BR9709361B1 - produção aumentada de taxanos por culturas de células de espécie taxus. - Google Patents

produção aumentada de taxanos por culturas de células de espécie taxus.

Info

Publication number: BR9709361B1
Authority: BR; Brazil
Prior art keywords: cell cultures; taxus species; species cell; taxane production; taxus
Prior art date: 1996-05-24

Application number

BRPI9709361-0A

Other languages

English (en)

Other versions

BR9709361A (pt

Inventor

Venkataraman Bringi

Prakash G Kadkade

Christopher L Prince

Braden L Roach

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-24

Filing date

1997-05-27

Publication date

2009-05-05

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24619244&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9709361(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-05-27 Application filed filed Critical

1999-08-10 Publication of BR9709361A publication Critical patent/BR9709361A/pt

2009-05-05 Publication of BR9709361B1 publication Critical patent/BR9709361B1/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0025—Culture media for plant cell or plant tissue culture
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/04—Plant cells or tissues
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P15/00—Preparation of compounds containing at least three condensed carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms

Landscapes

Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Biotechnology (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Microbiology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Botany (AREA)
General Chemical & Material Sciences (AREA)
Cell Biology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)

BRPI9709361-0A 1996-05-24 1997-05-27 produção aumentada de taxanos por culturas de células de espécie taxus. BR9709361B1 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US65303696A	1996-05-24	1996-05-24
PCT/US1997/008907 WO1997044476A1 (en)	1996-05-24	1997-05-27	Enhanced production of taxanes by cell cultures of taxus species

Publications (2)

Publication Number	Publication Date
BR9709361A BR9709361A (pt)	1999-08-10
BR9709361B1 true BR9709361B1 (pt)	2009-05-05

Family

ID=24619244

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI9709361-0A BR9709361B1 (pt)	1996-05-24	1997-05-27	produção aumentada de taxanos por culturas de células de espécie taxus.

Country Status (16)

Country	Link
US (2)	US8338143B2 (pt)
EP (3)	EP1398384A1 (pt)
JP (5)	JP4047929B2 (pt)
KR (7)	KR20120138251A (pt)
AT (1)	ATE315097T1 (pt)
AU (1)	AU727425B2 (pt)
BR (1)	BR9709361B1 (pt)
CA (2)	CA2638292A1 (pt)
DE (1)	DE69735059T2 (pt)
DK (1)	DK0954596T3 (pt)
ES (1)	ES2256887T3 (pt)
HU (2)	HU223267B1 (pt)
IL (1)	IL127062A (pt)
PT (1)	PT954596E (pt)
TR (1)	TR199802426T2 (pt)
WO (1)	WO1997044476A1 (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7264951B1 (en)	1992-02-20	2007-09-04	Phyton, Inc.	Enhanced production of taxol and taxanes by cell cultures of Taxus species
KR20120138251A (ko) *	1996-05-24	2012-12-24	디에프비 바이오테크 인코포레이티드	탁수스종의 세포 배양에 의한 탁산의 생산 증진 방법
KR100287465B1 (ko) *	1997-06-25	2001-05-02	나까니시 히로유끼	탁산형 디테르펜의 제조방법
TW200304947A (en)	2002-02-08	2003-10-16	Bristol Myers Squibb Co	Compositions and methods for latering biosynthesis of taxanes and taxane-related compounds
KR100797534B1 (ko)	2005-06-03	2008-01-24	주식회사 삼양제넥스	식물세포배양배지에 혼합당 처리를 통한 이차 대사산물의대량 생산방법
US8017397B2 (en) *	2005-10-31	2011-09-13	Unhwa Corporation	Isolated population of plant single cells and method of preparing same
US8053238B2 (en)	2005-10-31	2011-11-08	Unhwa Corporation	Isolated population of plant single cells and method of preparing the same
KR101064518B1 (ko)	2007-09-21	2011-09-19	주식회사 운화	저장근을 가지는 초본식물의 형성층 유래 식물줄기세포주 및 이의 분리방법
KR101100867B1 (ko) *	2008-05-14	2012-01-02	주식회사 운화	주목의 형성층 또는 전형성층 유래 식물줄기세포주를 유효성분으로 함유하는 항산화, 항염증 또는 항노화용 조성물
DK2443229T3 (da)	2009-06-18	2020-03-30	Phyton Holdings Llc	Fremstilling af alkaloider med cellekultur fra Veratrum californicum
FR2952072B1 (fr) *	2009-11-05	2013-09-27	Pf Medicament	Procede de production de triptolide
WO2013164834A1 (en) *	2012-05-04	2013-11-07	Phyto Biotech Pvt. Ltd.	Cost-effective process for commercial production of paclitaxel
CN103570647A (zh) *	2013-11-06	2014-02-12	湖南农业大学	从红豆杉细胞培养液中制备高纯度紫杉醇的方法
CA2930767C (en)	2013-12-02	2018-09-18	Phyton Holdings, Llc	Production of thapsigargins by thapsia cell suspension culture
US10058542B1 (en)	2014-09-12	2018-08-28	Thioredoxin Systems Ab	Composition comprising selenazol or thiazolone derivatives and silver and method of treatment therewith
EP3270686B1 (en)	2015-03-20	2019-12-18	Phyton Holdings, LLC	Production of ingenol, ingenol esters and/or tiglian-3-one derivatives by euphorbiaceae plant cell suspension cultures
CN105349592B (zh) *	2015-12-09	2018-11-27	天津艾赛博生物技术有限公司	代谢互补的植物细胞系混种培养生产次级代谢产物的方法
CN106636242A (zh) *	2016-12-20	2017-05-10	天津艾赛博生物技术有限公司	一种红豆杉细胞长期培养生产紫杉烷的调控方法
JP7359527B2 (ja) *	2017-05-31	2023-10-11	トヨタ自動車株式会社	電池搭載構造
CA3187303A1 (en)	2020-07-28	2022-02-03	Impello Biosciences, Inc.	Methods and compositions for altering secondary metabolites in plants
CN113416689B (zh) *	2021-08-04	2023-01-10	海南鑫开源医药科技有限公司	一种利用植物细胞发酵技术生产高丽槐素的方法
CN115948494B (zh) *	2022-09-12	2024-07-16	昆明理工大学	一种利用三七细胞合成齐墩果烷型皂苷的方法
WO2025058703A1 (en) *	2023-09-13	2025-03-20	Bedoukian Research, Inc	Method of controlling or reducing senescencein plants and seeds

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0071999B1 (en) *	1981-08-11	1986-03-26	Mitsui Petrochemical Industries, Ltd.	Method for producing secondary metabolites of plants
EP0198863A1 (fr)	1984-10-19	1986-10-29	ZARUDIANSKY, Alain	Systeme de lunettes
JPH0833258B2 (ja)	1987-10-09	1996-03-29	三洋電機株式会社	吸収冷凍装置
DE3801023A1 (de)	1988-01-13	1989-07-27	Schering Ag	Verfahren zur steigerung von enzym-aktivitaeten und der syntheseleistung von organismen
EP0378921A3 (en)	1988-12-21	1990-09-19	Idaho Research Foundation, Inc.	Enhancement of plant metabolite production by timed elicitation
US5019504A (en) *	1989-03-23	1991-05-28	The United States Of America As Represented By The Secretary Of Agriculture	Production of taxol or taxol-like compounds in cell culture
US5334529A (en) *	1989-06-27	1994-08-02	Escagenetics Corporation	Stably transformed coffee plant cells and plantlets
US5015744A (en) *	1989-11-14	1991-05-14	Florida State University	Method for preparation of taxol using an oxazinone
WO1991018512A1 (en)	1990-05-25	1991-12-12	Washington State University Research Foundation, Inc.	Method of inducing plant defense mechanisms
EP0529083B1 (en)	1991-02-12	1996-12-18	Nippon Steel Corporation	Process for producing taxol by cell culture of taxus species
US5244775A (en) *	1991-03-20	1993-09-14	Hitachi, Ltd.	Method of manufacturing an optical disc
WO1992018492A1 (en)	1991-04-19	1992-10-29	The University Of Mississippi	Methods and compositions for isolating taxanes
US5248625A (en) *	1991-06-06	1993-09-28	Lsi Logic Corporation	Techniques for forming isolation structures
KR930702323A (ko)	1991-07-17	1993-09-08	하지메 나까가와	항종양 활성을 가진 화합물(nsc-lsc1) 및 그의 제조방법
US5344775A (en) *	1991-11-15	1994-09-06	Escagenetics Corporation	Synthesis of taxanes in culture using pseudocalluscells
US5407816A (en) *	1992-02-20	1995-04-18	Phyton Catalytic, Inc.	Enhanced production of taxol and taxanes by cell cultures of taxus species
US5445809A (en) *	1992-03-03	1995-08-29	Research And Development Institute At Montana State University	Production of taxol from the yew tree
US5451392A (en) *	1992-03-03	1995-09-19	The Research And Development Institute At Montana State University	Production of taxol
JPH05244971A (ja)	1992-03-06	1993-09-24	Nippon Oil Co Ltd	タキサン類化合物の製造方法
WO1993019585A1 (en) *	1992-04-01	1993-10-14	Union Camp Corporation	Induction of somatic embryogenesis in taxus, and the production of taxane-ring containing alkaloids therefrom
US5850032A (en) *	1992-04-01	1998-12-15	Union Camp Corporation	Method for production of plant biological products in precocious neomorphic embryoids
CA2092849C (en) *	1992-04-07	2003-11-18	Paul M. Cino	Callus cell induction and the preparation of taxanes
US5322779A (en) *	1992-04-16	1994-06-21	The Research And Development Institute, Inc. At Montana State University	Taxol production by taxomyces andreanae
CA2136213A1 (en)	1992-05-21	1993-11-25	Richard N. Arteca	Cultured taxu tissues as a source of taxol, related taxanes and other novel anti-tumor/anti-viral compounds
JP2967532B2 (ja)	1992-06-11	1999-10-25	日石三菱株式会社	タキサン類化合物の製造方法
US5279953A (en) *	1992-06-24	1994-01-18	Esca Genetics Corporation	In vivo production of taxanes
JP3162217B2 (ja)	1992-12-24	2001-04-25	三井化学株式会社	タキサン型ジテルペンの製造方法
JP3144947B2 (ja)	1993-04-08	2001-03-12	三井化学株式会社	タキサン型ジテルペンの製造方法
JPH06296493A (ja)	1993-04-14	1994-10-25	Nippon Steel Corp	タキソールの生産方法
KR950005081B1 (ko)	1993-07-06	1995-05-18	산림청임목육종연구소	주목 종자의 씨눈 유래의 체세포배 및 체세포배성세포 혹은 그 배양배지로부터 택솔(Taxol) 및 그 유도체를 생산하는 방법
JPH0856680A (ja) *	1994-08-25	1996-03-05	Mitsui Petrochem Ind Ltd	タキサン型ジテルペンの製造方法
JPH08116981A (ja)	1994-10-18	1996-05-14	Mitsui Petrochem Ind Ltd	タキサン型ジテルペンの製造方法
JPH07308196A (ja)	1994-05-18	1995-11-28	Mitsui Petrochem Ind Ltd	タキサン型ジテルペンの製造方法
JP3434892B2 (ja)	1994-06-28	2003-08-11	三井化学株式会社	タキサン型ジテルペンの製造方法
EP1348764A1 (en) *	1993-11-15	2003-10-01	Mitsui Chemicals, Inc.	A Method of Producing a Taxane-Type Diterpene and Method of Obtaining Cultured Cells which Produce the Taxane-Type Diterpene at a High Rate
JPH07308197A (ja)	1994-05-18	1995-11-28	Mitsui Petrochem Ind Ltd	タキサン型ジテルペンの製造方法
JPH0856681A (ja)	1994-08-25	1996-03-05	Mitsui Petrochem Ind Ltd	タキサン型ジテルペンの製造方法
JP3488492B2 (ja)	1993-11-15	2004-01-19	三井化学株式会社	タキサン型ジテルペン高産生培養細胞の取得方法
JP2967034B2 (ja)	1994-03-07	1999-10-25	三井化学株式会社	タキサン型ジテルペンの製造方法
JPH07255495A (ja)	1994-03-28	1995-10-09	Ishikawajima Harima Heavy Ind Co Ltd	タキソールの製造方法
US5547866A (en) *	1994-07-20	1996-08-20	The Regents Of The University Of California	Taxane production in haploid-derived cell cultures
JPH0870880A (ja)	1994-09-05	1996-03-19	Osaka Organic Chem Ind Ltd	タキソールの培養生産法
CA2163614C (en) *	1994-11-25	2002-12-31	Yukihito Yukimune	Method of producing a taxane-type diterpene
JP3549594B2 (ja)	1994-11-25	2004-08-04	三井化学株式会社	タキサン型ジテルペンの製造方法
JPH08163991A (ja)	1994-12-15	1996-06-25	Mitsui Petrochem Ind Ltd	タキサン型ジテルペンの製造方法
JPH08149984A (ja)	1994-11-30	1996-06-11	Mitsui Petrochem Ind Ltd	タキサン型ジテルペンの製造方法
JP3746550B2 (ja)	1994-12-05	2006-02-15	三井化学株式会社	タキサン型ジテルペンの製造方法
JPH08205881A (ja) *	1994-12-05	1996-08-13	Mitsui Petrochem Ind Ltd	タキサン型ジテルペンの製造方法
JPH08154693A (ja)	1994-12-05	1996-06-18	Mitsui Petrochem Ind Ltd	タキサン型ジテルペンの製造方法
JP3019736B2 (ja)	1994-12-07	2000-03-13	三井化学株式会社	タキサン型ジテルペンの製造方法
JPH08198863A (ja) *	1995-01-25	1996-08-06	Mitsui Petrochem Ind Ltd	タキサン型ジテルペンの製造方法
US5620875A (en) *	1995-02-17	1997-04-15	University Of Portland	Transfer of taxol from yew tree cuttings into a culture medium over time
KR960037826A (ko) *	1995-04-27	1996-11-19	김경환	택서스속 식물세포의 반연속식 배양방법
US6248572B1 (en) *	1995-04-27	2001-06-19	Samyang, Genex, Corporation	Production of taxol from taxus plant cell culture adding silver nitrate
CN1166780C (zh)	1995-04-29	2004-09-15	(株)三养吉尼克斯	从紫杉属植物大量生产紫杉醇的方法
JPH08298993A (ja)	1995-05-02	1996-11-19	Nippon Steel Corp	イチイの組織培養によるタキサン化合物の製造法
US5965438A (en)	1995-06-07	1999-10-12	Phyton, Inc.	Cryopreservation of plant cells
JPH0928392A (ja)	1995-07-17	1997-02-04	Mitsui Petrochem Ind Ltd	タキサン型ジテルペンの製造方法
JPH0956387A (ja)	1995-08-22	1997-03-04	Mitsui Petrochem Ind Ltd	タキサン型ジテルペンの製造方法
US5670663A (en) *	1996-02-14	1997-09-23	Regents Of The University Of California	Recovery of taxanes from conifers
KR20120138251A (ko) *	1996-05-24	2012-12-24	디에프비 바이오테크 인코포레이티드	탁수스종의 세포 배양에 의한 탁산의 생산 증진 방법
JPH1042888A (ja)	1996-07-30	1998-02-17	Jumoku Seiri Kinousei Butsushitsu Gijutsu Kenkyu Kumiai	タキソールの培養生産方法
JPH1052295A (ja)	1996-08-09	1998-02-24	Nippon Oil Co Ltd	タキサン類化合物の製造方法（ｉｉ）
JPH1052294A (ja)	1996-08-09	1998-02-24	Nippon Oil Co Ltd	タキサン類化合物の製造方法（ｉ）
JPH1052296A (ja)	1996-08-09	1998-02-24	Nippon Oil Co Ltd	タキサン類化合物の製造方法（ｉｉｉ）
CA2278588C (en) *	1997-02-19	2005-02-08	Phytobiotech Inc.	Method for increasing the growth of plant cell cultures
KR100287465B1 (ko) *	1997-06-25	2001-05-02	나까니시 히로유끼	탁산형 디테르펜의 제조방법
JPH1146782A (ja)	1997-08-05	1999-02-23	Mitsui Chem Inc	ラジカル発生剤処理による植物二次代謝産物の生産促進方法
US6030818A (en) *	1997-12-22	2000-02-29	Bcm Developpement, Inc.	Bacterial mass production of taxanes and paclitaxel
JP3897267B2 (ja)	1998-03-26	2007-03-22	三井化学株式会社	タキサン型ジテルペンの製造方法
JP2000106893A (ja)	1998-10-06	2000-04-18	Kobe Tennenbutsu Kagaku Kk	タキサン型ジテルペン類の製造方法
JP3815919B2 (ja)	1999-05-26	2006-08-30	三井化学株式会社	タキサン型ジテルペンの製造方法
US6365407B1 (en) *	2001-03-05	2002-04-02	Council Of Scientific & Industrial Research	Culture medium composition useful for induction and proliferation of Taxus calli

1997
- 1997-05-27 KR KR1020127032650A patent/KR20120138251A/ko not_active Ceased
- 1997-05-27 KR KR1020077020228A patent/KR20070094867A/ko not_active Ceased
- 1997-05-27 CA CA002638292A patent/CA2638292A1/en not_active Abandoned
- 1997-05-27 KR KR1020147011093A patent/KR20140062179A/ko not_active Ceased
- 1997-05-27 AU AU31430/97A patent/AU727425B2/en not_active Ceased
- 1997-05-27 KR KR1020107012489A patent/KR20100070388A/ko not_active Ceased
- 1997-05-27 BR BRPI9709361-0A patent/BR9709361B1/pt not_active IP Right Cessation
- 1997-05-27 AT AT97926731T patent/ATE315097T1/de not_active IP Right Cessation
- 1997-05-27 CA CA002256357A patent/CA2256357C/en not_active Expired - Lifetime
- 1997-05-27 JP JP54282497A patent/JP4047929B2/ja not_active Expired - Fee Related
- 1997-05-27 DK DK97926731T patent/DK0954596T3/da active
- 1997-05-27 KR KR1019980709509A patent/KR100897457B1/ko not_active Expired - Lifetime
- 1997-05-27 KR KR1020087030132A patent/KR20090005241A/ko not_active Ceased
- 1997-05-27 IL IL12706297A patent/IL127062A/xx not_active IP Right Cessation
- 1997-05-27 EP EP20030026211 patent/EP1398384A1/en not_active Ceased
- 1997-05-27 KR KR1020107012491A patent/KR20100070389A/ko not_active Ceased
- 1997-05-27 WO PCT/US1997/008907 patent/WO1997044476A1/en not_active Ceased
- 1997-05-27 EP EP05002665A patent/EP1538214A1/en not_active Ceased
- 1997-05-27 HU HU0302357A patent/HU223267B1/hu not_active IP Right Cessation
- 1997-05-27 TR TR1998/02426T patent/TR199802426T2/xx unknown
- 1997-05-27 EP EP97926731A patent/EP0954596B1/en not_active Expired - Lifetime
- 1997-05-27 PT PT97926731T patent/PT954596E/pt unknown
- 1997-05-27 HU HU9901788A patent/HUP9901788A3/hu unknown
- 1997-05-27 DE DE69735059T patent/DE69735059T2/de not_active Expired - Lifetime
- 1997-05-27 ES ES97926731T patent/ES2256887T3/es not_active Expired - Lifetime
2007
- 2007-02-07 JP JP2007028425A patent/JP2007143557A/ja not_active Withdrawn
2008
- 2008-02-25 JP JP2008043232A patent/JP2008167764A/ja not_active Withdrawn
2010
- 2010-12-17 US US12/972,064 patent/US8338143B2/en not_active Expired - Fee Related
2011
- 2011-08-03 JP JP2011170533A patent/JP2011212029A/ja active Pending
2012
- 2012-09-14 US US13/618,284 patent/US20130017582A1/en not_active Abandoned
- 2012-12-06 JP JP2012267338A patent/JP2013046643A/ja active Pending

Also Published As

Publication number	Publication date
KR20100070388A (ko)	2010-06-25
HU223267B1 (hu)	2004-04-28
EP0954596A1 (en)	1999-11-10
EP1538214A1 (en)	2005-06-08
WO1997044476A1 (en)	1997-11-27
JP2008167764A (ja)	2008-07-24
HUP9901788A2 (hu)	1999-09-28
EP0954596B1 (en)	2006-01-04
US20110086397A1 (en)	2011-04-14
KR20100070389A (ko)	2010-06-25
DE69735059T2 (de)	2006-08-31
HU0302357D0 (en)	2003-09-29
JP4047929B2 (ja)	2008-02-13
AU3143097A (en)	1997-12-09
BR9709361A (pt)	1999-08-10
DE69735059D1 (de)	2006-03-30
CA2256357A1 (en)	1997-11-27
IL127062A0 (en)	1999-09-22
AU727425B2 (en)	2000-12-14
JP2007143557A (ja)	2007-06-14
TR199802426T2 (xx)	2001-01-22
JP2013046643A (ja)	2013-03-07
JP2011212029A (ja)	2011-10-27
HUP9901788A3 (en)	2002-07-29
US8338143B2 (en)	2012-12-25
CA2638292A1 (en)	1997-11-27
KR20070094867A (ko)	2007-09-21
US20130017582A1 (en)	2013-01-17
EP1398384A1 (en)	2004-03-17
ES2256887T3 (es)	2006-07-16
IL127062A (en)	2005-09-25
JP2000511420A (ja)	2000-09-05
KR100897457B1 (ko)	2009-12-18
KR20140062179A (ko)	2014-05-22
KR20120138251A (ko)	2012-12-24
DK0954596T3 (da)	2006-05-15
ATE315097T1 (de)	2006-02-15
CA2256357C (en)	2008-08-12
KR20090005241A (ko)	2009-01-12
PT954596E (pt)	2006-05-31
KR20000015952A (ko)	2000-03-25

Publication	Publication Date	Title
BR9709361B1 (pt)	2009-05-05	produção aumentada de taxanos por culturas de células de espécie taxus.
DK0672162T3 (da)	2000-12-18	Forøget produktion af taxol og taxaner ved hjælp af cellekulturer af Taxus-arter
EP1130043A3 (en)	2004-01-07	Polyhydroxyalkanoate containing 3-hydroxythienylalkanoic acid as monomer unit and method for producing the same
PT95088A (pt)	1991-05-22	Processo para a preparacao de zeaxantina e de composicoes que contem zeaxantina
DK0568821T3 (da)	2000-03-06	Calluscelleinduktion og fremstilling af taxaner
PT1212448E (pt)	2004-03-31	Processo de producao de exopolissacaridos
BR9806934A (pt)	2000-05-02	Método para produzir um óxido, meio de cultura e óxido
BR9501136A (pt)	1996-06-04	Processo para a produção de pilocarpina
DE50202362D1 (de)	2005-04-07	Verfahren zur Erhöhung der Wachstumsrate von Zellen in statischen Flüssigmedien
WO2002064811A3 (fr)	2003-03-20	Procede pour produire des proteines recombinantes, marquees par au moins un isotope
AU2001251065A1 (en)	2001-11-07	Method for screening of microorganisms under nutrient limited conditions
IT1275575B (it)	1997-08-07	Caledotricine
TWI266803B (en)	2006-11-21	A culture system for generating somatic cells
JPS5588695A (en)	1980-07-04	Removal of methylguanidine
KR910012253A (ko)	1991-08-07	폴리-3-히드록시부티르산의 생합성 방법

Legal Events

Date	Code	Title	Description
2007-08-21	B07A	Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
2008-02-26	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2009-02-17	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2009-07-28	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 28/07/2009, OBSERVADAS AS CONDICOES LEGAIS.
2016-09-20	B21F	Lapse acc. art. 78, item iv - on non-payment of the annual fees in time	Free format text: REFERENTE A 19A ANUIDADE.
2017-01-10	B24J	Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)	Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2385 DE 20-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.