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EA199900581A1 - Производные индана или дигидроиндола - Google Patents

Производные индана или дигидроиндола

Info

Publication number
EA199900581A1
EA199900581A1 EA199900581A EA199900581A EA199900581A1 EA 199900581 A1 EA199900581 A1 EA 199900581A1 EA 199900581 A EA199900581 A EA 199900581A EA 199900581 A EA199900581 A EA 199900581A EA 199900581 A1 EA199900581 A1 EA 199900581A1
Authority
EA
Eurasian Patent Office
Prior art keywords
dihydroindola
indana
derivatives
compounds
dihydroindole
Prior art date
Application number
EA199900581A
Other languages
English (en)
Other versions
EA002158B1 (ru
Inventor
Енс Кристиан Перрегор
Бенни Банг-Андерсен
Хенрик Педерсен
Иван Миккельсен
Роберт Дансер
Original Assignee
Х.Лундбекк А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Х.Лундбекк А/С filed Critical Х.Лундбекк А/С
Publication of EA199900581A1 publication Critical patent/EA199900581A1/ru
Publication of EA002158B1 publication Critical patent/EA002158B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • G—PHYSICS
    • G11—INFORMATION STORAGE
    • G11C—STATIC STORES
    • G11C5/00—Details of stores covered by group G11C11/00
    • G11C5/02—Disposition of storage elements, e.g. in the form of a matrix array
    • G11C5/025—Geometric lay-out considerations of storage- and peripheral-blocks in a semiconductor storage device
    • G—PHYSICS
    • G11—INFORMATION STORAGE
    • G11C—STATIC STORES
    • G11C7/00—Arrangements for writing information into, or reading information out from, a digital store
    • G11C7/10—Input/output [I/O] data interface arrangements, e.g. I/O data control circuits, I/O data buffers
    • G11C7/1048—Data bus control circuits, e.g. precharging, presetting, equalising

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Настоящее изобретение относится к замещенным соединениям индана или дигидроиндола формулы (I), в которой А обозначает индол. Эти соединения обладают высокой аффинностью по отношению к рецепторам D.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900581A 1996-12-20 1997-12-19 Производные индана или дигидроиндола EA002158B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK151496 1996-12-20
PCT/DK1997/000587 WO1998028293A1 (en) 1996-12-20 1997-12-19 Indane or dihydroindole derivatives

Publications (2)

Publication Number Publication Date
EA199900581A1 true EA199900581A1 (ru) 2000-04-24
EA002158B1 EA002158B1 (ru) 2001-12-24

Family

ID=8105631

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900581A EA002158B1 (ru) 1996-12-20 1997-12-19 Производные индана или дигидроиндола

Country Status (27)

Country Link
US (3) US6262087B1 (ru)
EP (1) EP0946542B1 (ru)
JP (1) JP3251300B2 (ru)
KR (1) KR100432297B1 (ru)
CN (3) CN1146556C (ru)
AR (1) AR008545A1 (ru)
AT (1) ATE225784T1 (ru)
AU (1) AU731243B2 (ru)
BG (1) BG63968B1 (ru)
BR (1) BR9714039A (ru)
CZ (1) CZ297416B6 (ru)
DE (1) DE69716296T2 (ru)
DK (1) DK0946542T3 (ru)
EA (1) EA002158B1 (ru)
ES (1) ES2185058T3 (ru)
HU (1) HUP0000079A3 (ru)
IL (1) IL130133A (ru)
IS (1) IS2018B (ru)
NO (2) NO318978B1 (ru)
NZ (1) NZ335973A (ru)
PL (1) PL188418B1 (ru)
PT (1) PT946542E (ru)
SK (1) SK283678B6 (ru)
TR (1) TR199901407T2 (ru)
UA (1) UA66778C2 (ru)
WO (1) WO1998028293A1 (ru)
ZA (1) ZA9711376B (ru)

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NZ512073A (en) 1998-12-23 2003-10-31 H Method for the preparation of 5-cyanophthalide and citalopram
PT1173431E (pt) 1999-04-14 2003-09-30 Lundbeck & Co As H Metodo de preparacao do citalopram
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WO2001043740A1 (en) 1999-12-17 2001-06-21 Bristol-Myers Squibb Company Antipsychotic heterocycle compounds
AR028685A1 (es) * 2000-06-14 2003-05-21 Lundbeck & Co As H Derivados de indol
DK1294710T3 (da) * 2000-06-14 2005-10-03 Lundbeck & Co As H Indolderivater, der er egnede til behandlingen af CNS-lidelser
CN100415737C (zh) * 2000-06-14 2008-09-03 H·隆德贝克有限公司 用于治疗cns疾病的吲哚衍生物
ATE268765T1 (de) * 2000-06-29 2004-06-15 Lundbeck & Co As H Indolderivate zum gebrauch in der behandlung von zns-störungen
IL144816A (en) 2000-08-18 2005-09-25 Lundbeck & Co As H Method for the preparation of citalopram
AR032712A1 (es) * 2001-02-21 2003-11-19 Solvay Pharm Bv Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen
AR033287A1 (es) * 2001-05-09 2003-12-10 Lundbeck & Co As H Tratamiento del adhd
AU2003215529A1 (en) * 2002-03-27 2003-10-08 H. Lundbeck A/S The use of 3-(1-(2-(1-acetyl-2,3-dihydro-1h-indol-3-yl)ethyl)-3,6-dihydro-2h-pyridin-4-yl)-6-chloro-1h-indole or its enantiomers for the treatment of diseases and disorders responsive to 5-ht (serotonin) re-uptake inhibition
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AU2003257407A1 (en) * 2002-08-29 2004-03-19 H. Lundbeck A/S S-(+)-3-{1-(2-(2,3-dihydro-1h-indol-3-yl)ethyl)-3,6-dihydro-2h-pyridin-4-yl}-6-chloro-1h-indole and acid addition salts thereof
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BRPI0719590A2 (pt) * 2006-11-28 2014-01-21 Valeant Pharmaceuticals Int Análogos de retigabina 1,4 diamino bicíclica como modulares de canal de potássio
PL395469A1 (pl) 2011-06-29 2013-01-07 Adamed Spólka Z Ograniczona Odpowiedzialnoscia Pochodne indoloamin do leczenia chorób osrodkowego ukladu nerwowego
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Also Published As

Publication number Publication date
ZA9711376B (en) 1998-07-21
IS2018B (is) 2005-06-15
DK0946542T3 (da) 2003-02-10
US20010021777A1 (en) 2001-09-13
CZ297416B6 (cs) 2006-12-13
BG103561A (en) 2000-06-30
SK283678B6 (sk) 2003-11-04
NO20044514L (no) 1999-08-13
WO1998028293A1 (en) 1998-07-02
HUP0000079A3 (en) 2002-11-28
HK1025775A1 (en) 2000-11-24
AU731243B2 (en) 2001-03-29
IS5061A (is) 1999-05-28
KR20000069621A (ko) 2000-11-25
PT946542E (pt) 2003-02-28
CN1146556C (zh) 2004-04-21
BR9714039A (pt) 2000-05-09
AR008545A1 (es) 2000-01-19
CZ222799A3 (cs) 1999-12-15
PL334011A1 (en) 2000-01-31
EA002158B1 (ru) 2001-12-24
US20010020095A1 (en) 2001-09-06
CN1244558C (zh) 2006-03-08
CN1282644C (zh) 2006-11-01
ES2185058T3 (es) 2003-04-16
JP2000513731A (ja) 2000-10-17
IL130133A0 (en) 2000-06-01
IL130133A (en) 2005-08-31
DE69716296T2 (de) 2003-09-11
TR199901407T2 (xx) 1999-08-23
KR100432297B1 (ko) 2004-05-20
CN1246117A (zh) 2000-03-01
US6262087B1 (en) 2001-07-17
NO992895D0 (no) 1999-06-14
CN1495165A (zh) 2004-05-12
EP0946542B1 (en) 2002-10-09
NO318978B1 (no) 2005-05-30
UA66778C2 (ru) 2004-06-15
US6552044B2 (en) 2003-04-22
DE69716296D1 (de) 2002-11-14
PL188418B1 (pl) 2005-01-31
NO992895L (no) 1999-08-13
NZ335973A (en) 2000-11-24
US6352988B2 (en) 2002-03-05
CN1515551A (zh) 2004-07-28
JP3251300B2 (ja) 2002-01-28
HUP0000079A2 (hu) 2001-10-28
BG63968B1 (bg) 2003-08-29
AU5310998A (en) 1998-07-17
EP0946542A1 (en) 1999-10-06
SK81399A3 (en) 1999-12-10
ATE225784T1 (de) 2002-10-15

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