (en) * 1991-08-28 2000-01-04 Imperial College Of Science Technology & Medicine Steroid sulphatase inhibitors
GB9118478D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
GB9625334D0 (en) * 1996-12-05 1997-01-22 Imperial College Compound
DE4447714C2 (de) * 1994-08-09 1998-02-05 Jenapharm Gmbh Verwendung von Estra-1,3,5(10)-trien-Derivaten zur Hormonsubstitutions-Therapie
DE4429397C2 (de) * 1994-08-09 2003-11-20 Jenapharm Gmbh Estra-1,3,5(10)-trien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE19540233B4 (de) * 1995-10-19 2005-08-25 Schering Ag Sulfamat-Derivate von 1,3,5(10)-Estratrien-Derivaten, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE19712488A1 (de) * 1997-03-25 1998-10-01 Knoell Hans Forschung Ev Steroidsulfamate, Verfahren zu ihrer Herstellung und Anwendung derselben
US6046186A (en) * 1997-12-24 2000-04-04 Sri International Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use
ES2310943T3 (es) * 1998-06-10 2009-01-16 Sterix Limited Composicion farmaceutica con factor de necrosis tumoral a y 2-metoxiestrona-3-o-sulfamato para la inhibicion de la estrona sulfatasa.
GB9913536D0 (en) 1999-06-10 1999-08-11 Sterix Ltd Use
DE19943708B4 (de) 1999-09-08 2007-12-20 Bayer Schering Pharma Ag Neue C13-substituierte Estra-1,3,5(10)-trien-3-yl-sulfamate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
US6583130B1 (en) 1999-09-13 2003-06-24 Schering Ag C13-substituted estra-1,3,5,(10)-trien-3-yl sulfamates, methods of preparing same, and pharmaceutical compositions containing these compounds
AU8838601A (en) 2000-11-27 2002-06-03 Entremed Inc Antiangiogenic agents
US7071190B2 (en) * 2002-02-15 2006-07-04 Rigel Pharmaceuticals, Inc. Inhibitors to tubulin polymerization
DE10307105A1 (de) * 2003-02-19 2004-09-09 Schering Ag Antitumor wirksame 2-substituierte 18a-Homoestra-1,3,5(10)-trien-3-yl sulfamate
DE10307104A1 (de) 2003-02-19 2004-09-23 Schering Ag Antitumor wirksame 2-substituierte Estra-1,3,5(10)-trien-3-yl sulfamate

Also Published As

Publication number Publication date
US20090221841A1 (en) 2009-09-03
WO2004074307A1 (de) 2004-09-02
ATE489399T1 (de) 2010-12-15
ES2355379T3 (es) 2011-03-25
EP1599493B1 (de) 2010-11-24
DE10307104A1 (de) 2004-09-23
RU2005128831A (ru) 2007-03-27
JP4933250B2 (ja) 2012-05-16
US20060160782A1 (en) 2006-07-20
DE502004011919D1 (de) 2011-01-05
EP1599493A1 (de) 2005-11-30
AU2004213146A1 (en) 2004-09-02
US8492570B2 (en) 2013-07-23
MXPA05008906A (es) 2005-10-05
US7427610B2 (en) 2008-09-23
CA2516177A1 (en) 2004-09-02
JP2006517945A (ja) 2006-08-03
CN1751059A (zh) 2006-03-22

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A , 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2129 DE 25/10/2011.