AU2018285710B2 - Methods and compositions for treating cancer - Google Patents

Methods and compositions for treating cancer Download PDF

Info

Publication number: AU2018285710B2
Authority: AU; Australia
Prior art keywords: polypeptide; val; elane; leu; gly
Prior art date: 2017-06-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

AU2018285710A

Other languages

English (en)

Other versions

AU2018285710A1 (en

Inventor

Lev BECKER

Chang CUI

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

University of Chicago

Original Assignee

University of Chicago

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2017-06-15

Filing date

2018-06-15

Publication date

2025-02-13

2018-06-15 Application filed by University of Chicago filed Critical University of Chicago

2020-01-23 Publication of AU2018285710A1 publication Critical patent/AU2018285710A1/en

2025-02-13 Application granted granted Critical

2025-02-13 Publication of AU2018285710B2 publication Critical patent/AU2018285710B2/en

Status Active legal-status Critical Current

2038-06-15 Anticipated expiration legal-status Critical

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/26—Endoribonucleases producing 5'-phosphomonoesters (3.1.26)
- C12Y301/26003—Ribonuclease III (3.1.26.3)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21037—Leukocyte elastase (3.4.21.37), i.e. neutrophil-elastase

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Immunology (AREA)
Public Health (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Gastroenterology & Hepatology (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicinal Preparation (AREA)
Enzymes And Modification Thereof (AREA)

AU2018285710A 2017-06-15 2018-06-15 Methods and compositions for treating cancer Active AU2018285710B2 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US201762520325P	2017-06-15	2017-06-15
US62/520,325		2017-06-15
US201762610711P	2017-12-27	2017-12-27
US62/610,711		2017-12-27
PCT/US2018/037800 WO2018232273A1 (en)	2017-06-15	2018-06-15	Methods and compositions for treating cancer

Publications (2)

Publication Number	Publication Date
AU2018285710A1 AU2018285710A1 (en)	2020-01-23
AU2018285710B2 true AU2018285710B2 (en)	2025-02-13

Family

ID=64659547

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU2018285710A Active AU2018285710B2 (en)	2017-06-15	2018-06-15	Methods and compositions for treating cancer

Country Status (9)

Country	Link
US (1)	US20210299234A1 (da)
EP (2)	EP4292606B1 (da)
JP (3)	JP7189160B2 (da)
CN (1)	CN111032075A (da)
AU (1)	AU2018285710B2 (da)
CA (1)	CA3066738A1 (da)
DK (1)	DK3638293T5 (da)
ES (1)	ES2962985T3 (da)
WO (1)	WO2018232273A1 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2019403393A1 (en) *	2018-12-20	2021-08-05	The University Of Chicago	Methods and compositions related to therapeutic peptides for cancer therapy
US20230365958A1 (en) *	2020-08-18	2023-11-16	Onchilles Pharma, Inc.	Modified porcine pancreatic elastase proteins
AU2021329330A1 (en) *	2020-08-18	2023-02-02	Onchilles Pharma, Inc.	Modified serine protease proproteins
CN112812150A (zh) *	2021-01-29	2021-05-18	深圳海创生物科技有限公司	一种活性环肽、活性环肽组合物及其在制备具有抗氧化或抗炎作用的产品中的应用
CN113736742B (zh) *	2021-09-08	2023-07-21	河南省医药科学研究院	Prtn3基因作为肿瘤免疫治疗中激活细胞毒性免疫细胞靶点的应用
CN115040642B (zh) *	2022-06-30	2025-03-28	德博尔(成都)生物科技有限公司	一种胰弹性蛋白酶的新用途
CN118443941A (zh) *	2024-04-29	2024-08-06	山东大学齐鲁医院	中性粒细胞作为诊疗膀胱癌的靶标的应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3941763A (en)	1975-03-28	1976-03-02	American Home Products Corporation	PGlu-D-Met-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 and intermediates
US4235871A (en)	1978-02-24	1980-11-25	Papahadjopoulos Demetrios P	Method of encapsulating biologically active materials in lipid vesicles
US4501728A (en)	1983-01-06	1985-02-26	Technology Unlimited, Inc.	Masking of liposomes from RES recognition
US4837028A (en)	1986-12-24	1989-06-06	Liposome Technology, Inc.	Liposomes with enhanced circulation time
BR9106732A (pt) *	1990-08-03	1993-08-17	Vertex Pharma	Processo catalisado por enzima para preparar um produto selecionado,processos para produzir aspartame,imobilizar uma enzima e imobilizar termolisina,cristais de enzima e de termolisina imobilizadas reticuladas,dispositivos que compreendem as mesmas e biossensor para detectar um analito de interesse em um fluido
US5698518A (en) *	1994-03-30	1997-12-16	Oklahoma Medical Research Foundation	Method for regulating inflammation and tumor growth with calmodulin, calmodulin analogues or calmodulin antagonists
WO2003083084A2 (en) *	2002-03-29	2003-10-09	Incyte Corporation	Protein modification and maintenance molecules
CA2500405A1 (en)	2002-09-30	2004-04-15	Oncotherapy Science, Inc.	Genes and polypeptides relating to human myeloid leukemia
JP4408615B2 (ja)	2002-10-07	2010-02-03	独立行政法人科学技術振興機構	好酸球カチオン性タンパク質を含有する組成物
US8068990B2 (en) *	2003-03-25	2011-11-29	Hologic, Inc.	Diagnosis of intra-uterine infection by proteomic analysis of cervical-vaginal fluids
KR20060031809A (ko) *	2003-06-09	2006-04-13	더 리젠츠 오브 더 유니버시티 오브 미시간	암 치료 및 진단용 조성물 및 방법
EP1649289B1 (en) *	2003-07-21	2008-10-22	Roche Diagnostics GmbH	Use of proteins proteinase 3 (prn3) and leukocyte elastase inhibitor (ileu) as a marker for colorectal cancer
US7432419B2 (en) *	2004-05-14	2008-10-07	Los Alamos National Security, Llc	Compositions and methods for the treatment of Pierce's disease
US20060008891A1 (en) *	2004-06-23	2006-01-12	The Government Of Usa As Repersented By The Secretary, Department Of Health And Human Services	Cathepsin G-related peptides as modulators of formylpeptide receptors (FPR)
US8501449B2 (en) *	2007-12-04	2013-08-06	Proteon Therapeutics, Inc.	Recombinant elastase proteins and methods of manufacturing and use thereof
MX2011000655A (es) *	2008-07-18	2011-03-21	Oragenics Inc	Composiciones para la deteccion y tratamiento de cancer colorrectal.
GB201121070D0 (en)	2011-12-07	2012-01-18	Isis Innovation	composition for delivery of biotherapeutics
WO2016125330A1 (ja) *	2015-02-02	2016-08-11	原　英彰	網膜再生促進薬

2018
- 2018-06-15 US US16/621,549 patent/US20210299234A1/en active Pending
- 2018-06-15 DK DK18817894.1T patent/DK3638293T5/da active
- 2018-06-15 CN CN201880053084.1A patent/CN111032075A/zh active Pending
- 2018-06-15 ES ES18817894T patent/ES2962985T3/es active Active
- 2018-06-15 JP JP2019569454A patent/JP7189160B2/ja active Active
- 2018-06-15 CA CA3066738A patent/CA3066738A1/en active Pending
- 2018-06-15 EP EP23191473.0A patent/EP4292606B1/en active Active
- 2018-06-15 WO PCT/US2018/037800 patent/WO2018232273A1/en not_active Ceased
- 2018-06-15 AU AU2018285710A patent/AU2018285710B2/en active Active
- 2018-06-15 EP EP18817894.1A patent/EP3638293B1/en active Active
2022
- 2022-12-01 JP JP2022192891A patent/JP7529754B2/ja active Active
2024
- 2024-07-25 JP JP2024119305A patent/JP2024150679A/ja active Pending

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
AI-SHENG HO ET AL: "Neutrophil elastase as a diagnostic marker and therapeutic target in colorectal cancers", ONCOTARGET, 30 January 2014, pages 473 - 480, www.ncbi.nlm.nih.gov/pmc/articles/PMC3964222/pdf/oncotarget-05-473.pdf *
PRISCILA OLIVEIRA DE LIMA ET AL: "Effect of eosinophil cationic protein on human oral squamous carcinoma cell viability", MOLECULAR AND CLINICAL ONCOLOGY, vol. 3, no. 2, 16 December 2014 (2014-12-16), GR, pages 353 - 356. *

Also Published As

Publication number	Publication date
JP2020524141A (ja)	2020-08-13
JP7529754B2 (ja)	2024-08-06
JP2023022242A (ja)	2023-02-14
EP3638293B1 (en)	2023-10-04
CN111032075A (zh)	2020-04-17
EP4292606B1 (en)	2025-11-12
CA3066738A1 (en)	2018-12-20
US20210299234A1 (en)	2021-09-30
ES2962985T3 (es)	2024-03-22
DK3638293T5 (da)	2024-08-26
WO2018232273A1 (en)	2018-12-20
EP4292606A3 (en)	2024-02-21
EP4292606A2 (en)	2023-12-20
JP7189160B2 (ja)	2022-12-13
EP3638293A1 (en)	2020-04-22
AU2018285710A1 (en)	2020-01-23
JP2024150679A (ja)	2024-10-23
EP3638293A4 (en)	2021-03-10
DK3638293T3 (da)	2023-11-06

Publication	Publication Date	Title
AU2018285710B2 (en)	2025-02-13	Methods and compositions for treating cancer
KR101720562B1 (ko)	2017-03-30	Ｍａｓｐ-2 의존적 보체 활성화와 관련된 질병을 치료하는 방법
EP2234642B1 (en)	2017-09-27	Method of increasing immunological effect
US20230201305A9 (en)	2023-06-29	Immune checkpoint inhibitor combinations
WO2019213686A1 (en)	2019-11-14	Therapeutic compositions and uses therefor
JP6793748B2 (ja)	2020-12-02	放射性および化学的損傷を予防及び治療するための方法
EP2833900B1 (en)	2018-09-19	Extracellular matrix metalloproteinase inducer (emmprin) peptides and binding antibodies
US20220000977A1 (en)	2022-01-06	Methods and compositions related to therapeutic peptides for cancer therapy
HK40102823A (en)	2024-06-14	Compositions for treating cancer
HK40029045A (en)	2021-02-11	Compositions for treating cancer
HK40029045B (en)	2024-05-17	Compositions for treating cancer
Orsolic	2013	Possible molecular targets of bee venom in the treatment of cancer: application and perspectives
JP2011500580A (ja)	2011-01-06	急性ヒト骨髄性白血病細胞を死滅させるトロンボポエチン受容体作用薬（ＴｐｏＲＡ）
US20150353912A1 (en)	2015-12-10	Methods for treating and preventing radiation injury using activated protein c polypeptides
EP3773690A1 (en)	2021-02-17	New vaccinal strategy
WO2017042318A1 (en)	2017-03-16	Chemerin polypeptide for the treatment of cancer-induced cachexia
US20150258194A1 (en)	2015-09-17	Modulating transendothelial migration and recruitment of granulocytes by modulating c-met pathway
Wagner	2018	Investigation of a Novel Small Molecule TRAIL Inducer, ONC201: Pre-clinical Anti-cancer Efficacy, Anti-metastasis Effects, Tumor Immunity; and the Structure-activity Relationships (SAR) and Mechanism of Action of Potential Analogues
HK1150303A (en)	2011-11-25	Method of increasing immunological effect

Legal Events

Date	Code	Title	Description
2025-06-12	FGA	Letters patent sealed or granted (standard patent)