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BR9714039A - Indano ou derivados de diidroindol; utilização do composto e método para o tratamento - Google Patents

Indano ou derivados de diidroindol; utilização do composto e método para o tratamento

Info

Publication number
BR9714039A
BR9714039A BR9714039-2A BR9714039A BR9714039A BR 9714039 A BR9714039 A BR 9714039A BR 9714039 A BR9714039 A BR 9714039A BR 9714039 A BR9714039 A BR 9714039A
Authority
BR
Brazil
Prior art keywords
compound
treatment
indane
derivatives
dihydroindole derivatives
Prior art date
Application number
BR9714039-2A
Other languages
English (en)
Inventor
Jens Kristian Perregaard
Benny Bang-Andersen
Henrik Pedersen
Ivan Mikkelsen
Robert Dancer
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of BR9714039A publication Critical patent/BR9714039A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • G—PHYSICS
    • G11—INFORMATION STORAGE
    • G11C—STATIC STORES
    • G11C5/00—Details of stores covered by group G11C11/00
    • G11C5/02—Disposition of storage elements, e.g. in the form of a matrix array
    • G11C5/025—Geometric lay-out considerations of storage- and peripheral-blocks in a semiconductor storage device
    • G—PHYSICS
    • G11—INFORMATION STORAGE
    • G11C—STATIC STORES
    • G11C7/00—Arrangements for writing information into, or reading information out from, a digital store
    • G11C7/10—Input/output [I/O] data interface arrangements, e.g. I/O data control circuits, I/O data buffers
    • G11C7/1048—Data bus control circuits, e.g. precharging, presetting, equalising

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

<B>"INDANO OU DERIVADOS DE DIIDROINDOL; UTILIZAçãO DO COMPOSTO E MéTODO PARA O TRATAMENTO"<D>. A presente invenção refere-se ao indano substituído ou compostos de diidroindol da Fórmula (I), onde A é um indol. Esses compostos possuem grande afinidade com os receptores D4.
BR9714039-2A 1996-12-20 1997-12-19 Indano ou derivados de diidroindol; utilização do composto e método para o tratamento BR9714039A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK151496 1996-12-20
PCT/DK1997/000587 WO1998028293A1 (en) 1996-12-20 1997-12-19 Indane or dihydroindole derivatives

Publications (1)

Publication Number Publication Date
BR9714039A true BR9714039A (pt) 2000-05-09

Family

ID=8105631

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9714039-2A BR9714039A (pt) 1996-12-20 1997-12-19 Indano ou derivados de diidroindol; utilização do composto e método para o tratamento

Country Status (27)

Country Link
US (3) US6262087B1 (pt)
EP (1) EP0946542B1 (pt)
JP (1) JP3251300B2 (pt)
KR (1) KR100432297B1 (pt)
CN (3) CN1244558C (pt)
AR (1) AR008545A1 (pt)
AT (1) ATE225784T1 (pt)
AU (1) AU731243B2 (pt)
BG (1) BG63968B1 (pt)
BR (1) BR9714039A (pt)
CZ (1) CZ297416B6 (pt)
DE (1) DE69716296T2 (pt)
DK (1) DK0946542T3 (pt)
EA (1) EA002158B1 (pt)
ES (1) ES2185058T3 (pt)
HU (1) HUP0000079A3 (pt)
IL (1) IL130133A (pt)
IS (1) IS2018B (pt)
NO (2) NO318978B1 (pt)
NZ (1) NZ335973A (pt)
PL (1) PL188418B1 (pt)
PT (1) PT946542E (pt)
SK (1) SK283678B6 (pt)
TR (1) TR199901407T2 (pt)
UA (1) UA66778C2 (pt)
WO (1) WO1998028293A1 (pt)
ZA (1) ZA9711376B (pt)

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ZA9711376B (en) 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
TWI242011B (en) 1997-03-31 2005-10-21 Eisai Co Ltd 1,4-substituted cyclic amine derivatives
AU3479299A (en) * 1998-04-08 1999-10-25 American Home Products Corporation N-aryloxyethyl-indoly-alkylamines for the treatment of depression
US6150533A (en) * 1998-04-08 2000-11-21 American Home Products Corp. N-aryloxyethyl-indoly-alkylamines for the treatment of depression
TW528754B (en) * 1998-04-29 2003-04-21 Wyeth Corp Indolyl derivatibes as serotonergic agents
US6204274B1 (en) 1998-04-29 2001-03-20 American Home Products Corporation Indolyl derivatives as serotonergic agents
CA2319174A1 (en) * 1998-06-08 1999-12-16 Advanced Medicine, Inc. Novel therapeutic agents that modulate 5-ht receptors
AU4550699A (en) * 1998-06-08 1999-12-30 Advanced Medicine, Inc. Multibinding agents that modulate the 5-ht transporter
US6362371B1 (en) * 1998-06-08 2002-03-26 Advanced Medicine, Inc. β2- adrenergic receptor agonists
EA004248B1 (ru) * 1998-06-19 2004-02-26 Х.Лундбекк А/С Производные 4-, 5-, 6- и 7-замещенного индола и индолина, их получение и применение
AU765317C (en) * 1998-06-19 2004-05-20 H. Lundbeck A/S 4,5,6 and 7-indole and indoline derivatives, their preparation and use
EP0982030A3 (en) 1998-08-17 2000-05-10 Pfizer Products Inc. 2,7-substituted octahydro-pyrrolo 1,2-a]pyrazine derivatives as 5ht 1a ligands
AR020773A1 (es) * 1998-10-16 2002-05-29 Duphar Int Res Compuesto derivados de 3-(tetrahidropiridin-4-il)indol, metodo para prepararlo, una composicion farmaceutica que los contiene, metodo para preparar dicha composicion y uso del compuesto
UA70979C2 (uk) 1998-12-23 2004-11-15 Х. Луннбек А/С Спосіб одержання 5-ціанофталіду
HK1048122B (zh) 1999-04-14 2005-01-14 H‧隆德贝克有限公司 製備西酞普蘭的方法
CA2373855A1 (en) * 1999-05-12 2000-11-23 Solvay Pharmaceuticals B.V. Method of treating psychotic disorders
AU5487300A (en) * 1999-06-14 2001-01-02 Neurogen Corporation Benzylpiperazinyl-indolinylethanones
US6355644B1 (en) 1999-06-14 2002-03-12 Neurogen Corporation Benzylpiperazinyl-indolinylethanones
AU5567000A (en) * 1999-06-24 2001-01-09 Toray Industries, Inc. Alpha1b-adrenergic receptor antagonists
MXPA02001919A (es) 1999-08-23 2003-07-21 Solvay Pharm Bv Fenilpiperazinas novedosas.
JP2003517481A (ja) 1999-12-17 2003-05-27 ブリストルーマイヤーズ スクイブ カンパニー 抗精神病複素環式化合物
AR028685A1 (es) * 2000-06-14 2003-05-21 Lundbeck & Co As H Derivados de indol
SK402003A3 (en) * 2000-06-14 2003-07-01 Lundbeck & Co As H Indole derivatives, pharmaceutical composition comprising same and their use
SI1294710T1 (en) * 2000-06-14 2005-10-31 H. Lundbeck A/S Indole derivatives useful for the treatment of cns disorders
HUP0300786A2 (hu) * 2000-06-29 2003-07-28 H. Lundbeck A/S A központi idegrendszer megbetegedéseinek kezelésére alkalmas indolszármazékok és ezeket tartalmazó gyógyszerkészítmények
CA2354880C (en) 2000-08-18 2003-06-03 H. Lundbeck A/S Method for the preparation of citalopram
AR032712A1 (es) * 2001-02-21 2003-11-19 Solvay Pharm Bv Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen
AR033287A1 (es) 2001-05-09 2003-12-10 Lundbeck & Co As H Tratamiento del adhd
WO2003080050A1 (en) * 2002-03-27 2003-10-02 H. Lundbeck A/S The use of 3-[1-[2-(1-acetyl-2,3-dihydro-1h-indol-3-yl)ethyl]-3,6-dihydro-2h-pyridin-4-yl]-6-chloro-1h-indole or its enantiomers for the treatment of diseases and disorders responsive to 5-ht (serotonin) re-uptake inhibition
AU2003236207A1 (en) * 2002-05-31 2003-12-19 H. Lundbeck A/S The hydrochloride of (s)-(+)-3-(1-(2-(1-acetyl-2,3-dihydro-1h-indol-3-yl)ethyl)-1,2,3,6-tetrahydropyridin-4-yl)-6-chloro-1h-indole
AU2003243930A1 (en) * 2002-07-05 2004-01-23 H. Lundbeck A/S Pharmaceutical composition comprising (s)-(+)-3-(1-(2-(1-acetyl-2,3-dihydro-1h-indol-3-yl)ethyl)-1,2,3,6-tetrahydropyridin-4-yl)-6-chloro-1h-indole
WO2004020437A1 (en) * 2002-08-29 2004-03-11 H. Lundbeck A/S S-(+)-3-{1-[2-(2,3-dihydro-1h-indol-3-yl)ethyl]-3,6-dihydro-2h-pyridin-4-yl}-6-chloro-1h-indole and acid addition salts thereof
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KR20070011552A (ko) * 2004-05-11 2007-01-24 에지스 지오기스제르기아르 엔와이알티. ５-ｈｔ７ 수용체 활성제로서 알킬 옥스인돌의 피리딘유도체
WO2006031513A2 (en) * 2004-09-09 2006-03-23 Merck & Co., Inc. Aryl spirolactam cgrp receptor antagonists
CA2585857A1 (en) * 2004-11-26 2006-06-01 Janssen Pharmaceutica N.V. Isoxazoline-indole derivatives with an improved antipsychotic and anxiolytic activity
US7544685B2 (en) 2005-08-17 2009-06-09 H. Lundbeck A/S 2,3-dihydroindole compounds
AR057748A1 (es) * 2005-08-17 2007-12-12 Lundbeck & Co As H Derivados de 2,3 dihidroindol. composiciones farmaceuticas
JP2009515833A (ja) * 2005-10-24 2009-04-16 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ３−ピペリジン−４−イル−インドールｏｒｌ−１受容体モジュレーター
WO2008015516A1 (en) * 2006-07-28 2008-02-07 Pfizer Products Inc. Fused tricyclic heterocycles for the treatment of schizophrenia
ATE538084T1 (de) * 2006-11-28 2012-01-15 Valeant Pharmaceuticals Int Bicyclische 1,4-retigabin-analoga als kaliumkanalhemmer
PL395469A1 (pl) 2011-06-29 2013-01-07 Adamed Spólka Z Ograniczona Odpowiedzialnoscia Pochodne indoloamin do leczenia chorób osrodkowego ukladu nerwowego
US9951038B2 (en) 2012-12-27 2018-04-24 Purdue Pharma L.P. Quinazolin-4(3H)-one-type piperidine compounds and uses thereof
US9963458B2 (en) 2012-12-27 2018-05-08 Purdue Pharma L.P. Indole and indoline-type piperidine compounds and uses thereof
US12077506B2 (en) 2018-10-17 2024-09-03 Nikang Therapeutics, Inc. Indane derivatives as hypoxia inducible factor-2(α) inhibitors
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Also Published As

Publication number Publication date
CN1515551A (zh) 2004-07-28
ZA9711376B (en) 1998-07-21
US20010021777A1 (en) 2001-09-13
CZ297416B6 (cs) 2006-12-13
DE69716296D1 (de) 2002-11-14
NO20044514L (no) 1999-08-13
UA66778C2 (uk) 2004-06-15
US20010020095A1 (en) 2001-09-06
AU5310998A (en) 1998-07-17
US6552044B2 (en) 2003-04-22
KR100432297B1 (ko) 2004-05-20
HUP0000079A2 (hu) 2001-10-28
KR20000069621A (ko) 2000-11-25
NZ335973A (en) 2000-11-24
CN1282644C (zh) 2006-11-01
NO318978B1 (no) 2005-05-30
CN1146556C (zh) 2004-04-21
ATE225784T1 (de) 2002-10-15
HK1025775A1 (en) 2000-11-24
IS2018B (is) 2005-06-15
EA002158B1 (ru) 2001-12-24
AR008545A1 (es) 2000-01-19
AU731243B2 (en) 2001-03-29
ES2185058T3 (es) 2003-04-16
IL130133A0 (en) 2000-06-01
EP0946542B1 (en) 2002-10-09
JP2000513731A (ja) 2000-10-17
BG63968B1 (bg) 2003-08-29
CZ222799A3 (cs) 1999-12-15
JP3251300B2 (ja) 2002-01-28
PL334011A1 (en) 2000-01-31
BG103561A (en) 2000-06-30
SK81399A3 (en) 1999-12-10
NO992895L (no) 1999-08-13
WO1998028293A1 (en) 1998-07-02
CN1495165A (zh) 2004-05-12
EP0946542A1 (en) 1999-10-06
CN1246117A (zh) 2000-03-01
EA199900581A1 (ru) 2000-04-24
DK0946542T3 (da) 2003-02-10
HUP0000079A3 (en) 2002-11-28
IS5061A (is) 1999-05-28
CN1244558C (zh) 2006-03-08
IL130133A (en) 2005-08-31
PL188418B1 (pl) 2005-01-31
US6352988B2 (en) 2002-03-05
US6262087B1 (en) 2001-07-17
TR199901407T2 (xx) 1999-08-23
PT946542E (pt) 2003-02-28
NO992895D0 (no) 1999-06-14
DE69716296T2 (de) 2003-09-11
SK283678B6 (sk) 2003-11-04

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