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AU2015301390B2 - Methods and materials for assessing homologous recombination deficiency - Google Patents

Methods and materials for assessing homologous recombination deficiency Download PDF

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Publication number
AU2015301390B2
AU2015301390B2 AU2015301390A AU2015301390A AU2015301390B2 AU 2015301390 B2 AU2015301390 B2 AU 2015301390B2 AU 2015301390 A AU2015301390 A AU 2015301390A AU 2015301390 A AU2015301390 A AU 2015301390A AU 2015301390 B2 AU2015301390 B2 AU 2015301390B2
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AU2015301390A1 (en
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Victor Abkevich
Alexander Gutin
Julia Reid
Kirsten Timms
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Myriad Genetics Inc
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Assigned to MYRIAD GENETICS, INC. reassignment MYRIAD GENETICS, INC. Request for Assignment Assignors: ABKEVICH, VICTOR, GUTIN, ALEXANDER, MYRIAD GENETICS, INC., REID, JULIA, TIMMS, KIRSTEN
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
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AU2015301390A 2014-08-15 2015-08-17 Methods and materials for assessing homologous recombination deficiency Active AU2015301390B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2021273600A AU2021273600B2 (en) 2014-08-15 2021-11-25 Methods and materials for assessing homologous recombination deficiency

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462037764P 2014-08-15 2014-08-15
US62/037,764 2014-08-15
US201414507412A 2014-10-06 2014-10-06
US14/507,412 2014-10-06
PCT/US2015/045561 WO2016025958A1 (en) 2014-08-15 2015-08-17 Methods and materials for assessing homologous recombination deficiency

Related Child Applications (1)

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AU2021273600A Division AU2021273600B2 (en) 2014-08-15 2021-11-25 Methods and materials for assessing homologous recombination deficiency

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AU2015301390A1 AU2015301390A1 (en) 2017-02-02
AU2015301390B2 true AU2015301390B2 (en) 2021-08-26

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AU2015301390A Active AU2015301390B2 (en) 2014-08-15 2015-08-17 Methods and materials for assessing homologous recombination deficiency
AU2021273600A Active AU2021273600B2 (en) 2014-08-15 2021-11-25 Methods and materials for assessing homologous recombination deficiency

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US (4) US10400287B2 (es)
EP (4) EP4234711B1 (es)
JP (4) JP6877334B2 (es)
AU (2) AU2015301390B2 (es)
CA (1) CA2958801A1 (es)
DK (3) DK4234711T3 (es)
ES (3) ES3039109T3 (es)
PT (1) PT3180447T (es)
WO (1) WO2016025958A1 (es)

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CN112397145A (zh) * 2020-11-19 2021-02-23 河南省肿瘤医院 一种基于芯片检测的hrd评分计算方法
WO2022150063A1 (en) * 2021-01-10 2022-07-14 Act Genomics (Ip) Co., Ltd. Homologous recombination deficiency determining method and kit thereof
EP4274908A1 (en) * 2021-01-10 2023-11-15 Act Genomics (IP) Limited Homologous recombination deficiency determining method and kit thereof
CN112820351A (zh) * 2021-03-01 2021-05-18 江苏医联生物科技有限公司 检测肿瘤患者的突变和hrd评分指导用药的方法
CN112980834B (zh) * 2021-04-22 2021-08-17 菁良基因科技(深圳)有限公司 一种同源重组修复缺陷参考品及其制备方法和试剂盒
CN113948151B (zh) * 2021-06-28 2022-07-05 北京橡鑫生物科技有限公司 一种低深度wgs下机数据的处理方法
CN113658638B (zh) * 2021-08-20 2022-06-03 江苏先声医学诊断有限公司 一种基于ngs平台的同源重组缺陷的检测方法和质控体系
CN113462784B (zh) * 2021-08-31 2021-12-10 迈杰转化医学研究(苏州)有限公司 一种构建用于同源重组修复缺陷检测的靶标集合的方法
JP2025503390A (ja) * 2021-12-08 2025-02-04 ミリアド ジェネティクス，インコーポレーテッド 乳がんサブタイプにおける相同組換え欠損を評価するための方法及び材料
CN114242170B (zh) * 2021-12-21 2023-05-09 深圳吉因加医学检验实验室 一种同源重组修复缺陷的评估方法、装置和存储介质
CN114283889B (zh) * 2021-12-27 2024-12-10 深圳吉因加医学检验实验室 一种矫正同源重组修复缺陷评分的方法及装置
KR102523938B1 (ko) * 2022-02-04 2023-04-19 가톨릭대학교 산학협력단 상동 재조합 결핍증 예측 모델의 모델링 방법
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