BR0007749A - Vacinação não-invasiva através da pele - Google Patents
Vacinação não-invasiva através da peleInfo
- Publication number
- BR0007749A BR0007749A BR0007749-6A BR0007749A BR0007749A BR 0007749 A BR0007749 A BR 0007749A BR 0007749 A BR0007749 A BR 0007749A BR 0007749 A BR0007749 A BR 0007749A
- Authority
- BR
- Brazil
- Prior art keywords
- substance
- droplet
- substances
- times smaller
- diameter
- Prior art date
Links
- 238000002255 vaccination Methods 0.000 title abstract 3
- 239000000126 substance Substances 0.000 abstract 9
- 239000000427 antigen Substances 0.000 abstract 3
- 102000036639 antigens Human genes 0.000 abstract 3
- 108091007433 antigens Proteins 0.000 abstract 3
- 239000013566 allergen Substances 0.000 abstract 2
- 239000011248 coating agent Substances 0.000 abstract 2
- 238000000576 coating method Methods 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 239000012530 fluid Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- 229960005486 vaccine Drugs 0.000 abstract 2
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 239000003125 aqueous solvent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000005489 elastic deformation Effects 0.000 abstract 1
- 210000003743 erythrocyte Anatomy 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000000149 penetrating effect Effects 0.000 abstract 1
- 150000003904 phospholipids Chemical class 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
Patente de Invenção: "VACINAçãO NãO-INVASIVA ATRAVéSDA PELE". A presente invenção refere-se a novas vacinas para aadministração transcutânea, não-invasiva de antígenosassociados com veículos ultradeformáveis, para o propósito devacinação profilática ou terapêutica. As vacinas compreendem (a)um veículo transdérmico que é um penetrante, suspenso oudisperso em um solvente aquoso na forma de uma gotículadiminuta de fluído circundada por um revestimento tipo membranade uma ou diversas camadas de pelo menos duas diferentessubstâncias ou duas formas diferentes de um substrato com atendência a agregar, as referidas substâncias ou formas de umasubstância diferindo pelo menos pelo fator de 10 em solubilidadeem um meio líquido, preferivelmente aquoso, tal que o diâmetromédio de homoagregados da substância ou forma mais solúvel dasubstância ou o diâmetro médio dos heteroagregados consistindoem ambas as referidas substâncias ou formas da referidasubstância é menor do que o diâmetro médio de homoagregadosda substância ou forma menos solúvel da substância, e/ou onde ocomponente mais solúvel tende a solubilizar a gotícula depenetração e onde o conteúdo de tais quantidades componentesde até 99 mol% da concentração requerida para solubilizar agotícula ou ainda corresponde a até 99 mol% da concentração desaturação na gotícula não-solubilizada, qualquer que seja é maior,e/ou onde a energia de deformação elástica da gotículacircundando o revestimento tipo membrana é pelo menos 5 vezesmenor, mais preferivelmente é pelo menos 10 vezes menor eidealmente é mais do que 10 vezes menor do que aquela dascélulas vermelhas do sangue ou das bicamadas fosfolipídicas comcadeias alifáticas fluídas, (b) um composto que especificamentelibera ou especificamente induz a atividade de citocina ouanticitocina ou exerce uma tal atividade em si, e (c) um antígeno,um alérgeno, uma mistura de antígenos e/ou uma mistura dealérgenos. A invenção ainda refere-se a métodos para a vacinaçãode mamíferos para obter uma resposta imune protetora outerapêutica.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99101479A EP1031346B1 (en) | 1999-01-27 | 1999-01-27 | Noninvasive vaccination through the skin |
| PCT/EP2000/000597 WO2000044349A1 (en) | 1999-01-27 | 2000-01-26 | Non-invasive vaccination through the skin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0007749A true BR0007749A (pt) | 2001-11-13 |
Family
ID=8237425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0007749-6A BR0007749A (pt) | 1999-01-27 | 2000-01-26 | Vacinação não-invasiva através da pele |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7867480B1 (pt) |
| EP (2) | EP1031346B1 (pt) |
| JP (1) | JP2002535350A (pt) |
| KR (2) | KR20070094662A (pt) |
| CN (1) | CN1230151C (pt) |
| AR (1) | AR037312A1 (pt) |
| AT (1) | ATE216875T1 (pt) |
| AU (1) | AU778972B2 (pt) |
| BR (1) | BR0007749A (pt) |
| CA (1) | CA2360692C (pt) |
| DE (1) | DE69901377T2 (pt) |
| DK (1) | DK1031346T3 (pt) |
| ES (1) | ES2173678T3 (pt) |
| HK (1) | HK1030363A1 (pt) |
| HU (1) | HU225170B1 (pt) |
| MX (1) | MXPA01007657A (pt) |
| PT (1) | PT1031346E (pt) |
| SI (1) | SI1031346T1 (pt) |
| WO (1) | WO2000044349A1 (pt) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5980898A (en) | 1996-11-14 | 1999-11-09 | The United States Of America As Represented By The U.S. Army Medical Research & Material Command | Adjuvant for transcutaneous immunization |
| US6797276B1 (en) | 1996-11-14 | 2004-09-28 | The United States Of America As Represented By The Secretary Of The Army | Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response |
| US20060002949A1 (en) | 1996-11-14 | 2006-01-05 | Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. | Transcutaneous immunization without heterologous adjuvant |
| ATE420112T1 (de) | 1998-07-31 | 2009-01-15 | Int Inst Cancer Immunology Inc | Krebsantigene, basierend auf dem tumorunterdrückenden genprodukt wt1 |
| EP1031346B1 (en) | 1999-01-27 | 2002-05-02 | Idea Ag | Noninvasive vaccination through the skin |
| EP1031347B1 (en) | 1999-01-27 | 2002-04-17 | Idea Ag | Transnasal transport/immunisation with highly adaptable carriers |
| AU5409699A (en) | 1999-07-05 | 2001-01-22 | Idea Ag | A method for the improvement of transport across adaptable semi-permeable barriers |
| DK1372708T3 (da) | 2001-02-13 | 2008-10-20 | Us Gov Sec Army | Vaccine til transkutan immunisering mod rejsediarre |
| US7635488B2 (en) | 2001-03-13 | 2009-12-22 | Dbv Technologies | Patches and uses thereof |
| FR2822049B1 (fr) | 2001-03-13 | 2003-08-01 | Dbv Medica 1 | Patch destine notamment a depister l'etat de sensibilisation d'un sujet a un allergene, procede de fabrication et utilisation |
| DE60224508T2 (de) | 2001-03-22 | 2008-12-24 | International Institute of Cancer Immunology, Inc., Suita-shi | Wti-modifiziertes peptid |
| US20020193729A1 (en) | 2001-04-20 | 2002-12-19 | Cormier Michel J.N. | Microprojection array immunization patch and method |
| EP1447091A4 (en) | 2001-09-28 | 2008-02-13 | Institute Of Can International | NEW METHOD FOR INDUCTION OF ANTIGEN SPECIFIC T CELLS |
| JPWO2003028758A1 (ja) * | 2001-09-28 | 2005-01-13 | 治夫 杉山 | 抗原特異的ｔ細胞の誘導方法 |
| NZ539008A (en) * | 2002-10-02 | 2006-10-27 | Nordic Vaccine Technology As | Composition for vaccination by transdermal delivery |
| US7473432B2 (en) | 2002-10-11 | 2009-01-06 | Idea Ag | NSAID formulations, based on highly adaptable aggregates, for improved transport through barriers and topical drug delivery |
| GB0417487D0 (en) | 2004-08-05 | 2004-09-08 | Novartis Ag | Organic compound |
| KR101248799B1 (ko) | 2006-04-28 | 2013-04-02 | 젤티크 애스세틱스, 인코포레이티드. | 피하 지질 과다 세포의 개선된 냉각을 위한 치료 장치와 함께 사용하기 위한 동결 방지제 |
| US20080077201A1 (en) | 2006-09-26 | 2008-03-27 | Juniper Medical, Inc. | Cooling devices with flexible sensors |
| US8192474B2 (en) | 2006-09-26 | 2012-06-05 | Zeltiq Aesthetics, Inc. | Tissue treatment methods |
| US9132031B2 (en) | 2006-09-26 | 2015-09-15 | Zeltiq Aesthetics, Inc. | Cooling device having a plurality of controllable cooling elements to provide a predetermined cooling profile |
| US20080287839A1 (en) | 2007-05-18 | 2008-11-20 | Juniper Medical, Inc. | Method of enhanced removal of heat from subcutaneous lipid-rich cells and treatment apparatus having an actuator |
| US8523927B2 (en) | 2007-07-13 | 2013-09-03 | Zeltiq Aesthetics, Inc. | System for treating lipid-rich regions |
| EP3488833B1 (en) | 2007-08-21 | 2025-10-22 | Zeltiq Aesthetics, Inc. | Monitoring the cooling of subcutaneous lipid-rich cells, such as the cooling of adipose tissue |
| FR2924350B1 (fr) | 2007-12-03 | 2010-08-13 | Dbv Tech | Procede et compositions pour la vaccination par voie cutanee |
| FR2924349B1 (fr) | 2007-12-03 | 2010-01-01 | Dbv Tech | Methode de desensibilitation aux allergenes |
| US8603073B2 (en) | 2008-12-17 | 2013-12-10 | Zeltiq Aesthetics, Inc. | Systems and methods with interrupt/resume capabilities for treating subcutaneous lipid-rich cells |
| EP4066797A1 (en) | 2009-04-30 | 2022-10-05 | Zeltiq Aesthetics, Inc. | Device for removing heat from subcutaneous lipid-rich cells |
| WO2011000889A1 (en) * | 2009-06-30 | 2011-01-06 | William Henry | Topical vaccine formulations and methods of treating drug addiction using same |
| GB2486371A (en) | 2009-08-21 | 2012-06-13 | Targeted Delivery Technologies Ltd | Vesicular formulations |
| US9314368B2 (en) | 2010-01-25 | 2016-04-19 | Zeltiq Aesthetics, Inc. | Home-use applicators for non-invasively removing heat from subcutaneous lipid-rich cells via phase change coolants, and associates devices, systems and methods |
| US8676338B2 (en) | 2010-07-20 | 2014-03-18 | Zeltiq Aesthetics, Inc. | Combined modality treatment systems, methods and apparatus for body contouring applications |
| GB201205642D0 (en) | 2012-03-29 | 2012-05-16 | Sequessome Technology Holdings Ltd | Vesicular formulations |
| GB201212010D0 (en) * | 2012-07-05 | 2012-08-22 | Sigmoid Pharma Ltd | Formulations |
| US8652457B2 (en) | 2012-07-13 | 2014-02-18 | Wisconsin Alumni Research Foundation | Interleukin-10 peptides and antibodies thereof for inhibiting adverse effects of protozoan infection |
| US9545523B2 (en) | 2013-03-14 | 2017-01-17 | Zeltiq Aesthetics, Inc. | Multi-modality treatment systems, methods and apparatus for altering subcutaneous lipid-rich tissue |
| US9844460B2 (en) | 2013-03-14 | 2017-12-19 | Zeltiq Aesthetics, Inc. | Treatment systems with fluid mixing systems and fluid-cooled applicators and methods of using the same |
| ES2542088B1 (es) * | 2014-01-29 | 2016-05-05 | Enoc Solutions, S.L. | Composición de azufre liposomado |
| US20150216719A1 (en) | 2014-01-31 | 2015-08-06 | Zeltiq Aesthetics, Inc | Treatment systems and methods for treating cellulite and for providing other treatments |
| US10675176B1 (en) | 2014-03-19 | 2020-06-09 | Zeltiq Aesthetics, Inc. | Treatment systems, devices, and methods for cooling targeted tissue |
| USD777338S1 (en) | 2014-03-20 | 2017-01-24 | Zeltiq Aesthetics, Inc. | Cryotherapy applicator for cooling tissue |
| US10952891B1 (en) | 2014-05-13 | 2021-03-23 | Zeltiq Aesthetics, Inc. | Treatment systems with adjustable gap applicators and methods for cooling tissue |
| US9821028B2 (en) * | 2014-07-11 | 2017-11-21 | Wisconsin Alumni Research Foundation | Methods of controlling parasitic worms in animals |
| US10935174B2 (en) | 2014-08-19 | 2021-03-02 | Zeltiq Aesthetics, Inc. | Stress relief couplings for cryotherapy apparatuses |
| US10568759B2 (en) | 2014-08-19 | 2020-02-25 | Zeltiq Aesthetics, Inc. | Treatment systems, small volume applicators, and methods for treating submental tissue |
| CA3026466A1 (en) | 2015-06-30 | 2017-01-05 | Sequessome Technology Holdings Limited | Blended formulations |
| ES2892598T3 (es) | 2015-10-19 | 2022-02-04 | Zeltiq Aesthetics Inc | Métodos de tratamiento vascular para enfriar estructuras vasculares |
| AU2017206118B2 (en) | 2016-01-07 | 2021-09-30 | Zeltiq Aesthetics, Inc. | Temperature-dependent adhesion between applicator and skin during cooling of tissue |
| US10765552B2 (en) | 2016-02-18 | 2020-09-08 | Zeltiq Aesthetics, Inc. | Cooling cup applicators with contoured heads and liner assemblies |
| US10555831B2 (en) | 2016-05-10 | 2020-02-11 | Zeltiq Aesthetics, Inc. | Hydrogel substances and methods of cryotherapy |
| US11382790B2 (en) | 2016-05-10 | 2022-07-12 | Zeltiq Aesthetics, Inc. | Skin freezing systems for treating acne and skin conditions |
| US10682297B2 (en) | 2016-05-10 | 2020-06-16 | Zeltiq Aesthetics, Inc. | Liposomes, emulsions, and methods for cryotherapy |
| US10369190B2 (en) | 2016-09-13 | 2019-08-06 | Allergan, Inc. | Non-protein clostridial toxin compositions |
| US11076879B2 (en) | 2017-04-26 | 2021-08-03 | Zeltiq Aesthetics, Inc. | Shallow surface cryotherapy applicators and related technology |
| ES2940650T3 (es) | 2017-09-12 | 2023-05-10 | Wisconsin Alumni Res Found | Péptidos del receptor 2 de interleucina-10, anticuerpos, composiciones y métodos de uso de los mismos |
| KR20210038661A (ko) | 2018-07-31 | 2021-04-07 | 젤티크 애스세틱스, 인코포레이티드. | 피부 특성을 개선시키기 위한 방법, 장치, 및 시스템 |
| CN114075551B (zh) * | 2021-06-11 | 2024-01-26 | 华中农业大学 | 沙林鼠种布鲁氏菌脂多糖的单克隆抗体及应用 |
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-
1999
- 1999-01-27 EP EP99101479A patent/EP1031346B1/en not_active Expired - Lifetime
- 1999-01-27 SI SI9930060T patent/SI1031346T1/xx unknown
- 1999-01-27 DK DK99101479T patent/DK1031346T3/da active
- 1999-01-27 PT PT99101479T patent/PT1031346E/pt unknown
- 1999-01-27 ES ES99101479T patent/ES2173678T3/es not_active Expired - Lifetime
- 1999-01-27 AT AT99101479T patent/ATE216875T1/de active
- 1999-01-27 DE DE69901377T patent/DE69901377T2/de not_active Expired - Lifetime
-
2000
- 2000-01-26 AU AU27988/00A patent/AU778972B2/en not_active Ceased
- 2000-01-26 HU HU0200315A patent/HU225170B1/hu not_active IP Right Cessation
- 2000-01-26 KR KR1020077018740A patent/KR20070094662A/ko not_active Ceased
- 2000-01-26 CA CA2360692A patent/CA2360692C/en not_active Expired - Fee Related
- 2000-01-26 WO PCT/EP2000/000597 patent/WO2000044349A1/en not_active Ceased
- 2000-01-26 BR BR0007749-6A patent/BR0007749A/pt not_active Application Discontinuation
- 2000-01-26 KR KR1020017009479A patent/KR20010112252A/ko not_active Ceased
- 2000-01-26 JP JP2000595653A patent/JP2002535350A/ja active Pending
- 2000-01-26 MX MXPA01007657A patent/MXPA01007657A/es not_active IP Right Cessation
- 2000-01-26 CN CNB008044538A patent/CN1230151C/zh not_active Expired - Fee Related
- 2000-01-26 US US09/890,335 patent/US7867480B1/en not_active Expired - Fee Related
- 2000-01-26 EP EP00906231A patent/EP1146858A1/en not_active Withdrawn
- 2000-01-27 AR ARP000100372A patent/AR037312A1/es unknown
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2001
- 2001-02-16 HK HK01101136A patent/HK1030363A1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002535350A (ja) | 2002-10-22 |
| MXPA01007657A (es) | 2003-06-24 |
| US7867480B1 (en) | 2011-01-11 |
| WO2000044349A1 (en) | 2000-08-03 |
| EP1146858A1 (en) | 2001-10-24 |
| CN1230151C (zh) | 2005-12-07 |
| CN1342066A (zh) | 2002-03-27 |
| EP1031346B1 (en) | 2002-05-02 |
| DE69901377T2 (de) | 2003-01-02 |
| CA2360692C (en) | 2011-01-04 |
| HUP0200315A2 (en) | 2002-05-29 |
| PT1031346E (pt) | 2002-09-30 |
| AR037312A1 (es) | 2004-11-03 |
| ATE216875T1 (de) | 2002-05-15 |
| ES2173678T3 (es) | 2002-10-16 |
| KR20010112252A (ko) | 2001-12-20 |
| AU2798800A (en) | 2000-08-18 |
| HK1030363A1 (en) | 2003-05-06 |
| EP1031346A1 (en) | 2000-08-30 |
| DK1031346T3 (da) | 2002-08-12 |
| AU778972B2 (en) | 2004-12-23 |
| HU225170B1 (en) | 2006-07-28 |
| DE69901377D1 (de) | 2002-06-06 |
| KR20070094662A (ko) | 2007-09-20 |
| SI1031346T1 (en) | 2002-08-31 |
| CA2360692A1 (en) | 2000-08-03 |
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